Journal
HUMAN & EXPERIMENTAL TOXICOLOGY
Volume 30, Issue 9, Pages 1313-1321Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0960327110389499
Keywords
Obesity; high-fat diet; insulin; leptin; caspase; antioxidant enzymes
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Funding
- University Grants Commission, New Delhi, India
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The consumption of a high-fat diet (HFD) is considered a risk factor for obesity development. Nonetheless, a causal role of dietary fat has never been documented, because of inadequate animal models. In our study, one group of rats was fed with standard rat diet, while other group of rats fed with high-fat diet for 4 weeks. After 4 weeks of feeding, the hemodynamic parameters in the rats fed with HFD were significantly increased as compared with control rats. Rats fed with HFD had elevated levels of serum lipids, insulin, leptin, glucose and apolipoprotein B. Lipid peroxides and caspase-3 levels were increased while serum apolipoprotein A1 and antioxidant enzymes levels in heart tissues were decreased in HFD-induced obesity in rats as compared to normal healthy control rats fed on standard rat pellet diet. This model of diet-induced obesity will be a useful tool for studying the mechanisms by which dietary fat induces the obesity in humans.
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