Review
Biochemistry & Molecular Biology
Hiroki Kitakata, Jin Endo, Hidehiko Ikura, Hidenori Moriyama, Kohsuke Shirakawa, Yoshinori Katsumata, Motoaki Sano
Summary: This review discusses the molecular mechanisms of DOX-induced cardiotoxicity, focusing on apoptosis and ferroptosis as the two forms of programmed cell death. Possible therapeutic strategies to prevent DOX cardiotoxicity are also outlined, along with the significance of mitochondrial homeostasis disruption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Michael A. Bauer, Valentina K. Todorova, Annjanette Stone, Weleetka Carter, Matthew D. Plotkin, Ping-Ching Hsu, Jeanne Y. Wei, Joseph L. Su, Issam Makhoul
Summary: This study investigated the DNA methylation state of peripheral blood mononuclear cells (PBMCs) as a potential predictor of cardiotoxicity in breast cancer patients receiving doxorubicin (DOX)-based chemotherapy. Significant differences in DNA methylation patterns of PBMCs were associated with the risk of cardiotoxicity, suggesting a potential for personalized medicine to tailor treatment and reduce heart toxicity. Further studies are needed to confirm these preliminary findings and assess the utility of PBMC DNA methylation profiles in predicting DOX-induced cardiotoxicity.
Article
Pharmacology & Pharmacy
Thawatchai Khuanjing, Benjamin Ongnok, Chayodom Maneechote, Natthaphat Siri-Angkul, Nanthip Prathumsap, Apiwan Arinno, Titikorn Chunchai, Busarin Arunsak, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: The study showed that donepezil can alleviate doxorubicin-induced cardiotoxicity, reduce cardiac damage, and improve cardiac function.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Ekaterina Yu Podyacheva, Ekaterina A. Kushnareva, Andrei A. Karpov, Yana G. Toropova
Summary: Currently, there is an expansion in the pharmacological possibilities of treating cancer, leading to an increase in life expectancy with chemotherapy and supportive treatment. However, complications such as anthracycline-induced cardiomyopathy are a significant concern, requiring further research to understand its development mechanisms through new models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Xiao-yi Du, Dao-chun Xiang, Ping Gao, Hua Peng, Ya-li Liu
Summary: PRR inhibition can weaken the RAC1-NOX4 pathway and alleviate DOX-induced heart failure by reducing ROS production.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Ye Chen, Saixian Shi, Yan Dai
Summary: Doxorubicin (DOX) is an effective chemotherapy agent for treating malignant tumors, but its use is limited due to dose-dependent cardiotoxicity. This study evaluates the effects of various drugs on DOX-induced cardiomyopathy, providing insights for future clinical treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Mohamed Essam, Nashwa Barakat, Ahmed Elkashef, Amira Awadalla, A. E. Behery, Mahmoud Abdel-Maboud
Summary: The study showed that aliskiren significantly improved renal function, reduced necrosis and inflammatory cell infiltration in the cortex and medulla during acute and chronic partial ureteral obstruction in rat solitary kidney. Aliskiren also upregulated BCL-2 and downregulated IL-6, TGF-beta 1, collagen I, and fibronectin gene expression, while increasing GSH and SOD activity and reducing MDA and NO activity, leading to a more renoprotective effect when administered for four weeks compared to two weeks.
Article
Pharmacology & Pharmacy
Xiaoyu Fu, Mathew Eggert, Sieun Yoo, Nikhil Patel, Juming Zhong, Ian Steinke, Manoj Govindarajulu, Emine Akyuz Turumtay, Shravanthi Mouli, Peter Panizzi, Ronald Beyers, Thomas Denney, Robert Arnold, Rajesh H. Amin
Summary: Doxorubicin (DOX) is a cancer chemotherapeutic agent with cardiotoxicity issues, while PAESe has shown effectiveness in mitigating DOX-induced cardiac hypertrophy through its antioxidative properties. The study found that DOX affects mitochondrial function and iron-sulfur cluster biogenesis, whereas PAESe protects against these effects and enhances cellular respiration.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mingxiang Zhu, Yibing Chen, Liting Cheng, Xin Li, Yanying Shen, Ge Guo, Xiang Xu, Hanlu Li, Hao Yang, Chunlei Liu, Kunlun He
Summary: Our findings demonstrated that CLSTN1 promotes the pathogenesis of doxorubicin-induced DCM. CLSTN1 could be a therapeutic target to prevent the development of doxorubicin-induced DCM.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Oncology
Pooja P. P. Advani, Kathryn J. J. Ruddy, Joerg Herrmann, Jordan C. C. Ray, Emily C. C. Craver, Greg Yothers, Reena S. S. Cecchini, Corey Lipchik, Huichen C. Feng, Priya Rastogi, Eleftherios P. P. Mamounas, Sandra M. M. Swain, Charles E. E. Geyer, Norman Wolmark, Soonmyung Paik, Katherine L. L. Pogue-Geile, Gerardo Colon-Otero, Edith A. A. Perez, Nadine Norton
Summary: This study conducted genetic testing on breast cancer patients and found that TRPC6 rs77679196 and CBR3 rs1056892 are associated with congestive heart failure. However, other genetic variations previously linked to decline in left ventricular ejection fraction showed inconsistent results between different studies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Neurosciences
Sami Alzarea, Hassan H. Alhassan, Abdulaziz Alzarea, Ziad H. Al-Oanzi, Muhammad Afzal
Summary: The study aims to determine the impact of renin inhibitor Aliskiren on lipopolysaccharide-induced depressive-like behavior and neuroinflammation in mice. The results demonstrate that Aliskiren can mitigate the negative effects of lipopolysaccharide on mouse behavior and brain inflammation.
Article
Biochemistry & Molecular Biology
Hoda E. E. Mohamed, Mervat E. E. Askar, Mohamed A. A. Shaheen, Alaa E. E. Salama, Reham A. A. Idris, Nahla N. N. Younis
Summary: The release of TNF-alpha is increased in plasma and myocardium of heart failure patients, and plays an important role in the pathogenesis of cardiomyopathy. In this study, the role of TNF-alpha inhibitor (infliximab; IFX) in regulating dilated cardiomyopathy (DCM) induced in rats was investigated. Treatment with RPL and/or IFX suppressed TNF-alpha and consequently improved cardiac function, hypertrophy, and inflammation in DCM rats. Combined RPL and IFX treatment showed the best therapeutic efficacy.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Gang She, Jin-Chan Du, Wei Wu, Tian-Tian Pu, Yu Zhang, Ru-Yue Bai, Yi Zhang, Zheng-Da Pang, Hui -Fang Wang, Yu-Jie Ren, Junichi Sadoshima, Xiu-Ling Deng, Xiao-Jun Du
Summary: Chemotherapy is commonly used for cancer treatment, but it can cause cardiomyopathy, which puts cancer patients at risk of another life-threatening condition. The Hippo pathway plays important roles in cancerogenesis and heart disease, but its involvement in chemotherapy-induced cardiomyopathy is not fully understood.
Review
Medicine, General & Internal
Nadine Norton, Raegan M. Weil, Pooja P. Advani
Summary: Anthracyclines, widely used in oncology, have a significant side effect of cardiotoxicity, but progress is being made in predicting high-risk individuals and developing individualized cardioprotective plans through methodology and pharmacogenetic studies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Nonhlakanipho F. Sangweni, Kwazi Gabuza, Ruzayda van Aarde, Lawrence Mabasa, Derick van Vuuren, Barbara Huisamen, Reenen Barry, Rabia Johnson
Summary: In this study, the protective effects of 7-hydroxyflavanone (7H), a flavonoid with antioxidative properties, against doxorubicin-induced cardiotoxicity (DIC) were investigated in an in vitro model. The results showed that 7H co-treatment alleviated oxidative stress, improved mitochondrial function, and attenuated apoptosis and necrosis. These findings suggest that 7H could be a potential cardioprotective agent against DIC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Instruments & Instrumentation
Tinku, Mohd. Mujeeb, Abdul Ahad, Mohd. Aqil, Waseem Ahmad Siddiqui, Abul Kalam Najmi, Mymoona Akhtar, Apeksha Shrivastava, Abdul Qadir, Thasleem Moolakkadath
Summary: This study successfully optimized rubiadin-loaded niosomes using Box-Behnken design for the management of diabetic nephropathy in Wistar rats. The optimized formulation showed significant anti-diabetic activity and improvement in biochemical parameters in Wistar rats. The findings suggest that the prepared RLN formulation has potential for the management of STZ-NA-induced DN.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Sana Khan, Soumya Pati, Shailja Singh, Mohd. Akhtar, Piush Khare, Saba Khan, Sadat Shafi, Abul Kalam Najmi
Summary: This study aims to understand the role of hypercoagulation in triggering the progression of neurodegeneration in MetS. It also offers a few interventions to prevent the progression of AD in MetS targeting hypercoagulation.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Neurosciences
Noorul Hasan, Saima Zameer, Abul Kalam Najmi, Suhel Parvez, Mohd Akhtar
Summary: This study investigated the therapeutic potential of the PDE-4 inhibitor roflumilast in Alzheimer's disease. The results showed that roflumilast improved learning and memory capacities in rats, reduced neuroinflammation and amyloid deposition, and activated the cAMP/BDNF signaling pathway.
NEUROTOXICITY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Juheb Akhter, Jasim Khan, Madhu Baghel, Mirza Masroor Ali Beg, Poonam Goswami, Mohd Amir Afjal, Shahzad Ahmad, Haroon Habib, Abul Kalam Najmi, Sheikh Raisuddin
Summary: This study investigated the therapeutic effects of rosmarinic acid (RA) against inflammation-induced acute kidney injury (AKI) and found that RA can effectively prevent cisplatin-induced AKI by inhibiting the activation of the NLRP3 signaling pathway and other related signal molecules.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Manel Dhahri, Mawadda Alghrably, Hamdoon A. Mohammed, Syed Lal Badshah, Noreen Noreen, Fouzi Mouffouk, Saleh Rayyan, Kamal A. Qureshi, Danish Mahmood, Joanna Izabela Lachowicz, Mariusz Jaremko, Abdul-Hamid Emwas
Summary: Neurodegenerative diseases pose a significant public health burden globally, particularly among aging populations. Despite advances in understanding the underlying mechanisms, effective therapeutic strategies are lacking. Natural polysaccharides have shown neuroprotective and therapeutic effects, making them a potential avenue for prevention and treatment of neurodegenerative diseases.
Article
Pharmacology & Pharmacy
Asad Ali, Mohd Aqil, Syed Sarim Imam, Abdul Ahad, Arshiya Parveen, Abdul Qadir, Mohd Humair Ali, Mohd Akhtar
Summary: The study aimed to prepare and optimize Embelin-loaded liposomes, resulting in the promising formulation EMB-NLop with enhanced antioxidant activity and permeation. Experimental data indicated that EMB-NLop is a promising and effective formulation for intranasal delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Plant Sciences
Amir Mahgoub Awadelkareem, Eyad Al-Shammari, AbdElmoneim O. Elkhalifa, Mohd Adnan, Arif Jamal Siddiqui, Danish Mahmood, Z. R. Azaz Ahmad Azad, Mitesh Patel, Khalid Mehmood, Corina Danciu, Syed Amir Ashraf
Summary: This study investigated the effect of Eruca sativa Miller crude extract on biofilms of food-borne bacteria and found that it exhibited strong antibacterial activity and reduced the viability of bacterial cells within biofilms. The crude extract also interacted with adhesion proteins, suggesting a possible mechanistic approach for inhibiting biofilms.
Article
Chemistry, Medicinal
Kashif Haider, Kamal Ahmad, Abul Kalam Najmi, Subham Das, Alex Joseph, M. Shahar Yar
Summary: A series of 2-aminobenzothiazole derivatives were synthesized and evaluated for their anticancer activity. Compound 8i showed the most potent inhibitory activity and high selectivity against PI3K alpha, inducing apoptosis in a dose-dependent manner.
ARCHIV DER PHARMAZIE
(2022)
Article
Chemistry, Medicinal
Kashif Haider, Shivani Sharma, Yuba Raj Pokharel, Subham Das, Alex Joseph, Abul Kalam Najmi, Faiz Ahmad, Mohammad Shahar Yar
Summary: This report presents a new series of indole-tethered pyrazoline derivatives as potent anticancer agents. The compounds showed strong cytotoxicity against A431, HeLa, and MDAMB-231 cell lines. In addition, they exhibited inhibitory effects on colony formation, migration, and cell cycle arrest. The compounds also demonstrated potential as topoisomerase inhibitors and were found to be safe in vivo.
DRUG DEVELOPMENT RESEARCH
(2022)
Review
Immunology
Syed Sufian Ahmad, Faraha Ahmed, Ruhi Ali, Mohammed M. Ghoneim, Sultan Alshehri, Abul Kalam Najmi, Sayeed Ahmad, Mohammad Zaki Ahmad, Javed Ahmad, Mohammad Ahmed Khan
Summary: Osteoporosis, characterized by low bone mass and deteriorated bone microarchitecture, is a major cause of fractures and morbidity worldwide. Recent studies have identified the role of the immune system in the skeletal system, leading to the emergence of osteoimmunology. Immune dysregulation can cause inflammation and adversely affect bone integrity. T-lymphocyte subsets (Th17) play a significant role in the pathogenesis of osteoporosis. Therefore, studying osteoimmunology is important for understanding osteoporosis and developing immunotherapy strategies.
Review
Chemistry, Medicinal
Farazul Hoda, Afifa Khanam, Mehak Thareja, Mawrah Arshad, Mohd Ahtar, Abul Kalam Najmi
Summary: This systematic review summarizes the effects of Nigella sativa in the management of Type 2 Diabetes Mellitus (T2DM). The available evidence suggests that Nigella sativa can significantly improve glucose and insulin levels in patients with T2DM, and has a positive impact on the treatment outcomes of T2DM and its complications.
Article
Biochemistry & Molecular Biology
Sonal Gupta, Monika Saini, Nishant Joshi, Sadat Shafi, Abul Kalam Najmi, Shailja Singh
Summary: This study investigated the localization and druggability of serpentine receptors in Plasmodium, and demonstrated the strong binding interaction between PfSR12 and R138727. The findings suggest the importance of purinergic signaling and PfSR12 in the survival and development of the malaria parasite, and indicate that Prasugrel may serve as a potential antimalarial therapy targeting PfSR12.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Shaista Amin, Khursheed A. Sheikh, Ashif Iqubal, Mohammad Ahmed Khan, M. Shaquiquzzaman, Sharba Tasneem, Suruchi Khanna, A. K. Najmi, Mymoona Akhter, Anzarul Haque, Tarique Anwer, M. Mumtaz Alam
Summary: Despite advancements in Diabetes mellitus management, designing and synthesizing drug molecules that effectively improve hyperglycemia and associated complications in diabetic patients remains challenging. In this study, pyrimidine-thiazolidinedione derivatives were synthesized, characterized, and evaluated for their anti-diabetic properties. The synthesized compounds were analyzed using various techniques, including NMR, FTIR, and Mass Spectrometry. In-silico ADME studies confirmed the compounds met Lipinski's rule of five. In-vivo evaluation in diabetic rats showed that compounds 6e and 6m significantly reduced blood glucose levels without causing weight gain. Biochemical and histopathological analyses further supported the anti-diabetic effects of these compounds. Based on these findings, pyrimidine-based thiazolidinedione derivatives could be considered as novel anti-diabetic agents with minimal side effects.
BIOORGANIC CHEMISTRY
(2023)
Review
Oncology
Preeti Sharma, Mohammad Ahmed Khan, Abul Kalam Najmi, Shubhra Chaturvedi, Mohd Akhtar
Summary: Breast cancer is a major cause of malignant death in females, and triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis. Myricetin (MYR), a naturally occurring compound, has been found to have anti-cancer effects in various cancers, including TNBC. It regulates multiple signaling pathways to inhibit cell proliferation and invasion and promote cell apoptosis. The PI3K/AKT/mTOR pathway is identified as a potential therapeutic target for MYR in TNBC treatment.
