Review
Endocrinology & Metabolism
Fuqiong Chen, Qinqin Xu, Wenzhu Yue, Xuefeng Yu, Shiying Shao
Summary: This is a case report of hyperparathyroidism caused by MEN1 gene mutation. The patient was diagnosed with a mutation in the MEN1 gene through genetic analysis. The patient's condition improved after undergoing parathyroidectomy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Gurjeet Kaur, Sanjay Kumar Bhadada, Mithun Santra, Rimesh Pal, Phulen Sarma, Naresh Sachdeva, Vandana Dhiman, Divya Dahiya, Uma Nahar Saikia, Anuradha Chakraborty, Ashwani Sood, Mahesh Prakash, Arunanshu Behera, Sudhaker D. Rao
Summary: This study investigates the role of MEN1 mutations in sporadic PHPT in Indian patients and identifies certain MEN1 variants associated with disease recurrence and the detection of other endocrine tumors. The findings suggest that early screening for MEN1-related tumors and disease recurrence can be prompted by detecting MEN1 variations, especially those with disease-specific potential.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Natalia G. Mokrysheva, Anna K. Eremkina, Alina R. Elfimova, Elena V. Kovaleva, Anastasiia P. Miliutina, Ekaterina E. Bibik, Anna M. Gorbacheva, Ekaterina A. Dobreva, Irina S. Maganeva, Julia A. Krupinova, Rustam H. Salimkhanov, Lizaveta A. Aboishava, Elena V. Karaseva, Galina A. Melnichenko, Ivan I. Dedov
Summary: The aim of this study was to estimate the clinical and biochemical profile, complications, surgical intervention, and medical therapy of patients with primary hyperparathyroidism (PHPT) in the Russian Federation. The results showed that the detection rate of PHPT has increased in recent years, but most patients still had significant alterations in phosphorus-calcium metabolism, indicating delayed diagnosis and the need for further improvement in medical care.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Arslan Y. Pannu, Magdalena R. O'Connor-Manson, Lynda Wyld, Saba P. Balasubramanian
Summary: NIRAF showed potential benefits in aiding parathyroid identification during surgery for primary hyperparathyroidism, however, it did not improve cure rates compared to traditional methods. Further studies on larger patient cohorts and fluorescence patterns are needed to explore the full potential of NIRAF in surgical settings.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Isabel Mazarico-Altisent, Ismael Capel, Neus Baena, Maria Rosa Bella-Cueto, Santi Barcons, Xavier Guirao, Rocio Pareja, Andreea Muntean, Valeria Arsentales, Assumpta Caixas, Mercedes Rigla
Summary: Genetic screening in a Mediterranean cohort of suspected familial hyperparathyroidism revealed a high prevalence of germline variants, leading to early diagnosis and treatment for patients and early intervention in their relatives. It is recommended to conduct genetic testing for patients with primary hyperparathyroidism who present high-risk features.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Zhenping Han, Tingting Li, Siyi Wang, Li Gao, Ying Hu, Yu Zhao, Jieping Yan
Summary: This case report describes a 52-year-old male patient diagnosed with multiple endocrine neoplasia type 1 (MEN1) through gastrinoma, parathyroid adenoma and gene detection. The patient had relapsed primary hyperparathyroidism (PHPT) and received ultrasound-guided radiofrequency ablation (RFA) as a treatment. The patient showed remarkable recovery after RFA for the relapsed PHPT. RFA may be considered as an alternative treatment for MEN1 patients with high surgical risk or those unwilling or unable to undergo surgery.
Review
Endocrinology & Metabolism
I. Pliakos, A. Chorti, Moysis Moysidis, G. Kotsovolis, T. Kaltsas, A. Pana, A. Ioannidis, TS. Papavramidis
Summary: Parathyroid adenoma in pregnancy is a rare condition, and early diagnosis is crucial for surgical treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lukasz Obolonczyk, Izabela Karwacka, Piotr Wisniewski, Krzysztof Sworczak, Tomasz Oseka
Summary: This study presents the experience with 143 cases of P-FNAB with iPTH-WC assessment and compares it with other imaging techniques. The results show that P-FNAB with iPTH-WC is a highly sensitive method for localizing parathyroid adenoma during PHPT, surpassing the sensitivity of Tc99-MIBI. Furthermore, P-FNAB has mild complications and can be considered a safe procedure.
Article
Endocrinology & Metabolism
Rachel Chava Rosenblum, Orit Twito, Liat Barzilay-Yoseph, Erez Ramaty, Noa Klein, Pnina Rotman-Pikielny
Summary: This study evaluated the efficacy and safety of pamidronate for moderate-to-severe parathyroid hormone-related hypercalcemia (PTHRH) and found that pamidronate is effective and safe for treating PTHRH, with close laboratory monitoring of calcium and phosphorus metabolism recommended. Larger prospective studies are needed to further establish the role of pamidronate and other potent bisphosphonates in moderate-to-severe PTHRH.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul M. Bunch, Christopher J. Nguyen, Erik D. Johansson, Reese W. Randle
Summary: This study aimed to assess the importance of routine CT in the diagnosis of primary hyperparathyroidism. The results showed that enlarged parathyroid glands were frequently visible on CT images, which corresponded to pathologically proven parathyroid lesions. Almost half of the patients developed hyperparathyroidism-related comorbidities between CT and subsequent biochemical screening.
ACADEMIC RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Anna Zenno, Bhavishya Ramamoorthy, Dima A. Hammoud, Martha Quezado, Martha A. Zeiger, Smita Jha
Summary: We present a case of a 9-year-old girl with symptomatic hypercalcemia from primary hyperparathyroidism (PHPT). The patient had persistent hyperparathyroidism after initial surgical intervention, but a successful redo parathyroidectomy cured her condition. We also review common locations for ectopic parathyroid adenomas.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Surgery
Bruno Miguel Fernandes, Tiago Pimenta, Lucia Costa, Miguel Bernardes
Summary: We report a rare case of a 39-year-old woman with ankylosing spondylitis who was simultaneously diagnosed with primary hyperparathyroidism and familial hypocalciuric hypercalcemia. This study highlights the importance of considering familial hypocalciuric hypercalcemia as a possible diagnosis, even in patients with an established diagnosis of primary hyperparathyroidism.
INDIAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Corbin Frye, Sai Anusha Sanka, Janessa Sullivan, Michael Brunt, William E. Gillanders, T. K. Pandian, Taylor C. Brown
Summary: The aim of this study was to identify preoperative predictors of single-gland primary hyperparathyroidism (SG-PHPT). The study found that lower phosphate levels were associated with SG-PHPT, while normal phosphate levels were associated with multigland PHPT (MG-PHPT). Additionally, elevated parathyroid hormone and positive imaging were confirmed as predictors of SG-PHPT.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Surgery
Thomas Szabo Yamashita, Maxwell Mirande, Chieh-Ting Huang, Ann Kearns, Ria Fyffe-Freil, Ravinder Singh, Trenton Foster, Geoffrey Thompson, Melanie Lyden, Travis McKenzie, Robert A. Wermers, Benzon Dy
Summary: This study evaluated the persistence and recurrence of hypercalcemia in patients with primary hyperparathyroidism after parathyroidectomy. The results showed that the recurrence rate of hypercalcemia after successful treatment is higher than previously reported. Most cases are transient and often associated with other factors, with only a minority of patients requiring treatment. Long-term follow-up of serum calcium should be considered in patients after successful parathyroidectomy.
Article
Oncology
Magnus Holm, Peter Vestergaard, Morten Moller Poulsen, Ase Krogh Rasmussen, Ulla Feldt-Rasmussen, Mette Bay, Lars Rolighed, Stefano Londero, Henrik Baymler Pedersen, Christoffer Holst Hahn, Klara Bay Rask, Heidi Hvid Nielsen, Mette Gaustadnes, Maria Caroline Rossing, Anne Pernille Hermann, Christian Godballe, Jes Sloth Mathiesen
Summary: Studies of primary hyperparathyroidism (PHPT) in multiple endocrine neoplasia type 2A (MEN 2A) have shown varying frequencies, definitions, and clinical characteristics. This nationwide population-based retrospective study provides a representative frequency and strict definition of PHPT in MEN 2A. The findings reveal a lower frequency and later onset of PHPT than previously reported, suggesting a milder course of the disease.
Article
Endocrinology & Metabolism
Antonio J. Amor, Irene Vinagre, Maite Valverde, Xavier Urquizu, Eva Meler, Eva Lopez, Carmen Quiros, Marga Gimenez, Laura Codina, Ignacio Conget, Maria J. Barahona, Veronica Perea
Summary: The study found that the persistence of lipoprotein abnormalities in type 1 diabetes and/or pre-eclampsia may be associated with cardiovascular disease, and the impact of lipid abnormalities on the risk of atherosclerosis differs among different groups.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Endocrinology & Metabolism
Antonio J. Amor, Irene Vinagre, Maite Valverde, Xavier Urquizu, Eva Meler, Eva Lopez, Nuria Alonso, Adriana Pane, Marga Gimenez, Laura Codina, Ignacio Conget, Maria J. Barahona, Veronica Perea
Summary: This study evaluated the role of plasma metabolomics in atherosclerosis based on the presence of type 1 diabetes (T1D) or previous preeclampsia in 105 women. The results showed significant differences in lipidic-, energetic- and nitrogen-related metabolites according to the presence of T1D/preeclampsia, with lipidomic-related metabolites being associated with atherosclerosis in the whole sample. Stronger associations were observed in women with previous preeclampsia for certain metabolites.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Cardiac & Cardiovascular Systems
Antonio J. Amor, Irene Vinagre, Maite Valverde, Nuria Alonso, Xavier Urquizu, Eva Meler, Eva Lopez, Marga Gimenez, Laura Codina, Ignacio Conget, Maria J. Barahona, Veronica Perea
Summary: The study found that high H-1-NMR-glycoprotein concentrations have a negative impact on carotid atherosclerosis in women with preeclampsia, regardless of their type 1 diabetes status. White blood cells and hsCRP were not related to atherosclerosis.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Genetics & Heredity
Juan Luque, Ingrid Mendes, Beatriz Gomez, Beatriz Morte, Miguel Lopez de Heredia, Enrique Herreras, Virginia Corrochano, Juan Bueren, Pia Gallano, Rafael Artuch, Cristina Fillat, Luis A. Perez-Jurado, Lluis Montoliu, Angel Carracedo, Jose M. Millan, Susan M. Webb, Francesc Palau, Pablo Lapunzina
Summary: CIBERER, a thematic area of CIBER, focuses on rare disease research. It aims to facilitate collaboration between biomedical and clinical research groups and provide new tools for the diagnosis and therapy of low-prevalence diseases.
Correction
Cardiac & Cardiovascular Systems
Antonio J. Amor, Irene Vinagre, Maite Valverde, Nuria Alonso-Carril, Xavier Urquizu, Eva Meler, Eva Lopez, Marga Gimenez, Laura Codina, Ignacio Conget, Maria J. Barahona, Veronica Perea
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Medicine, General & Internal
Andreu Simo-Servat, Montse Ibarra, Mireia Libran, Silvia Rodriguez, Veronica Perea, Carmen Quiros, Aida Orois, Noelia Perez, Rafael Simo, Maria-Jose Barahona
Summary: This study found that measuring thigh muscle thickness (TMT) using musculoskeletal ultrasound (MUS) can be a simple and feasible method to identify sarcopenic obesity (SO). The TMT value can predict skeletal muscle index (SMI) evaluated by bioelectrical impedance analysis (BIA), with a cutoff point of 1.57 cm.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Aida Orois, Eva Lopez-Quesada, Gloria Jalencas, Maria-Jose Barahona, Veronica Perea
Summary: The effectiveness of universal screening for thyroid disease in pregnancy remains controversial.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Endocrinology & Metabolism
Veronica Perea, Andreu Simo-Servat, Carmen Quiros, Nuria Alonso-Carril, Maite Valverde, Xavier Urquizu, Antonio J. Amor, Eva Lopez, Maria-Jose Barahona
Summary: This study found that pregestational obesity is associated with a higher risk of ADHD in offspring of GDM pregnancies. However, excessive weight gain during pregnancy does not have an independent effect on ADHD risk. Only the joint association of obesity and excessive weight gain during pregnancy remains significant in relation to ADHD risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Veronica Perea, Xavier Urquizu, Maite Valverde, Marina Macias, Anna Carmona, Esther Esteve, Gemma Escribano, Nuria Pons, Oriol Gimenez, Teresa Girones, Andreu Simo-Servat, Andrea Domenech, Nuria Alonso-Carril, Carme Quiros, Antonio J. Amor, Eva Lopez, Maria Jose Barahona
Summary: This study suggests that maternal diabetes increases the risk of offspring developing attention-deficit/hyperactivity disorder (ADHD) in the postnatal period, while maternal type 2 diabetes mellitus (T2DM) after childbirth is not related to the development of ADHD.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Endocrinology & Metabolism
Carmen Quiroes, Nuria Alonso-Carril, Silvia Rodriguez-Rodriguez, Maria-Jose Barahona, Aida Orois, Andreu Simoe-Servat, Montserrat Ramos, Veronica Perea
Summary: Improvements in continuous glucose monitoring have revolutionized the treatment of type 1 diabetes, and the Medtronic 780G system has been shown to achieve and maintain good glycemic control over a 6-month period in real-life conditions.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2023)
Article
Surgery
A. Simo-Servat, M. Ibarra, M. Libran, C. Quiros, N. Puertolas, N. Alonso, V. Perea, R. Simo, M. J. Barahona
Summary: The study evaluates the usefulness of musculoskeletal ultrasound (MUS) and bioelectrical impedance (BIA) in assessing body composition and quality of life (QoL) in patients undergoing bariatric surgery (BS). The results indicate that MUS can complement BIA for evaluating and following up on body composition after BS. Quadriceps muscle thickness provides relevant information on regional sarcopenia and correlates significantly with QoL.
Meeting Abstract
Endocrinology & Metabolism
C. Quiros, N. Alonso, V. Perea, M. J. Barahona, A. Orois, M. Ramos, A. Simo, I. Berges, S. Rodriguez
DIABETES TECHNOLOGY & THERAPEUTICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
O. Simo-Servat, E. Cordero-Vazquez, H. Brosa, A. Simo-Servat, M. Barraso, X. Valldeperas, M. Barahona, J. Garcia-Arumi, M. Rivas, C. Hernandez, L. Lehr, D. Zingg, R. Simo
Article
Endocrinology & Metabolism
Maria D. Ballesteros Pomar, Nuria Vilarrasa Garcia, Miguel Angel Rubio Herrera, Maria Jose Barahona, Marta Bueno, Assumpta Caixas, Alfonso Calanas Continente, Andreea Ciudin, Fernando Cordido, Ana de Hollanda, Maria Jesus Diaz, Lilliam Flores, Pedro Pablo Garcia Luna, Fernando Garcia Perez-Sevillano, Albert Goday, Albert Lecube, Juan Jose Lopez Gomez, Inka Minambres, Maria Jose Morales Gorria, Rosa Morinigo, Joana Nicolau, Silvia Pellitero, Javier Salvador, Sergio Valdes, Irene Breton Lesmes
Summary: Obesity is a major challenge in healthcare with implications for health that require comprehensive management. This document provides practical and evidence-based recommendations for the diagnosis and management of obesity in Spain, supported by the Spanish Society of Endocrinology and Nutrition.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2021)
Review
Endocrinology & Metabolism
Andreea Ciudin, Andreu Simo-Servat, Fiorella Palmas, Maria Jose Barahona
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2020)
