Article
Psychology, Developmental
Kate Cooper, William Mandy, Catherine Butler, Ailsa Russell
Summary: The study found that autistic people are overrepresented in gender clinic settings, but there is limited evidence to guide clinical decision making for this patient group. Participants agreed on the need for autism adaptations in gender clinics, but had varying perspectives on how autism impacts self-knowledge. Autistic adults were more likely to see autism as an important identity compared to young people.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychiatry
Milla Karvonen, Kirstin Goth, Sami J. Eloranta, Riittakerttu Kaltiala
Summary: Adolescents with features of gender dysphoria (GD) show no significant problems in identity development, and may even have a better integration of their identity compared to the general population.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Devita Singh, Susan J. Bradley, Kenneth J. Zucker
Summary: This study reports follow-up data on a large sample of boys clinic-referred for gender dysphoria, showing a high rate of desistance and a high rate of biphilic/androphilic sexual orientation among those referred in childhood. The implications for current models of care for the treatment of gender dysphoria in children are discussed.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Obstetrics & Gynecology
Malene Hilden, Dorte Glintborg, Marianne Skovsager Andersen, Natacha Kyster, Steen Christian Rasmussen, Anders Tolstrup, Ojvind Lidegaard
Summary: This study examined the trend in the number of individuals with gender incongruence in Denmark over the past 40 years and found a substantial increase in legal sex-changes and healthcare contacts related to gender-identity conditions, with a more than 10-fold increase in the last decade. This calls for further research on possible reasons for this increase, as well as the short-term and long-term health consequences of hormonal and surgical treatments, and the need for adequate healthcare facilities.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Pediatrics
Ramesh Babu, Utsav Shah
Summary: Gender assignment in infants with DSD is a challenging decision, as some may develop gender identity disorder (GID) later in life. This review analyzed GID prevalence in adolescents and adults with DSD to assist in appropriate sex assignment to prevent GID development. GID varied among different DSD conditions, with lower rates in females with CAH, CAIS, and CGD, and higher rates in females with 5ARD and 17HSD. Recommendations for sex assignment were unclear in PAIS or MGD cases.
JOURNAL OF PEDIATRIC UROLOGY
(2021)
Article
Psychology, Multidisciplinary
Claudia C. Garcia, Karine Schwarz, Angelo B. Costa, Cesar A. Bridi Filho, Maria Ines R. Lobato
Summary: The study found that transgender women's perceptions of their mothers were significantly different from those concerning their fathers. Transgender men and women had a positive perception of their relationship with their mothers and a negative perception of their fathers. In terms of parenting practices, women felt that their mothers exhibited more positive practices than their fathers.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Behavioral Sciences
Ludivine Brunissen, Eli Rapoport, Katarzyna Chawarska, Andrew Adesman
Summary: This study found that girls with ASD are more likely to have gender expressions and behaviors during childhood that do not conform to traditional gender norms, and experience greater distress over gender-related concerns, highlighting the need for individualized support.
Article
Surgery
Allison Mak, Rosa Hovang, Gary Nace Jr, Myron Allukian III, Michael L. Nance
Summary: This study retrospectively evaluated the procedural outcomes and changing trends of utilization among patients undergoing histrelin implantation at a large pediatric tertiary care center over 15 years. The study found that histrelin procedures have increased in frequency overall, with a greater increase noted in the gender dysphoria cohort. This study demonstrates that histrelin procedures can be safely performed in the clinic setting through the establishment of streamlined processes and a dedicated team.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Diana Klinger, Stefan Riedl, Heidi Elisabeth Zesch, Sofia-Marie Oehlke, Sabine Voelkl-Kernstock, Paul L. L. Plener, Andreas Karwautz, Oswald D. D. Kothgassner
Summary: This study aimed to assess and compare the mental health of transgender youth by sex assigned at birth. The results showed that assigned male at birth (AMAB) adolescents were more likely to have internalizing problems, while assigned female at birth (AFAB) adolescents were more likely to have externalizing problems.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Psychology, Developmental
David J. Piekarski, Natalie L. Colich, Tiffany C. Ho
Summary: Adolescence is a period of rapid brain development, and the changes in white matter are partly attributed to hormonal fluctuations. This systematic review examines the associations between hormonal changes and white matter properties across species, with a focus on sex differences. The review finds that increases in gonadal hormones during puberty are associated with structural changes in white matter tracts, particularly in the corpus callosum, which align with findings in non-human animals. The paper concludes with recommendations for future research in order to further understand the neuroscience of puberty.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Review
Health Care Sciences & Services
Pierluigi Diana, Susanna Esposito
Summary: While the significance of gender has recently been recognized, its influence on neurological development and neuropsychiatric disorders among young people has long been understood. Gender disparities in these disorders exist among pediatric population, indicating the necessity of new guidelines. Further research is urgently needed to understand the role of gender in diagnosis, development, and treatment of neurologic and neuropsychiatric diseases, particularly in children and adolescents. It is also important to consider unique risks associated with gender disorders and gender dysphoria when approaching pediatric patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Connor Grannis, Scott F. Leibowitz, Shane Gahn, Leena Nahata, Michele Morningstar, Whitney Mattson, Diane Chen, John F. Strang, Eric E. Nelson
Summary: This study found that gender affirming treatment with testosterone (T) is associated with lower levels of internalizing symptoms, greater body satisfaction, and stronger connectivity in neural circuit related to anxiety and depression among transgender adolescent boys. Satisfaction with body image was also found to play a role in the relationship between testosterone and depression/suicidality, while amygdala-prefrontal co-activation moderated the effect of testosterone on anxiety symptoms.
PSYCHONEUROENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Bonnie Liang, Ada S. Cheung, Brendan J. Nolan
Summary: Compared to the general population, transgender individuals have a higher prevalence of Klinefelter syndrome according to observational studies. However, underdiagnosis in the general population limits the accuracy of the conclusions. Routine karyotype analysis is not recommended in transgender individuals initiating gender-affirming hormone therapy unless there are clinical features of Klinefelter syndrome. Transgender individuals with Klinefelter syndrome who desire feminizing gender-affirming hormone therapy need to manage unique risk profiles.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Psychology, Multidisciplinary
Cesar Augusto Bridi Filho, Saulo Batinga Cardoso, Bianca Machado Borba Soll, Marcelo Froeelich Noal, Karine Schwarz, Tiago Elias Rosito, Nicolino Cesar Rosito, Maria Ines Rodrigues Lobato
Summary: Research data on the consequences of Disorders of Sex Development (DSD) on sex life show that individuals with DSD tend to have atypical sexual experiences, such as delayed sexual debut, limited sexual relationships, and occurrence of Gender Dysphoria.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Developmental
Jack L. Turban, Brett Dolotina, Thomas M. Freitag, Dana King, Alex S. Keuroghlian
Summary: This study evaluated the rapid-onset gender dysphoria (ROGD) hypothesis by analyzing the 2015 US Transgender Survey. The findings suggest that a significant proportion of transgender adults realize their gender identity during adolescence or later and it takes several years to share their identity with others. The results do not support the ROGD hypothesis.
JOURNAL OF ADOLESCENT HEALTH
(2023)
Review
Urology & Nephrology
M. Ozer, S. Poor Toulabi, L. Gijs, B. P. C. Kreukels, M. G. Mullender
Summary: This study aimed to understand the sexual well-being and evaluation tools used in the medical context for transgender individuals. The study identified 10 themes related to sexual well-being, and more than 50 different tools used to measure sexual well-being. The study also found that there is currently a lack of valid tools for assessing sexual well-being in the transgender population.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Article
Psychology, Clinical
Jason van Heesewijk, Martijn D. Steenwijk, Baudewijntje P. C. Kreukels, Dick J. Veltman, Julie Bakker, Sarah M. Burke
Summary: This study investigated the neurobiological differences between transgender adolescents and cisgender peers, and found lower fractional anisotropy (FA) values in specific brain regions of transgender adolescents. The study also observed similar differences in prepubertal children. These findings provide important insight into the neural correlates of gender incongruence.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Annelou L. C. de Vries
Summary: Adolescent transgender care is controversial, but studies have shown the effectiveness of medical interventions such as puberty blockers. The article refutes concerns about Dutch studies and emphasizes the importance of careful evaluation and informed consent for transgender adolescents.
JOURNAL OF SEX & MARITAL THERAPY
(2023)
Article
Psychology, Developmental
Lieke Josephina Jeanne Johanna Vrouenraets, Annelou L. C. de Vries, Marijn Arnoldussen, Sabine E. Hannema, Ramon J. L. Lindauer, Martine C. de Vries, Irma M. Hein
Summary: This study explores the perspectives of transgender adolescents, their parents, and clinicians on the medical decision-making competence (MDC) to start puberty suppression (PS). The findings suggest that assessing MDC is challenging, but understanding, appreciating, reasoning, and communicating a choice are important criteria. While most participants believe understanding and appreciating PS is important for MDC, they also acknowledge that adolescents may not fully comprehend the consequences. Parental support is considered essential in the decision-making process, and clinicians find it difficult to assess and implement MDC consistently.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Bodi Huisman, Anouk Verveen, Nastasja M. de Graaf, Thomas D. Steensma, Baudewijntje P. C. Kreukels
Summary: This study investigates the desires and motives for gender affirming medical treatment in non-binary and/or genderqueer individuals. The findings suggest that these individuals have different treatment needs and experience less body dissatisfaction compared to binary transgender individuals. The study highlights the importance of specialized care and addressing specific needs in gender affirming medical treatment for non-binary and/or genderqueer people.
INTERNATIONAL JOURNAL OF TRANSGENDER HEALTH
(2023)
Article
Psychology, Clinical
Freek P. W. de Rooij, Wouter B. van der Sluis, Brechje L. Ronkes, Thomas D. Steensma, Muhammed Al-Tannimi, R. Jeroen A. van Moorselaar, Mark-Bram Bounnan, Garry L. S. Pigot
Summary: The choice of whether to perform Urethral Lengthening (UL) during phalloplasty has become increasingly relevant. This comparison of surgical outcomes and urinary functioning can assist in making the most suitable choice for phalloplasty.
INTERNATIONAL JOURNAL OF TRANSGENDER HEALTH
(2023)
Article
Psychology, Clinical
E. Coleman, A. E. Radix, W. P. Bouman, G. R. Brown, A. L. C. de Vries, M. B. Deutsch, R. Ettner, L. Fraser, M. Goodman, J. Green, A. B. Hancock, T. W. Johnson, D. H. Karasic, G. A. Knudson, S. F. Leibowitz, H. F. L. Meyer-Bahlburg, S. J. Monstrey, J. Motmans, L. Nahata, T. O. Nieder, S. L. Reisner, C. Richards, L. S. Schechter, V Tangpricha, A. C. TisheInnan, M. A. A. Van Trotsenburg, S. Winter, K. Ducheny, N. J. Adams, T. M. Adrian, L. R. Allen, D. Azul, H. Bagga, K. Basar, D. S. Bathory, J. J. Belinky, J. U. Berli, R. O. Bluebond-Langner, M-B Bouman, M. L. Bowers, P. J. Brassard, J. Byrne, L. Capitan, C. J. Cargill, J. M. Carswell, S. C. Chang, G. Chelvakumar, T. Corneil, K. B. Dalke, G. De Cuypere, E. de Vries, M. Den Heijer, A. H. Devor, C. Dhejne, A. D'Marco, E. K. Edmiston, L. Edwards-Leeper, R. Ehrbar, D. Ehrensaft, J. Eisfeld, E. Elaut, L. Erickson-Schroth, J. L. Feldman, A. D. Fisher, M. M. Garcia, L. Gijs, S. E. Green, B. P. Hall, T. L. D. Hardy, M. S. Irwig, L. A. Jacobs, A. C. Janssen, K. Johnson, D. T. Klink, B. P. C. Kreukels, L. E. Kuper, E. J. Kvach, M. A. Malouf, R. Massey, T. Mazur, C. McLachlan, S. D. Morrison, S. W. Mosser, P. M. Neira, U. Nygren, J. M. Oates, J. Obedin-Maliver, G. Pagkalos, J. Patton, N. Phanuphak, K. Rachlin, T. Reed, G. N. Rider, J. Ristori, S. Robbins-Cherry, S. A. Roberts, K. A. Rodriguez-Wallberg, S. M. Rosenthal, K. Sabir, J. D. Safer, A. Scheim, L. J. Seal, T. J. Sehoole, K. Spencer, C. St Amand, T. D. Steensma, J. F. Strang, G. B. Taylor, K. Tilleman, G. G. T'Sjoen, L. N. Vala, N. M. Van Mello, J. F. Veale, J. A. Vencill, B. Vincent, L. M. Wesp, M. A. West, J. Arcelus
Summary: This study introduces the latest developments in transgender healthcare and the role of the World Professional Association for Transgender Health (WPATH) and its Standards of Care (SOC). SOC-8 is a new set of guidelines for transgender healthcare, aiming to provide healthcare professionals with clinical guidance to assist transgender and gender diverse (TGD) individuals in achieving comfort and overall health. The guidelines are based on the best available science and expert consensus, and recommendations were developed through systematic literature reviews and expert opinions.
INTERNATIONAL JOURNAL OF TRANSGENDER HEALTH
(2022)
Article
Psychology, Developmental
Marijn Arnoldussen, Frederique B. B. de Rooy, Annelou L. C. de Vries, Anna I. R. van der Miesen, Arne Popma, Thomas D. Steensma
Summary: Transgender adolescents may seek gender identity specialty services earlier or later in adolescence. This study found that there are differences between "younger" and "older" presenters among a large cohort of transgender adolescents. Older presenters were more likely to be assigned female at birth, while younger presenters were more likely to live with both biological parents. Older presenters were also more dissatisfied with their bodies, while younger presenters showed more childhood gender nonconformity.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Urology & Nephrology
Maria A. T. C. van der Loos, Daniel T. Klink, Sabine E. Hannema, Sjoerdje Bruinsma, Thomas D. Steensma, Baudewijntje P. C. Kreukels, Peggy T. Cohen-Kettenis, Annelou L. C. de Vries, Martin den Heijer, Chantal M. Wiepjes
Summary: This study found that the number of children and adolescents seeking treatment for gender dysphoria has been increasing over time, with a shift towards more assigned female at birth (AFAB) individuals. The age of initial assessment and the age of starting hormone treatment have also been getting older. While a substantial number of eligible adolescents do not receive medical treatment, the risk of retransitioning among those who do is very low.
JOURNAL OF SEXUAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Annelou L. C. de Vries, Sabine E. Hannema
Summary: This week, Chen et al. published a primary report in the Journal on 2 years of gender-affirming hormones (GAH) in transgender adolescents. The Dutch model, which includes early treatment with puberty blockers and GAH for youth from 16 years of age, has become the dominant medical care model. However, controversies and debates regarding the long-term outcomes have led some European countries to adapt their guidelines and restrict access to care.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Orthopedics
Floyd W. Timmermans, Lian Elfering, Thomas D. Steensma, Mark-Bram Bouman, Wouter B. van der Sluis
Summary: A retrospective study found that mastectomy after breast reduction is a safe procedure in the trans male population, with no clear disadvantages observed.
JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
(2023)
Article
Psychology, Clinical
Iris de Nie, Joyce D. Asseler, Marijn Arnoldussen, Silke Baas, Annelou L. C. de Vries, Judith A. F. Huirne, Thomas D. Steensma, Martin den Heijer, Norah M. van Mello
Summary: This study examined the reproductive decisions of adults who underwent gender-affirming hormone treatment in adolescence. Data was collected through an online survey with 89 participants. The results showed that 96% of participants underwent gonadectomy, resulting in permanent infertility, and 27% of them found it troublesome. The study also found that 44% of AFAB and 35% of AMAB individuals in the current TGD population would pursue fertility preservation. Furthermore, the percentage of participants desiring children increased from 34% during adolescence to 56% in adulthood, with 23% of them having started a family.
TRANSGENDER HEALTH
(2023)
Editorial Material
Public, Environmental & Occupational Health
Anke J. M. Oerlemans, Wyke J. P. Stommel, Chris M. Verhaak, Annelou L. C. De Vries, Floor A. H. Cuijpers, Mieke Breukelman, Marij A. Hillen
Summary: Research on uncertainty in medical practice lacks consensus and integration due to its scattered nature across disciplines. This hinders understanding of when and how uncertainty occurs, its impact on stakeholders and medical decision-making. The paper argues for a more integrated approach to uncertainty, using adolescent transgender care as an example.
PATIENT EDUCATION AND COUNSELING
(2023)
Article
Psychology, Clinical
Noor C. Gieles, Tim C. van de Grift, Els Elaut, Gunter Heylens, Inga Becker-Hebly, Timo O. Nieder, Ellen T. M. Laan, Baudewijntje P. C. Kreukels
Summary: This study aims to explore sexual pleasure in transgender individuals and identify factors associated with sexual pleasure. The results showed that transgender participants had significantly lower sexual pleasure scores compared to cisgender individuals, and lower age, current happiness, and genital body satisfaction were associated with a higher tendency to experience sexual pleasure.
INTERNATIONAL JOURNAL OF TRANSGENDER HEALTH
(2023)
Article
Psychology, Clinical
Maeghan B. Ross, Tim C. van de Grift, Els Elaut, Timo O. Nieder, Inga Becker-Hebly, Gunter Heylens, Baudewijntje P. C. Kreukels
Summary: This study evaluated the barriers of care experienced by treatment-seeking trans individuals in three large European clinics. The majority of participants reported various barriers, with lack of support from family and friends, as well as travel time and costs, being the most frequently reported. Additionally, some individuals felt the need to convince their healthcare providers to receive care. Higher number of reported barriers was associated with more mental health problems, lower income, and female gender.
INTERNATIONAL JOURNAL OF TRANSGENDER HEALTH
(2023)
Article
Behavioral Sciences
Farrah N. Madison, Verner P. Bingman, Tom Smulders, Christine R. Lattin
Summary: Although research on the avian hippocampus has been limited, it is crucial for understanding its evolution and changes over time. The avian hippocampus plays important roles in spatial cognition as well as regulating anxiety, approach-avoidance behavior, and stress responses. Future research should focus on elucidating the cellular and molecular mechanisms, including endocrinology, to resolve outstanding questions about avian hippocampal function and organization.
HORMONES AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Judith A. H. Smit, Riet Vooijs, Peter Lindenburg, Alexander T. Baugh, Wouter Halfwerk
Summary: This study investigates the effects of urbanization on hormone levels in tungara frogs and found that urban frogs and forest frogs have different endocrine phenotypes. Exposure to urban noise and light pollution led to an increase in testosterone and a decrease in corticosterone in urban frogs, while forest frogs showed no endocrine response to sensory pollutants. These results suggest that urbanization can modulate hormone levels and influence behavior in frogs.
HORMONES AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Hannah D. Fulenwider, Yangmiao Zhang, Andrey E. Ryabinin
Summary: Social hierarchies have significant effects on overall health of individuals in animal groups, particularly the lowest-ranking individuals. Tube test can be used to determine social rank in male and female mice, and the complex interactions between social rank, sex, environment, and testing length influence peptide levels.
HORMONES AND BEHAVIOR
(2024)
