Article
Agriculture, Dairy & Animal Science
Nuria Saiz, Lisbeth Herrera-Castillo, Nuria de Pedro, Maria Jesus Delgado, Sven David Arvidsson, Miguel Angel Marugal-Lopez, Esther Isorna
Summary: This research investigates the effects of disruption of circadian rhythms on stress and anxiety-like behavior in fish. The study finds that both continuous light and randomly scheduled meals induce anxiety-like behavior and increased energy expenditure in goldfish. The findings also suggest a possible chronic stress response in fish under continuous light. These results highlight the importance of considering circadian disruption for animal welfare.
Article
Physiology
Vi Pham, Joshua G. Pemberton, John P. Chang, Ayelen Melisa Blanco, Atefeh Nasri, Suraj Unniappan
Summary: This study provides evidence that nesfatin-1 is a stress responsive peptide which modulates stress axis hormones in fish. It was found that nesfatin-1 affects cortisol release, ACTH secretion, and mRNA levels of CRF in various tissues of goldfish under stress conditions. The presence of nucb2/nesfatin-1-like immunoreactivity in the hypothalamus, pituitary, and interrenal cells points to the potential role of nesfatin-1 in regulating the HPI axis.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Ida Bahnsen, Kristina V. Riddersholm, Leonardo V. de Knegt, Thomas S. Bruun, Charlotte Amdi
Summary: Physiological stress in sows can affect foetal development and piglet birth weight, with factors such as management practices, feeding systems, and parity potentially influencing cortisol levels. Further research is needed to understand the relationship between cortisol concentrations, stress, and its impact on foetal growth.
Article
Psychiatry
Susana Barbosa-Mendez, Gilberto Perez-Sanchez, Enrique Becerril-Villanueva, Alberto Salazar-Juarez
Summary: Melatonin can reduce cocaine-induced locomotor activity and self-administration behavior, as well as decrease dopamine levels, indicating its potential therapeutic effect in reducing cocaine abuse; the study suggests that MT1 and MT2 receptors could be effective therapeutic targets for drug abuse disorder.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Clinical Neurology
Eunsoo Moon, Paola Lavin, Kai-Florian Storch, Outi Linnaranta
Summary: Antipsychotics may affect healthy circadian rhythms, decreasing cortisol, melatonin, and body temperature amplitudes. Longitudinal real-time monitoring of specific circadian markers is necessary to determine the optimal timing for administering antipsychotics.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
A. S. M. Kamruzzaman, Susumu Hiragaki, Yasuhiko Watari, Takashi Natsukawa, Akie Yasuhara, Naoyuki Ichihara, Amr A. Mohamed, Azza M. Elgendy, Makio Takeda
Summary: Melatonin plays a role in orchestrating daily and seasonal rhythms in organisms, impacting locomotor activity. The enzyme aaNAT is a key regulator of the circadian system in cockroaches, influencing the synchronization of locomotor rhythms. Additionally, the receptor mediating Melatonin function in cockroaches is likely similar to the mammalian MT2, with Melatonin and aaNAT constituting a circadian output pathway for locomotor activity.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Neurosciences
Zixuan Xu, Wen Li, Yixin Sun, Wen Jin, Li Yu, Jingyuan Yang, Qi Wang
Summary: This study found that melatonin has the potential therapeutic effect on PTSD-like symptoms in mice, and melatonin receptor 1 mediated the effect.
PSYCHOPHARMACOLOGY
(2023)
Article
Biology
Xuewei Fan, Zeqing Chen, Wenqi Li, Haokuan Qin, Shijie Huang, Zhicheng Lu, Yinghua Li, Muqing Liu
Summary: This study found that blue and red cutaneous exposure had no significant effect on central rhythm oscillation, while intraocular irradiation could significantly change the central clock of mice. The impact of blue light was stronger than red light, suggesting that intraocular nonvisual channels still play a dominant role in rhythmic regulation.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Priyanka Sarena, Ashish Sharma, Maiko T. Urmera, Murtaza M. Tambuwala, Alaa A. A. Aljabali, Dinesh Kumar Chellappan, Kamal Dua, Rajeev Taliyan, Rohit Goyal
Summary: This study investigated the effects of chronic exposure to light-light conditions on circadian rhythm dysfunction and dementia in Wistar rats. The results showed that the LL period significantly increased brain glutamate and cortisol levels, and impaired spatial memory, working memory, decision making, and exploration of novel objects. Histological study revealed neuropathological changes in the hippocampus, cortex, and cerebellum regions. Furthermore, oxidative stress in brain tissue was observed. However, treatment with dextromethorphan, mifepristone, and melatonin reversed the pathological states caused by LL.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Aridany Suarez-Trujillo, Nguyen Hoang, Leela Robinson, Conor J. McCabe, Dawn Conklin, Radiah C. Minor, Jonathan Townsend, Karen Plaut, Uduak Z. George, Jacquelyn Boerman, Theresa M. Casey
Summary: The metabolic, circadian, sleep, and reproductive systems are interconnected and regulated, but the understanding of their mechanism is limited. This study disrupted the circadian timing system in pregnant nonlactating cows and found that body temperature and hormone concentrations were affected, especially in relation to gestation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Narasimha Pullaguri, Andrea R. Kagoo, Anamika Bhargava
Summary: The antimicrobial agent triclosan can inhibit the activity of acetylcholinesterase (AChE) both by direct binding and indirectly through increased oxidative stress, resulting in neurotoxicity.
Article
Agronomy
Sara Garcia-Sanchez, Antonio Cano, Josefa Hernandez-Ruiz, Marino B. Arnao
Summary: This study presented preliminary data on the promoting role of melatonin in almond seed germination and seedling growth, and highlighted its significant impact under light conditions.
Article
Endocrinology & Metabolism
Kazuki Watanabe, Masaki Nakano, Yusuke Maruyama, Jun Hirayama, Nobuo Suzuki, Atsuhiko Hattori
Summary: The neurohormone melatonin regulates the circadian rhythm and glucose homeostasis. In a study on goldfish, melatonin injection increased glucose uptake in the brain and liver, while melatonin receptor antagonist reduced glucose uptake in liver cells. This suggests that melatonin is a circadian regulator of glucose balance independent of insulin effect.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shuang Chen, You Li, Shuai Fu, Yang Li, Chao Wang, Ping Sun, Hairu Li, Jiawei Tian, Guo-Qing Du
Summary: High levels of AVP induce cardiomyoblast apoptosis and mitochondrial dysfunction, while melatonin can reduce apoptosis and enhance antioxidative responses through the Mst1-Nrf2 pathway re-activation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Xiao-Qian Chen, Xiu-Min Jiang, Qing-Xiang Zheng, Hai-Wei Wang, Heng Xue, Yu-Qing Pan, Yan-Ping Liao, Xiao-Xia Gao
Summary: This study aimed to explore the factors influencing sub-health and circadian rhythm disorder among midwives and examine the relationship between circadian rhythm disorder and sub-health. A cross-sectional study was conducted among 91 Chinese midwives from six hospitals using cluster sampling. The results showed that sub-health and circadian rhythm disorder were common among midwives and were significantly related to age, exercise duration, working hours, job satisfaction, cortisol rhythm, and melatonin rhythm. Nurse administrators should take measures to prevent sub-health and circadian rhythm disorder among midwives.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Behavioral Sciences
Miguel Gomez-Boronat, Esther Isorna, Marta Conde-Sieira, Maria J. Delgado, Jose L. Soengas, Nuria de Pedro
HORMONES AND BEHAVIOR
(2020)
Article
Agriculture, Dairy & Animal Science
Nuria Saiz, Miguel Gomez-Boronat, Nuria De Pedro, Maria Jesus Delgado, Esther Isorna
Summary: The circadian system synchronizes physiology and behavior to predictable environmental variations, and disruptions of this system can lead to overactivation of the stress axis. This study focused on how the absence of external signals, such as the light-dark cycle and feeding schedule, impact the oscillators in the hypothalamus-pituitary-interrenal axis of goldfish. The results showed that environmental conditions can impact the HPI axis, affecting endocrine and circadian functioning, and that uncertainty of food availability may be as stressful as the absence of a light-dark cycle.
Article
Physiology
Jack Falcon, Maria Jesus Herrero, Laura Gabriela Nisembaum, Esther Isorna, Elodie Peyric, Marilyn Beauchaud, Joel Attia, Denis Coves, Michael Fuentes, Maria Jesus Delgado, Laurence Besseau
Summary: The hormone melatonin plays a crucial role in regulating pituitary hormone production in European sea bass, influenced by factors like photoperiod, temperature, and salinity. Seasonal variations in mRNA abundance of pituitary hormones and melatonin receptors were observed in different fish groups raised in sea water and brackish water. In vitro experiments showed that melatonin's effects on pituitary hormones varied based on concentration, month investigated, and fish's prior adaptation to different salinities, highlighting the diverse responses of the pituitary gland in fish facing changing environmental conditions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Laura Gabriela Nisembaum, Guillaume Loentgen, Thibaut L'Honore, Patrick Martin, Charles-Hubert Paulin, Michael Fuentes, Karine Escoubeyrou, Maria Jesus Delgado, Laurence Besseau, Jack Falcon
Summary: Fish rely on external temperature and photoperiod to regulate their metabolism, physiology, and behavior. Recent studies have found that TRPV1 and TRPV4 channels play a role in regulating melatonin production in Atlantic salmon, possibly in response to temperature changes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nuria Saiz, Lisbeth Herrera-Castillo, Esther Isorna, Maria Jesus Delgado, Marta Conde-Sieira, Jose Luis Soengas, Nuria de Pedro
Summary: This study demonstrates, for the first time in fish, the effects of REV-ERB alpha activation via SR9009, promoting a negative energy balance by reducing energetic inputs and regulating lipid and glucose metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Miguel Gomez-Boronat, Nuria De Pedro, angel L. Alonso-Gomez, Maria J. Delgado, Esther Isorna
Summary: The circadian system, composed of oscillators in central and peripheral tissues, regulates rhythmic processes in vertebrates. Nuclear receptors PPARs, REV-ERBs, and RORs have been proposed as key genes linking metabolism and temporal homeostasis. This study investigated the effects of light-dark cycle and feeding time on the synchronization of central and peripheral clocks and nuclear receptors in goldfish. The results showed that the hypothalamus is mainly light-entrained, while the liver is food-entrained. Nuclear receptors are identified as key elements in the timekeeping of temporal homeostasis, particularly in the liver.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Ignacio Ruiz-Jarabo, Blanca Partida, Maria Page, Diego Madera, Nuria Saiz, Aitana Alonso-Gomez, Lisbeth Herrera-Castillo, Esther Isorna, Angel L. Alonso-Gomez, Ana I. Valenciano, Nuria de Pedro, Jorge Saez, Maria J. Delgado
Summary: Artisanal fishing is prevalent worldwide, but changes in fishing legislation can have detrimental effects if not adapted to quickly. This study proposes potential improvements for the sector through a pilot study, evaluating the survival and possible recapture of discarded fish. The findings provide a foundation for regulating artisanal fisheries by offering scientific data on discard survival rates and sale prices.
Article
Agriculture, Dairy & Animal Science
Aitana Alonso-Gomez, Diego Madera, Angel Luis Alonso-Gomez, Ana Isabel Valenciano, Maria Jesus Delgado
Summary: This study investigates the daily variations in the expression of insulin-like growth factor-1 (IGF-1) system components in the liver of goldfish and the influence of environmental cues and feeding time on this rhythmicity. The results show that both environmental cues and feeding time synchronize the daily rhythms of the components of the IGF-1 system in the liver. This highlights the importance of IGF-1 and its binding proteins as potential rhythmic outputs of the liver clock in fish.
Article
Behavioral Sciences
Farrah N. Madison, Verner P. Bingman, Tom Smulders, Christine R. Lattin
Summary: Although research on the avian hippocampus has been limited, it is crucial for understanding its evolution and changes over time. The avian hippocampus plays important roles in spatial cognition as well as regulating anxiety, approach-avoidance behavior, and stress responses. Future research should focus on elucidating the cellular and molecular mechanisms, including endocrinology, to resolve outstanding questions about avian hippocampal function and organization.
HORMONES AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Judith A. H. Smit, Riet Vooijs, Peter Lindenburg, Alexander T. Baugh, Wouter Halfwerk
Summary: This study investigates the effects of urbanization on hormone levels in tungara frogs and found that urban frogs and forest frogs have different endocrine phenotypes. Exposure to urban noise and light pollution led to an increase in testosterone and a decrease in corticosterone in urban frogs, while forest frogs showed no endocrine response to sensory pollutants. These results suggest that urbanization can modulate hormone levels and influence behavior in frogs.
HORMONES AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Hannah D. Fulenwider, Yangmiao Zhang, Andrey E. Ryabinin
Summary: Social hierarchies have significant effects on overall health of individuals in animal groups, particularly the lowest-ranking individuals. Tube test can be used to determine social rank in male and female mice, and the complex interactions between social rank, sex, environment, and testing length influence peptide levels.
HORMONES AND BEHAVIOR
(2024)