Review
Medicine, General & Internal
Anna Boguslawska, Marta Korbonits
Summary: GH-secreting pituitary tumors are highly genetically determined, with both germline and somatic mutations. Mutations can occur in known genes such as AIP, PRKAR1A, GPR101, GNAS, and others. Identifying genetic mutations can help in screening associated comorbidities and finding affected family members before clinical manifestation of the disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Cuiqi Zhou, Stephen Shen, Rosemary Moran, Nan Deng, Eduardo Marban, Shlomo Melmed
Summary: This study validates the production of exosomes derived from the pituitary gland in both humans and rats, shedding light on their biological actions. Exosomes derived from the pituitary gland can regulate signaling pathways and protein synthesis in liver cells, as well as modulate the motility and metastasis of tumor cells.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Amit Akirov, Ilan Shimon, Maria Fleseriu, Idit Dotan, Yossi Manisterski, Nirit Aviran-Barak, Varda Nadler, Sandra Alboim, Tzipora Shochat, Gloria Tsvetov, Dania Hirsch
Summary: This study compared the clinical and biochemical characteristics of patients with corticotroph microadenomas and macroadenomas. It was found that macroadenomas had higher levels of ACTH but no association was found between tumor size and cortisol hypersecretion or clinical features of hypercortisolemia. Furthermore, patients with macroadenomas with sphenoid or cavernous sinus invasion had higher biochemical burden, highlighting that extent/location of the adenoma may be more important than size per se.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Shlomo Melmed, Ursula B. Kaiser, M. Beatriz Lopes, Jerome Bertherat, Luis Syro, Gerald Raverot, Martin Reincke, Gudmundur Johannsson, Albert Beckers, Maria Fleseriu, Andrea Giustina, John A. H. Wass, Ken K. Y. Ho
Summary: Pituitary neoplasms are common and mostly benign, but can have diverse effects on health. Understanding the clinical biology of these neoplasms is important for implementing appropriate treatment strategies and improving quality of life and mortality.
Review
Medicine, General & Internal
Tongxin Xiao, Lian Duan, Shi Chen, Lin Lu, Yong Yao, Xinxin Mao, Huijuan Zhu, Hui Pan
Summary: Pituicytomas are rare gliomas located in the neurohypophysis or infundibulum, and can be misdiagnosed as pituitary adenoma due to similar location and occasional endocrine disturbances. In some cases, pituicytoma is associated with Cushing's disease, leading to pituitary hypofunction after surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Elzbieta Moszczynska, Elzbieta Marczak, Mieczyslaw Szalecki, Krzysztof Kadziolka, Marcin Roszkowski, Patrycja Zagata-Lesnicka
Summary: This study analyzed the diagnostic accuracy of BIPSS in pediatric patients with CD, showing that BIPSS has high accuracy in identifying the underlying cause and guiding surgical intervention, but limited value in tumor localization.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Sunita M. C. De Sousa, Angeline Shen, Christopher J. Yates, Roderick Clifton-Bligh, Stephen Santoreneos, James King, John Toubia, Giampaolo Trivellin, Andrea G. Lania, Constantine A. Stratakis, David J. Torpy, Hamish S. Scott
Summary: Loss-of-function variants in PAM gene were found to be enriched in pathological pituitary hypersecretion, specifically in somatotrophinoma and corticotrophinoma, indicating its role in hormone synthesis and regulation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Xin Lian, Zhuoran Xu, Shuai Sun, Weiping Wang, Huijuan Zhu, Lin Lu, Xiaorong Hou, Fuquan Zhang
Summary: The study aimed to investigate the efficacy and toxicity of intensity-modulated radiotherapy (IMRT) in treating Cushing's Disease (CD). The results showed that IMRT was a highly effective therapy with low side effects for CD patients, with comparable rates of endocrine remission, tumor control, and recurrence to previous reports.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Kyungwon Kim, Yae Won Park, Daham Kim, Sung Soo Ahn, Ju Hyung Moon, Eui Hyun Kim, Eun Jig Lee, Cheol Ryong Ku
Summary: In patients with visible tumors, the presence of cavernous sinus invasion at diagnosis may be an unfavorable predictor for biochemical remission after CAB discontinuation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Anna Cho, Greisa Vila, Wolfgang Marik, Sigrid Klotz, Stefan Wolfsberger, Alexander Micko
Summary: In patients with small sellar lesions, Prolactin-Volume-Ratios greater than 100 may serve as a potential predictive marker for the diagnosis of prolactin-producing pituitary adenomas.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Mengqi Chang, Zihao Wang, Jun Gao, Chengxian Yang, Ming Feng, Yamei Niu, Wei-Min Tong, Xinjie Bao, Renzhi Wang
Summary: This study demonstrates that m(6)A methyltransferase METTL3 promotes tumor growth and hormone secretion by increasing the expression of GNAS and GADD45 gamma in a m(6)A-dependent manner. Hence, METTL3 and the methylated RNAs may serve as suitable targets for clinical treatment of GH-PAs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Samridhi Banskota, David C. Adamson
Summary: Pituitary adenomas are tumors that arise in the anterior pituitary gland, most commonly benign and exerting their effects through excess hormone secretion or mass effect. The clinical presentation varies based on the size and hormone secretion of the adenoma.
Article
Clinical Neurology
Malte Ottenhausen, Jens Conrad, Lea-Marie Wolters, Florian Ringel
Summary: The initial treatment for prolactinoma is usually conservative with dopamine agonists. However, surgical therapy may be considered earlier due to favorable outcomes and low complications. This study aims to analyze the surgical resection outcomes of prolactinoma and discuss the role of surgery in modern therapy.
NEUROSURGICAL REVIEW
(2023)
Article
Clinical Neurology
Robert C. Osorio, Matheus P. Pereira, Taemin Oh, Rushikesh S. Joshi, Alexander F. Haddad, Kaitlyn M. Pereira, Kevin C. Donohue, Zain Peeran, William Carson, Aarav Badani, Elaina J. Wang, Sweta Sudhir, Ankush Chandra, Saket Jain, Angad Beniwal, Jose Gurrola II, Ivan H. El-Sayed, Lewis S. Blevins Jr, Philip V. Theodosopoulos, Sandeep Kunwar, Manish K. Aghi
Summary: This study assessed the correlation between tumor volume and prolactin level in prolactinoma and its impact on surgical outcomes. The results showed a strong association between tumor volume and prolactin levels, with an increase in tumor volume leading to a significant increase in prolactin levels in patients without biochemical remission after surgery.
JOURNAL OF NEUROSURGERY
(2023)
Article
Endocrinology & Metabolism
Craig Edward Stiles, Guy Lloyd, Sanjeev Bhattacharyya, Richard Paul Steeds, Kambiz Boomla, Jonathan Paul Bestwick, William Martyn Drake
Summary: The study found that there was no significant association between low-dose cabergoline treatment for prolactinoma and clinically significant valvulopathy. Results showed that the proportion of patients undergoing valve surgery or heart failure was similar between cabergoline-treated patients and the control group, and statistical analysis did not demonstrate a clear correlation between cabergoline treatment and cardiac complications.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Martin O. Savage, Helen L. Storr, Philippe F. Backeljauw
Summary: The continuum of growth hormone (GH)-IGF-I axis defects ranges from severe to mild GH deficiency, including GH insensitivity, with various endocrine, biochemical, phenotypic and genetic abnormalities. While extreme cases are easily diagnosed, milder cases are less well defined and may overlap with idiopathic short stature conditions.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Environmental Sciences
Matteo Zoli, Giacomo Sollini, Fulvio Zaccagna, Viscardo Paolo Fabbri, Lorenzo Cirignotta, Arianna Rustici, Federica Guaraldi, Sofia Asioli, Caterina Tonon, Ernesto Pasquini, Diego Mazzatenta
Summary: Infratemporal and pterygopalatine fossae are complex areas in the skull base that contain important neurovascular and osteomuscular structures. They are closely connected to various craniofacial areas and can be affected by tumors, infections, or inflammation. The introduction of the endoscope in skull base surgery has allowed for a direct and safe approach for the treatment of ITF and PPF tumors, reducing the risk of complications.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Marco Montalti, Aurelia Salussolia, Alice Masini, Elisa Manieri, Flavia Rallo, Sofia Marini, Marta Agosta, Martina Paterno, Michela Stillo, Davide Resi, Federica Guaraldi, Davide Gori, Laura Dallolio
Summary: Social distancing measures during the COVID-19 pandemic had a negative impact on adolescent education and relationships. A study conducted in Bologna, Italy, found that the internet was the most common source of sexual and reproductive health (SRH) education for adolescents, followed by peers. The study also revealed that 61.3% of 17-year-olds had already engaged in sexual intercourse, and 90% of 15-year-olds had experienced romantic or sexual attraction. Additionally, 58.2% of the adolescents reported that the COVID-19 pandemic had negative effects on their relationships and sexual life. The research emphasizes the importance of involving healthcare professionals and educators in designing structured SRH education programs tailored to the needs of adolescents, starting from an early age.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Environmental Sciences
Giusy La Fauci, Marco Montalti, Zeno Di Valerio, Davide Gori, Maria Giulia Salomoni, Aurelia Salussolia, Giorgia Solda, Federica Guaraldi
Summary: The COVID-19-related lockdown has led to weight gain, especially among obese individuals who are at a higher risk of severe infection. This weight gain is mainly caused by increased consumption of calorie-dense/unhealthy food and reduced physical activity, often accompanied by disrupted sleep patterns. Additionally, obesity increases the risk of hospital admission compared to those with normal weight.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Endocrinology & Metabolism
Avinaash Maharaj, Ruth Kwong, Jack Williams, Christopher Smith, Helen Storr, Ruth Krone, Debora Braslavsky, Maria Clemente, Nanik Ram, Indraneel Banerjee, Semra Cetinkaya, Federica Buonocore, Tulay Guran, John C. Achermann, Louise Metherell, Rathi Prasad
Summary: SPLIS is a syndrome characterized by various endocrine disorders, with glucocorticoid insufficiency and adrenal insufficiency being the most common manifestations. Other endocrine abnormalities include mineralocorticoid deficiency, primary gonadal insufficiency, and mild primary hypothyroidism. There is no clear genotype-phenotype correlation, but certain variants are consistently associated with specific endocrine phenotypes.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Federica Guaraldi, Luca Morandi, Matteo Zoli, Diego Mazzatenta, Alberto Righi, Stefania Evangelisti, Francesca Ambrosi, Caterina Tonon, Caterina Giannini, Ricardo V. Lloyd, Sofia Asioli
Summary: Genetic mutations and DNA methylation levels of genes involved in cell proliferation/differentiation, miRNA/LncRNA-post-transcriptional regulators, and therapy targets vary between non-aggressive and aggressive PAs/PitNETs. Methylation profiles also differ according to gender. Combined genetic-epigenetic analysis, along with clinical-radiological-pathological data, could aid in predicting the behavior of PA/PitNET.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Joseph Freer, Joanna Orr, Joan K. Morris, Robert Walton, Leo Dunkel, Helen L. Storr, Andrew J. Prendergast
Summary: Short stature at age 3 is associated with lower language development scores from 3 to 11 years of age in UK children, and this association remains significant after adjusting for other factors.
Article
Pediatrics
Aurelia Salussolia, Jacopo Lenzi, Marco Montalti, Flavia Rallo, Martina Paterno, Marta Agosta, Davide Resi, Michela Stillo, Federica Guaraldi, Davide Gori, Laura Dallolio, Alice Masini
Summary: This study found that COVID-19 has had a significant impact on the physical activity levels and well-being of children and adolescents in the City of Bologna, Italy. Overall, there has been a decrease in physical activity levels, particularly among adolescents, and an increase in concerns about the future, sleep difficulties, and attention difficulties.
Article
Primary Health Care
H. L. Storr, J. Freer, J. Child, J. H. Davies
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Editorial Material
Primary Health Care
Justin H. Davies, Jenny Child, Joseph Freer, Helen L. Storr
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Review
Clinical Neurology
Matteo Zoli, Giacomo Sollini, Arianna Rustici, Federica Guaraldi, Sofia Asioli, Maria Vittoria Altavilla, Agnese Orsatti, Marco Faustini-Fustini, Ernesto Pasquini, Diego Mazzatenta
Summary: The endoscopic trans-orbital approach (eTOA) has been widely studied for sphenoorbital tumors. eTOA can achieve favorable patient outcomes and optimal cosmetic results with minimal morbidity and quick recovery. This approach can be combined with other surgical routes or adjuvant therapies.
WORLD NEUROSURGERY
(2023)
Article
Health Care Sciences & Services
Federica Guaraldi, Marco Montalti, Davide Gori
Summary: Vaccine hesitancy has become a major concern during the COVID-19 pandemic, characterized by the delay or refusal of vaccination. Attitudes, beliefs, and external influences play significant roles in influencing vaccine hesitancy. Addressing vaccine hesitancy requires a systematic assessment of its determinants within specific contexts and population groups. Increasing awareness, engaging with social media, and employing tailored strategies can promote spontaneous adherence to vaccination programs, eliminating the need for coercive measures.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2023)
Article
Neurosciences
Alessandro Carretta, Matteo Zoli, Federica Guaraldi, Giacomo Sollini, Arianna Rustici, Sofia Asioli, Marco Faustini-Fustini, Ernesto Pasquini, Diego Mazzatenta
Summary: The role of the endoscopic transplanum-transtuberculum approach (ETTA) in the treatment of pituitary adenomas/PitNETs (PAs) is feasible but associated with higher morbidity compared to the conventional endoscopic approach.
Review
Pediatrics
Arianna Dondi, Giacomo Sperti, Davide Gori, Federica Guaraldi, Marco Montalti, Lorenza Parini, Bianca Maria Piraccini, Marcello Lanari, Iria Neri
Summary: COVID-19 can present with various skin manifestations in children, and mucocutaneous manifestations may be early signs that physicians should be familiar with.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Gemma White, Shakira Cosier, Afiya Andrews, Lee Martin, Ruben Willemsen, Martin O. Savage, Helen L. Storr
Summary: This observational study evaluated the sensitivity and specificity of UK and Dutch referral criteria for predicting pathological short stature. The UK criteria showed limited sensitivity and specificity, while the Dutch criteria had higher sensitivity. Considering the child's genetic height potential before referral can prevent unnecessary assessments.
BMJ PAEDIATRICS OPEN
(2022)