Article
Endocrinology & Metabolism
Ravi Retnakaran, Chang Ye, Anthony J. Hanley, Philip W. Connelly, Mathew Sermer, Bernard Zinman
Summary: This study compared postpartum glucose tolerance between women treated for gestational diabetes mellitus (GDM) and those not treated. The results showed that treating GDM lowers birth weight but does not disrupt the association between gestational glycemia and maternal prediabetes/diabetes after pregnancy. Insulin sensitivity and beta-cell function decreased, while fasting and 2-h glucose levels increased progressively across the five groups.
Review
Pediatrics
Wayne Cutfield, Ahila Ayyavoo
Summary: 'Small for Gestational Age' (SGA) refers to children born with low birth weight and/or short birth length, most of whom experience catch-up growth within 6 months of age. Treatment with recombinant human growth hormone (rhGH) can help SGA children achieve normal adult height, although they may still face long-term consequences such as insulin resistance, abdominal fat accumulation, and metabolic disorders.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Evelin Major, Ferenc Gyory, Daniel Horvath, Ilka Keller, Istvan Tamas, Karen Uray, Peter Fulop, Beata Lontay
Summary: In hyperthyroidism, SMTNL1 plays a crucial role in regulating insulin sensitivity, inhibiting JNK activity and non-genomic effects of T3, and restoring normal glucose transport responsiveness. It also controls glucose phosphorylation and balances glycolysis and glycogen synthesis by downregulating hexokinase II. SeaHorse analysis revealed that SMTNL1 overexpression counteracts the shift to glycolysis induced by T3 overload, suggesting its potential as a therapeutic target in insulin resistance associated with hyperthyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Karen L. Lindsay, Lauren E. Gyllenhammer, Sonja Entringer, Pathik D. Wadhwa
Summary: Objective: The study aimed to determine the association between rate of gestational weight gain (rGWG) and glucose-insulin metabolism in Hispanic pregnant women with overweight and obesity. The findings revealed that rGWG was inversely associated with beta-cell function in a high-risk population of Hispanic pregnant women with overweight and obesity, potentially contributing to the development of type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Akinobu Nakamura
Summary: SGLT2 inhibitors not only lower blood glucose levels but also have protective effects on organs such as the heart and kidneys. These inhibitors prevent beta-cell dysfunction by reducing glucose overload, leading to increased beta-cell proliferation and decreased apoptosis. Clinical and preclinical data support the protective effect of SGLT2 inhibitors on beta-cell mass and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Simona Moffa, Chiara M. A. Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Giuseppe Quero, Alfredo Pontecorvi, Andrea Mari, Sergio Alfieri, Andrea Giaccari
Summary: This study aimed to verify the acute effect of reduced beta cell mass on the development of hyperglycemia. The research found that reduced first-phase insulin secretion and glucose sensitivity were predictors of eventual development of impaired glucose tolerance and diabetes. Thus, these functional alterations may play a key role in the pathogenesis of type 2 diabetes (T2DM).
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Ping Luo, Ying Fan, Yusha Xiong, Chunlin Zhang, Zhiping Yang, Fenglan Sun, Bing Mei
Summary: This study describes the metabolic characteristics of gestational diabetes mellitus (GDM) in the central Chinese population and evaluates their effects on perinatal outcomes. The study found that beta cell dysfunction, rather than insulin resistance, determines the occurrence of GDM. Women with predominant insulin secretion defects have a similar risk of adverse perinatal outcomes to women with normal glucose tolerance (NGT). This study provides a basis for selecting glucose metabolism monitoring indicators for the prevention of adverse perinatal outcomes.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Review
Pediatrics
Irene Netchine, Manouk van der Steen, Abel Lopez-Bermejo, Ekaterina Koledova, Mohamad Maghnie
Summary: Children born small for gestational age (SGA) face a range of growth and metabolic issues, with some potentially needing growth hormone treatment to promote linear growth and address metabolic abnormalities.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Camille E. Powe, Miriam S. Udler, Sarah Hsu, Catherine Allard, Alan Kuang, Alisa K. Manning, Patrice Perron, Luigi Bouchard, William L. Lowe, Denise Scholtens, Jose C. Florez, Marie-France Hivert
Summary: This study identified genetic and physiological pathways that differ between gestational diabetes mellitus (GDM) and type 2 diabetes (T2D), confirming that GDM is a distinct metabolic disorder.
Article
Environmental Sciences
Pengfei Gong, Danielle Bailbe, Stefania Tolu, Gaelle Pommier, Junjun Liu, Jamileh Movassat
Summary: Since the restricted use of BPA due to its endocrine disruptor properties, BPS has been widely used as a substitute. However, BPS has similar effects on metabolic health as BPA. Previous studies have documented the effects of maternal exposure to BPA and BPS on offspring, but the impact of preconceptional paternal exposure to BPS remains unexplored. This study showed that preconceptional paternal exposure to BPS had non-monotonic and sex-specific effects on the metabolic health of offspring, suggesting that BPS is not a safe substitute for BPA regarding the inter-generational transmission of metabolic disorders through the paternal lineage.
Article
Endocrinology & Metabolism
Martina Chiriaco, Lorenzo Nesti, Allan Flyvbjerg, Alain Golay, Julie-Anne Nazare, Christian-Heinz Anderwald, Asimina Mitrakou, Roberto Bizzotto, Andrea Mari, Andrea Natali
Summary: The impact of obesity on glucose homeostasis varies greatly among individuals, which may be attributed to different concentrations of adipokines. Subjects with inappropriately elevated leptin levels for their fat mass show whole-body/adipose tissue insulin resistance and hyperinsulinemia, regardless of BMI.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Multidisciplinary Sciences
Louise Sondergaard Rold, Caspar Bundgaard-Nielsen, Julie Niemann Holm-Jacobsen, Per Glud Ovesen, Peter Leutscher, Soren Hagstrom, Suzette Sorensen
Summary: While there is an association between gestational diabetes mellitus and gut microbiota dysbiosis, no specific gut microbiota composition characteristic of GDM has been identified. Studies vary in methodology and design, leading to highly heterogeneous findings. Future research should consider multiple time points and potential confounding factors.
Article
Biochemistry & Molecular Biology
Michihiro Kon, Yoshiko Ebi, Kohei Nakagaki
Summary: The study demonstrated that acute SIT significantly increased the secretion of FSTL1 and apelin, which could improve glucose metabolism and insulin sensitivity.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Regis Coutant, Bruno Leheup, Marc Nicolino, Jean-Pierre Salles
Summary: This observational study examined the long-term effects of growth hormone therapy in children born small for gestational age in France. The study found that 66.3% of children achieved normal height standard deviation score, and 24.7% reached their final adult height. Factors associated with normal height outcomes included baseline height score, age at treatment start, treatment duration, and absence of chronic disease.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Agriculture, Dairy & Animal Science
H. Wang, Y. W. Zhu, J. Yang, X. Y. Wang, Y. C. Zhan, W. C. Wang, L. Yang
Summary: This study aimed to investigate the developmental changes in glucose metabolism and insulin signaling in goose embryos. The results showed that there were linear and quadratic decreases in relative body weight, relative liver weight, and relative body length, as well as a linear decrease in relative yolk weight. Serum glucose, insulin, and free triiodothyronine levels increased linearly with incubation time. The hepatic mRNA expression related to glucose catabolism and insulin signaling increased quadratically from embryonic day 19 to day of hatchment, while the expression of citrate synthase and isocitrate dehydrogenase mRNA decreased linearly and quadratically respectively. Serum glucose levels were positively related to serum insulin and free triiodothyronine levels, as well as the hepatic mRNA expression of insulin receptor, insulin receptor substrate protein, extracellular signal-regulated kinase, and ribosomal protein S6 kinase, 70 ku, related to insulin signaling.
Article
Rheumatology
Cristina Cecamore, Manuela Marsili, Roberta Salvatore, Roberto Troiani, Maurizia D'Egidio, Nicola Tinari, Piernicola Pelliccia, Francesco Chiarelli, M. Loredana Marcovecchio, Luciana Breda
MODERN RHEUMATOLOGY
(2018)
Article
Endocrinology & Metabolism
Liangjian Lu, M. Loredana Marcovecchio, R. Neil Dalton, David Dunger
PEDIATRIC DIABETES
(2018)
Article
Medicine, General & Internal
Marianna I. Petrosino, Alessandra Scaparrotta, M. Loredana Marcovecchio, Daniele Panichi, Daniele Rapino, Marina Attanasi, Paola Di Filippo, Sabrina Di Pillo, Francesco Chiarelli
ARCHIVES OF MEDICAL SCIENCE
(2018)
Article
Endocrinology & Metabolism
Kim C. Donaghue, M. Loredana Marcovecchio, R. P. Wadwa, Emily Y. Chew, Tien Y. Wong, Luis Eduardo Calliari, Bedowra Zabeen, Mona A. Salem, Maria E. Craig
PEDIATRIC DIABETES
(2018)
Article
Cardiac & Cardiovascular Systems
Scott T. Chiesa, Marietta Charakida, Eve McLoughlin, Helen C. Nguyen, Georgios Georgiopoulos, Laura Motran, Yesmino Elia, M. Loredana Marcovecchio, David B. Dunger, R. Neil Dalton, Denis Daneman, Etienne Sochett, Farid H. Mahmud, John E. Deanfield
EUROPEAN HEART JOURNAL
(2019)
Article
Respiratory System
Alessandra Scaparrotta, Marica Franzago, Maria Loredana Marcovecchio, Sabrina Di Pillo, Francesco Chiarelli, Angelika Mohn, Liborio Stuppia
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2019)
Article
Endocrinology & Metabolism
M. Loredana Marcovecchio, R. Neil Dalton, Denis Daneman, John Deanfield, Timothy W. Jones, Andrew W. Neil, David B. Dunger, C. Acerini, F. Ackland, B. Anand, T. Barrett, V. Birrell, F. Campbell, M. Charakida, T. Cheetham, T. Chiesa, J. Deanfield, C. Cooper, I. Doughty, A. Dutta, J. Edge, A. Gray, J. Hamilton-Shield, N. Mann, M. L. Marcovecchio, S. Marshall, G. Rayman, J. M. Robinson, M. Russell-Taylor, V. Sankar, A. Smith, N. Thalange, C. Yaliwal, P. Benitez-Aguirre, F. Cameron, A. Cotterill, J. Couper, M. Craig, E. Davis, K. Donaghue, T. W. Jones, B. King, C. Verge, P. Bergman, C. Rodda, C. Clarson, J. Curtis, D. Daneman, F. Mahmud, E. Sochett
NATURE REVIEWS ENDOCRINOLOGY
(2019)
Article
Genetics & Heredity
M. Loredana Marcovecchio
MOLECULAR DIAGNOSIS & THERAPY
(2020)
Article
Endocrinology & Metabolism
Maria Loredana Marcovecchio, Marco Colombo, Raymond Neil Dalton, Paul M. McKeigue, Paul Benitez-Aguirre, Fergus J. Cameron, Scott T. Chiesa, Jennifer J. Couper, Maria E. Craig, Denis Daneman, Elizabeth A. Davis, John E. Deanfield, Kim C. Donaghue, Timothy W. Jones, Farid H. Mahmud, Sally M. Marshall, Andrew Neil, Helen M. Colhoun, David B. Dunger
PEDIATRIC DIABETES
(2020)
Article
Medicine, General & Internal
Mohammed Kamal Badawy, Vidya Viswanath, Babita Khetriwal, Swati Pradhan, Rachel M. Williams, Nazima Pathan, Maria Loredana Marcovecchio
Summary: We present a case of a girl with new-onset type 1 diabetes, who experienced severe diabetic ketoacidosis accompanied by profound hypokalemia and hypernatremia. The clinical course, management challenges, and the potential impact of concomitant COVID-19 infection in complicating this case are described.
CLINICAL CASE REPORTS
(2022)
Article
Medicine, Research & Experimental
David B. Dunger, Sylvaine F. A. Bruggraber, Adrian P. Mander, M. Loredana Marcovecchio, Timothy Tree, Piotr Jaroslaw Chmura, Mikael Knip, Anke M. Schulte, Chantal Mathieu
Summary: The INNODIA consortium has established an infrastructure to evaluate clinical data and identify biomarkers for future clinical trials in newly diagnosed type 1 diabetes. They have developed a master protocol to improve phase 2 studies, including standardized assessment, collection of mechanistic data, and evaluation of combination therapies.
Article
Endocrinology & Metabolism
S. Francesca Annan, Laurie A. Higgins, Elisabeth Jelleryd, Tamara Hannon, Shelley Rose, Sheryl Salis, Juliana Baptista, Paula Chinchilla, Maria Loredana Marcovecchio
PEDIATRIC DIABETES
(2022)
Editorial Material
Endocrinology & Metabolism
Maria E. Craig, Ethel Codner, Farid H. Mahmud, M. Loredana Marcovecchio, Linda A. DiMeglio, Leena Priyambada, Joseph I. Wolfsdorf
PEDIATRIC DIABETES
(2022)
Review
Health Care Sciences & Services
Enza Mozzillo, Roberto Franceschi, Francesca Di Candia, Alessia Ricci, Letizia Leonardi, Martina Girardi, Francesco Maria Rosanio, Maria Loredana Marcovecchio
Summary: The systematic review aimed to investigate the optimal timing of insulin bolus in youths with type 1 diabetes. The findings suggest that pre-meal administration of insulin is associated with lower postprandial blood glucose levels and reduced HbA1c without increasing the risk of hypoglycemia. Furthermore, postprandial administration of fast-acting analogues is superior to rapid-acting analogues in controlling postprandial glycemia. These results have important implications for improving blood glucose control and quality of life in patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Letter
Medicine, General & Internal
Joseph T. Flynn
NEW ENGLAND JOURNAL OF MEDICINE
(2018)