Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Peter A. C. Wing, Peter Jianrui Liu, James M. Harris, Andrea Magri, Thomas Michler, Xiaodong Zhuang, Helene Borrmann, Rosalba Minisini, Nicholas R. Frampton, Jochen M. Wettengel, Laurent Mailly, Valentina D'Arienzo, Tobias Riedl, Luis Nobre, Michael P. Weekes, Mario Pirisi, Mathias Heikenwalder, Thomas F. Baumert, Ester M. Hammond, David R. Mole, Ulrike Protzer, Peter Balfe, Jane A. McKeating
Summary: HIFs play a crucial role in regulating HBV replication, revealing an evolutionary mechanism by which HBV exploits the HIF signaling pathway to persist in the low oxygen environment of the liver.
JOURNAL OF HEPATOLOGY
(2021)
Review
Cell Biology
Lovis Kling, Adrian Schreiber, Kai-Uwe Eckardt, Ralph Kettritz
Summary: Hypoxia affects myeloid cells, while HIFs play a crucial role in modulating myeloid cell functions to adapt to low oxygen environments. HIF-1α and HIF-2α are key players in the innate immune response, though with different impact mechanisms.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Biochemical Research Methods
Simon d'Oelsnitz, Joshua D. Love, Daniel J. Diaz, Andrew D. Ellington
Summary: Genetic biosensors play a crucial role in synthetic biology, particularly in high-throughput screening, dynamic feedback regulation, and diagnostic applications. To provide a reliable resource for engineering applications, we have developed GroovDB, a web-accessible database of ligand-inducible transcription factors that includes all the necessary information for building chemically responsive genetic circuits. Ligand-DNA interaction data have been verified and a custom tool allows visualization of the natural genetic context of biosensor entries.
ACS SYNTHETIC BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Dan Du, Yugang Zhang, Canjun Zhu, Hong Chen, Jia Sun
Summary: The earliest function of hypoxia-inducible factor (HIF) was to respond to hypoxic conditions as a transcription factor. Recent studies have shown that HIF plays an essential role in central regulation of metabolism, affecting the central nervous system's response to glucose, inflammation, and hormonal influence on systemic metabolism. HIF primarily inhibits energy uptake and promotes energy expenditure in the hypothalamus, with its role depending on various factors and mechanisms within the hypothalamus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Nirvana Sadaghianloo, Julie Contenti, Serge Declemy, Damien Ambrosetti, Masa Zdralevic, Mounia Tannour-Louet, Lucilla Fabbri, Gilles Pages, Frederic Bost, Reda Hassen-Khodja, Jacques Pouyssegur, Elixene Jean-Baptiste, Alan Dardik, Nathalie M. Mazure
Summary: Patients with end-stage renal failure need AVFs for dialysis, but these AVFs often fail due to excessive venous thickness. This study found that venous cells adapt their metabolism depending on oxygen concentration, and targeting the hypoxic response pathway with drugs can help decrease excessive venous thickness. In a mouse model, inhibiting HIFs decreased neointimal hyperplasia, suggesting that drugs targeting HIFs could prevent AVF failure.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Immunology
Jinwei Zhang, Xiaoqian Wu, Jideng Ma, Keren Long, Jing Sun, Mingzhou Li, Liangpeng Ge
Summary: Hypoxia and HIF signaling have important regulatory roles in cell biology, but their role in B cell biology is still controversial. Studies have found that hypoxia niches exist in different developmental stages of B cells, suggesting that hypoxia and HIF signaling may play a crucial role in the development, metabolism, and function of B cells. A better understanding of the role of hypoxia in B cell-mediated adaptive immunity could provide new strategies for vaccine adjuvant research and the treatment of immunity-related or infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andrey A. Poloznikov, Sergey V. Nikulin, Dmitry M. Hushpulian, Anna Yu. Khristichenko, Andrey I. Osipyants, Andrey F. Asachenko, Olga V. Shurupova, Svyatoslav S. Savin, Sue H. Lee, Irina N. Gaisina, Gregory R. J. Thatcher, Anthony Narciso, Eric P. Chang, Sergey V. Kazakov, Nancy Krucher, Vladimir I. Tishkov, Bobby Thomas, Irina G. Gazaryan
Summary: This study evaluated the differences in action of commercially available 2-oxoglutarate mimetics and branched-tail oxyquinoline inhibitors of hypoxia-inducible factor prolyl hydroxylase (HIF PHD). Novel oxyquinoline inhibitors were identified to be more active than existing ones and showed opposite effects on certain signaling pathways.
Article
Dermatology
F. Toberer, H. A. Haenssle, M. Heinzel-Gutenbrunner, A. Enk, W. Hartschuh, P. Helmbold, H. Kutzner
Summary: The study highlights the crucial role of HIF-1α in MCC pathogenesis and suggests significant metabolic differences between McPyV(+) and McPyV(-) tumors.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Cell Biology
Romina J. Bevacqua, Jonathan Y. Lam, Heshan Peiris, Robert L. Whitener, Seokho Kim, Xueying Gu, Mollie S. H. Friedlander, Seung K. Kim
Summary: This study found that SIX2 and SIX3 play important roles in the functional maturation of human pancreatic beta cells, particularly in insulin secretion. SIX2 primarily regulates genes governing insulin processing and output, while SIX3 affects genes normally expressed in fetal cells and non-beta cells.
GENES & DEVELOPMENT
(2021)
Article
Multidisciplinary Sciences
Romana Bohuslavova, Valeria Fabriciova, Ondrej Smolik, Laura Lebron-Mora, Pavel Abaffy, Sarka Benesova, Daniel Zucha, Lukas Valihrach, Zuzana Berkova, Frantisek Saudek, Gabriela Pavlinkova
Summary: NEUROD1 is a transcription factor that plays an important role in pancreatic development and is crucial for the differentiation of endocrine cells. Its deficiency disrupts endocrine cell identity acquisition and compromises their differentiation and functional properties.
NATURE COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Xinguo Jiang, Wen Tian, Dongeon Kim, Alexander S. McQuiston, Ryan Vinh, Stanley G. Rockson, Gregg L. Semenza, Mark R. Nicolls
Summary: Lymphedema is a chronic inflammatory disorder with incomplete understanding of its pathology and lack of approved pharmacological therapy. Studying hypoxia-regulated pathways in lymphedema may lead to new treatment approaches.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shuyan Zhu, Huimin Shan, Jianqiao Li, Lijie Pan, Shudan Wang, Jing Zhu, Hui Guo, Fenghua Mi, Xinyi Wu, Kunpeng Pang
Summary: The transdifferentiation of keratocytes into myofibroblasts is a major cause of corneal fibrosis and scarring. In this study, the researchers investigated the role of Hypoxia Inducible Factor (HIF) in corneal fibrosis and found that topical administration of acriflavine (ACF), a drug inhibiting HIF dimerization, significantly inhibited corneal fibrosis in a mouse model. The researchers also demonstrated that ACF suppressed the expression of key markers of myofibroblast differentiation and the production of disorganized extracellular matrix molecules.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Xiang Wang, Xiang-Yu Zhao
Summary: NK cells develop primarily through the action of IL-15, which is produced by both hematopoietic and nonhematopoietic cells and delivered to NK cells through a process called transpresentation, activating multiple signaling pathways to facilitate development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
P. Perimenis, T. Bouckenooghe, J. Delplanque, E. Moitrot, E. Eury, S. Lobbens, P. Gosset, L. Devisme, B. Duvillie, A. Abderrahmani, L. Storme, P. Fontaine, P. Froguel, A. Vambergue
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2014)
Editorial Material
Endocrinology & Metabolism
Bertrand Duvillie
Article
Endocrinology & Metabolism
Andrea Soggia, Cyrille Ramond, Haruhiko Akiyama, Raphael Scharfmann, Bertrand Duvillie
Review
Medicine, Research & Experimental
Bertrand Duvillie
M S-MEDECINE SCIENCES
(2013)
Article
Cell Biology
E. Hoarau, V. Chandra, P. Rustin, R. Scharfmann, B. Duvillie
CELL DEATH & DISEASE
(2014)
Article
Genetics & Heredity
Riyad El-Khoury, Eric Dufour, Malgorzata Rak, Nelina Ramanantsoa, Nicolas Grandchamp, Zsolt Csaba, Bertrand Duvillie, Paule Benit, Jorge Gallego, Pierre Gressens, Chamsy Sarkis, Howard T. Jacobs, Pierre Rustin
Review
Endocrinology & Metabolism
Bertrand Duvillie, Rayane Kourdoughli, Sabine Druillennec, Alain Eychene, Celio Pouponnot
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
B. Duvillie
Summary: Diabetes increases the risk of viral infection, with several SARS-CoV-2 positive patients developing new-onset diabetes. Infection of pancreatic endocrine cells leads to the release of cytokines, causing the death of α and β cells.
CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION
(2021)
Article
Endocrinology & Metabolism
Bertrand Duvillie
CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION
(2018)
Article
Endocrinology & Metabolism
Bertrand Duvillie
CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION
(2018)
Meeting Abstract
Endocrinology & Metabolism
Benjamin Broche, Selma Ben Fradj, Fatna Makaci, Clotilde Alvesguerra, Raphael Scharfmann, Bertrand Duvillie
Article
Medicine, Research & Experimental
Marie-Jose Lecomte, Severine Pechberty, Cecile Machado, Sandra Da Barroca, Philippe Ravassard, Raphael Scharfmann, Paul Czernichow, Bertrand Duvillie
Article
Endocrinology & Metabolism
Bertrand Duvillie
CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION
(2015)
Article
Endocrinology & Metabolism
Bertrand Duvillie
CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION
(2012)
Article
Endocrinology & Metabolism
Benjamin Broche, Selma Ben Fradj, Esther Aguilar, Tiphaine Sancerni, Matthieu Benard, Fatna Makaci, Claire Berthault, Raphael Scharfmann, Marie-Clotilde Alves-Guerra, Bertrand Duvillie