Article
Oncology
Jin Wang, Jilong Yang
Summary: This study aimed to identify effective treatment targets for improving the prognosis of SKCM. The results showed that CYP1B1 and PRKCB were overexpressed and correlated with poor prognosis in SKCM.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Johan Falkenius, Johanna Keskitalo, Lena Kanter, Hemming Johansson, Veronica Hoiom, Johan Hansson, Suzanne Egyhazi Brage
Summary: Ulceration is an adverse prognostic factor in cutaneous malignant melanoma, and additional markers like BRAF mutation, proliferation, and presence of TILs can help identify patients at high risk for recurrence. The study found that a combination of BRAF wildtype/low proportion of mutated alleles, low proliferation, and high presence of TILs can significantly decrease recurrence rates in ulcerated CMM patients.
Article
Pathology
Karina Aivazian
Summary: Tumour regression, driven by the immune system, leads to the disappearance of tumour cells. CD8+ T lymphocytes are recognized as the primary factors in the anti-tumour response, but the interaction between melanoma and the immune system remains complex and not fully understood. Recent progress in understanding the pathogenesis of melanoma regression has led to the identification of therapeutic targets, including immune checkpoint inhibitors. Advanced techniques in spatial analysis of the tumour microenvironment offer insights into the immune drivers of melanoma regression, aiding clinical decision-making.
Article
Oncology
Jianzhong Peng, Tao Wang, Chao Yue, Xianyan Luo, Peng Xiao
Summary: In this study, the relationship between necroptosis-related genes and cutaneous melanoma was analyzed, and it was found that PGAM5 is a biomarker associated with poor prognosis of cutaneous melanoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hao Pang, Yongting Zhou, Jie Wang, Hao Wu, Chenyang Cui, Zhibo Xiao
Summary: The study revealed that SKA3 is highly expressed in skin cutaneous melanoma tissues and its overexpression is associated with poor prognosis and immune status. Knockdown of SKA3 inhibited cell viability, migration, and invasion of melanoma cells, indicating its potential as a prognostic biomarker and therapeutic target.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Roberto Patuzzo, Ilaria Mattavelli, Gianfranco Gallino, Carlotta Galeone, Barbara Valeri, Simone Mocellin, Paolo Del Fiore, Simone Ribero, Mario Mandala, Francesca Tauceri, Maurizio Lombardo, Andrea Maurichi
Summary: This study aimed to evaluate the prognostic value of tumor mitotic rate (TMR) in cutaneous melanoma and assess its significance as a predictor for overall, melanoma-specific, and recurrence-free survival. The study found a clear association between increasing TMR and decreased overall survival, melanoma-specific survival, and recurrence-free survival.
Review
Dermatology
Aikaterini Tsiogka, Adam I. Rubin, Stamatios Gregoriou, Stergios Soulaidopoulos, Helena Belyayeva, Dimitris Rigopoulos
Summary: This study provides a comprehensive systematic review and meta-analysis of the prevalence rates of subungual melanoma (SUM). The overall prevalence of SUM is estimated at 1.9%, showing stable trends over time and significant variability between different geographical regions.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Oncology
Grace H. Attrill, Peter M. Ferguson, Umaimainthan Palendira, Georgina V. Long, James S. Wilmott, Richard A. Scolyer
Summary: The field of tumor immunology has advanced rapidly in the past decade, leading to effective immunotherapies for patients with advanced cancers. Understanding immune cell function in the tumor immune microenvironment (TIME) is crucial for elucidating the complex interactions between tumors and the immune system. This knowledge can contribute to improved treatment strategies and outcomes for cancer patients.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Dermatology
Adrienne B. Shannon, Cimarron E. Sharon, Richard J. Straker, Michael J. Carr, Andrew J. Sinnamon, Kita Bogatch, Alexandra Thaler, Nicholas Kelly, John T. Vetto, Graham Fowler, Danielle DePalo, Vernon K. Sondak, John T. Miura, Mark B. Faries, Edmund K. Bartlett, Jonathan S. Zager, Giorgos C. Karakousis
Summary: Sentinel lymph node biopsy is not routinely recommended for T1a cutaneous melanoma due to low risk of positivity. This study identified age, primary tumor location, lymphovascular invasion, and mitotic rate as factors associated with positive sentinel lymph node in T1a melanoma patients.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Oncology
Yoshinari Asai, Naoki Yanagawa, Mitsumasa Osakabe, Noriyuki Yamada, Ryo Sugimoto, Ayaka Sato, Kazuhiro Ito, Yoshihiko Koike, Takayuki Tanji, Minoru Sakuraba, Takashi Sato, Tamotsu Sugai
Summary: The phenotype of tumor-associated macrophages (TAMs) plays a crucial role in tumor growth and prognosis. This study found that high expression of CD68/c-Maf is a predictor of worse prognosis in patients with cutaneous malignant melanoma (CMM), while CD68/pSTAT1 expression is rare.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Xiaoyue Huang, Lingyu Jiang, Sufang Lu, Mingqing Yuan, Hui Lin, Baijun Li, Zhaoke Wen, Yonglong Zhong
Summary: This study investigated the role and molecular mechanism of ERCC6L in LUAD. The results showed that ERCC6L was upregulated in LUAD tissues and associated with clinical characteristics and survival outcomes. ERCC6L may regulate LUAD through the cell cycle, DNA damage, proliferation, invasion, and EMT. Knockdown of ERCC6L inhibited cell growth, migration, and invasion, and promoted apoptosis and cell cycle arrest. ERCC6L may regulate the EMT process through the Wnt/β-catenin and Wnt/Notch 3 signaling pathways.
Article
Oncology
Li Yuan, Jingli Xu, Yunfu Shi, Zhiyuan Jin, Zhehan Bao, Pengcheng Yu, Yi Wang, Yuhang Xia, Jiangjiang Qin, Bo Zhang, Qinghua Yao
Summary: The study found that CD3D protein is highly expressed in gastric cancer tissues and is associated with prognosis and factors such as tumor infiltrating lymphocytes. CD3D may play an important regulatory role in the tumor immune microenvironment of gastric cancer and could potentially serve as a marker for prognosis and immunotherapy response.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Rui Mao, Fan Yang, Tongtong Zhang, Ji Li
Summary: The incidence of cutaneous melanoma is rising, and better markers are needed to predict prognosis and immunotherapy effectiveness. By analyzing TCGA data and developing a signature based on immune checkpoint proteins, researchers were able to accurately predict prognosis and response to therapy in melanoma patients. The signature was found to be an independent prognostic factor and a nomogram based on the signature was more effective than the signature alone.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ruijiang Lin, Xiaohua Chen, Fei Su, Hongbin Wang, Biao Han, Yanhui Chen, Cuixiang Zhang, Minjie Ma
Summary: The significance of germline HLA-A and HLA-B supertypes in the tumour microenvironment of non-small-cell lung cancer was investigated. HLA-A02 and HLA-B62 supertypes were found to be associated with higher levels of PD-L1-positive tumour and stromal cells, CD68+ cells, and CD68+PD-L1+ cells. Patients with both HLA-A02 and HLA-B62 supertypes had shorter progression-free survival after surgery.
Article
Multidisciplinary Sciences
Ke-Jun Chen, Feng-Zeng Li, Qian Ye, Meng Jia, Sheng Fang
Summary: Heat shock protein 105 (HSP105) is overexpressed in cutaneous malignant melanoma (CMM) and is closely associated with different clinicopathological variables. Lesions in exposed sites, recurrent and metastatic lesions, nodular melanoma, and lentigo maligna melanoma show higher HSP105 expression, suggesting HSP105 as a potential target for the diagnosis, treatment, and prognostic prediction of CMM.
