Article
Radiology, Nuclear Medicine & Medical Imaging
Jonathan H. Chung, Ayodeji Adegunsoye, Justin M. Oldham, Rekha Vij, Aliya Husain, Steven M. Montner, Ronald A. Karwoski, Brian J. Bartholmai, Mary E. Strek
Summary: The study indicates that VRS can differentiate patients with UIP histological features from non-IPF diagnosis in CT images, showing predictive value. The sensitivity and specificity of VRS in predicting pathological UIP are comparable to standard qualitative CT assessment.
EUROPEAN RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nora Melinda Toth, Veronika Muller, Tamas Nagy, Lorinc Polivka, Peter Horvath, Aniko Bohacs, Noemi Eszes
Summary: Elevated serum progranulin (PGRN) levels may help differentiate between idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILDs). Non-IPF ILD patients had significantly higher serum PGRN levels compared to healthy subjects and IPF patients. Non-UIP patterns on high-resolution computed tomography (HRCT) were associated with significantly elevated PGRN levels, while UIP patterns were associated with normal PGRN levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Akira Yamagata, Machiko Arita, Hiromasa Tachibana, Fumiaki Tokioka, Chikatoshi Sugimoto, Hiromitsu Sumikawa, Tomonori Tanaka, Hideki Yasui, Tomoyuki Fujisawa, Yutaro Nakamura, Takafumi Suda, Tadashi Ishida
Summary: BAL lymphocytosis is associated with favorable outcomes in patients treated with anti-inflammatory drugs, indicating its potential as a predictive biomarker for identifying IIP patients likely to benefit from anti-inflammatory therapy. However, BAL lymphocytosis does not have prognostic value in patients managed without anti-inflammatory therapy.
RESPIRATORY RESEARCH
(2021)
Article
Medicine, General & Internal
Theodoros Karampitsakos, Vasilios Tzilas, Ourania Papaioannou, Serafeim Chrysikos, Eirini Vasarmidi, Pierre-Antoine Juge, Styliani Vizirianaki, Eleni Bibaki, Argyro Reppa, Prodromos Sidiropoulos, Matthaios Katsaras, Vasilina Sotiropoulou, Panagiota Tsiri, Electra Koulousousa, Eva Theochari, Georgios Tsirikos, Ioannis Christopoulos, Elli Malakounidou, Eirini Zarkadi, Fotios Sampsonas, Georgios Hillas, Theofanis Karageorgas, Dimitrios Daoussis, Christina Kalogeropoulou, Katerina Dimakou, Nikolaos Tzanakis, Raphael Borie, Philippe Dieude, Katerina Antoniou, Bruno Crestani, Demosthenes Bouros, Argyris Tzouvelekis
Summary: Myositis associated ILD is a commonly under-recognized condition. This multicenter retrospective study identified 75 patients with myositis associated-ILD and found that specific ILD radiographic patterns can indicate underlying inflammatory myopathies. Incorporating these radiological patterns in the diagnostic criteria may improve timely interventions and positively impact patients' survival.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Mariko Fukui, Kazuhiro Suzuki, Katsutoshi Ando, Takeshi Matsunaga, Aritoshi Hattori, Kazuya Takamochi, Shuko Nojiri, Kenji Suzuki
Summary: This study evaluated the surgical outcomes after surgery in patients with stage I lung cancer and idiopathic interstitial pneumonia (IIP), and found that the overall survival of patients with IIP was poor, which was related to the high prevalence of cancer-specific and respiratory-related deaths. It was also found that sublobar resection is not always feasible and the procedure on patients with IIP should be selected carefully according to the characteristics of each case. Nodal dissection should be performed to evaluate for metastasis, regardless of the extent of lung resection.
Article
Critical Care Medicine
Joseph L. Barnett, Toby M. Maher, Jennifer K. Quint, Alex Adamson, Zhe Wu, David J. F. Smith, Bhavin Rawal, Arjun Nair, Simon L. F. Walsh, Sujal R. Desai, Peter M. George, Maria Kokosi, Gisli Jenkins, Vasilis Kouranos, Elisabetta A. Renzoni, Alex Rice, Andrew G. Nicholson, Felix Chua, Athol U. Wells, Philip L. Molyneaux, Anand Devaraj
Summary: This study found that increased BAL lymphocyte proportion is rare in patients with extensive fibrosis or a UIP pattern on CT, and in patients without extensive fibrosis or a non-UIP pattern, an increased BAL lymphocyte proportion is associated with a lower likelihood of disease progression.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Veterinary Sciences
Megan M. Ahearne, Ligia L. Pentzke-Lemus, Ashley M. Romano, Eileen D. Larsen, Allison M. Watson, Elsbeth A. O'Fallon, Gabriele A. Landolt
Summary: This study describes the clinical and diagnostic findings, outcome, and pathologic lesions associated with influenza pneumonia in donkeys. The clinical signs of equine influenza virus infection in donkeys are similar to those observed in horses. The prognosis for survival is generally good, but deaths have been observed especially in foals born to seronegative dams, highlighting the importance of prenatal vaccination protocols in all equids, including donkeys.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Respiratory System
Tori Vigeland Lerum, Trond Mogens Aalokken, Eivind Bronstad, Bernt Aarli, Eirik Ikdahl, Kristine Marie Aarberg Lund, Michael T. Durheim, Jezabel Rivero Rodriguez, Carin Meltzer, Kristian Tonby, Knut Stavem, Ole Henning Skjonsberg, Haseem Ashraf, Gunnar Einvik
Summary: The long-term pulmonary outcomes of COVID-19 after 3 months of hospital admission include chest CT opacities and reduced diffusing capacity in one-fourth of the participants. ICU patients did not show significant differences in dyspnoea scores and lung function, but had a higher prevalence of abnormal chest CT findings.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Respiratory System
Hyun Kyu Cho, Man Pyo Chung, Kyung Soo Lee, Myung Jin Chung, Joungho Han, O. Jung Kwon, Hongseok Yoo
Summary: This study aimed to determine the outcomes of fibrotic NSIP and the prognostic factors for progression, relapse, and survival. Results showed that preserved lung function, BAL lymphocytosis, and treatment with corticosteroids and azathioprine were associated with lower risks of disease progression and relapse.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kum Ju Chae, Myoung Ja Chung, Gong Yong Jin, Young Ju Song, Ae Ri An, Hyemi Choi, Jin Mo Goo
Summary: By evaluating the correlation between radiologic and histologic features, it was found that subpleural fibrotic interstitial lung abnormalities (ILAs) are associated with pathologic usual interstitial pneumonia (UIP) patterns. The recognition of subpleural fibrotic ILAs on CT scans is important for predicting disease progression and mortality risk.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Damiano Caruso, Michela Polici, Marta Zerunian, Francesco Pucciarelli, Tiziano Polidori, Gisella Guido, Carlotta Rucci, Benedetta Bracci, Emanuele Muscogiuri, Chiara De Dominicis, Andrea Laghi
Summary: Quantitative Chest CT can differentiate COVID-19 from non-COVID-19 patients, with ground-glass opacities and fibrotic alterations playing significant roles in this distinction.
Article
Medicine, General & Internal
Natalia Buda, Jolanta Cylwik, Katarzyna Mroz, Renata Rudzinska, Pawel Dubik, Agnieszka Malczewska, Aleksandra Oraczewska, Szymon Skoczynski, Anna Suska, Tomasz Gorecki, Konrad Mendrala, Jakub Piotrkowski, Wojciech Gola, Elena Segura-Grau, Anna Zamojska, Marcin Welnicki
Summary: A multicenter registry study found that LUS is highly sensitive and specific in detecting interstitial pneumonia in COVID-19 patients, especially in hospitalized patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pathology
Soo-Ryum Yang, Mary B. Beasley, Andrew Churg, Thomas V. Colby, Evans R. Fernandez Perez, David Lynch, Nestor L. Muller, William D. Travis
Summary: Assessment of lung biopsies for the diagnosis of hypersensitivity pneumonitis (HP) is challenging. The American College of Chest Physicians has published guidelines for the diagnosis of HP to address these challenges. This review explores the multidisciplinary diagnostic evaluation of HP, highlighting histologic features and the correlation of lung biopsies with computed tomography findings.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Respiratory System
Nevins W. Todd, Sergei P. Atamas, Stella E. Hines, Irina G. Luzina, Nirav G. Shah, Edward J. Britt, Andrew J. Ghio, Jeffrey R. Galvin
Summary: The focus of research on idiopathic interstitial pneumonias (IIPs) lies in understanding the association between radiologic and histologic patterns of lung injury and various diseases and environmental factors. The term idiopathic is misleading as these diseases are often associated with diverse etiologies, and a shift towards more etiology-focused nomenclature is beneficial for better management and understanding of interstitial lung diseases (ILDs).
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Article
Respiratory System
Quentin Philippot, Caroline Kannengiesser, Marie Pierre Debray, Clement Gauvain, Ibrahima Ba, Margherita Vieri, Anne Gondouin, Jean-Marc Naccache, Martine Reynaud-Gaubert, Yurdagul Uzunhan, Benjamin Bondue, Dominique Israel-Biet, Philippe Dieude, Cecile Fourrage, Elodie Lainey, Effrosyne Manali, Spyros Papiris, Lidwine Wemeau, Sandrine Hirschi, Herve Mal, Hilario Nunes, Frederic Schlemmer, Elodie Blanchard, Fabian Beier, Vincent Cottin, Bruno Crestani, Raphael Borie
Summary: This study describes the phenotype of patients with interstitial lung disease (ILD) and heterozygous PARN mutations, showing that idiopathic pulmonary fibrosis is common among individuals with PARN mutation. Other ILD subtypes may also be observed, and some patients may experience disease progression leading to death or lung transplantation despite specific treatment.
Letter
Rheumatology
Florence Jeny, Raphael Lhote, Gwenael Lorillon, Nicolas Belhomme, Gregory Pugnet, Raphael Borie, Aurelien Justet, Stephane Jouneau, Nathalie Freymond, Arsene Mekinian, Robin Dhote, Yacine Tandjaoui-Lambiotte, Nathalie Saindenberg, Pierre Gazengel, Baptiste Hervier, Julien Haroche, Alexis Mathian, Miguel Hie, Thibaud Chazal, Dov Taieb, Yurdagul Uzunhan, Jerome Le Pavec, Isabella Annesi-Maesano, Emmanuel Bergot, Abdellatif Tazi, Zahir Amoura, Dominique Valeyre, Hilario Nunes, Fleur Cohen-Aubart
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Surgery
Mathilde Phillips-Houlbracq, Herve Mal, Vincent Cottin, Clement Gauvain, Fabian Beier, Flore Sicre de Fontbrune, Sabrina Sidali, Jean Francois Mornex, Sandrine Hirschi, Antoine Roux, Gaelle Weisenburger, Arnaud Roussel, Lidwine Wemeau-Stervinou, Jerome Le Pavec, Christophe Pison, Sylvain Marchand Adam, Antoine Froidure, Romain Lazor, Jean-Marc Naccache, Stephane Jouneau, Hilario Nunes, Martine Reynaud-Gaubert, Aurelie Le Borgne, David Boutboul, Ibrahima Ba, Catherine Boileau, Bruno Crestani, Caroline Kannengiesser, Raphael Borie
Summary: This study reviewed the outcomes after lung transplantation in carriers of TRG gene mutations, identifying myelodysplasia and short telomeres as predictors of post-LT survival. All patients experienced anemia, with 66% having thrombocytopenia and 39% having neutropenia post-LT. Hematological evaluation should be conducted systematically before lung transplantation to improve outcomes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Respiratory System
Quentin Philippot, Caroline Kannengiesser, Marie Pierre Debray, Clement Gauvain, Ibrahima Ba, Margherita Vieri, Anne Gondouin, Jean-Marc Naccache, Martine Reynaud-Gaubert, Yurdagul Uzunhan, Benjamin Bondue, Dominique Israel-Biet, Philippe Dieude, Cecile Fourrage, Elodie Lainey, Effrosyne Manali, Spyros Papiris, Lidwine Wemeau, Sandrine Hirschi, Herve Mal, Hilario Nunes, Frederic Schlemmer, Elodie Blanchard, Fabian Beier, Vincent Cottin, Bruno Crestani, Raphael Borie
Summary: This study describes the phenotype of patients with interstitial lung disease (ILD) and heterozygous PARN mutations, showing that idiopathic pulmonary fibrosis is common among individuals with PARN mutation. Other ILD subtypes may also be observed, and some patients may experience disease progression leading to death or lung transplantation despite specific treatment.
Article
Immunology
Mathilde Lecuit, Pierre Aucouturier, Aicha Abbas, Jacques Cadranel, Christine Silvain, Jean-Marie Berthelot, Anne-Laure Fauchais, Paul Loubet, Claude Bachmeyer, Francoise Montravers, Antoine Dossier, Hilario Nunes, Pascale Cervera, Paul Coppo
Summary: IgG4-related disease is characterized by tissue infiltration leading to fibrosis and organomegaly, with clinical presentation varying widely. High serum IgG4 concentration, previously considered a diagnostic hallmark, may not always be present in patients. Elevated IgG2, IgG1, and IgG3 levels were observed in some cases, underscoring the complexity of diagnosing IgG4-RD.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Respiratory System
Nadia Nathan, Marie-Emeline Montagne, Odile Macchi, Paul-Andre Rosental, Simon Chauveau, Florence Jeny, Lucile Sese, Rola Abou Taam, Manon Brocvielle, Jacques Brouard, Mickael Catinon, Catherine Chapelon-Abric, Fleur Cohen-Aubart, Christophe Delacourt, Celine Delestrain, Antoine Deschildre, Antoine Dossier, Ralph Epaud, Julien Haroche, Veronique Houdouin, Dominique Israel-Biet, Karine Juvin, Sylvain Le Jeune, Francois Lionnet, Ulrich Meinzer, Marie Mittaine, Hilario Nunes, Sarah Mattioni, Jean-Marc Naccache, Marie-Helene Odievre, Michel Vincent, Annick Clement, Dominique Valeyre, Catherine Cavalin
Summary: The study found that pediatric sarcoidosis is associated with patients' indirect exposure to inorganic particles, their family members' occupations, and heating sources, especially factors like construction and metal dust which may increase the risk of the disease.
Article
Respiratory System
Laurent Savale, Marloes Huitema, Oksana Shlobin, Vasilis Kouranos, Steven D. Nathan, Hiliaro Nunes, Rohit Gupta, Jan C. Grutters, Daniel A. Culver, Marco C. Post, Daniel Ouellette, Elyse E. Lower, Tamara Al-Hakim, Athol U. Wells, Marc Humbert, Robert P. Baughman
Summary: Sarcoidosis-associated pulmonary hypertension (SAPH) is a significant complication of advanced sarcoidosis. A task force was established to summarize the current knowledge and provide guidance for patient management, including screening and diagnosis. The committee has developed consensus regarding screening and further testing, as well as the need for joint decision-making with experts in sarcoidosis and pulmonary hypertension for specific treatment. However, there are still significant knowledge gaps regarding SAPII that need to be addressed in future studies.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Rheumatology
France X. Mariette, O. Hermine, P-L Tharaux, M. Resche-Rigon, R. Porcher, P. Ravaud
Summary: Treatment with sarilumab did not improve early outcomes in patients with moderate-to-severe COVID-19 pneumonia. Further studies are warranted to evaluate the effect of sarilumab on long-term survival.
LANCET RHEUMATOLOGY
(2022)
Review
Medicine, General & Internal
Claudio Tana, Marjolein Drent, Hilario Nunes, Vasilis Kouranos, Francesco Cinetto, Naomi T. Jessurun, Paolo Spagnolo
Summary: Sarcoidosis is a heterogeneous disease that can affect various organs, and its interaction and coexistence with other diseases can complicate diagnosis and treatment.
ANNALS OF MEDICINE
(2022)
Letter
Respiratory System
Pierre Bay, Marc Pineton de Chambrun, Antoine Roux, Vincent Bunel, Alain Combes, Dominique Israel-Biet, Benjamin Zuber, Hilario Nunes, Yves Allenbach, Yurdagul Uzunhan
EUROPEAN RESPIRATORY JOURNAL
(2022)
Editorial Material
Infectious Diseases
Y. Tandjaoui-Lambiotte, F. Crockett, H. Nunes, I Annesi-Maesano, L. Sese
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2022)
Article
Obstetrics & Gynecology
Caroline Baldini Prudencio, Sthefanie Kenickel Nunes, Fabiane Affonso Pinheiro, Carlos Isaias Sartorao Filho, Flavia Ignacio Antonio, Guilherme Thomaz de Aquino Nava, Marilza Vieira Cunha Rudge, Angelica Mercia Pascon Barbosa
Summary: This study investigates the concentration of relaxin-2 in patients with gestational diabetes mellitus (GDM) and non-GDM during pregnancy, comparing urinary incontinence and pelvic function status. The results show that lower relaxin-2 concentration is associated with the presence of pregnancy-specific urinary incontinence, and the combination of GDM, pregnancy-specific urinary incontinence, and lower levels of pelvic floor strength leads to even lower levels of relaxin-2.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Clinical Neurology
Yann Nadjar, Pierre Levy, Vi-Huong Nguyen-Michel, Charles-Edouard Luyt, Louis Puybasset, Vincent Navarro
Summary: This study aimed to identify the features that may predict the outcome of patients with post anoxic coma (PAC) by analyzing electroencephalographic (EEG) patterns. The presence of EEG paroxysms (EP) and their regularity features were strongly associated with poor outcome in PAC patients. A global regularity score derived from visual EEG inspection could be a reliable prognostic tool.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Editorial Material
Medicine, General & Internal
P. Seve, Y. Jamilloux, A. Bert, T. El Jammal, D. Valeyre
REVUE DE MEDECINE INTERNE
(2022)
Article
Cardiac & Cardiovascular Systems
Dana Radu, Olivia Freynet, Marianne Kambouchner, Marouane Boubaya, Hilario Nunes, Yurdagul Uzunhan, Pierre-Yves Brillet, Patrice Guiraudet, Mohammad Zaahid Noorah, Dominique Israel-Biet, Francoise Le Pimpec-Barthes, Karine Juvin, Anne Charpentier, Laure Gibault, Jalal Assouad, Jean-Marc Naccache, Martine Antoine, Sebastian Tavolaro, Marco Alifano, Isabelle Honore, Jean Pierre L'Huillier, Denis Debrosse, Clairelyne Dupin, Pauline Pradere, Marie-Pierre Debray, Aurelie Cazes, Pierre Mordant, Yves Castier, Sadek Beloucif, Bruno Crestani, Vincent Levy, Emmanuel Martinod, Dominique Valeyre
Summary: This study prospectively assessed the yield of diagnosis and safety of video-assisted thoracoscopic surgical lung biopsy (VATS-LB) for ILD diagnosis in 103 patients. The results showed that VATS-LB dramatically changed preoperative hypothetical diagnoses and treatment in ILD of unknown cause.
ANNALS OF THORACIC SURGERY
(2022)
Article
Rheumatology
Paul Breillat, Kuberaka Mariampillai, Paul Legendre, Pauline Martins, Bertrand Dunogue, Jean Luc Charuel, Makoto Miyara, Claire Goulvestre, Romain Paule, Helene Vanquaethem, Felix Ackermann, Olivier Benveniste, Hilario Nunes, Luc Mouthon, Yves Allenbach, Yurdagul Uzunhan
Summary: This study identified three distinct clinical phenotypes and outcomes among patients with anti-PM-Scl-scleroderma antibodies positive autoimmune diseases. Skin thickening and non-specific interstitial pneumonia were crucial predictors in differentiating these subgroups.
