Article
Oncology
Natalia Domian, Grzegorz Mlynarczyk, Irena Kasacka
Summary: The study presented a case of penile squamous cell carcinoma and evaluated the expression of E-cadherin and beta-catenin through immunohistochemical analysis. It was found that E-cadherin expression decreased while beta-catenin expression slightly increased in tumor samples compared to healthy tissue, which may be related to tumor invasion and metastasis. The findings suggest potential roles of E-cadherin and beta-catenin in cell proliferation and adhesion during physiological and pathophysiological processes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Priyanka K. Shetty, Nitin Gonsalves, Dinkar Desai, Siddharth Pandit, Chethan Aradhya, Mohammed Shahid, Shubhalakshmi, Sharan J. Shetty
Summary: This study aimed to evaluate the difference in immunohistochemical expression of syndecan-1 in different grades of oral squamous cell carcinoma (OSCC) patients and control group. The results showed that as cellular differentiation was lost, syndecan-1 expression decreased.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Chemistry, Medicinal
Hyeong Sim Choi, Young-Kyun Kim, Pil-Young Yun
Summary: This study aimed to identify the gene expressions related to cisplatin resistance in oral squamous cell carcinoma (OSCC) cell lines. RNA sequencing (RNA-Seq) analysis was used to determine differentially expressed genes and perform functional enrichment and signaling pathway analyses. Several genes related to cell adhesion molecules and proteoglycans in cancer pathways were found to have altered expression in cisplatin-resistant samples. These findings may provide new insights for improving the clinical therapeutic outcomes of OSCC.
Article
Endocrinology & Metabolism
Wen-Hsuan Tsai, Tze-Chien Chen, Shuen-Han Dai, Yi-Hong Zeng
Summary: Adrenocortical carcinoma (ACC) is a rare malignancy with endocrinological issues and may present as neuroendocrine carcinoma. Pathological testing and immunohistochemical staining are crucial for diagnosis, and complete surveys are needed to determine whether the ectopic ACC is functional.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Ashley Wysong
Summary: Squamous-cell carcinoma is a common type of cancer in humans, with most cases being localized and treatable, but a small percentage of cases that recur or spread can be fatal. Immunocompromised patients are at particularly high risk.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Jingyun Wang, Zhuang Sun, Jing Wang, Qihai Tian, Runda Huang, Hanyu Wang, Xiaohui Wang, Fei Han
Summary: Elevated expression of PLEK2 was observed in HNSCC, correlated with metastasis and hypoxia, and associated with the focal adhesion pathway. PLEK2 and ITGA3 may be viewed as intricately linked in facilitating HNSCC metastasis.
Review
Oncology
Raneem Y. Hammouz, Damian Kolat, Zaneta Kaluzinska, Elzbieta Pluciennik, Andrzej K. Bednarek
Summary: In cells with invasive capabilities, altered proteins contribute to cancer invasion and metastasis. MicroRNAs play key roles in bladder cancer metastasis and angiogenesis, serving as potential therapeutic targets or diagnostic markers.
Article
Immunology
Miia Seppala, Laura Jauhiainen, Sanni Tervo, Ahmed Al-Samadi, Markus Rautiainen, Tuula Salo, Kaisa Lehti, Outi Monni, Sampsa Hautaniemi, Olli Tynninen, Antti Makitie, Laura K. Makinen, Timo Paavonen, Sanna Toppila-Salmi
Summary: Expression of CDH3 in tongue squamous cell carcinoma (TSCC) is not associated with prognosis, in contrast to its predictive value in oral squamous cell carcinoma (OSCC). The prognostic impact of CDH3 in TSCC was not validated in this study.
Article
Oncology
Diana Marzic, Blazen Marijic, Tamara Braut, Stefan Janik, Manuela Avirovic, Ita Hadzisejdic, Filip Tudor, Katarina Radobuljac, Miran Coklo, Boban M. Erovic
Summary: IMP3 expression is higher in malignant laryngeal lesions compared to dysplasia and benign lesions, serving as a useful marker to differentiate between invasive and noninvasive lesions. Higher IMP3 expression is associated with worse clinical outcomes in patients with squamous cell carcinoma of the larynx.
Article
Agriculture, Dairy & Animal Science
Ferran Solanes Vilanova, Tom Hellebuyck, Koen Chiers
Summary: This study investigated the histological characteristics of tumors from reptiles and proposed a histopathological classification for squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs) in reptiles. The study found that some tumors initially diagnosed as SCCs were re-classified as BCCs, and some SCCs were non-neoplastic lesions. Additionally, basal cell carcinomas were diagnosed in seven additional reptile species for the first time. Immunohistochemical staining showed differences between the examined SCCs and BCCs, indicating potential for differentiation.
Review
Pharmacology & Pharmacy
Umer Ejaz, Fahad Akhtar, Jinbing Xue, Xinyu Wan, Tong Zhang, Shuying He
Summary: Low molecular weight heparin, derived from commercial-grade heparin, has potential anti-tumor and anti-metastatic effects in addition to its anticoagulant activity. Studies suggest that it may inhibit tumor metastasis by influencing cell adhesion molecules.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Xiaoting Chen, Lanlan Huang, Tingting Yang, Jiexuan Xu, Chengyong Zhang, Zhendong Deng, Xiaorong Yang, Naihua Liu, Size Chen, Shaoqiang Lin
Summary: Recent studies have identified pleiotropic roles of METTL3 in tumor progression, but its specific role in esophageal squamous cell carcinoma (ESCC) is still unclear. Higher METTL3 expression in ESCC tissues was associated with poor prognosis, and it was shown to promote migration and invasion of ESCC cells by regulating GLS2. These findings suggest METTL3/GLS2 signaling as a potential therapeutic target for anti-metastatic strategies against ESCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Anatomy & Morphology
Ozlem Ucer, Nevin Kocaman
Summary: In this study, the researchers found that Suprabasin protein is increased in expression in squamous cell carcinoma (SCC) and decreases with increasing grade. They also observed no expression of Suprabasin in basal cell carcinoma (BCC). Therefore, Suprabasin can be used as a biomarker to differentiate SCC from BCC.
Article
Immunology
Gargi Mila Sinha, Veda Hegde
Summary: The study aimed to evaluate and detect the efficacy of the immunohistochemical marker (cytokeratin (CK) AE1/AE3) compared to routine Hematoxylin & Eosin (H&E) staining in detecting micro-metastasis in lymph nodes of oral squamous cell carcinoma (OSCC) cases. The results showed that the IHC marker CK cocktail (AE1/AE3) did not demonstrate any positive reactivity for the target antigen in all the 100 H&E stained lymph node sections evaluated in this study. The findings suggest that the IHC marker AE1/AE3 did not prove to be useful in detecting micro-metastasis in this study population.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Wenying Liu, Yu Xia, Mengyan Li, Gulinaer Abulajiang, Hui Wang, Liping Su, Chao Li, Yan Shi, Wenjing Zhang, Shanshan Xu, Yuqing Ma
Summary: This study investigated the impact of MTA1, SOX4, and EZH2 on the prognosis of patients with ESCC. The results suggest that MTA1 may serve as a prognostic and diagnostic marker for ESCC, and that MTA1-SOX4 signaling is associated with prognosis in ESCC. However, no significant association was found between SOX4 and EZH2 in this study, indicating the need for further investigation into the function of the MTA1-SOX4-EZH2 axis and the interactions of the proteins involved.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Letter
Cell Biology
Joshua Kibera, Jean-Joel Awoumou, Ephraim Zulu, Xavier Farre
Meeting Abstract
Oncology
Patrick Leo, Andrew Janowczyk, Robin Elliott, Nafiseh Janaki, Rakesh Shiradkar, Xavier Farre, Kosj Yamoah, Timothy Rebbeck, Natalie Shih, Francesca Khani, Brian D. Robinson, Lauri Eklund, Otto Ettala, Pekka Taimen, Peter Bostrom, Michael D. Feldman, Sanjay Gupta, Priti Lal, Anant Madabhushi
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Pathology
Wouter Bulten, Maschenka Balkenhol, Jean-Joel Awoumou Belinga, Americo Brilhante, Asli Cakir, Lars Egevad, Martin Eklund, Xavier Farre, Katerina Geronatsiou, Vincent Molinie, Guilherme Pereira, Paromita Roy, Gunter Saile, Paulo Salles, Ewout Schaafsma, Joelle Tschui, Anne-Marie Vos, Hester van Boven, Robert Vink, Jeroen van der Laak, Christina Hulsbergen-van der Kaa, Geert Litjens
Summary: The Gleason score is crucial for prostate cancer prognosis, and AI systems based on deep learning can help improve pathologist performance in grading. However, the performance of AI systems may degrade in the presence of artifacts. Integrating pathologists' expertise with AI feedback can lead to better results.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rakesh Shiradkar, Ananya Panda, Patrick Leo, Andrew Janowczyk, Xavier Farre, Nafiseh Janaki, Lin Li, Shivani Pahwa, Amr Mahran, Christina Buzzy, Ping Fu, Robin Elliott, Gregory MacLennan, Lee Ponsky, Vikas Gulani, Anant Madabhushi
Summary: Significant differences were observed in TCRs and T1 and T2 MRF between PCa, prostatitis, and normal PZ. T1 and T2 MRF showed correlations with epithelium and stroma of PCa, with T1 MRF in opposite directions between PCa and prostatitis. T2 MRF was positively correlated with lumen of PCa and prostatitis.
EUROPEAN RADIOLOGY
(2021)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Rakesh Shiradkar, Ananya Panda, Patrick Leo, Andrew Janowczyk, Xavier Farre, Nafiseh Janaki, Lin Li, Shivani Pahwa, Amr Mahran, Christina Buzzy, Pingfu Fu, Robin Elliott, Gregory MacLennan, Lee Ponsky, Vikas Gulani, Anant Madabhushi
Summary: The original version of this article, published on September 2, 2020, unfortunately contained a mistake.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Patrick Leo, Andrew Janowczyk, Robin Elliott, Nafiseh Janaki, Kaustav Bera, Rakesh Shiradkar, Xavier Farre, Pingfu Fu, Ayah El-Fahmawi, Mohammed Shahait, Jessica Kim, David Lee, Kosj Yamoah, Timothy R. Rebbeck, Francesca Khani, Brian D. Robinson, Lauri Eklund, Ivan Jambor, Harri Merisaari, Otto Ettala, Pekka Taimen, Hannu J. Aronen, Peter J. Bostrom, Ashutosh Tewari, Cristina Magi-Galluzzi, Eric Klein, Andrei Purysko, Natalie NC Shih, Michael Feldman, Sanjay Gupta, Priti Lal, Anant Madabhushi
Summary: Histotyping is an automated BCR prognosis method that is tissue non-destructive and utilizes computational image analysis of morphologic patterns in prostate tissue. Through training and validation on a large number of patients, Histotyping demonstrates good prognostic performance in various clinically stratified subsets, independently of other clinical parameters. Its performance outperforms Decipher in predicting post-RP BCR.
NPJ PRECISION ONCOLOGY
(2021)
Article
Urology & Nephrology
Patrick Leo, Sacheth Chandramouli, Xavier Farre, Robin Elliott, Andrew Janowczyk, Kaustav Bera, Pingfu Fu, Nafiseh Janaki, Ayah El-Fahmawi, Mohammed Shahait, Jessica Kim, David Lee, Kosj Yamoah, Timothy R. Rebbeck, Francesca Khani, Brian D. Robinson, Natalie N. C. Shih, Michael Feldman, Sanjay Gupta, Jesse McKenney, Priti Lal, Anant Madabhushi
Summary: Machine-based quantitative assessment of ICC area is important for predicting prognosis in prostate cancer patients, especially in those with Gleason grade group 2 cancer, where CAI shows strong prognostic value.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Biochemistry & Molecular Biology
Wouter Bulten, Kimmo Kartasalo, Po-Hsuan Cameron Chen, Peter Strom, Hans Pinckaers, Kunal Nagpal, Yuannan Cai, David F. Steiner, Hester van Boven, Robert Vink, Christina Hulsbergen-van de Kaa, Jeroen van der Laak, Mahul B. Amin, Andrew J. Evans, Theodorus van der Kwast, Robert Allan, Peter A. Humphrey, Henrik Gronberg, Hemamali Samaratunga, Brett Delahunt, Toyonori Tsuzuki, Tomi Hakkinen, Lars Egevad, Maggie Demkin, Sohier Dane, Fraser Tan, Masi Valkonen, Greg S. Corrado, Lily Peng, Craig H. Mermel, Pekka Ruusuvuori, Geert Litjens, Martin Eklund
Summary: The PANDA challenge is the largest histopathology competition to date, aiming to catalyze the development of reproducible AI algorithms for Gleason grading in prostate cancer. The submitted algorithms achieved pathologist-level performance and their diversity and generalization were validated through cross-continental cohorts.
Article
Pathology
Jonathan T. C. Liu, Sarah S. L. Chow, Richard Colling, Michelle R. Downes, Xavier Farre, Peter Humphrey, Andrew Janowczyk, Tuomas Mirtti, Clare Verrill, Inti Zlobec, Lawrence D. True
Summary: In recent years, nondestructive 3D pathology, which obtains high-resolution histological datasets from thick tissue specimens without physical sectioning, has made rapid advancements due to technological advances in tissue preparation, high-throughput volumetric microscopy, and computational infrastructure. While attractive for automated computational analysis, there is also a desire to use 3D pathology to improve the visual assessment of tissue histology. Challenges arise from the large 3D datasets that pathologists may not be trained to interpret, requiring artificial intelligence triaging algorithms and explainable analysis methods to assist in interpretation.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Urology & Nephrology
Xavier Farre, Joshua Kibera
AFRICAN JOURNAL OF UROLOGY
(2018)
Meeting Abstract
Pathology
A. Nadal, C. Romeu, X. Farre, A. Cardesa
Correction
Pathology
A. M. De Marzo, E. A. Platz, J. Epstein, T. Ali, A. Billis, T. Y. Chan, L. Cheng, M. Datta, L. Egevad, D. Ertoy-Baydar, X. Farree, S. W. Fine, K. A. Iczkowski, M. Ittmann, B. S. Knudsen, M. Loda, A. Lopez-Beltran, C. Magi-Galluzzi, G. Mikuz, R. Montironi, E. Pikarsky, G. Pizov, M. A. Rubin, H. Samaratunga, T. Sebo, I. A. Sesterhenn, R. B. Shah, S. Signoretti, J. Simko, G. Thomas, P. Troncoso, T. T. Tsuzuki, G. J. van Leenders, X. J. Yang, M. Zhou, W. D. Figg, A. Hoque, M. S. Lucia
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2006)
Article
Pathology
Angelo M. De Marzo, Elizabeth A. Platz, Jonathan I. Epstein, Tehmina Ali, Anthanase Billis, Teresa Y. Chan, Liang Cheng, Milton Datta, Lars Egevad, Dilek Ertoy-Baydar, Xavier Farree, Samson W. Fine, Kenneth A. Iczkowski, Michael Ittmann, Beatrice S. Knudsen, Massimo Loda, Antonio Lopez-Beltran, Cristina Magi-Galluzzi, Gregor Mikuz, Roldolfo Montironi, Eli Pikarsky, Galina Pizov, Mark A. Rubin, Hema Samaratunga, Thomas Sebo, Isabel A. Sesterhenn, Rajiv B. Shah, Sabina Signoretti, Jeffery Simko, George Thomas, Patricia Troncoso, Toyonori T. Tsuzuki, Geert J. van Leenders, Ximing J. Yang, Ming Zhou, William D. Figg, Ashrafal Hoque, M. S. Lucia
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2006)
Correction
Pathology
A. M. De Marzo, E. A. Platz, J. Epstein, T. Ali, A. Billis, T. Y. Chan, L. Cheng, M. Datta, L. Egevad, D. Ertoy-Baydar, X. Farre, S. W. Fine, K. A. Iczkowski, M. Ittmann, B. S. Knudsen, M. Loda, A. Lopez-Beltran, C. Magi-Galluzzi, G. Mikuz, R. Montironi, E. Pikarsky, G. Pizov, M. A. Rubin, H. Samaratunga, T. Sebo, I. A. Sesterhenn, R. B. Shah, S. Signoretti, J. Simko, G. Thomas, P. Troncoso, T. T. Tsuzuki, G. J. van Leenders, X. J. Yang, M. Zhou, W. D. Figg, A. Hoque, M. S. Lucia
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2007)