Article
Urology & Nephrology
E. Baten, F. Van der Aa, H. Goethuys, K. Slabbert, I Arijs, K. van Renterghem
Summary: Our study indicates that omitting antimicrobial prophylaxis is safe in patients undergoing transurethral resection of bladder tumor without an indwelling pre-operative catheter/nephrostomy/DJ and a negative pre-operative urinary culture.
WORLD JOURNAL OF UROLOGY
(2021)
Review
Urology & Nephrology
Eva Comperat, Andre Oszwald, Gabriel Wasinger, Donna E. Hansel, Rodolfo Montironi, Theodorus van der Kwast, Johannes A. Witjes, Mahul B. Amin
Summary: The optimal management of bladder cancer requires accurate, standardized, and timely pathological diagnosis, as well as close communication between surgeons and pathologists. This review highlights the importance of published reporting standards in improving diagnosis and treatment, as well as the evolving nature of pathological reporting in bladder cancer. Areas such as tumor sub-staging, lymph node staging, and specimen preparation offer opportunities for further standardization and improvement.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Sandip M. Prasad, William C. Huang, Neal D. Shore, Brian Hu, Marc Bjurlin, Gordon Brown, Pencho Genov, Dimitar Shishkov, Alexandre Khuskivadze, Tosho Ganev, Dobri Marchev, Igor Orlov, Evgeny Kopyltsov, Vadim Zubarev, Alexander Nosov, Dmitrii Komlev, Brent Burger, Sunil Raju, Andrew Meads, Mark Schoenberg
Summary: This study compared the efficacy and safety of UGN-102 with transurethral resection of bladder tumor for the treatment of low-grade intermediate-risk nonmuscle-invasive bladder cancer. The results suggest that UGN-102 may be a potential alternative to transurethral resection of bladder tumor.
JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Taylor Parisse, Katy Reines, Ramsankar Basak, Dana Mueller, Randall Teal, Maihan B. Vu, Jessica Carda-Auten, Kathryn Stein, Kara Giannone, Robert Lipman, Angela B. Smith
Summary: This study aimed to explore the perspectives of patients and providers on repeat transurethral resection of bladder tumors, in order to improve counseling and treatment options for nonmuscle-invasive bladder cancer. The findings showed differences in treatment preferences and emphasized the need for better communication and counseling in this area.
JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Tilman Todenhofer, Moritz Maas, Miriam Ketz, Nils Kossack, Christiane Colling, Bryan Qvick, Arnulf Stenzl
Summary: The photodynamic diagnosis using HAL-guided BL-TURB may reduce the recurrence risk in non-muscle invasive BCa compared to standard WL-TURB due to more sensitive tumor detection. The initial use of WL- vs. BL-TURB had comparable impact on follow-up costs.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Oncology
Chenyang Xu, Shuai Jiang, Lujia Zou, Lu Sheng, Guowei Shi, Bin Xu, Zhong Wang, Danfeng Xu, Xin Xie, Jianfeng Luo, Jianming Guo, Haowen Jiang
Summary: This study compared the efficacy of endoscopic balloon cryoablation (EBCA) with a single instillation of intravesical chemotherapy for bladder cancer. The results showed that EBCA had a higher local control rate than the single instillation of chemotherapy and improved patients' recurrence-free survival and progression-free survival.
Article
Pathology
Patrick Mullane, Shreyas Joshi, Mehmet Bilen, Adeboye O. Osunkoya
Summary: This study investigated the clinicopathologic features of patients with urothelial carcinoma (UCa) and lamina propria (LP) invasion and variant/divergent histology. It was found that 75% of patients had persistent UCa during early repeat biopsy/TUR. This study highlights the importance of repeat biopsy/TUR in this patient population.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Urology & Nephrology
Arighno Das, Jason E. Cohen, Oliver S. Ko, Brian J. Jordan, Alexander P. Glaser, Gregory B. Auffenberg, Joshua J. Meeks
Summary: The creation and distribution of individual surgeon scorecards improved detrusor muscle sampling during transurethral resection, leading to a decreased risk of disease recurrence in patients with nonmuscle invasive bladder cancer.
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Lorenzo Defidio, Michele Antonucci, Daniele Castellani, Angelo Civitella, Francesco Esperto, Roberto Mario Scarpa
Summary: Transurethral resection of bladder tumor (TURBT) remains the gold standard for nonmuscle invasive bladder cancer management while en bloc resection of bladder tumor (EBRT) offers potential advantages such as complete resection, precise and controlled removal, better sample orientation, presence of detrusor in the specimen, and reduced tumor seeding on normal urothelium by tumor fragments. This article aims to compare the techniques and outcomes of TURBT versus EBRT.
JOURNAL OF ENDOUROLOGY
(2021)
Review
Urology & Nephrology
Chiara Lonati, Francesco Esperto, Roberto M. Scarpa, Rocco Papalia, Juan Gomez Rivas, Mario Alvarez-Maestro, Luca Afferi, Christian D. Fankhauser, Agostino Mattei, Renzo Colombo, Francesco Montorsi, Alberto Briganti, Wojciech Krajewski, Roberto Carando, Ekaterina Laukhtina, Jeremy Yuen-Chun Teo, Stefania Zamboni, Claudio Simeone, Marco Moschini
Summary: Bladder perforation (BP) is a common complication during transurethral resection of bladder (TURB) for bladder cancer (BCa), with a higher incidence than expected. Risk factors include low body mass index (BMI), resection depth, and inexperienced surgeons. Conservative treatment is suitable for extraperitoneal BP, while surgical bladder closure is needed for intraperitoneal BP. Sepsis and extravesical tumor seeding may occur after BP.
MINERVA UROLOGY AND NEPHROLOGY
(2022)
Review
Urology & Nephrology
Takafumi Yanagisawa, Keiichiro Mori, Reza Sari Motlagh, Tatsushi Kawada, Hadi Mostafaei, Fahad Quhal, Ekaterina Laukhtina, Pawel Rajwa, Abdulmajeed Aydh, Frederik Koenig, Maximilian Pallauf, Benjamin Pradere, David D'Andrea, Eva Comperat, Jun Miki, Takahiro Kimura, Shin Egawa, Shahrokh F. Shariat
Summary: En bloc resection for bladder tumors appears to be safer and provides superior histopathological information compared to conventional transurethral resection of bladder tumors. However, it does not seem to improve the recurrence rate conclusively.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Kelly K. Bree, Andrea Kokorovic, Mary E. Westerman, Patrick J. Hensley, Nathan A. Brooks, Wei Qiao, Yu Shen, Ashish M. Kamat, Colin P. Dinney, Neema Navai
Summary: This study evaluated the impact of repeat transurethral resection of bladder tumor prior to radical cystectomy on oncologic outcomes. The results showed that repeat transurethral resection of bladder tumor was not associated with improved survival outcomes, but patients without residual tumor had better survival outcomes.
JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Takafumi Yanagisawa, Jun Miki, Takashi Yorozu, Kosuke Iwatani, Koki Obayashi, Shun Sato, Takahiro Kimura, Hiroyuki Takahashi, Shin Egawa
Summary: The study retrospectively analyzed 123 patients diagnosed with pT1 bladder cancer and found that muscularis mucosae invasion, invasion depth, and en bloc resection were significant prognostic factors.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Jamie S. Pak, Christopher R. Haas, Christopher B. Anderson, G. Joel DeCastro, Mitchell C. Benson, James M. McKiernan
Summary: The study found that complete transurethral resections (TURBT) prior to radical cystectomy may positively impact patients' overall survival and cancer-specific survival by reducing the number of visible tumors and variant histology preoperatively. Complete TURBT also led to a lower incidence of high-grade disease at surgery and encouraged patients to opt for active surveillance. These results indicate that undergoing complete TURBT can improve patients' prognosis.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Urology & Nephrology
Hye Won Lee, Hyung Ho Lee, Eun Young Park, Weon Seo Park, Sung Han Kim, Jae Young Joung, Jinsoo Chung, Ho Kyung Seo
Summary: This study aimed to assess the efficacy and safety of neoadjuvant intravesical mitomycin-C in reducing recurrence and progression of nonmuscle-invasive bladder cancer after transurethral resection of bladder tumor. The results showed that two doses of neoadjuvant intravesical mitomycin-C were safe and effective in reducing the risk of bladder cancer recurrence and progression.
JOURNAL OF UROLOGY
(2023)
Article
Multidisciplinary Sciences
Bojing Liu, Yinxi Wang, Philippe Weitz, Johan Lindberg, Johan Hartman, Wanzhong Wang, Lars Egevad, Henrik Gronberg, Martin Eklund, Mattias Rantalainen
Summary: This study suggests that deep learning can detect potential prostate cancer in benign prostate biopsies, reducing false negatives and indicating men who could benefit from rebiopsies.
Editorial Material
Urology & Nephrology
Kenneth A. Iczkowski, Mariel Molina, Lars Egevad, David G. Bostwick, Geert J. L. H. van Leenders, Francisco G. La Rosa, Theodorus van der Kwast, Daniel M. Berney, Andrew J. Evans, Thomas M. Wheeler, Katia R. M. Leite, Hemamali Samaratunga, John Srigley, Murali Varma, Toyonori Tsuzuki, Marshall Scott Lucia, Elward David Crawford, Richard G. Harris, Philip Stricker, Nathan Lawrentschuk, Henry H. Woo, Neil E. Fleshner, Neal D. Shore, John Yaxley, Ola Bratt, Peter Wiklund, Matthew Roberts, Liang Cheng, Brett Delahunt
Article
Cell Biology
S. Menon, H. Moch, D. M. Berney, I. A. Cree, J. R. Srigley, T. Tsuzuki, E. Comperat, A. Hartmann, G. Netto, M. A. Rubin, A. J. Gill, S. Turajlic, P. H. Tan, M. R. Raspollini, S. K. Tickoo, M. B. Amin
Summary: Squamous cell carcinoma (SCC) is the most common malignant tumor of the penis. The 2022 WHO classification reinforces the 2016 classification and subclassifies precursor lesions and tumors into human papillomavirus (HPV)-associated and HPV-independent types. The use of p16 immunohistochemistry is practical for differentiating HPV-associated from HPV-independent penile SCC. The classification and reporting of scrotal tumors is provided for the first time in the fifth edition of the WHO Blue book, following the schema of penile cancer classification.
Article
Pathology
Rachel N. Flach, Lars Egevad, Martin Eklund, Theodorus H. van der Kwast, Brett Delahunt, Hemamali Samaratunga, Britt B. M. Suelmann, Peter-Paul M. Willemse, Richard P. Meijer, Paul J. van Diest
Summary: This study investigated the effect of e-learning on the interobserver variability of prostate cancer grading using the ISUP Education web platform. The results showed that e-learning reduced variability in PCa grading, making it a cost-effective method for standardisation of pathology.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Letter
Pathology
Hemamal Samaratunga, Tony Gianduzzo, Joanna Perry-Keene, Lars Egevad, Brett Delahunt
Letter
Cell Biology
Andres M. Acosta, Maurizio Colecchia, Daniel M. Berney
Article
Cell Biology
Lars Egevad, Brett Delahunt, Kenneth A. Iczkowski, Theo van der Kwast, Geert J. L. H. van Leenders, Katia R. M. Leite, Chin-Chen Pan, Hemamali Samaratunga, Toyonori Tsuzuki, Nita Mulliqi, Xiaoyi Ji, Henrik Olsson, Masi Valkonen, Pekka Ruusuvuori, Martin Eklund, Kimmo Kartasalo
Summary: There is evidence that cribriform morphology is associated with a worse prognosis for prostatic adenocarcinoma. This study aimed to investigate the reproducibility of cribriform cancer diagnosis in prostate needle biopsies. A panel of nine prostate pathology experts independently reviewed 304 digitised biopsies and achieved a 2/3 consensus diagnosis of cribriform and noncribriform cancer in 90% of the cases. Strict diagnostic criteria were used to identify cribriform patterns and generate a set of consensus cases for standardization.
Article
Medicine, General & Internal
M. Alvaro Berbis, David S. McClintock, Andrey Bychkov, Jeroen Van der Laak, Liron Pantanowitz, Jochen K. Lennerz, Jerome Y. Cheng, Brett Delahunt, Lars Egevad, Catarina Eloy, Alton B. Farris III, Filippo Fraggetta, Raimundo Garcia del Moral, Douglas J. Hartman, Markus D. Herrmann, Eva Hollemans, Kenneth A. Iczkowski, Aly Karsan, Mark Kriegsmann, Mohamed E. Salama, John H. Sinard, J. Mark Tuthill, Bethany Williams, Cesar Casado-Sanchez, Victor Sanchez-Turrion, Antonio Luna, Jose Aneiros-Fernandez, Jeanne Shen
Summary: AI is expected to be routinely and impactfully used in pathology practice by 2030, according to experts in the field. This consensus study highlights the anticipated short-to-mid-term impact of AI and raises important practical, ethical, and legal challenges that need to be addressed prior to its clinical implementation.
Article
Oncology
Naveen S. Vasudev, Ghislaine Scelo, Kate I. Glennon, Michelle Wilson, Louis Letourneau, Robert Eveleigh, Nazanin Nourbehesht, Madeleine Arseneault, Antoine Paccard, Lars Egevad, Juris Viksna, Edgars Celms, Sharon M. Jackson, Behnoush Abedi-Ardekani, Anne Y. Warren, Peter J. Selby, Sebastian Trainor, Michael Kimuli, Jon Cartledge, Naeem Soomro, Adebanji Adeyoju, Poulam M. Patel, Magdalena B. Wozniak, Ivana Holcatova, Antonin Brisuda, Vladimir Janout, Estelle Chanudet, David Zaridze, Anush Moukeria, Oxana Shangina, Lenka Foretova, Marie Navratilova, Dana Mates, Viorel Jinga, Ljiljana Bogdanovic, Bozidar Kovacevic, Anne Cambon-Thomsen, Guillaume Bourque, Alvis Brazma, Jorg Tost, Paul Brennan, Mark Lathrop, Yasser Riazalhosseini, Rosamonde E. Banks
Summary: Targeted gene sequencing can help in risk prediction and adjuvant treatment decisions for patients with resected localized ccRCC. Mutations in the VHL gene have a significant impact on patient outcomes, independent of other gene mutations. Genomic characterization can personalize treatment discussions and inform future adjuvant trial design.
CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Daniel M. Berney, Kier Finnegan, Kim Chu, Samson W. Fine, Murali Varma, Jack Cuzick, Luis Beltran
Summary: This study aimed to determine the optimal method of measuring cancer extent in prostate cancer biopsies. The results showed that only the percentage of positive cores (%+cores) was a significant predictor of patient outcome in multivariate models. Thus, we propose using %+cores as a simple method of assessment, which is preferred over more complicated methods.
Editorial Material
Pathology
Murali Varma, Brett Delahunt, Liang Cheng, Runjan Chetty, Eva Comperat, Vikram Deshpande, Lars Egevad, Theodorus H. van der Kwast, Antonio Lopez-Beltran, W. Glenn McCluggage
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Letter
Pathology
Hemamali Samaratunga, Lars Egevad, Brett Delahunt
Review
Pathology
Murali Varma, Laura C. Collins, Runjan Chetty, Dipti M. Karamchandani, Karen Talia, John Dormer, Monika Vyas, Brendan Conn, Yaileen D. Guzman-Arocho, Adam Jones, Miranda Pring, W. Glenn Mccluggage
Summary: This paper highlights the importance of macroscopic examination and tissue sampling in histopathology reporting and discusses potential solutions and challenges. It emphasizes the need for adequate guidance and supervision in macroscopic examination and highlights the importance of clinical context, specimen fixation, macroscopic descriptions, and tissue sampling.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Urology & Nephrology
Joel Andersson, Thorgerdur Palsdottir, Anna Lantz, Markus Aly, Henrik Gronberg, Lars Egevad, Martin Eklund, Tobias Nordstrom
Summary: The study found that for men with PSA >= 3 ng/ml, a suspicious DRE indicates a more than threefold higher risk of significant prostate cancer. DRE as a variable adds significant precision to the Stockholm3 prediction model.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
Letter
Pathology
Hemamali Samaratunga, Brett Delahunt, John W. Yaxley, Shulammite Johannsen, Lars Egevad
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)