Article
Oncology
Vitoria Ramos Jayme, Gilton Marques Fonseca, Isaac Massaud Amim Amaral, Fabricio Ferreira Coelho, Jaime Arthur Pirola Kruger, Vagner Birk Jeismann, Rafael Soares Nunes Pinheiro, Evandro Sobroza de Mello, Paulo Herman
Summary: Infiltrative-type border in CRLM patients is associated with worse prognosis and higher intrahepatic recurrence. Larger margin size (> 1 cm) does not impact the prognosis in patients with infiltrative border, highlighting the importance of tumor biology in determining survival outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Fabian Stoegbauer, Manuela Lautizi, Mark Kriegsmann, Hauke Winter, Thomas Muley, Katharina Kriegsmann, Moritz Jesinghaus, Jan Baumbach, Peter Schueffler, Wilko Weichert, Tim Kacprowski, Melanie Boxberg
Summary: This study aimed to determine prognostic parameters for patients with squamous cell carcinomas of the lung (SCC-L). The study found that tumor cell budding (TCB), spread through air spaces (STAS), and immune cell infiltration were significant prognostic factors. These findings provide insights for prognostic evaluation in SCC-L patients.
Article
Pathology
Eva Karamitopoulou, Irene Esposito, Inti Zlobec, Andrea Cacciato Insilla, Martin Wartenberg, David F. Schaeffer, Steve Kalloger, Stefano La Rosa, Christine Sempoux, Irene Ramos Centeno, Philipp Lohneis
Summary: Tumor budding has been identified as an independent prognostic factor in pancreatic ductal adenocarcinoma (PDAC) and its assessment methods showed moderate agreement levels between pathologists in a multicenter interobserver study. The pancytokeratin 10HPF method demonstrated acceptable levels of agreement and is recommended for tumor budding assessment in PDAC resection specimens. Implementing machine learning applications should be considered to improve interobserver agreement levels.
Editorial Material
Oncology
Roger M. Feakins, Maurice B. Loughrey, Andrew Silver
Summary: Tumour budding and poorly differentiated clusters may indicate a worse outcome in colorectal carcinoma and other cancers, and they may be related to epithelial-mesenchymal transition.
JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Tomohiro Fujiwara, Jonathan Stevenson, Michael Parry, Yusuke Tsuda, Yoichi Kaneuchi, Lee Jeys
Summary: The study found that in patients with non-infiltrative soft-tissue sarcomas, a surgical margin width greater than 5 mm minimizes the risk of local failure, while a negative margin is essential for optimizing local control. Risk stratification for LR can be accurately done using metric distance.
Review
Dentistry, Oral Surgery & Medicine
Peter A. Brennan, Flavia Dylgjeri, Ricardo D. Coletta, Gururaj Arakeri, Alexander M. Goodson
Summary: There are various prognostic indicators used to predict tumor recurrence and overall prognosis in oral squamous cell carcinoma (OSCC), with the width of excision margins being an important factor. However, there is still conflicting data in the literature about the ideal margin width for this cancer.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2022)
Article
Urology & Nephrology
Nicolas Vamour, Anis Gasmi, Xavier Leroy, Philippe Puech, Mohamed Koussa, Arnauld Villers, Jean-Christophe Fantoni, Nicolas Doumerc, Karim Bensalah, Jonathan Olivier, Zine-Eddine Khene
Summary: This study evaluated the impact of positive vascular margins (PVMs) following surgical resection of non-metastatic renal cell carcinoma (RCC) with inferior vena cava (IVC) tumor thrombus. Results indicated that PVMs were associated with a higher risk of local recurrence, but did not have a significant impact on systemic recurrence or overall mortality.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Pathology
Moritz Jesinghaus, Maxime Schmitt, Corinna Lang, Marianne Reiser, Alexander Scheiter, Bjoern Konukiewitz, Katja Steiger, Miguel Silva, Markus Tschurtschenthaler, Sebastian Lange, Sebastian Foersch, Karl F. Becker, Dieter Saur, Helmut Friess, Kathrin Halfter, Jutta Engel, Melanie Boxberg, Nicole Pfarr, Dirk Wilhelm, Wilko Weichert
Summary: The 2019 WHO classification of CRC has reclassified subtypes and introduced tumor budding as a major grading criterion. Tumor budding and CRC subtypes have been found to independently impact patient prognosis, surpassing the traditional grade classification system.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Medicine, General & Internal
Guhyun Kang, Jung-Soo Pyo, Nae Yu Kim, Dong-Wook Kang
Summary: This study evaluates the clinicopathological significance and prognostic implications of intratumoral budding (ITB) in colorectal cancers (CRCs) through a meta-analysis. The results show that high ITB is significantly correlated with aggressive tumor behaviors and worse prognosis in CRCs. The detection of ITB can be useful for predicting clinicopathologic features and the prognosis of CRC.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
D. Wankhede, P. Hofman, S. Grover
Summary: Tumour budding is a new and promising prognostic factor in patients with LSCC, associated with survival outcomes and clinicopathological parameters. However, heterogeneity and publication bias exist, requiring further research.
Article
Medicine, General & Internal
Marine Huin, Jerome Lorenzini, Flavie Arbion, Xavier Carcopino, Cyril Touboul, Yohann Dabi, Yohan Kerbage, Helene Costaz, Lise Lecointre, Vincent Lavoue, Pierre-Adrien Bolze, Cyrille Huchon, Alexandre Bricou, Geoffroy Canlorbe, Camille Mimoun, Sofiane Bendifallah, Tristan Gauthier, Gilles Body, Lobna Ouldamer
Summary: This study evaluated the development and prognosis of mucinous ovarian carcinomas (mOC) and found significant clinical and histological differences between expansile and infiltrative invasion. Expansile mOC had earlier stages at diagnosis and fewer metastatic lymph nodes compared to infiltrative mOC, resulting in higher survival rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Parbatraj Regmi, Aliza Paudyal, Pranita Paudyal, Hai-Jie Hu, Fei Liu, Wen-Jie Ma, Yan-Wen Jin, Fu-Yu Li
Summary: Tumor budding is identified as a significant predictor of poor survival for biliary tract cancer (BTC), associated with poor histologic differentiation, lymphovascular invasion, and other factors. It has the potential to serve as a prognostic marker for BTC, pending the development of a standardized international consensus.
Article
Cell Biology
Zhi-Wen Li, Lu He, Zhong Zheng, Qian Zhang, Yu-Ting Xu, Jie-Yu Chen, Jiong Shi, Wen-Bin Huang, Xiang-Shan Fan
Summary: This study introduced a novel Combined Grading system based on CNS and DR in ESCC, which demonstrated superior prognostic prediction compared to Cellular Dissociation Grading.
Article
Oncology
Liuhua Long, Bo Chen, Hongzhi Wang, Yuting Zhao, Fan Wu, Liming Wang, Weiqi Rong, Jianxiong Wu, Yexiong Li, Weihu Wang
Summary: This study evaluated the effects of postoperative radiotherapy (PORT) on prognosis and recurrence in patients with hepatocellular carcinoma (HCC) who underwent narrow-margin hepatectomy (NH). The results showed that the PORT group had significantly higher 5-year overall survival and disease-free survival rates compared to the non-PORT group, and the tumor recurrence rate was lower in the PORT group. Therefore, postoperative radiotherapy may have significant benefits in the treatment of HCC.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Qiao Ke, Zhiting Guo, Jian He, Zisen Lai, Fuli Xin, Yongyi Zeng, Lei Wang, Jingfeng Liu
Summary: The width of resection margin (RM) does not appear to have a significant impact on the prognosis of patients with solitary hepatocellular carcinoma (HCC) undergoing anatomical resection (AR). However, in certain selected patients, a wider RM may confer benefits.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)