Article
Gastroenterology & Hepatology
Jooyoung Lee, Jung Ho Bae, Su Jin Chung, Hae Yeon Kang, Seung Joo Kang, Min-Sun Kwak, Ji Yeon Seo, Ji Hyun Song, Sun Young Yang, Jong In Yang, Seon Hee Lim, Jeong Yoon Yim, Joo Hyun Lim, Goh Eun Chung, Eun Hyo Jin, Ji Min Choi, Yoo Min Han, Joo Sung Kim
Summary: Comprehensive optical diagnosis training with WASP classification significantly increased the overall SDR of expert endoscopists, while it did not have a significant impact on ADR.
DIGESTIVE ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Takashi Murakami, Taro Kurosawa, Hirofumi Fukushima, Tomoyoshi Shibuya, Takashi Yao, Akihito Nagahara
Summary: The term sessile serrated lesion (SSL) was introduced in the 2019 WHO Classification of Tumours of the Digestive System as an early precursor lesion in the serrated neoplasia pathway. These lesions can quickly progress into dysplastic or invasive carcinomas with high lymphatic invasion potential.
DIGESTIVE ENDOSCOPY
(2022)
Review
Cell Biology
Iris D. Nagtegaal, Dale C. Snover
Summary: The precursor lesion for around 30% of colon carcinomas, known as sessile serrated adenoma, remains controversial and has sparked debates over alternative names. Despite the term sessile serrated lesion being adopted by the World Health Organization in 2019, universal acceptance is still lacking.
Article
Pathology
Filippo Cappello, Valentina Angerilli, Luca Dal Santo, Giada Munari, Marianna Sabbadin, Marcello Lo Mele, Gianmaria Pennelli, Claudio Luchini, Paola Parente, Stefano Lazzi, Matteo Fassan
Summary: Adenomatous dysplasia may develop in sessile serrated lesions (SSL) as part of the serrated lesion. However, some of these lesions may represent collisions between a serrated polyp and a conventional adenoma. Based on mutational analysis and MMR status, we found that adenomatous dysplasia in SSL may develop as part of the serrated lesion, while polyps morphologically classified as mixed lesions are more likely to be collision lesions.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Jung Ho Kim, Jeong Hoon Hong, Yoon-La Choi, Ji Ae Lee, Mi-kyoung Seo, Mi-Sook Lee, Sung Bin An, Min Jung Sung, Nam-Yun Cho, Sung-Su Kim, Young Kee Shin, Sangwoo Kim, Gyeong Hoon Kang
Summary: The study revealed that NTRK-rearranged colorectal tumors develop exclusively through the serrated neoplasia pathway and can be initiated from non-dysplastic SSLs without BRAF/KRAS mutations prior to full occurrence of MSI-high/CIMP-high.
JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sangeeta Jaiswal, Bishnu Joshi, Jing Chen, Fa Wang, Michael K. Dame, Jason R. Spence, Gina M. Newsome, Erica L. Katz, Yatrik M. Shah, Sadeesh K. Ramakrishnan, Gaoming Li, Miki Lee, Henry D. Appelman, Rork Kuick, Thomas D. Wang
Summary: The study identified that Prdx1 is overexpressed on the cell surface in the presence of oxidative stress and can serve as an imaging biomarker for in vivo detection of SSAs.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Gastroenterology & Hepatology
Seung Wook Hong, Jeongseok Kim, Ji Young Lee, Jong-Soo Lee, Hye-Sook Chang, Hye Won Park, Gwang-Un Kim, Jiyoung Yoon, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jaewon Choe, Dong-Hoon Yang
Summary: This study found that individuals with synchronous SSL did not have a significantly increased risk of metachronous HRA/AA, but did have an increased risk of metachronous SSL compared to those without SSL.
DIGESTIVE ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Paul P. Shao, Changhan R. Shao, Tahmineh Romero, Felix W. Leung
Summary: This study found that water exchange significantly increases the detection rate of sessile serrated adenomas/polyps, and is superior to Endocuff and cap colonoscopy in detecting them.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Shin Ju Oh, Jung-Wook Kim, Chi Hyuk Oh
Summary: We report a rare case of a large pedunculated polyp with typical histological features of SSLs in the rectum. Endoscopic mucosal resection using a detachable snare was performed on the tumor for definite diagnosis and treatment.
Article
Gastroenterology & Hepatology
Toshihiro Nishizawa, Shuntaro Yoshida, Akira Toyoshima, Tomoharu Yamada, Yoshiki Sakaguchi, Taiga Irako, Hirotoshi Ebinuma, Takanori Kanai, Kazuhiko Koike, Osamu Toyoshima
Summary: This study aimed to develop a diagnostic score system for sessile serrated lesions (SSLs). The research found that tumor size, mucus cap, and indistinct borders were significant endoscopic features for the diagnosis of SSLs, and serrated polyps with these features should be removed during colonoscopy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Sayo Takahashi, Koichi Okamoto, Toshihito Tanahashi, Shota Fujimoto, Tadahiko Nakagawa, Masahiro Bando, Beibei Ma, Tomoyuki Kawaguchi, Yasuteru Fujino, Yasuhiro Mitsui, Shinji Kitamura, Hiroshi Miyamoto, Yasushi Sato, Naoki Muguruma, Yoshimi Bando, Toshiro Sato, Takahiro Fujimori, Tetsuji Takayama
Summary: The study identified multiple hypomethylated genes in the precursor lesion of colon cancer, SSA/P, with S100P, S100 alpha 2, PKP3, and MUC2 being the most common hypomethylated genes. Knockdown of the S100P gene in SSA/P tissues significantly inhibited cell growth. DNA hypomethylation, especially of the S100P gene, may play a crucial role in the SSA/P-cancer sequence.
Article
Pathology
Phoenix D. Bell, Joseph C. Anderson, Amitabh Srivastava
Summary: The serrated pathway of carcinogenesis is still not fully understood, and limitations in endoscopic detection and pathologic interpretation of serrated polyps have implications on risk prediction and surveillance recommendations.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Microbiology
Heihachiro Nishimura, Hirokazu Fukui, Xuan Wang, Nobuhiko Ebisutani, Takashi Nakanishi, Toshihiko Tomita, Tadayuki Oshima, Seiichi Hirota, Hiroto Miwa
Summary: The study suggests that Fusobacterium nucleatum may play a role in the proliferation of sessile serrated adenoma/polyps (SSA/Ps) by promoting nuclear translocation of beta-catenin and expression of REG I alpha.
Review
Medicine, Research & Experimental
David E. F. W. M. van Toledo, Joep E. G. IJspeert, Evelien Dekker
Summary: Recent studies have shown that serrated polyps (SPs) also have the potential to develop into colorectal cancer, leading to a paradigm shift in CRC prevention, diagnosis, and treatment. While understanding of SPs and associated CRC has improved, there is still much work to be done in the clinical management of SPs and serrated polyposis syndrome (SPS).
ANNUAL REVIEW OF MEDICINE
(2022)
Article
Oncology
Daisuke Ohki, Nobutake Yamamichi, Yoshiki Sakaguchi, Yu Takahashi, Natsuko Kageyama-Yahara, Mitsue Yamamichi, Chihiro Takeuchi, Yosuke Tsuji, Yasuhiro Sakai, Kouhei Sakurai, Shuta Tomida, Kazuhiko Koike, Mitsuhiro Fujishiro
Summary: This study elucidates the gene expression characteristics of sessile serrated adenoma/polyp (SSA/P), showing a strong resemblance to microsatellite instability-high (MSI-H) colorectal cancer (CRC). The downregulation of CDX2 expression plays an essential molecular mechanism in the initial stage of SSA/P tumorigenesis.