Journal
HIPPOCAMPUS
Volume 25, Issue 1, Pages 51-61Publisher
WILEY
DOI: 10.1002/hipo.22349
Keywords
neurogenesis; learning; memory; immature neuron maturation; hippocampus; consolidation
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Funding
- DGICYT [BFU2008-01552, BFU2011-27207, CSD2007-00023, BFU2012-39958]
- Fundacion Ramon Areces
- University Pablo de Olavide fellowship
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There is evidence that adult hippocampal neurogenesis influences hippocampal function, although the role these neurons fulfill in learning and consolidation processes remains unclear. Using a novel fast X-ray ablation protocol to deplete neurogenic cells, we demonstrate that immature adult hippocampal neurons are required for hippocampal learning and long-term memory formation. Moreover, we found that long-term memory formation in the object recognition and passive avoidance tests, two paradigms that involve circuits with distinct emotional components, had different temporal demands on hippocampal neurogenesis. These results reveal new and unexpected aspects of neurogenesis in cognitive processes. (c) 2014 Wiley Periodicals, Inc.
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