Article
Neurosciences
Shawn F. Sorrells, Mercedes F. Paredes, Zhuangzhi Zhang, Gugene Kang, Oier Pastor-Alonso, Sean Biagiotti, Chloe E. Page, Kadellyn Sandoval, Anthony Knox, Andrew Connolly, Eric J. Huang, Jose Manuel Garcia-Verdugo, Michael C. Oldham, Zhengang Yang, Arturo Alvarez-Buylla
Summary: Adult hippocampal neurogenesis was initially discovered in rodents, with subsequent studies identifying adult neural stem cells and their links to plasticity, behavior, and disease. The debate continues as to whether new neurons are produced in the human dentate gyrus during healthy aging. Recent research has shown conflicting results regarding the presence of dividing neuronal precursors in the adult human brain.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Gabriel Berdugo-Vega, Shonali Dhingra, Federico Calegari
Summary: This article reviews a wealth of research in cellular, anatomical, behavioral, and computational studies on the mammalian hippocampus, aiming to understand the fundamental mechanisms underlying cognition. Despite accumulating knowledge on how the hippocampus processes and stores information for learning and memory, our understanding of hippocampal cognitive function remains incomplete. The article discusses the structural separability of the two blades of the dentate gyrus in the hippocampus and proposes a model that suggests differences in connectivity and adult neurogenesis in the two blades may contribute to subtly different cognitive functions.
Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Anatomy & Morphology
Hajnalka Abraham, Hisae Kojima, Katalin Gotzer, Abigel Molnar, Tamas Tornoczky, Laszlo Seress
Summary: In this study, the maturation process of PV-immunoreactive interneurons in the human hippocampal formation was investigated. The results showed that no PV-immunoreactive neurons could be detected in the human hippocampus before birth. The number of PV-immunoreactive cells and their dendritic and axonal arborization gradually increased with age, indicating the long-lasting functional maturation of the human cortex.
FRONTIERS IN NEUROANATOMY
(2023)
Review
Cell Biology
Luka Culig, Xixia Chu, Vilhelm A. Bohr
Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.
AGEING RESEARCH REVIEWS
(2022)
Review
Cell & Tissue Engineering
Sebastian B. Arredondo, Daniela Valenzuela-Bezanilla, Sebastian H. Santibanez, Lorena Varela-Nallar
Summary: The subgranular zone of the hippocampal dentate gyrus is a neurogenic niche that contains neural stem cells capable of generating granule neurons. Wnt ligands play diverse roles in regulating adult hippocampal neurogenesis. Understanding the cellular source and mechanisms of Wnt signaling will be crucial for future therapeutic interventions.
Article
Neurosciences
Muhammad N. Arshad, Simon Oppenheimer, Jaye Jeong, Bilge Buyukdemirtas, Janice R. Naegele
Summary: GABAergic interneurons play a crucial role in regulating adult neurogenesis and their transplantation can alleviate seizures and increase synaptic inhibition in temporal lobe epilepsy. The transplantation also affects the types of progenitor cells involved in adult neurogenesis.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Cristian Morales, Juan Facundo Morici, Nelson Espinosa, Agostina Sacson, Ariel Lara-Vasquez, M. A. Garcia-Perez, Pedro Bekinschtein, Noelia Weisstaub, Pablo Fuentealba
Summary: Memory systems store and discriminate representations of similar experiences through pattern separation to guide future decisions efficiently. Somatostatin cells in the dentate gyrus play a crucial role in the acquisition of contextual and spatial overlapping memories.
Article
Biochemistry & Molecular Biology
Cassidy T. Burke, Iuliia Vitko, Justyna Straub, Elsa O. Nylund, Agnieszka Gawda, Kathryn Blair, Kyle A. Sullivan, Lara Ergun, Matteo Ottolini, Manoj K. Patel, Edward Perez-Reyes
Summary: Epileptogenesis involves changes in neuronal firing and gene transcription networks, which can be targeted by the activity-dependent transcription factor EpiPro. The study successfully validated the effectiveness of EpiPro in multiple rodent models of epilepsy, highlighting its potential as a gene therapy driver for epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Kelsey D. McDermott, M. Agustina Frechou, Jake T. Jordan, Sunaina S. Martin, J. Tiago Goncalves
Summary: Aging is associated with cognitive deficits, especially in spatial memory. The hippocampal dentate gyrus (DG) is important for processing spatial information but is vulnerable to aging. Using two-photon calcium imaging, researchers found that neuronal activity and spatial representations in the DG were impaired in aged mice. However, with repeated exposure to the same environment, spatial tuning and information levels in aged mice improved, while activity remained elevated.
Review
Neurosciences
Tasuku Araki, Yuji Ikegaya, Ryuta Koyama
Summary: Hippocampal neurogenesis continues throughout life and is tightly controlled by environmental conditions, with microglia and astrocytes playing key roles in modulating the process. Glial cells release factors that support adult neurogenesis under normal conditions, but can also contribute to inflammation and hinder neurogenesis in diseases like Alzheimer's, depression, and epilepsy.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Elijah A. Petter, Isabella P. Fallon, Ryan N. Hughes, Glenn D. R. Watson, Warren H. Meck, Francesco Paolo Ulloa Severino, Henry H. Yin
Summary: Animals can learn through reinforcement learning, and previous research has shown the importance of dopaminergic projections to the basal ganglia in this process. However, little is known about the role of the hippocampus. This study found that a specific population of hippocampal neurons, receiving dopaminergic input from the locus coeruleus and expressing D1 dopamine receptors, is involved in operant self-stimulation.
Article
Biology
Nannan Guo, Kelsey D. McDermott, Yu-Tzu Shih, Haley Zanga, Debolina Ghosh, Charlotte Herber, William R. Meara, James Coleman, Alexia Zagouras, Lai Ping Wong, Ruslan Sadreyev, J. Tiago Goncalves, Amar Sahay
Summary: This study reveals that the transcription factor Klf9 functions as a brake on symmetric self-renewal of radial-glial neural stem cells (RGLs) in mice. The loss of Klf9 promotes the activation state of RGLs and leads to increased symmetric self-renewal. The study also provides molecular insights into the genetic programs underlying RGL symmetric self-renewal, including Notch and mitogen signaling, cell cycle, fatty acid oxidation, and lipogenesis.
Article
Neurosciences
Minghua Li, Jessica L. Kinney, Yu-Qiu Jiang, Daniel K. Lee, Qiwen Wu, Daehoon Lee, Wen-Cheng Xiong, Qian Sun
Summary: A key mode of neuronal communication between distant brain regions is through excitatory synaptic transmission mediated by long-range glutamatergic projections. However, we found that the glutamatergic projection from the hypothalamic supramammillary nucleus (SuM) largely avoids pyramidal neurons in hippocampal CA3 region and instead targets interneurons to provide feedforward inhibition. This novel long-range glutamatergic pathway suppresses the activity of principal neurons and reveals a new means by which SuM regulates hippocampal activity.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Ana R. Machado-Santos, Eduardo Loureiro-Campos, Patricia Patricio, Bruna Araujo, Nuno Dinis Alves, Antonio Mateus-Pinheiro, Joana Sofia Correia, Monica Morais, Joao M. Bessa, Nuno Sousa, Ana J. Rodrigues, Joao Filipe Oliveira, Luisa Pinto
Summary: This study investigates the importance of de novo generated astrocytes in the pathophysiology and treatment of depression, revealing the potential of newborn astrocytes as therapeutic targets for future depression treatments.
Article
Biochemistry & Molecular Biology
Ranjana Pal, Zubaidah M. Ramdzan, Simran Kaur, Philippe M. Duquette, Richard Marcotte, Lam Leduy, Sayeh Davoudi, Nathalie Lamarche-Vane, Angelo Iulianella, Alain Nepveu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Anatomy & Morphology
Emily Capaldo, Angelo Iulianella
DEVELOPMENTAL DYNAMICS
(2016)
Review
Cell & Tissue Engineering
Makiko Yamada, Letizia De Chiara, Marco Seandel
STEM CELLS AND DEVELOPMENT
(2016)
Editorial Material
Genetics & Heredity
M. Yamada, M. Seandel
TRENDS IN GENETICS
(2017)
Review
Anatomy & Morphology
Angelo Iulianella, Richard J. Wingate, Cecilia B. Moens, Emily Capaldo
DEVELOPMENTAL DYNAMICS
(2019)
Article
Genetics & Heredity
Makiko Yamada, Winson Cai, Laura A. Martin, Thierry N'Tumba-Byn, Marco Seandel
Article
Developmental Biology
Angelo Iulianella, Danielle Stanton-Turcotte
MECHANISMS OF DEVELOPMENT
(2019)
Article
Developmental Biology
Hirotaka Tao, Jean-Philippe Lambert, Theodora M. Yung, Min Zhu, Noah A. Hahn, Danyi Li, Kimberly Lau, Kendra Sturgeon, Vijitha Puviindran, Xiaoyun Zhang, Wuming Gong, Xiao Xiao Chen, Gregory Anderson, Daniel J. Garry, R. Mark Henkelman, Yu Sun, Angelo Iulianella, Yasuhiko Kawakami, Anne-Claude Gingras, Chi-chung Hui, Sevan Hopyan
Article
Neurosciences
Emily Holt, Danielle Stanton-Turcotte, Angelo Iulianella
Summary: This article discusses the importance of integrating sensory information for an animal's movement through their environment and maintenance of homeostatic physiology. It covers the origins and development of the dorsal root ganglia (DRG) and the cells that populate it, as well as the diverse developmental and molecular processes that control sensory connectivity to the spinal cord.
Review
Biochemistry & Molecular Biology
Samantha A. Moore, Angelo Iulianella
Summary: This review discusses the development of the cortical hem in the vertebrate brain, as well as the key signaling pathways and molecules involved in patterning this specialized region. It also highlights the connections between the formation of the lateral ventricle choroid plexus and neurogenesis in the hippocampus during embryonic and postnatal stages.
Article
Developmental Biology
Kaitlin Mac Donald, Angelo Iulianella
Summary: BASP1, a protein highly expressed in the nervous system, plays a role in regulating the apical polarity of progenitor cells and axon trajectories from developing neurons.
Article
Neurosciences
Danielle Stanton-Turcotte, Karolynn Hsu, Samantha A. Moore, Makiko Yamada, James P. Fawcett, Angelo Iulianella
Summary: The role of Mllt11 in the migration and neurite outgrowth of callosal projection neurons during mouse brain formation is highlighted in this study. Mllt11 is expressed exclusively in developing neurons, particularly in the formation of the superficial cortical layers. Mllt11 is crucial for the morphogenesis and connectivity of upper layer projection neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Marley Blommers, Danielle Stanton-Turcotte, Angelo Iulianella
Summary: A study has found that the microtubule-interacting protein Mllt11 plays an important role in mammalian retinal cell migration. The research shows that the loss of Mllt11 in mouse retinal neuroblasts leads to the abnormal accumulation of ganglion and amacrine cells in the inner nuclear and plexiform layers of the retina.
DEVELOPMENTAL DYNAMICS
(2023)
Article
Anatomy & Morphology
Angelo Iulianella, Daisuke Sakai, Hiroshi Kurosaka, Paul A. Trainor
DEVELOPMENTAL DYNAMICS
(2018)