Review
Biochemistry & Molecular Biology
Gabriel Berdugo-Vega, Shonali Dhingra, Federico Calegari
Summary: This article reviews a wealth of research in cellular, anatomical, behavioral, and computational studies on the mammalian hippocampus, aiming to understand the fundamental mechanisms underlying cognition. Despite accumulating knowledge on how the hippocampus processes and stores information for learning and memory, our understanding of hippocampal cognitive function remains incomplete. The article discusses the structural separability of the two blades of the dentate gyrus in the hippocampus and proposes a model that suggests differences in connectivity and adult neurogenesis in the two blades may contribute to subtly different cognitive functions.
Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Neurosciences
Gaifen Li, Jia Liu, Yuying Guan, Xunming Ji
Summary: Hypoxia plays a crucial role in regulating various cell functions, including stem cells and neural stem cells. Hypoxia stimulation in specific brain regions can promote proliferation, migration, and maturation of neural stem cells, potentially offering a promising strategy for treating central nervous system diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Cell Biology
Luka Culig, Xixia Chu, Vilhelm A. Bohr
Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.
AGEING RESEARCH REVIEWS
(2022)
Article
Multidisciplinary Sciences
Bo Lei, Bilin Kang, Wantong Lin, Haichao Chen, Yuejun Hao, Jian Ma, Songhai Shi, Yi Zhong
Summary: This study reveals the role of adult newborn granule cells (anbGCs) in the emotional state-dependent adaptability of memory retrieval. Acute social reward enhances memory retrieval by increasing engram cell reactivation, while acute social stress weakens retrieval and reduces reactivation. This bidirectional regulation is mediated by distinct populations of anbGCs, which modulate dDG activity to regulate and predict memory retrieval performance.
Review
Biochemistry & Molecular Biology
Virendra Tiwari, Akanksha Mishra, Sonu Singh, Shubha Shukla
Summary: Neural stem cells (NSCs) are the functional and developmental unit of neurogenesis, and they have the ability to self-renew and generate new neurons in different neurogenic niches. Neurogenesis in adult brain is associated with synaptic plasticity, learning, and memory, particularly in the dentate gyrus (DG) of the hippocampus and olfactory bulb. Impaired neurogenesis has been implicated as a culprit in age-associated neurological disorders, including Alzheimer's disease (AD). This review provides evidence for the association between impaired neurogenesis and AD, and discusses the molecular and cellular regulation of neurogenesis in the young and aging brain. The review also summarizes therapeutic strategies for targeting the manipulation of the neural stem cell pool and factors affecting this pool in AD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Sara Bottes, Baptiste N. Jaeger, Gregor-Alexander Pilz, David J. Jorg, John Darby Cole, Merit Kruse, Lachlan Harris, Vladislav Korobeynyk, Izaskun Mallona, Fritjof Helmchen, Francois Guillemot, Benjamin D. Simons, Sebastian Jessberger
Summary: Researchers identified long-term self-renewing neural stem cells (NSCs) in the adult mouse hippocampus using intravital imaging and single-cell RNA sequencing. They found that Gli1-targeted NSCs exhibit long-term self-renewal, while Ascl1-targeted NSCs have limited proliferative activity before exhaustion. The study revealed the existence of heterogeneous NSC populations with diverse behavioral properties in contributing to neurogenesis in the adult hippocampus.
NATURE NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Fanny Ehret, Ricardo Moreno Traspas, Marie-Theres Neumuth, Bianca Hamann, Daniela Lasse, Gerd Kempermann
Summary: Notch3 is a regulator of adult hippocampal neurogenesis and mutations in Notch3 cause CADASIL. CADASIL transgenic mice showed deficits in spatial memory and adult neurogenesis, with Notch3 overexpression resulting in spatial strategy deficits and reduced neurogenesis. The CADASIL mutation had a specific effect on behavior, but not on adult neurogenesis, suggesting a loss of function.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
Sarah Houben, Megane Homa, Zehra Yilmaz, Karelle Leroy, Jean-Pierre Brion, Kunie Ando
Summary: AHN plays a critical role in sustaining hippocampal functions such as learning and memory, and impaired AHN in AD patients may contribute to cognitive deficits. NFTs and amyloid plaques are key neuropathological hallmarks of AD, with abnormal tau protein accumulation impacting AHN. Further research is needed to fully understand the relationship between tau pathology and AHN.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rada Jeremic, Sanja Pekovic, Irena Lavrnja, Ivana Bjelobaba, Marina Djelic, Sanja Dacic, Predrag Brkic
Summary: A growing body of evidence suggests that hyperbaric oxygenation (HBO) can affect the activity of adult neural stem cells (NSCs). In this study, the effects of sensorimotor cortex ablation (SCA) and HBO treatment (HBOT) on neurogenesis in the adult dentate gyrus (DG) were investigated. The results showed that SCA caused significant loss of neurons in the DG, while HBOT prevented the reduction of dendritic arborization and increased proliferation of progenitor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Aikaterini Lampada, Verdon Taylor
Summary: Neurogenesis stops in most areas of the mammalian brain before or shortly after birth, but in certain brain regions, the production of new neurons continues into adulthood. Neural stem cells in these neurogenic zones are situated within niches that govern their activity and fate. Majority of adult brain stem cells are mitotically inactive and can remain dormant for extended periods. The molecular mechanisms regulating neural stem cell maintenance and differentiation are of great interest, with Notch signaling identified as a critical regulator in various tissues, including the nervous system. This review examines the roles of Notch signaling, as well as the functions of different Notch receptors and ligands, in the regulation of adult neurogenesis in mice.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Nanami Kasakura, Yuka Murata, Asuka Shindo, Shiho Kitaoka, Tomoyuki Furuyashiki, Kanzo Suzuki, Eri Segi-Nishida
Summary: The dentate gyrus of the hippocampus plays a regulatory role in stress-related emotional behaviors and neurogenesis. NT-3 is expressed in the adult dentate gyrus and is enhanced under chronic stress conditions in rodents. However, the functional modulation of the dentate gyrus by NT-3 signaling is still unclear.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Cell Biology
Katarzyna Bartkowska, Beata Tepper, Krzysztof Turlejski, Ruzanna Djavadian
Summary: This article evaluates the developmental neurogenesis that occurs after birth in both marsupials and eutherians, with a focus on the generation of granule cells during the formation of the olfactory bulb, dentate gyrus, and cerebellum. The importance of immature neurons in the piriform cortex of young mammals is discussed, and the knowledge of adult neurogenesis in the olfactory bulb and dentate gyrus of marsupials is synthesized to determine the essentiality of adult-born neurons in a given area.
Article
Neurosciences
Max Rudolph, Christian W. Schmeer, Madlen Guenther, Florus Woitke, Carolin Kathner-Schaffert, Lina Karapetow, Julia Lindner, Thomas Lehmann, Gustav Jirikowski, Otto W. Witte, Christoph Redecker, Silke Keiner
Summary: After stroke, there is a transient increase in apoptotic cells in the dentate gyrus of the hippocampus, with impaired removal by microglia. However, phagocytosis of newly generated precursor cells is not affected. This disturbed phagocytosis in the hippocampus after a prefrontal stroke lesion may contribute to inflammatory processes and cognitive impairment, warranting further investigation.
Review
Cell & Tissue Engineering
Sebastian B. Arredondo, Daniela Valenzuela-Bezanilla, Sebastian H. Santibanez, Lorena Varela-Nallar
Summary: The subgranular zone of the hippocampal dentate gyrus is a neurogenic niche that contains neural stem cells capable of generating granule neurons. Wnt ligands play diverse roles in regulating adult hippocampal neurogenesis. Understanding the cellular source and mechanisms of Wnt signaling will be crucial for future therapeutic interventions.
Article
Anatomy & Morphology
Meike Zerwas, Stephanie Trouche, Kevin Richetin, Timothe Escude, Helene Halley, Rita Gerardy-Schahn, Laure Verret, Claire Rampon
BRAIN STRUCTURE & FUNCTION
(2016)
Article
Neurosciences
Stephanie Trouche, Pavel V. Perestenko, Gido M. van de Ven, Claire T. Bratley, Colin G. McNamara, Natalia Campo-Urriza, S. Lucas Black, Leon G. Reijmers, David Dupret
NATURE NEUROSCIENCE
(2016)
Article
Neurosciences
Gido M. van de Ven, Stephanie Trouche, Colin G. McNamara, Kevin Allen, David Dupret
Article
Neurosciences
Michael J. Darcy, Stephanie Trouche, Shan-Xue Jin, Larry A. Feig
Article
Neurosciences
Colin G. McNamara, Alvaro Tejero-Cantero, Stephanie Trouche, Natalia Campo-Urriza, David Dupret
NATURE NEUROSCIENCE
(2014)
Article
Geriatrics & Gerontology
Laure Verret, Alice Krezymon, Helene Halley, Stephanie Trouche, Meike Zerwas, Marine Lazouret, Jean-Michel Lassalle, Claire Rampon
NEUROBIOLOGY OF AGING
(2013)
Article
Neurosciences
Stephanie Trouche, Jennifer M. Sasaki, Tiffany Tu, Leon G. Reijmers
Article
Neurosciences
T. Goodman, S. Trouche, I. Massou, L. Verret, M. Zerwas, P. Roullet, C. Rampon
Article
Multidisciplinary Sciences
Stephanie Trouche, Bruno Bontempi, Pascal Roullet, Claire Rampon
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Neurosciences
Vitor Lopes-dos-Santos, Gido M. van de Ven, Alexander Morley, Stephanie Trouche, Natalia Campo-Urriza, David Dupret
Article
Biochemistry & Molecular Biology
Stephanie Trouche, Vadim Koren, Natalie M. Doig, Tommas J. Ellender, Mohamady El-Gaby, Vitor Lopes-dos-Santos, Hayley M. Reeve, Pavel V. Perestenko, Farid N. Garas, Peter J. Magill, Andrew Sharott, David Dupret
Article
Neurosciences
Emmanuel Perisse, Magdalena Miranda, Stephanie Trouche
Summary: Avoiding potentially dangerous situations is crucial for survival. Recent studies have shown that aversive signals during learning and decision-making involve complex computations and are influenced by past experiences and internal states. Novel methodologies have provided new circuit-based models for understanding how aversive value information is computed and how it influences value-based decisions.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Review
Neurosciences
Orsolya Folsz, Stephanie Trouche, Vincent Croset
Summary: Although most neurons are generated embryonically, neurogenesis continues at low rates in certain brain areas throughout adulthood, such as the dentate gyrus of the hippocampus. Adult-born neurons in the dentate gyrus play a role in pattern separation and the encoding of episodic-like memories. They compete with mature neurons for input and output and regulate hippocampal activity. These neurons exhibit transient hyperexcitability and hyperplasticity during maturation, contributing to their recruitment by experiences. They support pattern separation during encoding and aid in the degradation of old connections, promoting generalization and preventing interference.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Physiology
Stephanie Trouche, Marco N. Pompili, Gabrielle Girardeau
CURRENT OPINION IN PHYSIOLOGY
(2020)
