Journal
HIPPOCAMPUS
Volume 22, Issue 5, Pages 1092-1095Publisher
WILEY-BLACKWELL
DOI: 10.1002/hipo.20983
Keywords
discrimination; generalization; consolidation; muscimol; fear
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Funding
- Wellcome Trust
- CAPES (MEC)
- CNPq (MCT)
- PROPESQ (UFRGS)
- FINEP (Rede Instituto Brasileiro de Neurociencias'', IBN-Net) [01.06.0842-00]
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Hippocampus is hypothesized to play a temporary role in the retrieval of context memories. Similarly, previous studies have reported that the expression of context memories becomes more generalized as memory ages. We report, first, that contextual fear memory expression changes from being sensitive to dorsal hippocampus inactivation by muscimol at 2 days post-conditioning, to insensitive at 28 days, and second, that over the same period rats lose their ability to discriminate between a novel and conditioned context. Furthermore, we show thatrepeated brief memory reactivation sessions prevent memory from becoming both hippocampus-independent and generalized. (C) 2011 Wiley Periodicals, Inc.
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