Journal
HETEROCYCLES
Volume 88, Issue 1, Pages 297-308Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-13-S(S)16
Keywords
Terihanine; Isoterihanine; Total Synthesis; Microwave Irradiation; Aza-Electrocyclic Reaction
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Funding
- Japan Society for the Promotion of Science [20590026, 23590143]
- Grants-in-Aid for Scientific Research [20590026, 24590040, 23590143] Funding Source: KAKEN
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A new total synthesis of terihanine (2a) and isoterihanine (2b) was established by our new bond formation between the C4b and N5 positions of the benzo[c]phenanthridine ring based on a microwave-assisted thermal electrocyclic reaction of 2-cycloalkenylbenzaldoxime as an aza 6 pi-electron system. In addition, the antitumor activity of these synthesized compounds, including nitidine and nornitidine was evaluated in HCT-116 cells.
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