1-Hydroxyethylhalenaquinone: A New Proteasome Inhibitor from the Marine Sponge Xestospongia sp.

Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor

(2013) Michitaka Yamaguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hyrtioreticulins A–E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus

(2012) Rumi Yamanokuchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

(2012) Alexei F. Kisselev et al.   CHEMISTRY & BIOLOGY

Manadosterols A and B, Sulfonated Sterol Dimers Inhibiting the Ubc13–Uev1A Interaction, Isolated from the Marine Sponge Lissodendryx fibrosa

(2012) Shuntaro Ushiyama et al.   JOURNAL OF NATURAL PRODUCTS

Siladenoserinols A–L: New Sulfonated Serinol Derivatives from a Tunicate as Inhibitors of p53–Hdm2 Interaction

(2012) Yuichi Nakamura et al.   ORGANIC LETTERS

Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51

(2011) Motoki Takaku et al.   GENES TO CELLS

New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia

(2010) Arlette Longeon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor

(2010) Sachiko Tsukamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

(2010) Philip Cohen et al.   CELL

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

(2008) Michael Groll et al.   NATURE