RECENT PROGRESS IN METAL ASSISTED MULTICOMPONENT SYNTHESES OF HETEROCYCLES

This review highlights some remarkable achievements made recently in the application of metal-catalyzed processes to the design of multicomponent syntheses of heterocycles. The domino MCRs that are purely based upon metal catalysis opens a vast field for the discovery of new sequences in heterocyclic synthesis. Many of these methods have proven to be the most powerful and are currently applied in target- or diversity-oriented syntheses. These reactions can dramatically reduce the generation of chemical wastes, costs of starting materials, and the use of energy as well as manpower. Moreover, the reaction period can be substantially shortened. This review article aims to report the recent developments devoted to this important area, focusing on the metal catalysis in multicomponent synthesis of heterocycles.