☆ 4.2 Article

AN EFFICIENT ONE-POT THREE-COMPONENT SYNTHESIS OF HIGHLY FUNCTIONALIZED COUMARIN FUSED INDENODIHYDROPYRIDINE AND CHROMENO[4,3-b]QUINOLINE DERIVATIVES

HETEROCYCLES (2012)

Journal

HETEROCYCLES

Volume 85, Issue 7, Pages 1629-+

Publisher

Japan Inst Heterocyclic Chemistry

DOI: 10.3987/COM-12-12494

Keywords

Catalyst Free; One-Pot Synthesis; Environmental-Friendly conditions

Categories

Chemistry, Organic

Funding

Department of Chemistry, IIT Roorkee through MHRD, New Delhi

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Abstract

An efficient one-pot, three-component synthesis method of highly functionalized coumarin fused 7,13-dihydro-5-oxa-13-aza-indeno[2,1-b]phenanthrene and chromeno[4,3-b]quinoline derivatives was accomplished using aromatic aldehyde, 4-aminocoumarin and cyclic 1,3-dione in acetic acid at reflux temperature. Environmental-friendly protocol has advantages of high yields, creating three new bonds and one stereocenter in single operation. Further, XRD and DFT study confirmed the molecular structure, stability and different interaction in the crystal packing.

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