Sphingolipids and Glycosphingolipids — Their Synthesis and Bioactivities

Syntheses and biological activities of KRN7000 analogues having aromatic residues in the acyl and backbone chains with varying stereochemistry

(2010) Jeong-Ju Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological activity of ester and ether analogues of α-galactosylceramide (KRN7000)

(2010) Masao Shiozaki et al.   CARBOHYDRATE RESEARCH

Rational Design and Evaluation of a Branched-Chain-Containing Glycolipid Antigen That Binds to CD1d

(2010) Dong Jae Baek et al.   Chemistry-An Asian Journal

Induction of Th1-biased cytokine production by  -carba-GalCer, a neoglycolipid ligand for NKT cells

(2010) T. Tashiro et al.   INTERNATIONAL IMMUNOLOGY

Synthesis of phalluside-1 and Sch II using 1,2-metallate rearrangements

(2010) Fiona J. Black et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A general and concise asymmetric synthesis of sphingosine, safingol and phytosphingosines via tethered aminohydroxylation

(2010) Pradeep Kumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and Evaluation of Amino-Modified α-GalCer Analogues

(2010) Matthias Trappeniers et al.   ORGANIC LETTERS

RCAI-37, 56, 59, 60, 92, 101, and 102, cyclitol and carbasugar analogs of KRN7000: Their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines☆

(2009) Takuya Tashiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of 3″- and 4″-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000

(2009) Ravinder Raju et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Roles of 3′ and 4′ Hydroxy Groups in α-Galactosylceramide Stimulation of Invariant Natural Killer T Cells

(2009) Chengfeng Xia et al.   ChemMedChem

Aminocyclitol-Substituted Phytoceramides and their Effects on iNKT Cell Stimulation

(2009) Youssef Harrak et al.   ChemMedChem

Nonglycosidic Agonists of Invariant NKT Cells for Use as Vaccine Adjuvants

(2009) B. Gopal Reddy et al.   ChemMedChem

The Synthesis and in vivo Evaluation of 2′,2′-Difluoro KRN7000

(2009) Leo Leung et al.   ChemMedChem

Carbohydrate specificity of the recognition of diverse glycolipids by natural killer T cells

(2009) Dirk M. Zajonc et al.   IMMUNOLOGICAL REVIEWS

Identification of C-glycoside analogues that display a potent biological activity against murine and human invariant natural killer T cells

(2009) Xiangming Li et al.   IMMUNOLOGY

Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by Vα14 i NKT Cells

(2009) Barbara A. Sullivan et al.   JOURNAL OF IMMUNOLOGY

Focus on the Controversial Activation of Human iNKT Cells by 4-Deoxy Analogue of KRN7000

(2009) Vivien Lacône et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Evaluation of Potent NKT Cell Agonists: Implications for Design of Novel Stimulatory Ligands

(2009) André Schiefner et al.   JOURNAL OF MOLECULAR BIOLOGY

RCAI-17, 22, 24–26, 29, 31, 34–36, 38–40, and 88, the analogs of KRN7000 with a sulfonamide linkage: Their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines

(2008) Takuya Tashiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand

(2008) Jeong-Ju Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

α-S-GalCer: Synthesis and evaluation for iNKT cell stimulation

(2008) Marisa L. Blauvelt et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in vitro Evaluation of α‐GalCer Epimers

(2008) Matthias Trappeniers et al.   ChemMedChem

Crystal Structures of Mouse CD1d-iGb3 Complex and its Cognate Vα14 T Cell Receptor Suggest a Model for Dual Recognition of Foreign and Self Glycolipids

(2008) Dirk M. Zajonc et al.   JOURNAL OF MOLECULAR BIOLOGY

6′-Derivatised α-GalCer Analogues Capable of Inducing Strong CD1d-Mediated Th1-Biased NKT Cell Responses in Mice

(2008) Matthias Trappeniers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative Microarray Analysis of Intact Glycolipid−CD1d Interaction and Correlation with Cell-Based Cytokine Production

(2008) Pi-Hui Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000

(2008) Leo Leung et al.   ORGANIC LETTERS

The First Synthesis of a Thioglycoside Analogue of the Immunostimulant KRN7000

(2008) Ravindra T. Dere et al.   ORGANIC LETTERS

An Efficient and General Enantioselective Synthesis of Sphingosine, Phythosphingosine, and 4-Substituted Derivatives†

(2008) Josep Llaveria et al.   ORGANIC LETTERS

RCAI-61, the 6′-O-methylated analog of KRN7000: its synthesis and potent bioactivity for mouse lymphocytes to produce interferon-γ in vivo

(2008) Takuya Tashiro et al.   TETRAHEDRON LETTERS

Glycolipids as immunostimulating agents

(2007) Douglass Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

RCAI-8, 9, 18, 19, and 49–52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines

(2007) Ken-ichi Fuhshuku et al.   BIOORGANIC & MEDICINAL CHEMISTRY