Journal
HETEROCYCLES
Volume 81, Issue 12, Pages 2781-2792Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-10-12055
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
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Asymmetric acyl-Strecker reaction using novel thiourea organocatalyst is described. Screening experiments of the catalysts revealed that a bifunctional organocatalyst afforded an enantio-enriched product via an unique mechanism. That is, dihydroisoquinoline derivatives were converted to a corresponding 1-cyano-1,2,3,4-tetrahydroisoquinolines using the bifunctional thiourea catalyst derived from Betti base in moderate yield and enantioselectivity.
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