4.2 Article

RHODIUM-CATALYZED DIASTEREOSELECTIVE COUPLING OF PROPARGYLIC OXIRANES WITH ARYLBORONIC ACIDS IN WATER

Journal

HETEROCYCLES
Volume 77, Issue 1, Pages 193-199

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-08-S(F)24

Keywords

Rhodium; Reaction in Water; Propargylic Oxirane; Addition; Diastereoselective

Funding

  1. Japan Society for the Promotion of Science (JSPS)
  2. Takeda Science Foundation
  3. Astellas Foundation for Research on Medicinal Resources

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A diastereoselective coupling of propargylic oxiranes with arylboronic acids in aqueous condition is described. 4-Aryl-substituted 2,3-allenols having syn-geometries were selectively synthesized by the rhodium-catalyzed reactions in water.

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