Journal
HETEROCYCLES
Volume 78, Issue 3, Pages 645-655Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-08-11546
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Treatment of 1,4-disubstituted 1,2,3-triazoles with aryl iodides in the presence of a catalytic amount of copper chloride and lithium tert-butoxide (stoichiometric) in DMF at 140 degrees C leads to arylation at the 5-position. Various combinations of substituted aryl iodides and 1,4-disubstituted 1,2,3-triazoles bearing functional groups were found to be compatible.
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