Review
Chemistry, Applied
Qing-Feng Li, Jing Ma, Junjia Meng, Er-Qing Li
Summary: Nucleophilic Lewis base catalysis has emerged as an efficient method for the construction of diverse spirooxindoles. This review summarizes and classifies three catalytic strategies and highlights their applications in natural product synthesis.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Review
Chemistry, Physical
Bert Biesemans, Jeriffa De Clercq, Christian V. Stevens, Joris W. Thybaut, Jeroen Lauwaert
Summary: Aminated materials play a crucial role as aldol condensation catalysts, facilitating the reaction through an enamine mechanism. The reaction environment and the addition of small amounts of water are important factors. The development of water tolerant (bio)polymer supported amine catalysts has opened up opportunities for further catalyst development.
CATALYSIS REVIEWS-SCIENCE AND ENGINEERING
(2022)
Review
Chemistry, Physical
Hugo Santos, Lucas A. Zeoly, Manoel T. Rodrigues Jr, Fabio S. Fernandes, Ralph C. Gomes, Wanda P. Almeida, Fernando Coelho
Summary: Since its discovery in the late 1960s, the Morita-Baylis-Hillman (MBH) reaction has been a powerful carbon-carbon sigma-bond-forming reaction, producing small polyfunctionalized molecules. Advances in functional catalysts and reaction conditions have been made to improve the reaction rate, substrate scope, and enantioselectivity. This review provides an updated summary of the main improvements in catalytic systems for the MBH reaction over the past decade until nowadays, aiming to inspire further investigations and overcome the remaining challenges of this fascinating transformation.
Article
Chemistry, Multidisciplinary
Manman Song, Jing Zhao, Er-Qing Li
Summary: This review provides a comprehensive and updated summary of the use of tertiary amine Lewis bases as catalysts for annulation reactions of allenoates. The review highlights diverse reactivities, chemoselectivities, and detailed reaction mechanisms.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Qian Wang, Yinggao Meng, Lulu Wu, Er-Qing Li
Summary: Metal/nucleophilic Lewis base dual catalysis has been recognized as a reliable and promising strategy for finishing ideal organic synthesis. This new strategy expands the synthetic utility of chemical transformations by leveraging additional activation modes and has made considerable progress in the synthesis of a wide range of heterocyclic and biologically active compounds. In this review, the comprehensive and updated advances of metal/nucleophilic Lewis base dual catalytic annulation reactions are described, along with the highlighting of the related mechanism and application in natural product total synthesis.
CHINESE CHEMICAL LETTERS
(2023)
Review
Chemistry, Applied
Shengshu Liu, Bing-Qian Zhang, Wen-Ying Xiao, Yin-Long Li, Jun Deng
Summary: Heterocycles containing halogen or chalcogen elements are crucial building blocks in natural products and bioactive targets. Catalytic asymmetric functionalization of carbon-carbon unsaturated bonds with halogen or chalcogen electrophiles is an efficient method to obtain chiral heterocyclic backbones.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Review
Chemistry, Physical
Virgil Helaine, Cedric Gastaldi, Marielle Lemaire, Pere Clapes, Christine Guerard-Helaine
Summary: Aldolases are powerful enzymes for C-C bond formation in biocatalysis due to their outstanding stereoselectivity, ease of setting up reactions without cofactor recycling, availability of various types and families, and feasibility under mild operating conditions. Recent major discoveries have expanded the scope of both nucleophile and electrophile substrates, leading to significant advancements in the field.
Review
Chemistry, Multidisciplinary
Yinggao Meng, Lihui Chen, Er-Qing Li
Summary: Lewis base catalysis provides powerful synthetic strategies for the selective construction of carbon-carbon and carbon-heteroatom bonds. The nucleophilicity and steric hindrance of Lewis base catalyst often plays a major role in catalytic reactivity and selectivity in the reaction. Tremendous progress has been made in the divergent construction of valuable motifs under Lewis base catalysis in the past decades.
Review
Chemistry, Organic
Rodney A. A. Fernandes, Sanjita Moharana, Gulenur Nesha Khatun
Summary: This tutorial review highlights the recent efforts of researchers in the total synthesis of complex guaianolides. Various strategies and new methods, including catalytic reactions, have been employed to achieve these syntheses. The review also emphasizes the importance of enhancing diversity and sustainability in the synthesis of these natural products.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Chemistry, Organic
Jyoti M. Honnanayakanavar, Owk Obulesu, Surisetti Suresh
Summary: Copper-catalyzed N-arylation plays a crucial role in the total syntheses of therapeutic molecules, while the construction of fused N-heterocycles remains a vibrant area of research. Tandem reactions offer a convenient way to access complex organic molecules by reducing synthetic steps.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Daler Baidilov, Davit Hayrapetyan, Andrey Y. Khalimon
Summary: Catalytic transfer hydrogenation has become an appealing alternative for direct hydrogenation reactions due to its simplicity and mild reaction conditions. Research is now focused on developing sustainable catalysts using abundant first-row transition metals, with many novel examples appearing in the literature in recent decades.
Article
Chemistry, Multidisciplinary
Minghui Zhu, Peixin Wang, Qinglong Zhang, Wenjun Tang, Weiwei Zi
Summary: The aldol reaction is an important and versatile transformation in organic synthesis, but achieving stereoselectivity for the formation of diastereomeric products is challenging. In this study, a new catalytic system was developed to overcome the selectivity limitations of the reaction. Computational studies provided insights into the reaction mechanism and stereochemistry of the catalytic system.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Koushik Saha, Dipak Kumar Roy, Rian D. Dewhurst, Sundargopal Ghosh, Holger Braunschweig
Summary: This article discusses the coordination of an element-element sigma bond to a transition metal, focusing on its significance in metal-mediated bond activation and catalysis. Research has been conducted on sigma-borane/-borate complexes using two distinct approaches, leading to a deeper understanding of their structures and properties.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Wei Li, Donghao Jiang, Cheng Wang, Li-Jie Cheng
Summary: Transition metal-catalyzed carbonylation reactions provide a direct and atom-economical method for synthesizing carbonyl compounds or their derivatives using CO as a cheap and readily available C1 feedstock. Although carbonylation of less reactive unactivated alkyl electrophiles poses challenges, recent advances using earth-abundant base metals as catalysts have allowed for the synthesis of important and previously difficult-to-access carbonyl compounds or their derivatives.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Bing Xu, Quanpu Wang, Chao Fang, Zhan-Ming Zhang, Junliang Zhang
Summary: This review summarizes the latest advancements in enantioselective palladium-catalyzed cyclization reactions over the past eleven years. The review is organized into thirteen sections based on the different types of transformations involved. Chiral palladium catalysts have shown outstanding features in promoting a plethora of enantioselective cyclization reactions, providing convenient access to structurally diverse chiral carbo- and hetero-cycles.
CHEMICAL SOCIETY REVIEWS
(2023)
