Electrocatalytic Fast and Efficient Multicomponent Approach to Medicinally Relevant (2-Amino-4H-chromen-4-yl) phosphonate Scaffold

One-pot' electrocatalytic transformation of salicylaldehydes, malononitrile, and triethyl phosphite in an undivided cell results in the formation of diethyl (2-amino-3-cyano-4H-chromen-4-yl)phosphonates in 88-93% substance yields and 880-930% current efficiency via complex multicomponent process. This novel electrocatalytic chain process opens an effective, fast, and convenient way to cyano-functionalized (2-amino-4H-chromen-4-yl)phosphonate systems which are promising compounds for biomedical applications. This efficient electrocatalytic approach to the (2-amino-4H-chromen-4-yl)phosphonate scaffold represents novel synthetic concept for multicomponent reactions (MCR) strategy and allows to combine the synthetic virtues of conventional MCR with ecological benefits and convenience of facile electrocatalytic procedure.