Journal
HEPATOLOGY RESEARCH
Volume 45, Issue 6, Pages 705-710Publisher
WILEY-BLACKWELL
DOI: 10.1111/hepr.12391
Keywords
bone marrow metastasis; disseminated intravascular coagulation; disseminated carcinomatosis of the bone marrow; hepatocellular carcinoma
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A 50-year-old male patient was admitted to the hospital for persistent high fever and back pain. He was diagnosed with hepatocellular carcinoma (HCC), bone marrow metastasis and disseminated intravascular coagulation (DIC). Despite the diagnosis and treatment, the general condition deteriorated rapidly and he died of cerebral hemorrhage associated with generalized bleeding tendency. Autopsy showed multiple HCC in the liver and systemic metastasis including bone marrow. The case describes a rare complication of HCC with disseminated carcinomatosis of the bone marrow (DCBM) complicated with DIC, with rapid deterioration and death. This is the first case of DCBM from HCC. Physicians need to be aware of DCBM in patients with HCC.
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