Article
Chemistry, Physical
Konstantin A. Prosolov, Ekaterina G. Komarova, Ekaterina A. Kazantseva, Aleksandr S. Lozhkomoev, Sergei O. Kazantsev, Olga Bakina, Marina Mishina, Anastasia P. Zima, Sergei Krivoshchekov, Igor A. Khlusov, Yurii P. Sharkeev
Summary: Drug delivery systems based on calcium phosphate coatings have been recognized as potential treatments for bone diseases. This study introduces a new method, hybrid ultrasound-assisted micro-arc oxidation, for depositing calcium phosphate coatings for drug delivery. The resulting coatings exhibit suitable internal and surface porosity for drug delivery and demonstrate good cytotoxicity and antimicrobial activity.
Article
Microbiology
Menghuai Sun, Qian Lin, Chunyang Wang, Jiao Xing, Kunlong Yan, Zhifeng Liu, Yu Jin, Carol J. Cardona, Zheng Xing
Summary: The EV-A71 2B protein plays a crucial role in dysregulating JAK-STAT signaling by promoting caspase-3 dependent degradation of KPNA1, representing a novel strategy for EV-A71 to evade host antiviral innate immunity.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Ophthalmology
Wen Geng, Jia-Song Wang, Bing-Jie Shi, Hua-Tao Xie, Ming-Chang Zhang
Summary: This study demonstrates that combined use of IFN alpha 2b and 5-FU as primary treatment for OSSN is safe and effective, with a short duration of administration and low recurrence rate.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Oncology
Yiwen Qiu, Yi Yang, Tao Wang, Shu Shen, Wentao Wang
Summary: This study investigated the impact of microscopic portal vein invasion (MPVI) on the efficacy of postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE). The results showed that PA-TACE had better recurrence-free survival (RFS) and overall survival (OS) outcomes in patients without MPVI. However, for patients with MPVI, PA-TACE did not significantly improve RFS or OS outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Myeong-Hyeon Wang
Summary: This study prepared and characterized ROS responsive cerium oxide nanoparticles decorated with 5-fluorouracil loaded chitosan nanoparticles for enhanced anticancer activity in HepG2 cells. The nanoparticles were found to be spherical in shape and sized 200 nm. The controlled delivery of 5FU through the nanoparticles attenuated ROS formation in mouse embryonic fibroblasts and enhanced apoptosis in HepG2 cells. Furthermore, the nanoparticles showed no toxicity to red blood cells and chick chorioallantoic membrane.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Dafeng Xu, Yu Wang, Jincai Wu, Zhensheng Zhang, Jiacheng Chen, Mingwei Xie, Rong Tang, Chen Cheng, Liang Chen, Shiyun Lin, Xiangxiang Luo, Jinfang Zheng
Summary: This study identified MTIF2 as the hub immune infiltrating gene in hepatocellular carcinoma (HCC), and found that down-regulation of MTIF2 impairs the proliferation and migration capacity of HCC cells, leading to decreased chemoresistance. Further mechanistic investigations revealed that MTIF2 interacts with AIFM1 to suppress apoptosis and impair immunogenic cell death in HCC cells.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biophysics
Hui-Yan Li, Fang-Fei Yin, Xin-Yi Li, Wan-Nan Jia, Jia Ding, Li Zhang, Zhong-Hua Wang, Qin-Qin Hu, Jie-Liang Zuo, Hu-Liang Jia, Li-Hua Wang, Chun-Hai Fan, Hong-Zhou Gu, Jian Wu
Summary: In this study, an aptamer AP32 specific to SHh was obtained by SELEX technology and a novel aptamer-based assay was successfully developed. The method exhibited a broad detection range, high sensitivity, and could be used to predict early metastasis and poor prognosis in HCC, even in AFP-negative cases.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Medicine, General & Internal
Fengping Wu, Yikai Wang, Dandan Cui, Yan Tian, Rui Lu, Chenrui Liu, Mei Li, Yaping Li, Ning Gao, Zicheng Jiang, Xuemei Li, Song Zhai, Xin Zhang, Xiaoli Jia, Shuangsuo Dang
Summary: The study investigated the efficacy and safety of peg-IFN alpha-2b in re-treating patients with HBsAg recurrence after stopping peg-IFN alpha-based regimens. The results showed that a short-course of peg-IFN alpha-2b re-treatment significantly improved HBsAg clearance and seroconversion rates in patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Da Huang, Di Wu, Peng Wang, Yongli Wang, Wei Yuan, Danqing Hu, Junjian Hu, Yaqi Wang, Ran Tao, Fang Xiao, Xiaoping Zhang, Xiaojing Wang, Meifang Han, Xiaoping Luo, Weiming Yan, Qin Ning
Summary: This study found that patients with lower levels of HBcrAg and higher levels of HBsAb at the end of treatment are more likely to achieve durable functional cure post Peg-IFN-based therapy, which is associated with sustained immune responses.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Xinning Zhang, Yong Xu, Guodong Zhao, Rong Liu, Haisheng Yu
Summary: The study found that sorafenib suppressed the function of plasmacytoid dendritic cells (pDCs) and inhibited the production of interferon alpha (IFN-α) by peripheral blood mononuclear cells (PBMCs) or pDCs from healthy donors in a concentration-dependent manner. This suggests that the immunosuppressive effect of sorafenib on pDCs should be considered during cancer treatment.
Article
Chemistry, Medicinal
Meng Jin, Li Kong, Ying Han, Sen Zhang
Summary: The study showed that curcumin can enhance the chemosensitivity of HCC cells to 5-Fu by promoting apoptosis, arresting the cell cycle at G2/M phase, and blocking the PI3K/AKT/mTOR signaling pathway. In vivo, curcumin also significantly increased the sensitivity of H22 cells to 5-Fu and inhibited tumor growth, with gut microbiota playing a key role in its effects.
PHYTOTHERAPY RESEARCH
(2021)
Review
Oncology
Fei Xiong, Qi Wang, Guan-hua Wu, Wen-zheng Liu, Bing Wang, Yong-jun Chen
Summary: IFN-alpha 2b is a highly active cytokine that has antiviral, antitumour, antiparasitic, and immunomodulatory activities. Its antiproliferative effects are mainly mediated through the JAK-STAT pathway. Regulators of IFN-alpha 2b function may help improve its therapeutic efficacy.
BIOMARKER RESEARCH
(2022)
Article
Chemistry, Analytical
Boris Nikolaev, Ludmila Yakovleva, Viacheslav Fedorov, Natalia Yudintceva, Vyacheslav Ryzhov, Yaroslav Marchenko, Alexander Ischenko, Alexander Zhakhov, Anatoliy Dobrodumov, Stephanie E. Combs, Huile Gao, Maxim Shevtsov
Summary: Type I interferons, particularly IFNa-2b, play crucial roles in immune responses and are associated with the development of various diseases. Therefore, it is essential to develop a highly sensitive platform for the analysis of IFNa-2b and anti-IFNa-2b antibodies to improve diagnosis.
Article
Gastroenterology & Hepatology
Li-Qing Li, Ying Zhou, Yong Huang, Ping Liang, Shi-Xiong Liang, Ting-Shi Su
Summary: This study compared the long-term outcomes of robotic stereotactic body radiotherapy (SBRT) with intensity-modulated radiotherapy (IMRT) in advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). The results showed no significant difference in overall survival, progression-free survival, intrahepatic control, and local control between SBRT and IMRT groups. SBRT may be a safe and more time-efficient treatment for local advanced HCC with PVTT when high-precision tracking technology is available.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kanglian Zheng, Xu Zhu, Shijie Fu, Guang Cao, Wen-Qing Li, Liang Xu, Hui Chen, Di Wu, Renjie Yang, Kun Wang, Wei Liu, Hongwei Wang, Quan Bao, Ming Liu, Chunyi Hao, Lin Shen, Baocai Xing, Xiaodong Wang
Summary: This study compared the efficacy and safety of sorafenib plus 3cir-OFF hepatic arterial infusion chemotherapy (HAIC) with sorafenib alone for advanced hepatocellular carcinoma (HCC) with major portal vein tumor thrombosis (PVTT). The results showed that sorafenib plus HAIC achieved better overall survival (OS) and longer progression-free survival (PFS) compared to sorafenib alone, but also had more adverse events.
Article
Gastroenterology & Hepatology
Keisuke Kakisaka, Yuichi Yoshida, Yuji Suzuki, Takuro Sato, Hidekatsu Kuroda, Akio Miyasaka, Yasuhiro Takikawa
HEPATOLOGY RESEARCH
(2018)
Article
Gastroenterology & Hepatology
Keisuke Kakisaka, Yuji Suzuki, Kojiro Kataoka, Yohei Okada, Yasuhiro Miyamoto, Hidekatsu Kuroda, Yasuhiro Takikawa
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Medicine, General & Internal
Kei Endo, Hidekatsu Kuroda, Keisuke Kakisaka, Takayoshi Oikawa, Kei Sawara, Kazuyuki Ishida, Tamotsu Sugai, Yasuhiro Takikawa
Article
Acoustics
Tamami Abe, Hidekatsu Kuroda, Yudai Fujiwara, Yuichi Yoshida, Akio Miyasaka, Naohisa Kamiyama, Yasuhiro Takikawa
JOURNAL OF CLINICAL ULTRASOUND
(2018)
Article
Gastroenterology & Hepatology
Keisuke Kakisaka, Yuji Suzuki, Yudai Fujiwara, Tamami Abe, Miki Yonezawa, Hidekatsu Kuroda, Kazuyuki Ishida, Tamotsu Sugai, Yasuhiro Takikawa
JOURNAL OF GASTROENTEROLOGY
(2018)
Editorial Material
Medicine, General & Internal
Yuji Suzuki, Keisuke Kakisaka, Hidekatsu Kuroda, Tokio Sasaki, Yasuhiro Takikawa
KOREAN JOURNAL OF INTERNAL MEDICINE
(2018)
Article
Acoustics
Yudai Fujiwara, Hidekatsu Kuroda, Tamami Abe, Kazuyuki Ishida, Takuma Oguri, Sachiyo Noguchi, Tamotsu Sugai, Naohisa Kamiyama, Yasuhiro Takikawa
ULTRASOUND IN MEDICINE AND BIOLOGY
(2018)
Article
Gastroenterology & Hepatology
Kei Endo, Hidekatsu Kuroda, Takayoshi Oikawa, Yohei Okada, Yudai Fujiwara, Tamami Abe, Hiroki Sato, Kei Sawara, Yasuhiro Takikawa
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2018)
Letter
Gastroenterology & Hepatology
Keisuke Kakisaka, Yuji Suzuki, Yudai Fujiwara, Tamami Abe, Miki Yonezawa, Hidekatsu Kuroda, Kazuyuki Ishida, Tamotsu Sugai, Yasuhiro Takikawa
JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Gastroenterology & Hepatology
Keisuke Kakisaka, Yuji Suzuki, Yukina Jinnouchi, Jo Kanazawa, Tokio Sasaki, Takehiro Yonezawa, Yuichi Yoshida, Hidekatsu Kuroda, Yasuhiro Takikawa
HEPATOLOGY RESEARCH
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Hiroko Naganuma, Hideaki Ishida, Hidekatsu Kuroda, Yasuaki Suzuki, Masahiro Ogawa
JOURNAL OF MEDICAL ULTRASONICS
(2020)
Article
Oncology
Hidekatsu Kuroda, Tomoaki Nagasawa, Yudai Fujiwara, Hiroki Sato, Tamami Abe, Yohei Kooka, Kei Endo, Takayoshi Oikawa, Kei Sawara, Yasuhiro Takikawa
Summary: Microwave ablation using Thermosphere(TM) technology showed similar overall survival and recurrence-free survival outcomes compared to radiofrequency ablation for hepatocellular carcinoma. Despite no significant differences in survival outcomes between the two methods, microwave ablation required fewer insertions, making it a recommended treatment option for tumors larger than 2 cm.
Article
Oncology
Kazunari Tanaka, Kunihiko Tsuji, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Tomomitsu Matono, Hidekatsu Kuroda, Yutaka Yata, Hideko Ohama, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Keisuke Yokohama, Hiroki Nishikawa, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Takashi Kumada
Summary: This study aimed to evaluate the ability of a TM score involving AFP, AFP-L3, and DCP to predict the prognosis and therapeutic efficacy in HCC patients treated with Atez/Bev. The results showed that the TM score was useful in predicting the overall survival (OS) and progression-free survival (PFS) in these patients. The mALBI grade was also a good predictor of OS and PFS.
Article
Gastroenterology & Hepatology
Yuichi Yoshida, Miki Yonezawa, Takuya Okamoto, Yudai Fujiwara, Akiko Suzuki, Yuji Suzuki, Kei Endo, Keisuke Kakisaka, Takayoshi Oikawa, Hidekatsu Kuroda, Akio Miyasaka, Yasuhiro Takikawa
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2019)
Proceedings Paper
Engineering, Electrical & Electronic
Takuma Oguri, Naohisa Kamiyama, Sachiyo Noguchi, Yuko Kanayama, Yudai Fujiwara, Tamami Abe, Yuriko Mikami, Hidekatsu Kuroda
2018 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)
(2018)