Article
Pharmacology & Pharmacy
Emuri Abe, Lambert Assoumou, Pierre de Truchis, Karine Amat, Severine Gibowski, Guillaume Gras, Jonathan Bellet, Juliette Saillard, Christine Katlama, Dominique Costagliola, Pierre-Marie Girard, Roland Landman, Jean-Claude Alvarez
Summary: This study compared plasma concentrations of antiretroviral therapy during intermittent treatment and found that despite low or undetectable levels of PI/NNRTI in plasma during the OFF period, patients were able to maintain undetectable viral loads. Further investigation is needed to understand the mechanistic explanation.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Infectious Diseases
Stefanie Sammet, Veronique Touzeau-Roemer, Eva Wolf, Pia Schenk-Westkamp, Birgit Romano, Elke Gersbacher, Ulrich Kastenbauer, Christoph Boesecke, Juergen Rockstroh, Stefan Scholten, Stephan Schneeweiss, Julia Roider, Ulrich Seybold
Summary: This study shows that a combination therapy of doravirine and dolutegravir is a durable treatment option for HIV patients, even in those with extensive treatment history and resistance-associated mutations.
Article
Immunology
Roland Landman, Pierre de Truchis, Lambert Assoumou, Sidonie Lambert, Jonathan Bellet, Karine Amat, Benedicte Lefebvre, Clotilde Allavena, Christine Katlama, Yazdan Yazdanpanah, Jean-Michel Molina, Ventzislava Petrov-Sanchez, Severine Gibowski, Jean-Claude Alvarez, Jacques Leibowitch, Jacqueline Capeau, Soraya Fellahi, Martin Duracinsky, Laurence Morand-Joubert, Dominique Costagliola, Pierre-Marie Girard
Summary: This study aimed to evaluate the efficacy and safety of a 4-days-on and 3-days-off antiretroviral therapy (ART) compared to continuous treatment for patients with HIV-1. The results showed that the two treatment regimens had similar treatment success rates over a 48-week observation period, but the intermittent treatment group had higher life satisfaction and lower costs.
Article
Medicine, General & Internal
Shahin Lockman, Sean S. Brummel, Lauren Ziemba, Lynda Stranix-Chibanda, Katie McCarthy, Anne Coletti, Patrick Jean-Philippe, Ben Johnston, Chelsea Krotje, Lee Fairlie, Risa M. Hoffman, Paul E. Sax, Sikhulile Moyo, Nahida Chakhtoura, Jeffrey S. A. Stringer, Gaerolwe Masheto, Violet Korutaro, Haseena Cassim, Blandina T. Mmbaga, Esau Joao, Sherika Hanley, Lynette Purdue, Lewis B. Holmes, Jeremiah D. Momper, Roger L. Shapiro, Navdeep K. Thoofer, James F. Rooney, Lisa M. Frenkel, K. Rivet Amico, Lameck Chinula, Judith Currier
Summary: This study compared the safety and efficacy of three antiretroviral regimens started in pregnancy. The dolutegravir-containing regimens had superior virological efficacy at delivery compared with the efavirenz-containing regimen and the dolutegravir, emtricitabine, and tenofovir disoproxil fumarate regimen. The dolutegravir, emtricitabine, and tenofovir alafenamide fumarate regimen had the lowest frequency of composite adverse pregnancy outcomes and of neonatal deaths.
Article
Economics
Marwan-al-Qays Bousmah, Marie Liberee Nishimwe, Tamara Tovar-Sanchez, Martial Lantche Wandji, Mireille Mpoudi-Etame, Gwenaelle Maradan, Pierrette Omgba Bassega, Marie Varloteaux, Alice Montoyo, Charles Kouanfack, Eric Delaporte, Sylvie Boyer
Summary: This study compared the economic and patient outcomes of DTG-based and EFV400-based first-line antiretroviral regimens in treatment-naive HIV-1 adults in Cameroon. The results showed that at 2020 antiretroviral drug prices, the DTG-based regimen had a higher probability of being cost-effective over EFV400-based regimen in sub-Saharan Africa.
Article
Infectious Diseases
Antoine Cheret, Rebecca Bauer, Vincent Meiffredy, Pauline Lopez, Faiza Ajana, Karine Lacombe, Philippe Morlat, Caroline Lascoux, Jacques Reynes, Ruxandra Calin, Sylvie Abel, Cecile Goujard, Christine Rouzioux, Veronique Avettand-Fenoel, Laurence Meyer
Summary: The study found that both dolutegravir-based and darunavir-based regimens significantly and similarly reduced the blood reservoir size during primary HIV-1 infection. Considering the rapid viral suppression during a period of high HIV-1 transmission risk, dolutegravir-based regimens are an important first-line treatment option.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Melanie Plazy, Adama Diallo, Thabile Hlabisa, Nonhlanhla Okesola, Collins Iwuji, Kobus Herbst, Sylvie Boyer, France Lert, Nuala McGrath, Deenan Pillay, Francois Dabis, Joseph Larmarange, Joanna Orne-Gliemann
Summary: This study reports on the implementation and effectiveness of a linkage-to-care intervention in rural South Africa, which involved tracking HIV-positive individuals through phone calls and home visits. The results showed that this intervention was effective in improving the linkage-to-care rate among patients.
Review
Infectious Diseases
Mariantonietta Pisaturo, Lorenzo Onorato, Antonio Russo, Salvatore Martini, Paolo Chiodini, Simona Signoriello, Paolo Maggi, Nicola Coppola
Summary: This meta-analysis evaluated the efficacy of dual therapies compared to triple therapies in HIV-naive patients. The study found that there was no significant difference in treatment failure, virological failure, and adverse drug reactions between dual therapies and triple therapies at 48 weeks, except for a higher risk of treatment failure in patients with CD4+ count less than 200.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Yiping Li, Qinjian Wang, Shu Liang, Chuanteng Feng, Hong Yang, Hang Yu, Dan Yuan, Shujuan Yang
Summary: This study found that a PI-based ART regimen is beneficial for reducing mortality in people living with HIV and HIV-1 drug resistance. Efforts should be made to detect HIV-1 drug resistance earlier and ensure timely adjustment to PI-based ART, maximizing the benefits of early switch treatment for these patients.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Infectious Diseases
Guillaume Breton, Oumou Hawa Diallo, Mohamed Cisse, Oumou Hawa Diallo, Nene Aissatou Diallo, Seny Agnes Soumaoro, Yalikhatou Camara, Alice Montoye, Christine Rouzioux, Youssouf Koita, Gilles Peytavin, Roland Tubiana, Pierre Prange
Summary: This study investigated the feasibility of reinforced antiretroviral prophylaxis and early infant diagnosis in high-risk infants. The study found that reinforced antiretroviral prophylaxis and early infant diagnosis at birth are widely feasible. However, the lack of maternal disclosure of HIV status and the stigma associated with it affect the assessment of mother-to-child transmission risk and follow-up.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Pengfei Yang, Lili Song, Yongwei Zhang, Xiaoxi Zhang, Xiaoying Chen, Yunke Li, Lingli Sun, Yingfeng Wan, Laurent Billot, Qiang Li, Xinwen Ren, Hongjian Shen, Lei Zhang, Zifu Li, Pengfei Xing, Yongxin Zhang, Ping Zhang, Weilong Hua, Fang Shen, Yihan Zhou, Bing Tian, Wenhuo Chen, Hongxing Han, Liyong Zhang, Chenghua Xu, Tong Li, Ya Peng, Xincan Yue, Shengli Chen, Changming Wen, Shu Wan, Congguo Yin, Ming Wei, Hansheng Shu, Guangxian Nan, Sheng Liu, Wenhua Liu, Yiling Cai, Yi Sui, Maohua Chen, Yu Zhou, Qiao Zuo, Dongwei Dai, Rui Zhao, Qiang Li, Qinghai Huang, Yi Xu, Bengiang Deng, Tao Wu, Panping Lu, Xia Wang, Mark W. Parsons, Ken Butcher, Bruce Campbell, Thompson G. Robinson, Mayank Goyal, Diederik Dippei, Yvo Roos, Charles Majoie, Longde Wang, Yongjun Wang, Jianmin Liu, Craig S. Anderson
Summary: Intensive blood pressure control to lower than 120 mm Hg should be avoided in patients who have received endovascular thrombectomy for acute ischaemic stroke due to intracranial large-vessel occlusion, as it may compromise functional recovery. The more intensive treatment group showed a higher likelihood of poor functional outcome, early neurological deterioration, and major disability at 90 days compared to the less intensive treatment group.
Article
Immunology
Thokozile R. Malaba, Irene Nakatudde, Kenneth Kintu, Angela Colbers, Tao Chen, Helen Reynolds, Lucy Read, Jim Read, Lee-Ann Stemmet, Megan Mrubata, Kelly Byrne, Kay Seden, Adelline Twimukye, Helene Theunissen, Eva Maria Hodel, Justin Chiong, Nai-Chung Hu, David Burger, Duolao Wang, Josaphat Byamugisha, Yussif Alhassan, Sharon Bokako, Catriona Waitt, Miriam Taegtmeyer, Catherine Orrell, Mohammed Lamorde, Landon Myer, Saye Khoo
Summary: This study compared the efficacy and safety of dolutegravir and efavirenz in pregnant women and infants. The results showed that dolutegravir significantly reduced viral load more quickly, and it was safe and well tolerated in pregnant and breastfeeding women. However, HIV transmission to infants can still occur during breastfeeding despite persistent viral suppression in mothers.
Article
Radiology, Nuclear Medicine & Medical Imaging
Feng Han, Yanjie Wang, Xiaoxiao Dong, Qingguang Lin, Yixi Wang, Wenhong Gao, Miao Yun, Yan Li, Shunji Gao, Huilong Huang, Ningshan Li, Tingting Luo, Xiao Luo, Miaozhen Qiu, Dongsheng Zhang, Kun Yan, Anhua Li, Zheng Liu
Summary: This study investigated the efficacy and safety of sonochemotherapy for inoperable pancreatic ductal adenocarcinoma. The results showed that sonochemotherapy can prolong overall survival and improve disease control rate.
EUROPEAN RADIOLOGY
(2023)
Article
Infectious Diseases
Livingstone Tavul, Moses Laman, Cade Howard, Bethuel Kotty, Anna Samuel, Catherine Bjerum, Kobie O'Brian, Steven Kumai, Matthew Amuga, Lina Lorry, Zebedee Kerry, Melvin Kualawi, Stephan Karl, Leo Makita, Lucy N. John, Sibauk Bieb, James Wangi, Gary J. Weil, Charles W. Goss, Daniel J. Tisch, William Pomat, Christopher L. King, Leanne J. Robinson
Summary: A community-based cluster-randomised trial in Papua New Guinea showed that the co-administration of ivermectin, diethylcarbamazine, and albendazole (IDA) was well-tolerated and more effective than diethylcarbamazine and albendazole (DA) for clearing microfilariae in lymphatic filariasis (LF) patients.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Samir K. Gupta, Mezgebe Berhe, Gordon Crofoot, Paul Benson, Moti Ramgopal, James Sims, Cheryl McDonald, Peter Ruane, William E. Sanchez, Anita Scribner, Shan-Yu Liu, Laurie A. VanderVeen, Hadas Dvory-Sobol, Martin S. Rhee, Jared M. Baeten, Ellen Koenig
Summary: This study investigated the efficacy of lenacapavir as initial and maintenance therapy for HIV. The results showed that lenacapavir effectively suppressed viral replication in different combination regimens, suggesting its potential as an antiretroviral agent. Lenacapavir can be administered orally or subcutaneously.
Article
Gastroenterology & Hepatology
Maud Lemoine, Lambert Assoumou, Pierre-Marie Girard, Marc Antoine Valantin, Christine Katlama, Stephane De Wit, Pauline Campa, Hayette Rougier, Jean-Luc Meynard, Coca Necsoi, Anja D. Huefner, Jan Van Luzen, Julian Schulze Zur Wiesch, Jean-Philippe Bastard, Soraya Fellahi, Stefan Mauss, Metodi V. Stankov, Axel Baumgarten, Gerrit Post, Lawrence Serfaty, Vlad Ratziu, Yves Menu, Jerome Schlue, Pierre Bedossa, Jacqueline Capeau, Dominique Costagliola, Georg Behrens, Patrick Ingiliz
Summary: This study aimed to assess the prevalence and associated factors of liver steatosis and advanced fibrosis (AF) in HIV-monoinfected patients at risk of NAFLD. The results showed that two-thirds of the HIV-monoinfected patients with NAFLD had liver steatosis, and around 10% had advanced fibrosis. The CAP technique was accurate for screening steatosis in this population.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Coralie Amadou, Oumarou Nabi, Lawrence Serfaty, Karine Lacombe, Jerome Boursier, Philippe Mathurin, Celine Ribet, Victor de Ledinghen, Marie Zins, Marie-Aline Charles
Article
Immunology
Clotilde Allavena, Hubert Blain, Xian Abulizi, Laurence Slama, Christine Katlama, Pierre Delobel, Vanessa Rio, Carole Cagnot, Mariem Raho-Moussa, Alain Makinson, Laurence Meyer
Summary: This study aimed to assess the prevalence and risk factors of frailty in people aged 70 years or older with HIV who were on antiretroviral treatment. The results showed a low prevalence of frailty (13.5%) and a high prevalence of prefrailty (63.3%) in this population. Age, low socioeconomic status, and multimorbidities were associated with frailty. These findings highlight the importance of targeting these factors to promote successful aging in older individuals with HIV.
Article
Immunology
Jeanne Sibiude, Jerome Le Chenadec, Laurent Mandelbrot, Alexandre Hoctin, Catherine Dollfus, Albert Faye, Eida Bui, Emmanuelle Pannier, Jade Ghosn, Valerie Garrait, Veronique Avettand-Fenoel, Pierre Frange, Josiane Warszawski, Roland Tubiana
Summary: Antiretroviral therapy initiated before pregnancy and continued throughout pregnancy can significantly reduce perinatal transmission of HIV. Factors such as not breastfeeding, infant prophylaxis, and maternal viral suppression near delivery play important roles in preventing transmission.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Gastroenterology & Hepatology
Daniel Q. Huang, Philippe Mathurin, Helena Cortez-Pinto, Rohit Loomba
Summary: Global alcohol consumption has increased, leading to a rise in the incidence of alcohol-associated cirrhosis and hepatocellular carcinoma. Heavy alcohol consumption is a major cause of morbidity and mortality. Measures are needed to reduce the burden of alcohol-related liver diseases.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Chemistry, Medicinal
Peter J. Slavish, Maxime G. Cuypers, Mary Ashley Rimmer, Alireza Abdolvahabi, Trushar Jeevan, Gyanendra Kumar, Jamie A. Jarusiewicz, Sivaraja Vaithiyalingam, Jeremy C. Jones, John J. Bowling, Jeanine E. Price, Rebecca M. DuBois, Jaeki Min, Richard J. Webby, Zoran Rankovic, Stephen W. White
Summary: Influenza is a major cause of disease-related deaths globally. Strategies to inhibit influenza virus replication have resulted in the emergence of resistant strains. Baloxavir marboxil, a recently approved compound, is significantly less effective due to a mutation in the active site of the target enzyme. Raltegravir, an HIV inhibitor, shows moderate activity against the enzyme. In this study, researchers used structure-guided approaches to design molecules that effectively target the enzyme's active site and successfully developed potent inhibitors for both wild-type and baloxavir-resistant forms.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Infectious Diseases
Sophie Grabar, Valerie Potard, Lionel Piroth, Sophie Abgrall, Louis Bernard, Clotilde Allavena, Fabienne Caby, Pierre de Truchis, Claudine Duvivier, Patricia Enel, Christine Katlama, Marie-Aude Khuong, Odile Launay, Sophie Matheron, Giovanna Melica, Hugues Melliez, Jean-Luc Meynard, Juliette Pavie, Laurence Slama, Sylvie Bregigeon, Pierre Tattevin, Jacqueline Capeau, Dominique Costagliola
Summary: Many studies have found that starting an integrase strand-transfer inhibitor-based regimen for HIV-positive individuals who have not previously received antiretroviral therapy can lead to weight gain. This study examined the impact of early or advanced HIV disease progression and the specific drugs used in combination antiretroviral therapy (cART) on weight changes. The results showed that individuals with advanced disease progression experienced greater weight gain compared to those with early disease progression. The choice of antiretroviral drugs should take into account the risk of weight gain, particularly for patients with advanced disease or obesity.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Microbiology
Pauline Tremeaux, Frederic Lemoine, Adeline Melard, Marine Gousset, Faroudy Boufassa, Sylvie Orr, Valerie Monceaux, Olivier Gascuel, Olivier Lambotte, Laurent Hocqueloux, Asier Saez-Cirion, Christine Rouzioux, Veronique Avettand-Fenoel
Summary: In the search for ways to control HIV-1 infection without antiretroviral therapy, posttreatment controllers (PTCs) are models of HIV remission. We characterized the HIV blood reservoirs of PTCs in comparison with other groups and found that PTCs had lower proviral diversity and smaller amounts of defective proviruses than CHIs. These findings suggest potential mechanisms of control in PTCs and highlight the importance of further research in this area. Rating: 7/10.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Laurent Mandelbrot, Roland Tubiana, Pierre Frange, Gilles Peytavin, Jerome Le Chenadec, Ana Canestri, Philippe Morlat, Cecile Brunet-Cartier, Jeanne Sibiude, Delphine Peretti, Veronique Chambrin, Amelie Chabrol, Eida Bul, Caroline Simon-Toulza, Lucie Marchand, Christelle Paul, Sandrine Delmas, Veronique Avettand-Fenoel, Josiane Warszawski, Monogest Study Grp
Summary: This study evaluated a perinatal NRTI-sparing strategy to prevent perinatal HIV transmission. The primary objective was to determine the proportion of patients maintaining a viral load (VL) of <50 copies/mL on darunavir/ritonavir monotherapy without needing treatment intensification. The results showed that nearly 10% of cases required treatment intensification, limiting the widespread use of darunavir/ritonavir maintenance monotherapy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Matthieu Lafaurie, Claire Montlahuc, Solen Kerneis, Victoire de Lastours, Sophie Abgrall, Veronique Manceron, Carine Couzigou, Amelie Chabrol, Axelle de Raigniac, Xavier Lescure, Pascale Longuet, Philippe Lesprit, Dominique Vanjak, Raphael Lepeule
Summary: The objective of this study was to evaluate the efficacy of vancomycin catheter lock therapy (VLT) for the treatment of totally implantable venous access port-related infections (TIVAP-RI) due to CoNS. Results showed a low success rate of VLT, but nearly half of the patients were able to avoid TIVAP removal. Continuous locks should be preferred over intermittent locks.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Virology
Djeneba B. Fofana, Houdou Diarra, Ibrahima Guindo, Mahamadou K. Savadogo, Marceline d'Almeida, Fatoumata I. Diallo, Aliou Balde, Cathia Soulie, Amadou Kone, Anne-Genevieve Marcelin, Almoustapha I. Maiga, Sidonie Lambert-Niclot, Mamoudou Maiga, Sally McFall, Claudia A. Hawkins, Robert L. Murphy, Mariam Sylla, Christine Katlama, Jane L. Holl, Vincent Calvez, Laurence Morand-Joubert
Summary: Limited data exist on INI resistance in children living with HIV/AIDS in West Africa. A study was conducted on HIV-1-infected children in Benin and Mali, and it was found that no major INI resistance mutations were detected in INI-naive patients.
Article
Genetics & Heredity
Judit Burgaya, Julie Marin, Guilhem Royer, Benedicte Condamine, Benoit Gachet, Olivier Clermont, Francoise Jaureguy, Charles Burdet, Agnes Lefort, Victoire de Lastours, Erick Denamur, Marco Galardini, Francois Blanquart, Colibafi Septicoli grp, Coliville grp
Summary: This study analyzed 912 bloodstream infection (BSI) and 370 commensal Escherichia coli isolates collected in France, discovering significant differences in genetic backgrounds, virulence-associated genes, and antimicrobial resistance genes between pathogenic and commensal strains. A machine learning model accurately classified BSI and commensal strains and identified new genetic variants associated with pathogenicity. This study highlights the substantial genetic variation contributing to the transition between commensalism and pathogenicity in E. coli and suggests a gradual increase in pathogenicity in France.
Article
Multidisciplinary Sciences
Helene M. Roux, Amira Marouf, Jacques Dutrieux, Benedicte Charmeteau-De Muylder, Suzanne Figueiredo-Morgado, Veronique Avettand-Fenoel, Pelagia Cuvelier, Cecile Naudin, Fatma Bouaziz, Guillaume Geri, Anne Couedel-Courteille, Pierre Squara, Stefano Marullo, Remi Cheynier
Summary: Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. Genetic polymorphism that affects thymic output can modify SARS-CoV-2 immunity and disease severity. GG genotype is associated with stronger and long-lasting immune response and less severe lung involvement.
Article
Gastroenterology & Hepatology
Fabienne Marcellin, Sylvie Bregigeon-Ronot, Clemence Ramier, Camelia Protopopescu, Camille Gilbert, Vincent Di Beo, Claudine Duvivier, Morgane Bureau-Stoltmann, Eric Rosenthal, Linda Wittkop, Dominique Salmon-Ceron, Patrizia Carrieri, Philippe Sogni, Tangui Barre
Summary: This study aimed to investigate the prevalence of moderate-to-severe depression in people living with HIV and HCV after successful HCV treatment, and identify associated socio-behavioral factors. Through descriptive and logistic regression analyses of data from 398 participants, it was found that 23.9% of HCV-cured individuals had moderate-to-severe depression. Female sex, unhealthy alcohol use, sedentary lifestyle, and unhealthy eating behaviors were associated with increased odds of moderate-to-severe depression.