Article
Medicine, General & Internal
Sarang Hong, Dae Wook Hwang, Jae Hoon Lee, Ki Byung Song, Woohyung Lee, Bong Jun Kwak, Yejong Park, Song-Cheol Kim
Summary: The high modified Glasgow Prognostic Score (mGPS) is independently associated with poor overall survival and disease-free survival in patients undergoing curative surgery for pancreatic ductal adenocarcinoma (PDAC), especially for those with TNM stage I PDAC and tumors located at the pancreatic head or uncinate process. Preoperative mGPS is a significant prognostic factor for PDAC after curative resection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Li-Peng Peng, Jie Li, Xian-Feng Li
Summary: This study reviewed the prognostic value of NLR, PLR, LMR, and GPS in osteosarcoma patients. The results showed that higher NLR and GPS were significantly associated with poorer overall survival and disease-free survival, while there was no significant relationship between PLR and LMR and prognosis.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Mehmet Zahid Kocak, Seda Coban, Murat Araz, Melek Karakurt Eryilmaz, Mehmet Artac
Summary: The aim of this study was to determine the prognostic value of the prognostic nutritional index (PNI), the neutrophil to lymphocyte ratio (NLR), and the platelet to lymphocyte ratio (PLR) and their dynamic changes on survival outcomes in metastatic colorectal cancers (mCRC). The results showed that negative delta PNI is an independent predictor of poor prognosis in patients with colon cancer.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Jing-Houng Wang, Yen-Yang Chen, Kwong-Ming Kee, Chih-Chi Wang, Ming-Chao Tsai, Yuan-Hung Kuo, Chao-Hung Hung, Wei-Feng Li, Hsiang-Lan Lai, Yen-Hao Chen
Summary: Atezolizumab plus bevacizumab has been approved as the first-line treatment for unresectable hepatocellular carcinoma. This study examined the efficacy and safety of this treatment in real-world clinical practice and found that it is effective and well-tolerated. In addition, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were identified as independent prognostic factors for progression-free survival (PFS).
Review
Oncology
Jiali Leng, Fei Wu, Lihui Zhang
Summary: This meta-analysis found that pretreatment neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may serve as biomarkers for predicting poor prognosis in patients with endometrial cancer, while monocyte-lymphocyte ratio (MLR) is not associated with prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Anna Cho, Helena Untersteiner, Dorian Hirschmann, Fabian Fitschek, Christian Dorfer, Karl Roessler, Sabine Zoechbauer-Mueller, Brigitte Gatterbauer, Maximilian J. Hochmair, Josa M. Frischer
Summary: The study assessed the predictive value of NLR, PLR, LMR, and mGPS for NSCLC brain metastases patients undergoing radiosurgery. The results indicated that these factors are independent prognostic factors for survival.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Kaustav P. Shah, Haocan Song, Fei Ye, Douglas B. Johnson
Summary: In patients with BRAF(V600)-mutated melanoma, the number of distinct tumor sites at the initiation of targeted therapy is associated with survival, while serum lactate dehydrogenase values and the absolute lymphocyte count to absolute neutrophil count ratio are strong predictors of prognosis. Using both of these markers can help stratify prognosis for patients with metastatic melanoma receiving targeted therapy.
Article
Biochemistry & Molecular Biology
Andrea Plaja, Iris Teruel, Maria Ochoa-de-Olza, Marc Cucurull, Alvaro Javier Arroyo, Beatriz Pardo, Irene Ortiz, Marta Gil-Martin, Josep Maria Piulats, Helena Pla, Claudia Fina, Anna Carbo, Maria-Pilar Barretina-Ginesta, Sergio Martinez-Roman, Elvira Carballas, Andrea Gonzalez, Anna Esteve, Margarita Romeo
Summary: Despite a multimodal radical treatment, mortality of advanced epithelial ovarian cancer (AEOC) remains high. This study investigates the prognostic value of neutrophil, monocyte, and platelet to lymphocyte ratios (NLR, MLR, PLR) in newly diagnosed AEOC patients undergoing primary debulking surgery (PDS) or interval debulking surgery (IDS). The results suggest that NLR and PLR may have prognostic value in PDS, but not in IDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
Niall Woodley, Alexander D. G. Rogers, Katie Turnbull, Mohd Afiq Mohd Slim, Trung Ton, Jenny Montgomery, Catriona Douglas
Summary: The utility of various pre-treatment prognostic scoring systems for overall survival (OS) in laryngeal cancer, including NLR, PLR, LMR, mGPS and SIII, was evaluated. The results showed that NLR, PLR, LMR and SIII were significantly associated with improved OS and could be used as adjuvant decision-making tools.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Oncology
Deba Song, Xiaoxu Li, Xiaojian Zhang
Summary: This study explored the value of inflammatory markers, such as NLR, PLR, and LMR, in predicting the pathological features and prognosis of patients with BC. The findings suggest that these markers could become biological indicators for prognosis in invasive BC.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Clinical Neurology
Yanyan Wei, Junhui Feng, Jinbao Ma, Dongning Chen, Jingxu Chen
Summary: This study examines the role of alterations in the immune-inflammation system in affective disorders, specifically major depressive disorder (MDD) and bipolar disorder (BD). The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and monocyte/lymphocyte ratio (MLR) are investigated as inflammation markers. The findings reveal elevated NLR and MLR in first-episode and recurrent MDD patients, as well as higher NLR and MLR and lower PLR in BD patients. Moreover, BD manic episode patients have significantly higher NLR and MLR compared to BD depressive episode patients or MDD patients. Overall, this study highlights the importance of systemic inflammation in the pathophysiology of MDD and BD, particularly during manic BD episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Mi Su, Xiaoxiao Ouyang, Yongyan Song
Summary: This meta-analysis supports the association between depression and inflammation, with NLR being a potential indicator of depression. However, no significant differences were found in PLR and MLR values between depressed subjects and controls. Further large-scale studies are needed to evaluate the role of PLR and MLR in depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Oncology
Xianyang Hu, Tengfei Tian, Qin Sun, Wenxiu Jiang
Summary: This meta-analysis study investigated the relationship between high neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and laryngeal cancer prognosis. The results showed that high NLR was associated with poor overall survival, progression-free survival, and disease-free survival, while high PLR was linked to poor overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Lucy X. X. Ma, Yifan Wang, Osvaldo Espin-Garcia, Michael J. J. Allen, Gun Ho Jang, Amy Zhang, Anna Dodd, Stephanie Ramotar, Shawn Hutchinson, Mustapha Tehfe, Ravi Ramjeesingh, James Biagi, Julie M. M. Wilson, Faiyaz Notta, Sandra E. E. Fischer, George Zogopoulos, Steven Gallinger, Robert C. C. Grant, Rama Khokha, Nathan Chan, Barbara T. T. Gruenwald, Jennifer J. J. Knox, Grainne M. M. O'Kane
Summary: By comparing five systemic inflammatory scores in advanced pancreatic adenocarcinoma, researchers found that some of the scores have good prognostic value and can help select patients for clinical trials.
BRITISH JOURNAL OF CANCER
(2023)