Journal
HEMOGLOBIN
Volume 38, Issue 2, Pages 146-148Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/03630269.2013.875477
Keywords
delta Chain; anti-Lepore; Chinese; hemoglobin (Hb) variant
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Funding
- Guangzhou Health Bureau, People's Republic of China [20121A021012]
- Dongguan Science and Technology Bureau, People's Republic of China [2012105102015, 2012105102018]
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We have identified four Chinese individuals from three unrelated families with raised Hb A(2) levels. The anti-Lepore hybrid hemoglobin (Hb) variant was amplified using a pair of primers, 5' to the beta-globin gene Cap site and 3' to the delta-globin gene polyadenylation site (polyA) region, respectively. Direct sequencing of the beta delta fusion products confirmed the anti-Lepore Hong Kong (NG_000007.3: g.63154_70565dup) variant. We found that this anti-Lepore variant is positioned in zone 3 on the capillary electrophoresis system. It may help in differential diagnosis of Hb variants and providing better information in clinical counseling.
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