Article
Polymer Science
Zezhen Zhang, Shuman Feng, Qianyu Wei, Lili Wu
Summary: To improve the efficiency of polymeric hemodialysis membranes, researchers prepared polyethersulfone/tannic acid coblended ultrafiltration membranes modified with a heparin-like functionalized tannic acid coating. The coblended tannic acid improved the pore structure of the membranes and the modified coating further improved their performance. The final modified membranes exhibited ultrahigh water flux, improved dialysis performance, and excellent hemocompatibility.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Multidisciplinary Sciences
Masanori Abe, Ikuto Masakane, Atsushi Wada, Shigeru Nakai, Eiichiro Kanda, Kosaku Nitta, Hidetomo Nakamoto
Summary: This study investigated the association of different dialyzer types with 1-year mortality in Japan. The results showed that patients using type V dialyzers had significantly lower risk of mortality compared to those using type IV dialyzers. Additional long-term trials are needed to confirm whether high-performance type V dialyzers can improve prognoses.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Eiichiro Kanda, Daniel Muenz, Brian Bieber, Aleix Cases, Francesco Locatelli, Friedrich K. Port, Roberto Pecoits-Filho, Bruce M. Robinson, Jeffrey Perl
Summary: The study found a tenfold decrease in DRA-related hospitalization rates from 1998 to 2018. Even in the current era of high-flux HD, serum beta 2M remains positively associated with mortality, with mortality risk increasing monotonically with increasing beta 2M levels.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Endocrinology & Metabolism
Akinori Hayashi, Naoya Shimizu, Agena Suzuki, Kenta Matoba, Akari Momozono, Tsuguto Masaki, Akifumi Ogawa, Ibuki Moriguchi, Koji Takano, Naoyuki Kobayashi, Masayoshi Shichiri
Summary: Despite the use of dialysate containing 100-150 mg/dL glucose, patients with diabetes undergoing HD experienced HD-related hypoglycemia frequently. SGL showed a sustained decrease during HD, reaching a nadir lower than the dialysate glucose concentration, regardless of the dialysate glucose concentration.
Review
Medicine, General & Internal
Shuzo Kobayashi, Takayasu Ohtake
Summary: Patients undergoing hemodialysis (HD) have increased risk of cardiovascular complications, including peripheral arterial disease (PAD). Amputation and high mortality rates are common in dialysis patients who undergo revascularization procedures. Understanding the characteristics of dialysis membranes, particularly the AN69 membrane, can help improve prognosis by treating malnutrition and inflammation. Both the AN69 membrane and LDL-apheresis have similar anti-inflammatory and anti-thrombogenic effects, suggesting the potential for additive therapeutic benefits in HD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kichitaro Nakajima, Keiichi Yamaguchi, Masahiro Noji, Cesar Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Lianjie Zhou, Hirotsugu Ogi, Toru Ito, Ichiei Narita, Fumitake Gejyo, Hironobu Naiki, Suguru Yamamoto, Yuji Goto
Summary: Amyloid fibrils of beta 2-microglobulin (beta 2m) can cause dialysis-related amyloidosis. Decrease in serum albumin levels in long-term dialysis deteriorates the inhibitory effects of serum milieux on supersaturation-limited amyloid formation of beta 2m, suggesting that macromolecular crowding protects the onset of amyloidosis.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Chemical
Thanh-Tin Nguyen, Kyunghoon Jang, Namguk Her, Chang Seong Kim, Soo Wan Kim, In S. Kim
Summary: Developing a hemodialysis membrane that effectively removes both small-sized toxins and middle molecules is vital. This study successfully fabricated novel hemodialysis membranes with different inner diameters, demonstrating superior removal efficiency for both small molecules and middle molecules. The spinning conditions had a significant impact on the membrane properties, affecting the clearance of uremic toxins and protein loss/leaking. Overall, the study proposes a promising membrane for hemodialysis application that achieves increased removal of middle molecules while minimizing protein loss and leakage.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Satoshi Nakamura, Miki Yamada, Yosuke Iijima, Keisuke Sawada, Shunsuke Hino, Takahiro Kaneko, Norio Horie
Summary: We describe a case of early dialysis-related amyloidosis (DRA) on the tongue of a long-term dialysis patient. Clinicians should be aware that long-term dialysis can cause oral amyloidosis of the tongue.
CASE REPORTS IN DENTISTRY
(2022)
Article
Urology & Nephrology
Kenneth J. Woodside, Kaitlyn J. Repeck, Purna Mukhopadhyay, Douglas E. Schaubel, Vahakn B. Shahinian, Rajiv Saran, Ronald L. Pisoni
Summary: This study examined the procedural burden of interventions for arteriovenous fistulas (AVFs) and arteriovenous grafts (AVGs) during their maturation and maintenance phases in hemodialysis patients in the United States. The results showed that interventions were relatively common during maturation, but AVFs had lower maintenance intervention requirements once successfully matured. Geographic variations in intervention rates for AVF were observed during both maturation and maintenance phases, warranting further investigation.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Urology & Nephrology
Osama El Shamy, Graham Abra, Christopher Chan
Summary: The article discusses the complexity and multifactorial nature of writing a home hemodialysis prescription, emphasizing the importance of considering patient values, preferences, and lifestyle. It also introduces different home HD modalities and machines, along with their attributes and limitations, to guide providers in delivering a patient-centered home HD approach.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Nutrition & Dietetics
Cristina Garagarza, Ana Valente, Cristina Caetano, Ines Ramos, Joana Sebastiao, Mariana Pinto, Telma Oliveira, Anibal Ferreira, Catarina Sousa Guerreiro
Summary: This study found a high prevalence of inadequate zinc intake among HD patients, which is associated with poorer nutritional and body composition parameters, as well as a higher risk of mortality.
JOURNAL OF RENAL NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Noresah Said, Woei Jye Lau, Yeek-Chia Ho, Soo Kun Lim, Muhammad Nidzhom Zainol Abidin, Ahmad Fauzi Ismail
Summary: Dialyzers have been commercially used since the 1950s, with continuous progress in improving their efficiencies. This article reviews the commercial developments and laboratory research of dialyzers, discussing technical aspects and challenges in developing dialyzers to enhance properties such as flux and biocompatibility. The aim is to provide insights for researchers in creating an ideal dialyzer for better hemodialysis treatment outcomes for kidney disease patients.
Article
Multidisciplinary Sciences
Kazuhiko Tsuruya, Hisatomi Arima, Kunitoshi Iseki, Hideki Hirakata
Summary: The study revealed a significant association between DRA in patients undergoing long-term hemodialysis and a decrease in QOL. Patients who developed DRA during the 2-year follow-up experienced a more pronounced decline in QOL compared to those who had DRA from the beginning. Additionally, patients routinely treated with a beta 2-microglobulin adsorption column showed a lower decrease in utility score.
Article
Multidisciplinary Sciences
Ayesha Aslam, Shahid Shah, Ghulam Abbas, Anees Ur Rehman, Tauqeer Hussain Malhi, Nasser Hadal Alotaibi, Abdulaziz Ibrahim Alzarea, Muhammad Fawad Rasool, Haris Khurram, Sibgha Noureen, Muhammad Talha Saeed Bokhari
Summary: A study in Pakistan on hypertensive hemodialysis patients revealed that most patients had normal body mass index and reduced salt intake, with pain/discomfort being the most problematic dimension. Significant improvements were observed in self-care and usual activities during follow-up visits.
Article
Urology & Nephrology
Matthew Daubresse, G. Caleb Alexander, Deidra C. Crews, Dorry L. Segev, Krista Lentine, Mara A. McAdams-DeMarco
Summary: A study of individuals undergoing hemodialysis in the United States found that high-dose opioid utilization is associated with an increased risk of mortality, especially during periods of high-dose utilization. Therefore, patients and clinicians should carefully consider the risks and benefits of opioid doses exceeding 60MME per day.