Journal
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
Volume 24, Issue 5, Pages 793-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2010.06.005
Keywords
Genetic predisposition; History; High penetrance; Cancer
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The past three decades have witnessed an explosion in information regarding the genetic mutations underlying predisposition to common malignancies. Discoveries are now being made regarding genomic variants associated with disease risk for, and outcome following, treatment for cancer. Responsible translation of these discoveries to medical practice requires attention to principles of clinical utility as well as social and ethical aspects.
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