Article
Cell Biology
Kristina Breitenecker, Monika Homolya, Andreea C. Luca, Veronika Lang, Christoph Trenk, Georg Petroczi, Julian Mohrherr, Jaqueline Horvath, Stefan Moritsch, Lisa Haas, Margarita Kurnaeva, Robert Eferl, Dagmar Stoiber, Richard Moriggl, Martin Bilban, Anna C. Obenauf, Christiane Ferran, Balazs Dome, Viktoria Laszlo, Balazs Gyorffy, Katalin Dezso, Judit Moldvay, Emilio Casanova, Herwig P. Moll
Summary: Loss of A20 enhances lung tumorigenesis, reduces immune surveillance, and increases sensitivity to interferon-gamma, through the TBK1-STAT1-PD-L1 axis.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Koen Debackere, Lukas Marcelis, Sofie Demeyer, Marlies Vanden Bempt, Nicole Mentens, Olga Gielen, Kris Jacobs, Michael Broux, Gregor Verhoef, Lucienne Michaux, Carlos Graux, Iwona Wlodarska, Philippe Gaulard, Laurence de Leval, Thomas Tousseyn, Jan Cools, Daan Dierickx
Summary: This study identifies two fusion transcripts that activate T cell receptor complex signaling and confer therapeutic vulnerability in PTCL-NOS, contributing to the understanding of this poorly characterized subgroup of PTCL at the genetic level.
NATURE COMMUNICATIONS
(2021)
Review
Dentistry, Oral Surgery & Medicine
E. C. Mooney, S. E. Sahingur
Summary: Inflammation is triggered by innate sensors, and immune cell activation is a strictly regulated process supported by negative feedback mechanisms. Ubiquitination plays a critical role in regulating the immune system, with A20 serving as an important ubiquitin-editing enzyme in inflammation.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Hong-Ji Deng, QuZhen Deji, WangDui Zhaba, Jia-Qiang Liu, Sheng-Qing Gao, Yan-Ling Han, Meng-Liang Zhou, Chun-Xi Wang
Summary: The study showed that A20 can attenuate early brain injury after SAH by suppressing the NF-kappa B pathway and reducing inflammatory responses, thereby exerting neuroprotective effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yinuo Gu, Alan Chen-Yu Hsu, Xu Zuo, Xiaoping Guo, Zhengjie Zhou, Shengyu Jiang, Zhuoer Ouyang, Fang Wang
Summary: In this study, it was found that A20 acts as a crucial molecular switch to dampen the inflammatory responses caused by IAV infection. Chronic exposure to low-dose LPS can restrict excessive inflammation by increasing A20 expression. A20 and its induced PPAR-alpha and -gamma play a key role in suppressing excessive inflammatory responses in the chronic low-dose LPS environment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Ricardo J. Antonia, Eveliina Karelehto, Kan Toriguchi, Mary Matli, Robert S. Warren, Lawrence M. Pfeffer, David B. Donner
Summary: The study reveals that TNF activates STAT3, which in turn regulates the expression of inflammatory chemokines. Furthermore, Tnfaip3/A20 is identified as a downstream target of STAT3, and it functions to restrict TNF-induced inflammation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Qiudong Yang, Wenhua Zhao, Yuyi Chen, Yue Chen, Jiali Shi, Ran Qin, Hua Wang, Ruixia Wang, Hua Yuan, Wen Sun
Summary: The study reveals that the RelA/miR-30a/NLRP3 signaling axis is involved in rheumatoid arthritis by regulating the NLRP3 inflammasome in macrophages.
CELL DEATH & DISEASE
(2021)
Article
Gastroenterology & Hepatology
Dongliang Wang, Mengke Li, Jie Ling, Shuxia Chen, Qikai Zhang, Zhong Liu, Yanjing Huang, Caineng Pan, Yuheng Lin, Zhuoxing Shi, Ping Zhang, Yingfeng Zheng
Summary: Aging impairs the function of endothelial cells (ECs), which contributes to the development of vascular-related diseases. This study used single-cell RNA sequencing to analyze the transcriptome of ECs and identified two specialized subtypes specifically expressed in aged mice ECs: aged capillary ECs and pro-inflammation capillary ECs. These findings provide new insights into the molecular mechanisms associated with aging and may help in understanding senescence-related processes.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Xinying Zhou, Zelin Zhang, Hui Xu, Bo Zhu, Lijie Zhang, Linmiao Lie, Yingqi Huang, Xialin Du, Honglin Liu, Yanfen Li, Yulan Huang, Shengfeng Hu, Chaoying Zhou, Qian Wen, Mailkel P. Pepplenbosch, Li Ma
Summary: Viperin protein is increased in abundance in patients with lymphatic and pulmonary tuberculosis (TB), and its deficiency reduces mycobacterium tuberculosis bacterial loads and enhances macrophage responses. Viperin promotes Mtb infection by inhibiting host innate immune responses in macrophages.
Article
Biochemistry & Molecular Biology
Xiao-Yu Zhang, Zhuo-Chang Chen, Nan Li, Zhi-Hua Wang, Ya-Li Guo, Cui-Jie Tian, Dong-Jun Cheng, Xue-Yi Tang, Luo-Xian Zhang
Summary: Activated neutrophil-derived CRNDE is transferred to ASMCs through exosomes, activating the NF-kappa B pathway and promoting the proliferation and migration of ASMCs, which contributes to airway remodeling in asthma.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemical Research Methods
Chance M. Nowak, Tyler Quarton, Leonidas Bleris
Summary: The study reveals that cells rapidly become asynchronous after synchronization, and the factors controlling this process are largely unknown. Through experiments and simulations, it is found that the variability in cell cycle duration is the main factor causing cell desynchronization, which provides new insights into cell cycle research.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tobias Riedl, Suzanne Faure-Dupuy, Maude Rolland, Svenja Schuehle, Zohier Hizir, Silvia Calderazzo, Xiaodong Zhuang, Jochen Wettengel, Martin Alexander Lopez, Romain Barnault, Valbona Mirakaj, Sandra Prokosch, Danijela Heide, Corinna Leuchtenberger, Martin Schneider, Bernd Hessling, Benjamin Stottmeier, Isabel M. Wessbecher, Peter Schirmacher, Jane A. McKeating, Ulrike Protzer, David Durantel, Julie Lucifora, Emmanuel Dejardin, Mathias Heikenwalder
Summary: The stabilization of HIF1 alpha was found to inhibit the expression of APOBEC3B and its antiviral effects against HBV. Inhibiting the expression or stabilization of HIF1 alpha could serve as an anti-HBV strategy. High levels of HIF1 alpha may provide a reservoir for HBV survival in immune-active patients, and therefore should be considered as a constraining factor in the development of immune therapies.
Article
Biochemistry & Molecular Biology
Polly Downton, James S. Bagnall, Hazel England, David G. Spiller, Neil E. Humphreys, Dean A. Jackson, Pawel Paszek, Michael R. H. White, Antony D. Adamson
Summary: Cells respond to inflammatory stimuli by activating the NF-kappa B signaling pathway, resulting in the oscillatory translocation of p65 and I kappa B alpha proteins. Overexpression of I kappa B alpha reduces target gene expression, while overexpression of p65 partially rescues it. Nuclear accumulation of I kappa B alpha suppresses target gene expression by preventing p65 interaction with promoter binding sites. Modulating the expression levels of both I kappa B alpha and p65 has an anti-inflammatory effect on transcription.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Multidisciplinary Sciences
Marie Ito, Gloria Michelle Ducasa, Judith David Molina, Javier Varona Santos, Shamroop Kumar Mallela, Jin Ju Kim, Mengyuan Ge, Alla Mitrofanova, Alexis Sloan, Sandra Merscher, Imari Mimura, Alessia Fornoni
Summary: This study investigated the connection between decreased ATP Binding Cassette Transporter A1 (ABCA1) expression and caspase-4-mediated noncanonical inflammasome contribution in podocytes in diabetic kidney disease (DKD). The results showed that knockdown of ABCA1 led to increased mRNA and protein levels of IRF1, caspase-4, GSDMD, caspase-1, and IL1 beta. Further experiments revealed that APE1 accumulation and APE1 redox inhibitor could modulate the expression of IRF1 and caspase-4. The in vivo study confirmed the APE1/IRF1/Casp1 axis in BTBR ob/ob mice.
SCIENTIFIC REPORTS
(2023)