4.3 Article

Chemical Constituents of the Endophytic Fungus Phomopsis sp. A240 Isolated from Taxus chinensis var. mairei

Journal

HELVETICA CHIMICA ACTA
Volume 97, Issue 3, Pages 426-430

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.201300367

Keywords

Oxazoles; Phomopsis; Sesquiterpenes; Taxus chinensis; Fungi

Funding

  1. National Natural Science Foundation of China [81203006]
  2. Science Foundation for the Youth Scholars of Guangdong Academy of Science [qnjj201009]

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A new sesquiterpene, eremophil-9-ene-11,12,13-triol (1), a new oxazole, 4-(2-hydroxyethyl)-5-methyloxazole (2), and the two known lactones, 5 '-hydroxyalternariol (3) and alternariol (4), were isolated from the extract of Phomopsis sp. A240, an endophytic fungus isolated from the bark of Taxus chinensis var. mairei. The structures of the isolated compounds were determined by analyses of their spectroscopic data, as well as by comparison with literature reports. The isolated compounds were evaluated for their cytotoxic and antioxidant activities.

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