Journal
HELVETICA CHIMICA ACTA
Volume 95, Issue 9, Pages 1586-1592Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.201100500
Keywords
Ophioglossum pedunculosum; Quercetin glucosides; Inhibitory activity; Glucosides
Categories
Funding
- National Natural Science Foundation of China [31160074]
- Scientific Innovation Program of Postgraduates in Jiangsu Province [CX10B-384Z]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Syngenta
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The three new 3-O-methylquercetin glucosides 13, together with three known congeners and 3-O-methylquercetin, were isolated from the fern Ophioglossum pedunculosum (quercetin=2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one). The new compounds were identified on the basis of spectroscopic analysis as 5'-isoprenyl-3-O-methylquercetin 4',7-di-beta-D-glucopyranoside (1), 3-O-methylquercetin 4'-beta-D-glucopyranoside 7-[O-beta-D-glucopyranosyl-(1?2)-beta-D-glucopyranoside] (2), and 3-O-methylquercetin 7-[O-beta-D-glucopyranosyl-(1?2)-beta-D-glucopyranoside] (3). The effect of the isolated compounds on lipopolysaccharide (LPS)-induced NO production was evaluated. The inhibitory activity of 3-O-methylquercetin derivatives decreased markedly with the increasing number of glucosyl groups in the structures.
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