Article
Biotechnology & Applied Microbiology
Sarah R. Crossland, Heidi J. Siddle, Claire L. Brockett, Peter Culmer
Summary: This study evaluates the effects of speed and inclination on stance time, strain location and strain response using a low-cost novel strain measurement insole. Plantar strain active regions were seen to increase with increasing speed across all participants. With inclination, it was seen that strain active regions reduce in the hindfoot and show a tendency to forefoot with discretionary changes to strain seen.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Weiqin Chee, Claire R. Sharp, Corrin J. Boyd
Summary: This study examined the use of thawed plasma (TP) transfusion in dogs and found that it was most commonly used to treat anticoagulant rodenticide intoxication and traumatic hemorrhage, with favorable treatment outcomes and survival rates.
Article
Hematology
Lijie Yan, Tiantian Wang, Jihua Qiu, Xinsheng Zhang, Jun Peng, Yunhai Fang, Zi Sheng
Summary: This study identified a novel and likely pathogenic mutation of the F13A1 gene in a patient with inherited FXIII deficiency, which enriched the gene mutation spectrum of the disease. These findings may provide promising targets for the diagnosis and treatment of inherited FXIII deficiency.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yung-Tsung Kao, Yen-Ting Chen, Hueng-Chuen Fan, Tung-Chou Tsai, Shin-Nan Cheng, Ping-Shan Lai, Jen-Kun Chen, Chuan-Mu Chen
Summary: A novel nonviral gene therapy strategy utilizing DPPC-Fe3O4 to deliver BDD-FVIII plasmid was developed and successfully improved bleeding disorder in FVIII KO mice. The results suggest the potential of this approach for treating hemophilia A patients in clinical settings, with no observed adverse effects after treatment.
Article
Hematology
Sarah Beck, David Stegner, Stefan Loroch, Ayesha A. Baig, Vanessa Goeb, Cornelia Schumbrutzki, Eva Eilers, Albert Sickmann, Frauke May, Marc W. Nolte, Con Panousis, Bernhard Nieswandt
Summary: This study developed a humanized FXII mouse model by replacing the murine F12 gene with the human gene, tested it in in vitro coagulation assays and in vivo thrombosis models. The hF12(KI) mice were indistinguishable from wild-type mice in all tested assays, except for reduced expression levels of hFXII compared to human plasma. Targeting FXII with the anti-human FXIIa antibody 3F7 increased activated partial thromboplastin time dose-dependently and protected hF12(KI) mice in an arterial thrombosis model without affecting bleeding times.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Thermodynamics
Fan Jiang, Shuo Wang, Bin Xu, Wei Cheng, Xinqiang Ma, Shujun Chen
Summary: This study aims to enhance the localized energy of the plasma arc for thick metal plate welding by proposing a novel hybrid heat source, named laser-enhanced plasma arc (LPA). Experimental results show that adjusting the laser and plasma arc parameters can change the energy distribution of the hybrid source, which is beneficial for increasing the effective flame length of the plasma arc.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2021)
Article
Obstetrics & Gynecology
Shikha Sarkar, Michael Brimacombe, Victor Herson
Summary: This study retrospectively observed the use of fresh frozen plasma (FFP) and cryoprecipitate (CRYO) in a neonatal intensive care unit (NICU), and found that a large proportion of transfusions were not supported by evidence-based medicine, indicating the need for improvement in their use.
JOURNAL OF PERINATOLOGY
(2023)
Article
Geriatrics & Gerontology
Tapio Nevalainen, Arttu Autio, Maija Puhka, Marja Jylha, Mikko Hurme
Summary: Plasma contains various bioactive molecules in extracellular vesicles, including RNA, DNA, proteins, lipids, and metabolites, which are involved in cell-to-cell interactions. Research showed that a large proportion of plasma transcripts do not come from peripheral blood mononuclear cells (PBMCs), indicating contributions from other cell types. Aging leads to significant changes in plasma RNA composition, impacting important biological processes.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
A. F. Medina, B. R. Salu, M. V. de Brito, C. R. Bonturi, M. C. Z. Meneghetti, F. H. A. Maffei, M. L. V. Oliva
Summary: Recombinant kallikrein inhibitor and its related peptides prolonged clotting time, reduced thrombus size, and inhibited platelet aggregation, demonstrating potential for thrombosis therapy.
PROCESS BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Tommaso Gallingani, Elisa Resca, Massimo Dominici, Giuliana Gavioli, Romolo Laurita, Anna Liguori, Giorgio Mari, Luca Ortolani, Eva Pericolini, Arianna Sala, Giulia Laghi, Tiziana Petrachi, Gaelle Francoise Arnauld, Luca Accorsi, Rita Rizzoli, Vittorio Colombo, Matteo Gherardi, Elena Veronesi
Summary: Healthcare associated infections are a major health issue in industrialized countries, with medical devices being a common cause. Antibacterial coatings, such as silver nanoparticles embedded in organic coatings, show promise in reducing nosocomial infection rates without side effects or antibiotic resistance. In addition to nosocomial infections, clot formation is a concern for cardiovascular devices and catheters. A plasma-assisted process has been developed for depositing nanostructured coatings on substrates and catheters, and their stability and efficacy have been evaluated through various tests and experiments.
Article
Engineering, Environmental
Boyan Xu, Xiaohui Lu, Yuyao Fu, Liyue Diao, Heng Liang, Sungwoo Bae, How Yong Ng, Jun Ma
Summary: Marine harmful algae bloom (HAB) poses a threat to desalination plants worldwide. This study proposes a new pretreatment technology using ferrous iron/peroxymonosulfate (Fe2+/PMS) for seawater reverse osmosis (SWRO) under HAB. Fe2+/PMS achieved improved flocculation and removal of algal cells, turbidity, and algal organics matters (AOMs). The seawater matrix enhanced the generation of high-valent iron (FeO2+), leading to improved coagulation efficiency. Fe2+/PMS also resulted in reduced membrane fouling and lower operational cost compared to conventional coagulation techniques. This technology shows promise for high-performance and low-cost pretreatment for seawater desalination plants under HAB conditions.
Article
Biochemistry & Molecular Biology
Eva Dolezalova, Muhammad A. Malik, Loree Heller, Richard Heller
Summary: Plasma-assisted gene transfer is a minimally invasive approach that can reduce discomfort, with the study on mouse melanoma cells showing no significant impact on cell viability, optimal plasmid expression achieved with specific voltage, distance, and exposure time settings. The upregulation of TNF alpha mRNA after plasma delivery suggests oxidative stress, but this response did not translate to protein upregulation.
BIOELECTROCHEMISTRY
(2021)
Article
Hematology
William Quirke, Siobhan Toomey, Ali Sheikhi
Summary: This study examined the stability of coagulation parameters in refrigerated citrated plasma maintained on a cellular fraction for up to 24 hours. The results showed that PT and APTT values remained stable up to 4 hours post-phlebotomy, while D-Dimers results were reliable up to 8 hours. Fibrinogen and Protein C values were stable for at least 24 hours.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Article
Food Science & Technology
Yupan Zhu, Hangbo Xu, Dongjie Cui, Renwu Zhou, Yanping Wang, Aswathi Soni, Gale Brightwell, Jie Zhuang, Ruonan Ma, Zhen Jiao
Summary: This study investigated the effects of atmospheric cold plasma (ACP) treatment on the antioxidant pigment STX in S. aureus. Results showed that ACP treatment significantly decreased the survival rate of S. aureus and caused a decrease in STX content, making the bacteria more susceptible to hydrogen peroxide attack. ACP treatment also resulted in a decrease in cell membrane potential, accumulation of reactive oxygen species, and cell necrosis.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Article
Multidisciplinary Sciences
Lea Miebach, Eric Freund, Stefan Horn, Felix Niessner, Sanjeev Kumar Sagwal, Thomas von Woedtke, Steffen Emmert, Klaus-Dieter Weltmann, Ramona Clemen, Anke Schmidt, Torsten Gerling, Sander Bekeschus
Summary: Recent research focused on the potential of cold physical plasma in cancer therapy, with the study aiming to use a newly designed dual-jet neon plasma source for treating colorectal cancer cells. Results showed time-dependent generation of ROS/RNS inducing oxidation, growth retardation, and cell death in 3D tumor spheroids. The plasma devices (V)jet and kINPen exhibited differing effects on tumor growth and immunogenic cell death markers in in vitro and in vivo models. The study highlights the importance of evaluating optimal discharges for plasma cancer treatment based on plasma device-specific action on cancer cells.
SCIENTIFIC REPORTS
(2021)
