Article
Multidisciplinary Sciences
Hanlin Lu, Xiuxin Jiang, Lifan He, Xuyang Ji, Xinyun Li, Shaozhuang Liu, Yuanyuan Sun, Xiaoteng Qin, Xiwen Xiong, Sjaak Philipsen, Bo Xi, Meng Zhang, Jianmin Yang, Cheng Zhang, Yun Zhang, Wencheng Zhang
Summary: Sp1 and Sp3 play important roles in endothelial dysfunction and hypertension, and may be targets for the action of ACEIs. Captopril increases Sp1/Sp3 protein levels by inhibiting their degradation, and its beneficial effects are abolished when Sp1/Sp3 are deleted.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Hanlin Lu, Peidong Yuan, Xiaoping Ma, Xiuxin Jiang, Shaozhuang Liu, Chang Ma, Sjaak Philipsen, Qunye Zhang, Jianmin Yang, Feng Xu, Cheng Zhang, Yun Zhang, Wencheng Zhang
Summary: ACE inhibitors are commonly used to treat cardiovascular diseases and promote angiogenesis. This study reveals that endothelial USP7-Sp1/Sp3-Notch1 signaling plays a central role in pathophysiological angiogenesis in response to ACE inhibitor treatment.
NATURE COMMUNICATIONS
(2023)
Article
Physics, Multidisciplinary
Samir F. Matar
Summary: Hybrid trigonal carbon allotropes ene-C7 and yne-C8, obtained through crystal engineering by inserting sp2 and sp1 carbons into rhombohedral diamond-like C6, are found to be mechanically and dynamically stable with ultra-hard properties. These hybrid allotropes have different electronic band structures, making them suitable models for evaluating the properties of nanodiamonds in electronics.
CHINESE JOURNAL OF PHYSICS
(2023)
Article
Microbiology
Leilei Wu, Fei Jiang, Xiaobing Shen
Summary: CagA potentially regulates the biological function of GC cells through the miR-155-5p/SMAD2/SP1 axis. miR-155-5p could be a therapeutic target for GC related to CagA.
Article
Multidisciplinary Sciences
Liyan Bai, Hae Jin Kee, Xiongyi Han, Tingwei Zhao, Seung-Jung Kee, Myung Ho Jeong
Summary: Our study demonstrated that protocatechuic acid exerts protective effects against isoproterenol-induced cardiac hypertrophy by downregulating the expression of hypertrophic markers and inhibiting the ROCK1/Sp1/PKC gamma axis. These findings suggest that protocatechuic acid has promising therapeutic potential for the treatment of cardiac hypertrophy.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Shao-Jun Liu, Zhao-Qi Li, Xiao-Yan Wang, Fen Liu, Zhi-Ming Xiao, De-Cai Zhang
Summary: In colorectal cancer, the UCA1-miR-495-SP1/SP3 axis is dysregulated and contributes to malignant phenotypes. This study suggests that a positive feedback loop may exist between UCA1 and SP1/SP3 in CRC.
Article
Biochemistry & Molecular Biology
Christelle Gross, Gaetan Le-Bel, Pascale Desjardins, Manel Benhassine, Lucie Germain, Sylvain L. Guerin
Summary: This study investigated the transcriptional pattern of corneal epithelial cells during deep wound healing in hTECs, revealing a significant repression of CLU gene expression during wound closure, which may be a prerequisite for hTEC wound closure. The study also identified regulatory regions in the CLU gene promoter and demonstrated that transcription factors AP-1 and Sp1/Sp3 play a role in the repression of CLU gene expression during corneal wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Correction
Biochemistry & Molecular Biology
R. J. Sullivan, K. Flaherty
Summary: A correction to the paper has been published.
Article
Mathematical & Computational Biology
Eryk Kropiwnicki, John E. Evangelista, Daniel J. Stein, Daniel J. B. Clarke, Alexander Lachmann, Maxim Kuleshov, Minji Jeon, Kathleen M. Jagodnik, Avi Ma'ayan
Summary: By analyzing the molecular and structural similarities of drugs and small molecules, machine learning techniques can help identify drug repurposing opportunities and predict potential side effects. Databases and search engines provide rich knowledge in the field of pharmacology, supporting applications in systems pharmacology.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2021)
Article
Biochemical Research Methods
Qiong Wu, Tianzhou Ma, Qingzhi Liu, Donald K. Milton, Yuan Zhang, Shuo Chen
Summary: The study introduces a new computational package for extracting interconnected communities from gene co-expression networks, providing a more flexible approach to understanding gene regulatory mechanisms. By developing efficient algorithms and leveraging advanced graph norm shrinkage, the method demonstrates significant advantages in simulation studies. The approach is validated by applying it to RNA-seq data from a cancer study, identifying key biological pathways related to tumor cells' immune evasion mechanisms.
Article
Multidisciplinary Sciences
Lanlan Wang, Guojuan Xu, Lihua Li, Meiying Ruan, Anne Bennion, Guo-Liang Wang, Ran Li, Shaohong Qu
Summary: Receptor-like kinases (RLKs) in plants play diverse roles in plant development and stress responses by perceiving and transmitting environmental signals. In this study, a negative regulator named BDR1 was identified as a key player in rice resistance to the blast fungus Magnaporthe oryzae. BDR1 interacts with and phosphorylates MPK3, negatively regulating several defense-related pathways including jasmonate (JA) signaling and terpenoid biosynthesis. These findings contribute to our understanding of the molecular mechanisms underlying rice blast resistance.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Jason F. Cooper, Ryan J. Guasp, Meghan Lee Arnold, Barth D. Grant, Monica Driscoll
Summary: The study found that in Caenorhabditis elegans model, neurons under oxidative and osmotic stress can expel toxic protein aggregates through large vesicles called exophers. Additionally, fasting can significantly increase this clearance process. Furthermore, a nonautonomous network was identified to connect changes in food availability with remote neuronal responses, revealing the importance of lipid signaling in neuronal trash elimination.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Yongjin Xu, Chunxia Gao, Liliana Haversen, Thomas Lundback, Joakim Andreasson, Morten Grotli
Summary: In this study, the synthesis and characterization of a photoswitchable DFG-out kinase inhibitor were reported, and the photocontrol of the target kinase was demonstrated in both enzymatic and living cell assays.
CHEMICAL COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Deepak Mishra, Tristan Bepler, Brian Teague, Bonnie Berger, Jim Broach, Ron Weiss
Summary: The research team created a bistable toggle switch in Saccharomyces cerevisiae using a cross-repression topology, and developed a computational framework to search for and validate other large and similar bistable networks. This highlights the potential of building synthetic protein-protein networks.
Article
Biochemistry & Molecular Biology
Adam L. Poti, Laura Denes, Kinga Papp, Csaba Bato, Zoltan Banoczi, Attila Remenyi, Anita Alexa
Summary: Protein kinases are essential for cell signaling and have been targeted for therapeutic purposes for many years. Inhibiting kinase activity or interfering with kinase docking can be alternative strategies for controlling kinases. The development of phosphorylation-assisted luciferase complementation (PhALC) sensors allows for the quantitative analysis of kinase activity or kinase docking, making it a useful tool in research and high-throughput screening.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Ramon Ocadiz-Ruiz, Michael M. Hayes, Juanita L. Merchant
Meeting Abstract
Gastroenterology & Hepatology
Ramon Ocadiz-Ruiz, Michael M. Hayes, Juanita L. Merchant
Meeting Abstract
Gastroenterology & Hepatology
Sinju Sundaresan, Michael M. Hayes, Lin Ding, Juanita L. Merchant
Article
Gastroenterology & Hepatology
Yoshitatsu Sei, Jianying Feng, Leigh Samsel, Ayla White, Xilin Zhao, Sajung Yun, Deborah Citrin, J. Philip McCoy, Sinju Sundaresan, Michael M. Hayes, Juanita L. Merchant, Andrew Leiter, Stephen A. Wank
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Zhen Wang, Ramon Ocadiz-Ruiz, Sinju Sundaresan, Lin Ding, Michael Hayes, Nirakar Sahoo, Haoxing Xu, Juanita L. Merchant
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Hematology
Morgan Salmon, Basil Schaheen, Michael Spinosa, William Montgomery, Nicolas H. Pope, John P. Davis, William F. Johnston, Ashish K. Sharma, Gary K. Owens, Juanita L. Merchant, Zendra E. Zehner, Gilbert R. Upchurch, Gorav Ailawadi
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Junya Shiota, Nureen H. Mohamad Zaki, Juanita L. Merchant, Linda C. Samuelson, Nataliya Razumilava
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Sulaiman Sheriff, Karen Rico, Sammed Mandape, Ritu Pandey, Julie Starr, Bryson W. Katona, David C. Metz, Juanita L. Merchant
Meeting Abstract
Gastroenterology & Hepatology
Karen Rico, Sulaiman Sheriff, David C. Metz, Julie Starr, Bryson W. Katona, Juanita L. Merchant
Meeting Abstract
Gastroenterology & Hepatology
Akash Gupta, Ramon Ocadiz-Ruiz, Durga Attili, Michael K. Dame, Elaine Brady, D. K. Turgeon, Juanita L. Merchant
Meeting Abstract
Gastroenterology & Hepatology
Lin Ding, Qian Li, Andres Munoz, Milena Saqui-Salces, Juanita L. Merchant
Meeting Abstract
Gastroenterology & Hepatology
Lin Ding, Qian Li, Andres Munoz, Yana Zavros, Emmanuelle Faure, Dimitrios Iliopoulos, Jayati Chakrabarti, Juanita L. Merchant
Article
Gastroenterology & Hepatology
Nataliya Razumilava, Junya Shiota, Nureen H. Mohamad Zaki, Ramon Ocadiz-Ruiz, Christine M. Cieslak, Kais Zakharia, Benjamin L. Allen, Gregory J. Gores, Linda C. Samuelson, Juanita L. Merchant
HEPATOLOGY COMMUNICATIONS
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Junya Shiota, Nureen Hanisah Mohamad Zaki, Juanita L. Merchant, Linda C. Samuelson, Nataliya Razumilava
Meeting Abstract
Gastroenterology & Hepatology
Nataliya Razumilava, Junya Shiota, Nureen Hanisah, Mohamad Zaki, Juanita L. Merchant, Linda C. Samuelson