Article
Gastroenterology & Hepatology
Yongqiang Liang, Yuanhai Yang, Ruiheng Nong, Hao Huang, Xiuyun Chen, Ying Deng, Zhicong Huang, Jingyao Huang, Chunsheng Cheng, Mingzhu Ji, Yinggang Chen, Fulan Hu
Summary: H. pylori eradication significantly improves atrophic gastritis (AG) and intestinal metaplasia (IM) at an early stage. Various factors such as study design, lesion sites, regions, and follow-up time are important in determining this association.
Article
Gastroenterology & Hepatology
Young Jae Hwang, Yonghoon Choi, Nayoung Kim, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
Summary: The study found that both endoscopic and histologic improvements of atrophic gastritis and intestinal metaplasia were observed after H. pylori eradication, with endoscopic improvement taking significantly longer time than histologic improvement.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Hsuan Hsieh, Hsiao-Bai Yang, Bor-Shyang Sheu, Yao-Jong Yang
Summary: This study aimed to evaluate the histopathological pattern of H. pylori atrophic gastritis in children and the extent of precancerous lesions. The results showed that the prevalence rates of gastric glandular atrophy, intestinal metaplasia, and spasmolytic peptide-expressing metaplasia (SPEM) in children with H. pylori infection were 30.4%, 4.3%, and 8.7% respectively. SPEM and high-grade atrophy were more common in female patients.
Article
Medicine, General & Internal
Lina Feng, Mingyu Zhang, Jialun Guan, Yu Zhang, Yujie Huang, Ruonan Dong, Kai Zhao, Suhong Xia, Fang Xiao, Jiazhi Liao
Summary: A retrospective study found that esophageal/duodenal xanthelasma may not be associated with upper gastrointestinal diseases, but gastric xanthelasma (GX) is related to atrophic gastritis, intestinal metaplasia, gastric cancer, and H.pylori infection, especially multiple GXs which may serve as easily detectable warning signs for these diseases.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Massimo Rugge, Ludovica Bricca, Stefano Guzzinati, Diana Sacchi, Marco Pizzi, Edoardo Savarino, Fabio Farinati, Manuel Zorzi, Matteo Fassan, Angelo Paolo Dei Tos, Peter Malfertheiner, Robert M. Genta, David Y. Graham
Summary: The study found that autoimmune gastritis (AIG) patients exhibit oxyntic-predominant-mononuclear inflammation, PPM (more than IM), and ECL-cell hyperplasia/neoplasia as histological hallmarks. Over a cumulative follow-up time of 10,541 person years, there was no excess risk of gastric or other malignancies found, except for a (marginally significant) risk of thyroid cancer.
Article
Immunology
Fabiana Zingone, Valentina Pilotto, Romilda Cardin, Gemma Maddalo, Costanza Orlando, Matteo Fassan, Ilaria Marsilio, Eugenio Collesei, Filippo Pelizzaro, Fabio Farinati
Summary: This study analyzed the expression profile of selected miRNAs in patients with autoimmune atrophic gastritis, non-autoimmune multifocal atrophic gastritis, and healthy control subjects. The results showed that miR-21 was overexpressed in patients with gastric precancerous conditions, while miR-142 and miR-223 were underexpressed compared to healthy controls. Controlling miRNA expression could have significant implications for treating chronic autoimmune diseases and cancer progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Shi-yu Zheng, Lu Zhu, Lu-yi Wu, Hui-rong Liu, Xiao-peng Ma, Qi Li, Meng-die Wu, Wen-jia Wang, Jing Li, Huan-gan Wu
Summary: Chronic atrophic gastritis (CAG), caused by Helicobacter pylori (H. pylori) infection, is a pathological stage in the Correa's cascade. Cellular senescence, which is observed in gastric mucosal tissues of H. pylori-positive CAG patients, is an inducing factor for cancer occurrence.
Article
Gastroenterology & Hepatology
M. C. Mommersteeg, I Simovic, B. Yu, S. A. van Nieuwenburg, I. M. J. Bruno, M. Doukas, E. J. Kuipers, M. C. W. Spaander, M. P. Peppelenbosch, N. Castano-Rodriguez, G. M. Fuhler
Summary: The SNP in the ATG16L1 gene is associated with increased intestinal endoplasmic reticulum stress and progression of gastric cancer induced by H. pylori. Individuals with the G-allele are more prone to developing gastric cancer.
Article
Medicine, Research & Experimental
Tao Yang, Ruilin Wang, Honghong Liu, Lifu Wang, Jianyu Li, Shihua Wu, Xing Chen, Xiangdong Yang, Yanling Zhao
Summary: The study found that BBR can inhibit M1-polarized Mfs induced by H. pylori and LPS, and promote M2-polarized Mfs. BBR can protect gastric epithelial cells from damage caused by M1-polarized Mfs, which may be related to the inhibition of M1-polarized Mfs, promotion of M2-polarized Mfs, and activation of the IL-4-STAT6 signaling pathway by BBR.
Article
Gastroenterology & Hepatology
Lusheng Song, Minkyo Song, Charles S. Rabkin, Yunro Chung, Stacy Williams, Javier Torres, Alejandro H. Corvalan, Robinson Gonzalez, Enrique Bellolio, Mahasish Shome, Joshua LaBaer, Ji Qiu, M. Constanza Camargo
Summary: Our study provides a comprehensive assessment of anti-H. pylori antibody profiles in gastric intestinal metaplasia (IM). The identified novel antibodies against target antigens, in addition to CagA, may play a role in the progression of IM. Specific H. pylori antibodies, along with other biomarkers, can help identify IM patients for surveillance.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Hideki Mori, Hidekazu Suzuki, Juntaro Matsuzaki, Kaori Kameyama, Koji Igarashi, Tatsuhiro Masaoka, Takanori Kanai
Summary: The present study investigated the usefulness of plasma ghrelin levels as a marker for gastric mucosal atrophy and as a risk stratification marker for gastric cancer, even after H. pylori eradication.
ANNALS OF MEDICINE
(2022)
Review
Medicine, General & Internal
Hang Yang, Xinyue Zhou, Bing Hu
Summary: H. pylori infection is etiologically linked to gastric cancer, and chronic atrophic gastritis is a precancerous condition that may regress with eradication therapy. However, the reversibility of CAG is still controversial.
POSTGRADUATE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Weidong Liu, Junjie Tian, Wenjia Hui, Wenjie Kong, Yan Feng, Junqiang Si, Feng Gao
Summary: Based on antibody typing classification, Helicobacter pylori infection can be divided into type I and type II. The study found that type I H. pylori infection worsened the severity of gastric mucosal inflammation and activity, playing a key role in promoting atrophic gastritis progression. Individualized treatment for H. pylori eradication is recommended based on the findings.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Julia M. Lerch, Rish K. Pai, Ian Brown, Anthony J. Gill, Dhanpat Jain, Bence Kovari, Ryoji Kushima, Kieran Sheahan, Tomas Slavik, Amitabh Srivastava, Gregory Y. Lauwers, Cord Langner
Summary: Subtyping gastric intestinal metaplasia (GIM) on H&E-stained slides shows high interobserver agreement and can be used as a risk stratifying tool with a low rate of misclassification.
Article
Cell Biology
Xinhua Liang, Wenjun Du, Ling Huang, Li Xiang, Wenxu Pan, Fangying Yang, Fengfeng Zheng, Yongwu Xie, Lanlan Geng, Sitang Gong, Wanfu Xu
Summary: This study found that Helicobacter pylori promotes gastric intestinal metaplasia through the kynurenine pathway of tryptophan metabolism, which activates CDX2 gene expression in gastric epithelial cells. Inhibition of kynurenine aminotransferase II (KAT2) activity can reverse the effect of H. pylori on CDX2 expression.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Gastroenterology & Hepatology
Jin Hee Noh, Ji Yong Ahn, Jene Choi, Young Soo Park, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Jung Mogg Kim
Summary: This study confirmed the effectiveness and advantages of the RT-PCR detection method in detecting H. pylori infection and verifying CLR resistance. Compared to RUT, RT-PCR more accurately detected H. pylori infection and could verify the presence of CLR resistance through fluorescence melting curve analysis. Due to the high sensitivity and accessibility of the RT-PCR method, it can help clinicians select suitable treatment regimens and improve the eradication rate.
Article
Gastroenterology & Hepatology
Yonghoon Choi, Soo In Choi, Nayoung Kim, Ryoung Hee Nam, Jae Young Jang, Hee Young Na, Cheol Min Shin, Dong Ho Lee, Huitae Min, Yeon-Ran Kim, Yeong-Jae Seok
Summary: This study aimed to investigate the response of rat colon to a high-fat diet (HFD) and the effect of Clostridium butyricum on HFD-induced intestinal inflammation and production of short-chain fatty acids (SCFAs) according to sex. The results showed that HFD significantly increased inflammation scores and fat proportions. Clostridium butyricum improved HFD-induced colonic inflammation, increased SCFA production, and enhanced the expression of tight junction proteins. These effects were more pronounced in male rats, showing a sex difference.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Hyeong Ho Jo, Nayoung Kim, Hyeon Jeong Oh, Du Hyun Song, Yonghoon Choi, Jaehyung Park, Jongchan Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Hye Seung Lee, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung Ho Kim, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim, Soyeon Ahn
Summary: This study examined the proportion and characteristics of mixed carcinoma in gastric cancer patients and found that mixed carcinoma is associated with lymph node metastasis. It is more common to see submucosal invasion in early gastric cancer, but less likely to have venous invasion and distant metastasis in advanced gastric cancer.
Article
Gastroenterology & Hepatology
Su Youn Nam, Kwangwoo Nam, Ki-Nam Shim, Seoyon Yang, Chung Hyun Tae, Junwoo Jo, Nayoung Kim, Seon Mi Park, Young Sook Park, Seon Ja Park, Sung-Ae Jung
Summary: This study aimed to develop a rehabilitation program for musculoskeletal pain in gastrointestinal endoscopists and determine its usefulness. A multicenter cohort study was conducted with 118 participants, and it was found that 94% of them reported musculoskeletal pain at the beginning. The follow-up surveys revealed that musculoskeletal pain was associated with equipment/posture performance. Conclusion: Our rehabilitation program is effective and satisfactory in improving musculoskeletal pain in gastrointestinal endoscopists.
Article
Gastroenterology & Hepatology
Jung Won Lee, Nayoung Kim, Soo In Choi, Jae Young Jang, Chin Hee Song, Ryoung Hee Nam, Dong Ho Lee
Summary: This study assessed the antimicrobial resistance rates and trends of Helicobacter pylori in Korean patients. The results showed an increasing resistance rate to clarithromycin, metronidazole, and fluoroquinolones. The prevalence of multidrug resistance also significantly increased.
Article
Oncology
Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So -Young Jin, Joon Mee Kim, Yoon Jung Choi, Hee Kyung Chang, Soomin Ahn, Mee Soo Chang, Song-Hee Han, Yoonjin Kwak, An Na Seo, Sung Hak Lee, Mee-Yon Cho
Summary: This edition is composed of standard data elements and conditional data elements. Standard data elements contain basic pathological findings and necessary items to predict the prognosis of GC patients, while conditional data elements include additional diagnostic and prognostic factors relevant to adjuvant therapy, such as molecular biomarkers. They are designed to allow pathologists to selectively choose appropriate items based on their institution's environment. The standardized pathology report aims to improve GC diagnosis and facilitate large-scale research.
JOURNAL OF GASTRIC CANCER
(2023)
Review
Pathology
Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So -Young Jin, Joon Mee Kim, Yoon Jung Choi, Hee Kyung Chang, Soomin Ahn, Mee Soo Chang, Song-Hee Han, Yoonjin Kwak, An Na Seo, Sung Hak Lee, Mee-Yon Cho
Summary: The first edition of 'A Standardized Pathology Report for Gastric Cancer' was initiated by the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists and published 17 years ago. This second edition consists of standard data elements and conditional data elements, including basic pathologic findings and items necessary for predicting the prognosis of GC patients. Other factors relevant to adjuvant therapy are classified as conditional data elements. The standardized pathology report will be helpful for GC diagnosis and facilitate collaborative studies.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2023)
Correction
Oncology
Yonghoon Choi, Nayoung Kim, Chang Yong Yun, Yoon Jin Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Sang-Hoon Ahn, Do Joong Park, Hye Seung Lee, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim, Dong Ho Lee, Hyung-Ho Kim
Article
Gastroenterology & Hepatology
Du Hyun Song, Nayoung Kim, Hyeong Ho Jo, Sangbin Kim, Yonghoon Choi, Hyeon Jeong Oh, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, So Hyun Kang, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung Ho Kim, Ji-Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Jin Won Kim, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim, Soyeon Ahn, Young-Joon Surh
Summary: This study aimed to identify risk factors for synchronous multiple gastric cancer (SMGC). Data from 14,603 patients with gastric cancer were analyzed, and the incidence of SMGC was found to be 4.04%, which was associated with male sex, age ≥65 years, and early gastric cancer. Unlike single gastric cancer, SMGC had a high survival rate.
Article
Gastroenterology & Hepatology
Sang Bin Kim, Nayoung Kim, Jaehyung Park, In-Chang Hwang, Seon Hee Lim, Du Hyun Song, Yonghoon Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Soyeon Ahn
Summary: This study investigated the association between Helicobacter pylori (HP) infection and coronary heart disease (CHD). The results showed that HP eradication prevented CHD, but the effect varied based on age and sex.
Article
Multidisciplinary Sciences
Jina Choi, Nayoung Kim, Ryoung Hee Nam, Jin Won Kim, Chin-Hee Song, Hee Young Na, Gyeong Hoon Kang
Summary: This study investigated the influence of sex and tumor location on tumorigenic molecular characteristics in patients with colorectal tumors. The results showed that sex and tumor location have an impact on molecular features such as PD-L1, MMR/MSI status, and EGFR expression, suggesting a possible mechanism of sex-specific colorectal carcinogenesis.
Review
Gastroenterology & Hepatology
Nayoung Kim
Summary: The sex/gender of gastroenterologists has an impact on patients' satisfaction, compliance, and clinical outcomes. Female gastrointestinal (GI) endoscopist-patient gender concordance improves health-related outcomes, indicating the need for increased number of female GI endoscopists. While the number of women in the field of gastroenterology is increasing, it is not sufficient to meet the gender preferences of female patients. Gastroenterologists, particularly male endoscopists, are at a high risk of endoscopy-related injuries, with different distribution of injuries between males and females.
CLINICAL ENDOSCOPY
(2023)
Review
Andrology
Yonghoon Choi, Nayoung Kim
Summary: Colorectal cancer is a common cancer that affects both men and women, but there are significant sex differences. Men have a higher risk and earlier onset of CRC, suggesting a protective role of estrogen. Female patients are more likely to develop aggressive right-sided colon cancer. There are differences in carcinogenic mechanisms between left and right CRC, with sex-based biological and sociocultural factors playing a role.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Nursing
Nayoung Kim
KOREAN JOURNAL OF WOMEN HEALTH NURSING
(2023)