Article
Cardiac & Cardiovascular Systems
Anne-Kristin Schaefer, Klaus Distelmaier, Julia Riebandt, Georg Goliasch, Martin H. Bernardi, Daniel Zimpfer, Gunther Laufer, Dominik Wiedemann
Summary: The influence of primary arterial access in patients receiving peripheral postcardiotomy extracorporeal life support was assessed. The study found that the axillary artery group had a higher risk of stroke, while the femoral artery group was more prone to limb ischemia.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Critical Care Medicine
Mariusz Kowalewski, Kamil Zielinski, Daniel Brodie, Graeme MacLaren, Glenn Whitman, Giuseppe M. Raffa, Udo Boeken, Kiran Shekar, Yih-Sharng Chen, Christian Bermudez, David D'Alessandro, Xiaotong Hou, Jonathan Haft, Jan Belohlavek, Inga Dziembowska, Piotr Suwalski, Peta Alexander, Ryan P. Barbaro, Mario Gaudino, Michele Di Mauro, Jos Maessen, Roberto Lorusso
Summary: This study analyzed the trends in using venoarterial extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock from 2010 to 2018, finding a significant increase in its use over the years, especially in older patients. The most common surgeries that necessitated venoarterial ECMO were coronary artery bypass and valvular surgery.
CRITICAL CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Moritz Benjamin Immohr, Sophie Margaretha Eschlboeck, Philipp Rellecke, Hannan Dalyanoglu, Igor Tudorache, Udo Boeken, Payam Akhyari, Alexander Albert, Artur Lichtenberg, Hug Aubin
Summary: Patients treated with ECLS for therapy-refractory circulatory failure have favorable outcomes in terms of survival and functional recovery after 30 days, indicating the potential of ECLS therapy for patient recovery.
Review
Medicine, General & Internal
Filip Bursa, Michal Frelich, Peter Sklienka, Ondrej Jor, Jan Maca
Summary: Although extracorporeal life support is an expensive and risky method, it is widely accepted for organ support. Veno-venous extracorporeal membrane oxygenation (ECMO) is the preferred method for severe respiratory failure when mechanical ventilation is insufficient. Improving oxygenation or acid-base balance alone does not guarantee improved outcomes, but it helps prevent potential negative effects of mechanical ventilation, which is crucial for complex care. Long-term mortality and quality of life should be considered for ECMO-surviving patients, who may experience physical and psychological health problems but can still return to everyday life with minimal respiratory limitations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Silvia Mariani, Anne-Kristin Schaefer, Bas C. T. van Bussel, Michele Di Mauro, Luca Conci, Philipp Szalkiewicz, Maria Elena De Piero, Samuel Heuts, Justine Ravaux, Iwan C. C. van der Horst, Diyar Saeed, Matteo Pozzi, Antonio Loforte, Udo Boeken, Robertas Samalavicius, Karl Bounader, Xiaotong Hou, Jeroen J. H. Bunge, Hergen Buscher, Leonardo Salazar, Bart Meyns, Daniel Herr, Sacha Matteucci, Sandro Sponga, Graeme MacLaren, Claudio Russo, Francesco Formica, Pranya Sakiyalak, Antonio Fiore, Daniele Camboni, Giuseppe Maria Raffa, Rodrigo Diaz, I-wen Wang, Jae-Seung Jung, Jan Belohlavek, Vin Pellegrino, Giacomo Bianchi, Matteo Pettinari, Alessandro Barbone, Jose P. Garcia, Glenn Whitman, Kiran Shekar, Dominik Wiedemann, Roberto Lorusso, PELS Investigators
Summary: There are differences in weaning and survival rates in post-cardiotomy VA ECMO patients, with deaths mainly attributed to multiorgan failure and persistent heart failure during ECMO support and severe complications after weaning.
ANNALS OF THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Medhat Radwan, Karim Baghdadi, Aron Frederik Popov, Rodrigo Sandoval Boburg, Petar Risteski, Christian Schlensak, Thomas Walter, Rafal Berger, Fabian Emrich, Ornella Piazza, Arnaldo Dubin, Edward A. Bittner
Summary: This study analyzed the patient outcome and complication rate of axillary artery cannulation for veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients who could not be weaned from cardiopulmonary bypass after cardiothoracic surgery. The results showed that axillary artery cannulation is a safe and reliable method for VA-ECMO support with an acceptable complication rate.
MEDICINA-LITHUANIA
(2023)
Article
Surgery
Tim Jancelewicz, Max R. Langham, Mary E. Brindle, Zachary E. Stiles, Pamela A. Lally, Lei Dong, Jim Y. Wan, Yigit S. Guner, Matthew T. Harting
Summary: The use of ECMO is associated with excess mortality for low- and intermediate-risk neonates with CDH. However, it provides a significant survival advantage for high-risk infants, and this advantage is strongly influenced by center CDH volume and ECMO experience.
Article
Medicine, General & Internal
Rolf Erlebach, Lennart C. Wild, Benjamin Seeliger, Ann-Kathrin Rath, Rea Andermatt, Daniel A. Hofmaenner, Jens-Christian Schewe, Christoph C. Ganter, Mattia Mueller, Christian Putensen, Ruslan Natanov, Christian Kuehn, Johann Bauersachs, Tobias Welte, Marius M. Hoeper, Pedro D. Wendel-Garcia, Sascha David, Christian Bode, Klaus Stahl
Summary: V-VA ECMO in patients with ARDS and concomitant cardiocirculatory failure is associated with a high survival rate, with most patients surviving up to 2 years.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Anne Willers, Justyna Swol, Hergen Buscher, Zoe McQuilten, Sander M. J. van Kuijk, Hugo Ten Cate, Peter T. Rycus, Stephen McKellar, Roberto Lorusso, Joseph E. Tonna
Summary: Data on hospital outcomes in bleeding complications during extracorporeal life support (ECLS) have been lacking. This retrospective study analyzed data from 53,644 adult patients and found a steady decrease in bleeding complications over the past 20 years, mostly attributed to surgical and cannula-site-related bleeding. However, more data is needed to determine the exact reasons for the decrease in bleeding trends.
CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Moritz Benjamin Immohr, Sophie Margaretha Eschlboeck, Philipp Rellecke, Hannan Dalyanoglu, Igor Tudorache, Udo Boeken, Payam Akhyari, Alexander Albert, Artur Lichtenberg, Hug Aubin
Summary: ECLS therapy for refractory circulatory failure patients who survive the first 30 days shows favorable outcomes in subsequent survival and functional recovery, indicating the potential for patient recovery even after long periods of mechanical support.
Article
Cardiac & Cardiovascular Systems
Korbinian Lackermair, Stefan Brunner, Mathias Orban, Sven Peterss, Martin Orban, Hans D. Theiss, Bruno C. Huber, Gerd Juchem, Frank Born, Anne-Laure Boulesteix, Axel Bauer, Maximilian Pichlmaier, Joerg Hausleiter, Steffen Massberg, Christian Hagl, Sabina P. W. Guenther
Summary: This pilot study showed that randomized studies with ECLS in CS patients are feasible and safe. Small numbers of included patients impede meaningful conclusions about mortality and neurological outcome. Our findings of numerical differences in mortality and survival with severe neurological impairment give an urgent call for larger multi-centric randomized trials assessing the endpoint of all-cause mortality but also considering the effects on neurological outcome measures.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Engineering, Biomedical
Yigit Guner, Tim Jancelewicz, Matteo Di Nardo, Peter Yu, Mary Brindle, Adam M. Vogel, Sharada H. Gowda, Theresa R. Grover, Lindsay Johnston, Burhan Mahmood, Brian Gray, Rachel Chapman, Sarah Keene, Natalie Rintoul, John Cleary, Amir H. Ashrafi, Matthew T. Harting
Summary: The management of infants with congenital diaphragmatic hernia (CDH) receiving Extracorporeal Life Support (ECLS) is complex and varies among centers due to the lack of evidence guiding management decisions. This report aims to review existing evidence and provide management recommendations for CDH patients receiving ECLS treatment. Collaboratively developed by the Extracorporeal Life Support Organization CDH interest group, CDH Study Group, and Children's Hospitals Neonatal Consortium.
Article
Surgery
Yigit S. Guner, Patrick T. Delaplain, John Schomberg, Matteo Di Nardo, Peter T. Yu, Danny Lam, Tim Jancelewicz, Matthew T. Harting, Joanne P. Starr, Danh V. Nguyen
Summary: In neonates with CDH receiving ECLS treatment, the use of centrifugal pumps may increase hemolysis rates, along with other risk factors such as low 5-minute Apgar score, on-ECLS complications, and duration of ECLS.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Holger Thiele, Uwe Zeymer, Ibrahim Akin, Michael Behnes, Tienush Rassaf, Amir Abbas Mahabadi, Ralf Lehmann, Ingo Eitel, Tobias Graf, Tim Seidler, Andreas Schuster, Carsten Skurk, Daniel Duerschmied, Peter Clemmensen, Marcus Hennersdorf, Stephan Fichtlscherer, Ingo Voigt, Melchior Seyfarth, Stefan John, Sebastian Ewen, Axel Linke, Eike Tigges, Peter Nordbeck, Leonhard Bruch, Christian Jung, Jutta Franz, Philipp Lauten, Tomaz Goslar, Hans-Josef Feistritzer, Janine Poess, Eva Kirchhof, Taoufik Ouarrak, Steffen Schneider, Steffen Desch, Anne Freund, ECLS-SHOCK Investigators
Summary: In patients with acute myocardial infarction complicated by cardiogenic shock, early extracorporeal life support (ECLS) combined with standard medical treatment did not reduce mortality.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
Wytze C. Duinmeijer, Libera Fresiello, Justyna Swol, Pau Torrella, Jordi Riera, Valentina Obreja, Mateusz Puslecki, Marek Dabrowski, Jutta Arens, Frank R. Halfwerk
Summary: High-volume ECMO centers generally have better outcomes due to suitable exposure to ECMO cases. Simulation-based training (SBT) offers an option for education and clinical skills improvement. The classification of ECMO simulators as low-, mid-, or high-fidelity based on overall fidelity can be used to compare and enhance ECMO patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Enzo Luesebrink, Leonhard Binzenhoefer, Antonia Kellnar, Christoph Mueller, Clemens Scherer, Benedikt Schrage, Dominik Joskowiak, Tobias Petzold, Daniel Braun, Stefan Brunner, Sven Peterss, Joerg Hausleiter, Sebastian Zimmer, Frank Born, Dirk Westermann, Holger Thiele, Andreas Schaefer, Christian Hagl, Steffen Massberg, Martin Orban
Summary: Cardiogenic shock and cardiac arrest are leading causes of mortality in acute cardiovascular care. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has emerged as a treatment option for these life-threatening conditions, but in-hospital mortality is still high. Ongoing studies are evaluating whether VA-ECMO can reduce mortality in cardiogenic shock. Retrograde aortic flow during VA-ECMO treatment may have detrimental effects, and various venting strategies are being used to mitigate these effects.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Julius Steffen, David Andreae, Michael Nabauer, Nikolas Reissig, Philipp M. Doldi, Magda Haum, Martin Orban, Hans Theiss, Konstantinos Rizas, Daniel Braun, Sven Peterss, Joerg Hausleiter, Steffen Massberg, Simon Deseive
Summary: In this study, the researchers found that patients with normal-flow low-gradient aortic stenosis (NFLG-AS) are heterogeneous, with a subgroup resembling patients with high-gradient aortic stenosis (HG-AS) in characteristics and outcomes. Lower gradient NFLG-AS patients have increased long-term mortality, indicating that the use of transcatheter aortic valve replacement (TAVI) for these patients requires careful consideration.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Enzo Luesebrink, Clemens Scherer, Leonhard Binzenhoefer, Sabine Hoffmann, Julia Hoepler, Antonia Kellnar, Manuela Thienel, Dominik Joskowiak, Sven Peterss, Tobias Petzold, Simon Deseive, Ralph Hein, Stefan Brunner, Stefan Kaeaeb, Daniel Braun, Hans Theiss, Joerg Hausleiter, Christian Hagl, Steffen Massberg, Martin Orban
Summary: This study aimed to investigate the epidemiology, mortality, diagnosis, and clinical management of HIT occurring in VA-ECMO patients treated with UFH. The prevalence of HIT in VA-ECMO patients was found to be 3.5%, and it was not associated with a higher mortality rate. The functional assay was able to exclude HIT in 75% of VA-ECMO patients with clinical suspicion and positive anti-PF4/heparin antibody test. Argatroban appears to be a suitable and safe therapeutic option for confirmed HIT-positive patients on VA-ECMO support.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Clemens Scherer, Hans Theiss, Mario Istrefi, Leonhard Binzenhoefer, Danny Kupka, Thomas Stocker, Enzo Luesebrink, Era Stambollxhiu, Ahmed Alemic, Tobias Petzold, Konstantin Stark, Simon Deseive, Daniel Braun, Dominik Joskowiak, Sven Peterss, Joerg Hausleiter, Christian Hagl, Steffen Massberg, Martin Orban
Summary: In this study, the efficacy and safety of suture-based and plug-based vascular closure devices for VA-ECMO decannulation were compared. The results showed that plug-based devices had a higher rate of technically correct placement and a lower incidence of severe bleeding events during decannulation. Therefore, plug-based vascular closure should be considered as the preferred option for VA-ECMO decannulation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Sven Peterss, Jan Stana, Barbara Rantner, Joscha Buech, Caroline Radner, Nikolaos Konstantinou, Christian Hagl, Maximilian Pichlmaier, Nikolaos Tsilimparis
Summary: Type Ia endoleaks are crucial for long-term therapeutic success following TEVAR due to failed sealing or loss of landing zone. This expert opinion summarizes our institutional experience with different techniques in the context of recent scientific publications. The rapid turnover of technical innovations and outcome data highlight the need for patient-tailored treatment strategies and specialized aortic centers.
ASIAN CARDIOVASCULAR & THORACIC ANNALS
(2023)
Article
Cardiac & Cardiovascular Systems
Lukas Stolz, Michael Kirchner, Julius Steffen, Philipp M. Doldi, Daniel Braun, Ludwig T. Weckbach, Thomas J. Stocker, Kornelia Loew, Julius Fischer, Magda Haum, Hans D. Theiss, Konstantinos Rizas, Martin Orban, Sven Peterss, Michael Naebauer, Steffen Massberg, Joerg Hausleiter, Simon Deseive
Summary: This study evaluated the prevalence and prognostic value of cardiohepatic syndrome (CHS) in patients undergoing TAVR for severe aortic stenosis. The study found that CHS was present in 22.4% of TAVR patients and was associated with increased mortality after the procedure. Therefore, the impact of CHS should be considered in the decision-making process within the TAVR heart team.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Emergency Medicine
Fausto Biancari, Angelo M. Dell'Aquila, Giuseppe Gatti, Andrea Perrotti, Amelie Herve, Joseph Touma, Matteo Pettinari, Sven Peterss, Joscha Buech, Konrad Wisniewski, Tatu Juvonen, Mikko Jormalainen, Caius Mustonen, Andreas Rukosujew, Till Demal, Lenard Conradi, Marek Pol, Petr Kacer, Francesco Onorati, Cecilia Rossetti, Igor Vendramin, Daniela Piani, Mauro Rinaldi, Luisa Ferrante, Eduard Quintana, Robert Pruna-Guillen, Javier Rodriguez Lega, Angel G. Pinto, Metesh Acharya, Zein El-Dean, Mark Field, Amer Harky, Manoj Kuduvalli, Francesco Nappi, Sebastien Gerelli, Dario Di Perna, Enzo Mazzaro, Stefano Rosato, Antonio Fiore, Giovanni Mariscalco
Summary: This study aimed to evaluate the impact of individual institutions on the outcome of surgery for Stanford type A aortic dissection. The results showed that certain hospitals had a higher risk of in-hospital mortality, while others had a lower risk. Hospitals with lower in-hospital mortality rates also had a decreased rate of stroke and/or global brain ischemia. The study concluded that hospital volume may be a determinant of poor outcome in surgery for aortic dissection.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Surgery
Carlota F. Prendes, Paolo Spath, Jan Stana, Tarek Hamwi, Sven Peterss, Konstantinos Stavroulakis, Maximilian Pichlmaier, Nikolaos Tsilimparis
Summary: This study describes the transaxillary branch-to-branch-to-branch carotid catheterization technique, which enables cannulation of all supra-aortic vessels using only 1 femoral and 1 axillary access during triple-branch arch repair. This technique reduces the risk of complications associated with carotid surgical cutdown and manipulation.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Surgery
Tugce Oez, Barbara Rantner, Jan Stana, Konstantinos Stavroulakis, Sven Peterss, Maximilian Pichlmaier, Carlota Fernandez Prendes, Nikolaos Tsilimparis
Summary: Malperfusion is a common complication of aortic dissection, which increases the mortality of this deadly disease. Effective treatment requires a timely diagnosis based on clinical findings and available instruments, understanding the disease's pathomechanism, recognizing recommended therapy options, and being aware of diagnostic and therapeutic innovations. The treatment decision should be individualized. This study focuses on malperfusion after aortic dissection, considering it as a separate disease and providing important information for efficient therapy decisions in clinical practice.
ZENTRALBLATT FUR CHIRURGIE
(2023)
Letter
Cardiac & Cardiovascular Systems
Maximilian Pichlmaier, Sven Peterss, Barbara Rantner, Nikolaos Tsilimparis
Article
Cardiac & Cardiovascular Systems
Paolo Spath, Jan Stana, Giulia Marazzi, Sven Peterss, Carlota Fernandez-prendes, Nikolaos Tsilimparis
Summary: Complicated acute nonA-nonB dissection with malperfusion is associated with high mortality. We report a case of urgent treatment using physician-modified-endograft (PMEG) fenestrated-TEVAR for a complicated subacute aortic dissection with multiorgan malperfusion. The patient, who initially received only medical treatment, experienced persistent pain and was successfully treated with endovascular repair. The use of PMEG f-TEVAR with fenestration and carotid-subclavian bypass resulted in satisfactory outcomes.
JOURNAL OF CARDIOVASCULAR SURGERY
(2023)
Article
Surgery
Tatu Juvonen, Mikko Jormalainen, Caius Mustonen, Till Demal, Antonio Fiore, Andrea Perrotti, Amelie Herve, Enzo Mazzaro, Giuseppe Gatti, Matteo Pettinari, Sven Peterss, Joscha Buech, Francesco Nappi, Lenard Conradi, Angel G. Pinto, Javier Rodriguez Lega, Marek Pol, Petr Kacer, Angelo M. Dell'Aquila, Andreas Rukosujew, Konrad Wisniewski, Igor Vendramin, Daniela Piani, Luisa Ferrante, Mauro Rinaldi, Eduard Quintana, Robert Pruna-Guillen, Sebastien Gerelli, Dario Di Perna, Thierry Folliguet, Metesh Acharya, Mark Field, Manoj Kuduvalli, Francesco Onorati, Cecilia Rossetti, Timo Makikallio, Peter Raivio, Giovanni Mariscalco, Fausto Biancari
Summary: This study evaluated the impact of direct aortic cannulation versus innominate/subclavian/axillary artery cannulation on the outcome after surgery for type A aortic dissection. The results showed that direct aortic cannulation is associated with a significant reduction in in-hospital mortality and decreased postoperative complications compared to supra-aortic arterial cannulation.
WORLD JOURNAL OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Fausto Biancari, Francesco Nappi, Giuseppe Gatti, Andrea Perrotti, Amelie Herve, Stefano Rosato, Paola D'Errigo, Matteo Pettinari, Sven Peterss, Joscha Buech, Tatu Juvonen, Mikko Jormalainen, Caius Mustonen, Till Demal, Lenard Conradi, Marek Pol, Petr Kacer, Angelo M. Dell'Aquila, Konrad Wisniewski, Igor Vendramin, Daniela Piani, Luisa Ferrante, Timo Makikallio, Eduard Quintana, Robert Pruna-Guillen, Antonio Fiore, Thierry Folliguet, Giovanni Mariscalco, Metesh Acharya, Mark Field, Manoj Kuduvalli, Francesco Onorati, Cecilia Rossetti, Sebastien Gerelli, Dario Di Perna, Enzo Mazzaro, Angel G. Pinto, Javier Rodriguez Lega, Mauro Rinaldi
Summary: This study evaluated the prognostic significance of preoperative arterial lactate concentration on the outcome after surgery for acute type A aortic dissection (TAAD). The results showed that hyperlactatemia significantly increased the risk of mortality after surgery for TAAD and should be considered in the clinical assessment of these critically ill patients.
Article
Medicine, General & Internal
Julia von der Linden, Florian Herrmann, Sergey Belyaev, Gerd Juchem, Sven Peterss, Christian Hagl, Alexey Dashkevich
Summary: This study analyzed the feasibility of using RD SAVR to treat BAV. It was found that annular symmetry can be restored through precise prosthesis sizing and placement, and comparable clinical outcomes were observed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Becker, Jan Stana, Carlota F. Prendes, Nikolaos Konstantinou, Tugce Oez, Maximilian Pichlmaier, Sven Peterss, Nikolaos Tsilimparis
Summary: The study investigated the outcomes of using custom-made double or triple inner-branched arch endograft for repairing anastomotic aneurysms in patients after open surgical repair of the ascending aorta or proximal arch. The results showed that endovascular arch repair is technically feasible and a promising alternative for patients unfit for surgery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
