Article
Cardiac & Cardiovascular Systems
Richard D. Mainwaring, Lou Capecci, R. Thomas Collins, Frank L. Hanley
Summary: This study assessed the midterm fate of unifocalized major aortopulmonary collateral arteries (MAPCAs) in patients with retroesophageal MAPCAs. The majority of unifocalized MAPCAs remained widely patent, but a quarter developed stenoses or occlusion. Close vigilance is necessary for the management of these patients.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Hongbai Wang, Chaobin Zhang, Yinan Li, Yuan Jia, Su Yuan, Jianhui Wang, Fuxia Yan
Summary: This meta-analysis investigates the effect of dexmedetomidine infusion on the incidence of acute kidney injury (AKI) after cardiac surgery in pediatric patients. The results show that dexmedetomidine significantly reduces the postoperative incidence of AKI compared to placebo. However, the significant difference is only observed in pediatric patients receiving combination of intra- and postoperative dexmedetomidine infusion.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Surgery
Huan Chen, Jinglan Liu, Yuqing Wu, Li Jiang, Mi Tang, Xin Wang, Xiaoling Fang, Xi Wang
Summary: This study investigated inflammation-related genes in congenital heart disease (CHD) after cardiopulmonary bypass (CPB) using weighted gene co-expression network analysis (WGCNA) and bioinformatics methods. Through experimental validation, CDKN1A was identified as a critical gene in CHD after CPB, and its association with inflammation was discovered. This study has important biological implications for the accurate diagnosis and treatment of inflammation following CPB in the future.
FRONTIERS IN SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Jelle P. G. van der Ven, Eva van den Bosch, Vivian P. Kamphuis, Covadonga Terol, Devi Gnanam, Ad J. J. C. Bogers, Johannes M. P. J. Breur, Rolf M. F. Berger, Nico A. Blom, Laurens Koopman, Arend D. J. ten Harkel, Willem A. Helbing
Summary: Ventricular performance decreases temporarily after surgical or percutaneous closure of atrial septal defect, with a significant decrease in right ventricular global longitudinal strain observed in the surgical group. Left ventricular global longitudinal strain also decreased in the surgical group at 2 weeks post-intervention. At 1-year follow-up, left ventricular performance returned to baseline while right ventricular performance improved but remained below pre-intervention levels. Several biomarkers showed patterns similar to ventricular performance changes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Richard Issitt, John Booth, Richard Crook, Alex Robertson, Victoria Molyneux, Rebecca Richardson, Nigel Cross, Michael Shaw, Victor Tsang, Vivek Muthurangu, Neil J. Sebire, Michael Burch, Matthew Fenton
Summary: Comparing the outcomes of ABO-IA and ABO-PE for ABO-incompatible heart transplantation, it was found that ABO-IA patients were significantly older and had significantly reduced blood product utilization. However, there were no significant differences in other pre and post-operative indicators, rejection rates, and survival rates.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
L. Mac Felmly, Richard D. Mainwaring, R. Thomas Collins, Kirstie Lechich, Elisabeth Martin, Michael Ma, Frank L. Hanley
Summary: This study retrospectively analyzed the surgical treatment of peripheral pulmonary artery stenosis (PPAS) in 145 patients and found that the surgery significantly reduced right ventricular pressures and helped reduce the risk of death.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Yuan Sun, Xiao-Ming Deng, Ying Cai, Sai-E Shen, Li-Ya Dong
Summary: This retrospective study aimed to investigate the risk factors and features of post-cardiopulmonary bypass hypoxaemia in paediatric congenital heart disease surgery. The results showed that preoperative intracardiac right-to-left shunting and intraoperative pleural cavity entry were identified as independent risk factors for the development of post-cardiopulmonary bypass hypoxaemia. Most cases of hypoxaemia occurred within 2 hours after surgery, and moderate hypoxaemia had a relatively high occurrence rate.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Rafael Gonzalez Cortes, Javier Urbano Villaescusa, Maria J. Solana Garcia, Jorge Lopez Gonzalez, Sarah N. Fernandez Lafever, Blanca Ramirez Gomez, Jose R. Fuentes Moran, Irene Hidalgo Garcia, Ana Peleteiro Pensado, Ramon Perez-Caballero Martinez, Carlos A. Pardo Prado, Alejandro Rodriguez Ogando, Maria Lopez Blazquez, Jesus Lopez-Herce Cid
Summary: This study conducted a prospective, observational single-center analysis of pediatric patients undergoing congenital heart defect surgery, assessing sublingual microcirculation and clinical parameters at various time points. The study found that all microcirculatory parameters worsened during cardiopulmonary bypass but returned to baseline values after surgery. Additionally, body temperature was correlated with various microcirculation parameters, and patients with cyanotic disease exhibited distinct microvascular changes compared to other patients.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Dorothy E. Vatner, Jie Zhang, Xin Zhao, Lin Yan, Raymond Kudej, Stephen F. Vatner
Summary: Through pig experiments and gene analysis, it was found that sFRP3 is the only significantly upregulated gene in the fourth window of IPC model, and can induce cardioprotection when injected into the hearts of animals.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Critical Care Medicine
Asaad G. Beshish, Ozzie Jahadi, Ashley Mello, Vamsi V. Yarlagadda, Andrew Y. Shin, David M. Kwiatkowski
Summary: This retrospective study examined the association between hyperoxia during cardiopulmonary bypass and outcomes in infants undergoing cardiac surgery. The results showed that hyperoxia was associated with increased mortality risk, acute kidney injury, and prolonged postoperative length of stay. Further research is needed to validate these findings and understand the mechanisms behind this association.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Sachin Talwar, Neralakere Suresha Sujith, Palleti Rajashekar, Neeti Makhija, Vishnubhatla Sreenivas, Ashish Datt Upadhyay, Manoj Kumar Sahu, Choudhary Shiv Kumar
Summary: The study confirmed the benefits of increased hematocrit, reduced mechanical ventilation time, decreased need for inotropes, and lower interleukin-6 and Troponin-T levels by combining CUF and MUF in patients undergoing intracardiac repair of tetralogy of fallot. This group showed better postoperative outcomes.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Monique M. Gardner, Garrett Keim, Jill Hsia, Anh D. Mai, J. William Gaynor, Andrew C. Glatz, Nadir Yehya
Summary: This study assessed the predictive ability of the ICU-30 composite outcome for 6- and 12-month mortality in neonates requiring cardiopulmonary bypass surgery. The results showed that ICU-30 was associated with higher rates of 6- and 12-month mortality, highlighting its importance in clinical studies of neonatal heart disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Vincenzo Tarzia, Matteo Ponzoni, Demetrio Pittarello, Gino Gerosa
Summary: We propose a patient-tailored strategy that utilizes the ProtekDuo cannula in an innovative way to perform cardiopulmonary bypass during LVAD implantation in ECMO patients, considering the risk for postoperative right heart failure. Our preliminary study showed that this strategy is feasible for planned minimally invasive right ventricular support in ECMO patients scheduled for a durable LVAD implantation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Harish Bangalore, Michael J. Carter, Kiran Parmar, Conal Austin, Manu Shankar-Hari, Beverley J. Hunt, Shane M. Tibby
Summary: The degradation of glycocalyx during cardiopulmonary bypass surgery is associated with metabolic acidosis, renal dysfunction, capillary leak, and cardiovascular dysfunction. Protecting the glycocalyx during these procedures may be crucial in preventing such complications.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Lindsay E. Volk, Constantine D. Mavroudis, Tiffany Ko, Thomas Hallowell, Nile Delso, Anna L. Roberts, Jonathan Starr, William Landis, Yuxi Lin, Marco Hefti, Ryan W. Morgan, Richard W. Melchior, Tami M. Rosenthal, Alexander Chappell, Douglas Fisher, Molly Dreher, Daniel J. Licht, Jonathan Chen, J. William Gaynor, Christopher E. Mascio, Todd J. Kilbaugh
Summary: The study found that using cardiopulmonary bypass during cardiac surgery can lead to decreased cerebral mitochondrial respiration even in the absence of local markers of ischemia. Exposure to 4 hours of cardiopulmonary bypass resulted in a significant increase in cerebral mitochondrial reactive oxygen species formation.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Nutrition & Dietetics
Sergey M. Efremov, Tatiana I. Ionova, Tatiana P. Nikitina, Pavel E. Vedernikov, Timur A. Dzhumatov, Timofey S. Ovchinnikov, Abduvahhob A. Rashidov, Christian Stoppe, Daren K. Heyland, Vladimir V. Lomivorotov
Summary: Through a study of 1187 cardiac patients, it was found that preoperative malnutrition is not significantly associated with 8-year survival, but may be related to worse outcomes in the first 3 years for patients with heart valve disease.
Article
Biochemistry & Molecular Biology
Alina D. Nikotina, Snezhana A. Vladimirova, Elena Y. Komarova, Dmitry Alexeev, Sergey Efremov, Elizaveta Leonova, Rostislav Pavlov, Viktor G. Kartsev, Sergey G. Polonik, Boris A. Margulis, Irina Guzhova
Summary: This study found that Hsp70 chaperone is involved in the EMT of colon cancer cells under high glucose environment, and knocking down or inducing Hsp70 can affect EMT markers and cell migration capacity. Inhibiting Hsp70 can reduce EMT efficiency, and safe inhibitors are needed to hinder tumor metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anesthesiology
Alberto Zangrillo, Vladimir V. Lomivorotov, Vadim V. Pasyuga, Alessandro Belletti, Gordana Gazivoda, Fabrizio Monaco, Caetano Nigro Neto, Valery V. Likhvantsev, Nikola Bradic, Andrey Lozovskiy, Chong Lei, Nazar A. R. Bukamal, Fernanda Santos Silva, Andrey E. Bautin, Jun Ma, Chow Yen Yong, Cristiana Carollo, Jan Kunstyr, Chew Yin Wang, Evgeny Grigoryev, Hynek Riha, Chengbin Wang, Mohamed R. El-Tahan, Anna Mara Scandroglio, Marzida Mansor, Rosalba Lembo, Dmitry N. Ponomarev, Francisco Jose Lucena Bezerra, Laura Ruggeri, Alexander M. Chernyavskiy, Junmei Xu, Dmitry G. Tarasov, Paolo Navalesi, Andrey Yavorovskiy, Tiziana Bove, Artem Kuzovlev, Ludhmila A. Hajjar, Giovanni Landoni
Summary: The study investigates the effect of volatile anesthetics on postoperative myocardial infarction and cardiac death rates after coronary artery bypass graft. The results indicate that patients receiving volatile anesthetics have a lower incidence of myocardial infarction with hemodynamic complications and reduced long-term cardiac mortality.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Letter
Cardiac & Cardiovascular Systems
Alexander Romanov, Vladimir Lomivorotov, Alexander Chernyavskiy, Vladimir Murtazin, Elena Kliver, Dmitry Ponomarev, Igor Mikheenko, Alexander Yakovlev, Marina Yakovleva, Jonathan S. Steinberg
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
P. J. Devereaux, Andre Lamy, Matthew T. Chan, Rene Allard, Vladimir V. Lomivorotov, Giovanni Landoni, Hong Zheng, Domenico Paparella, Michael H. McGillion, Emilie P. Belley-Cote, Joel L. Parlow, Malcolm J. Underwood, Chew Yin Wang, Nazari Dvirnik, Marat Abubakirov, Evgeny Fominskiy, Stephen Choi, Stephen Fremes, Fabrizio Monaco, Gerard Urrutia, Marialuz Maestre, Ludhmila A. Hajjar, Graham S. Hillis, Nicholas L. Mills, Vito Margari, Joseph D. Mills, J. Stephen Billing, Emily Methangkool, Carisi A. Polanczyk, Roberto Sant'Anna, Dmitry Shukevich, David Conen, Peter A. Kavsak, Matthew J. McQueen, Katheryn Brady, Jessica Spence, Yannick Le Manach, Rajibul Mian, Shun Fu Lee, Shrikant Bangdiwala, Sara Hussain, Flavia K. Borges, Shirley Pettit, Jessica Vincent, Gordon H. Guyatt, Salim Yusuf, Joseph S. Alpert, Harvey D. White, Richard P. Whitlock
Summary: This study aimed to explore the relationship between high-sensitivity cardiac troponin I levels after cardiac surgery and 30-day mortality, and found that the levels associated with increased risk of death were significantly higher than the currently recommended threshold for clinically important periprocedural myocardial injury.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Chemistry, Medicinal
Alina D. Nikotina, Snezhana A. Vladimirova, Nadezhda E. Kokoreva, Elena Y. Komarova, Nikolay D. Aksenov, Sergey Efremov, Elizaveta Leonova, Rostislav Pavlov, Viktor G. Kartsev, Zhichao Zhang, Boris A. Margulis, Irina Guzhova
Summary: Despite advances in diagnosing and treating colorectal cancer, drug resistance remains a significant limitation. Researchers have explored combination therapy using inhibitors of the proteostasis system, chaperone machinery, and autophagy. In this study, they found that inhibiting HSF1 activity and autophagy effectively killed rectal cancer cells, suggesting a promising treatment approach.
Letter
Critical Care Medicine
Dmitry Ponomarev, Laurent Brochard, Ewan Goligher
Article
Cardiac & Cardiovascular Systems
Denis Losik, Alexander Romanov, Igor Grazhdankin, Vitaly Shabanov, Dmitry Ponomarev, Igor Mikheenko, Ivan Peregudov, Alexey Filippenko, Nikolay Bondar, Lucas Boersma, Jonathan S. S. Steinberg
Summary: The study aimed to assess the effectiveness of left atrial appendage occlusion (LAAO) combined with percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and atrial fibrillation (AF). 50 ACS patients without ST elevation and a history of AF were randomly assigned to receive either LAAO or conventional medical therapy after successful PCI. The primary endpoints were safety and length of hospitalization. The follow-up period was 30 days. The results showed that LAAO combined with PCI appeared to be safe for ACS patients with AF.
Letter
Cardiac & Cardiovascular Systems
Jonathan S. Steinberg, Nicholas Blount, Dmitry Ponomarev, Vitaly Shabanov, Evgeny Pokushalov, Alexander Romanov
Article
Respiratory System
Ignacio Martin-Loeches, Antoni Torres, Blin Nagavci, Stefano Aliberti, Massimo Antonelli, Matteo Bassetti, Lieuwe Bos, James Chalmers, Lennie Derde, Jan de Waele, Jose Garnacho-Montero, Marin Kollef, Carlos Luna, Rosario Menendez, Michael Niederman, Dimitry Ponomarev, Marcos Restrepo, David Rigau, Marcus Schultz, Emmanuele Weiss, Tobias Welte, Richard Wunderink
Summary: The ERS, ESICM, ESCMID and ALAT have developed the first international guidelines for severe community-acquired pneumonia (sCAP). These guidelines provide evidence-based recommendations for diagnosis, empirical treatment and antibiotic therapy for sCAP.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Critical Care Medicine
Ignacio Martin-Loeches, Antoni Torres, Blin Nagavci, Stefano Aliberti, Massimo Antonelli, Matteo Bassetti, Lieuwe Bos, James Chalmers, Lennie Derde, Jan de Waele, Jose Garnacho-Montero, Marin Kollef, Carlos Luna, Rosario Menendez, Michael Niederman, Dimitry Ponomarev, Marcos Restrepo, David Rigau, Marcus Schultz, Emmanuele Weiss, Tobias Welte, Richard Wunderink
Summary: The task force launched the first international guidelines for sCAP, providing evidence-based recommendations for diagnosis, empirical treatment, and antibiotic therapy. The recommendations were based on systematic literature searches and meta-analyses, following the GRADE approach.
INTENSIVE CARE MEDICINE
(2023)
Article
Endocrinology & Metabolism
T. I. Ionova, D. M. Buzanakov, R. A. Chernikov, S. M. Efremov, I. N. Gladkova, T. P. Nikitina, I. V. Sleptsov, A. V. Zolotoukho, K. A. Bubnov, V. V. Skvortsov, A. A. Vinogradova, V. F. Rusakov
Summary: This single-center study aimed to evaluate the impact of primary hyperparathyroidism (PHPT) on patients' quality of life (QoL) and identify changes in QoL at early and long-term follow-up after surgery. The results showed that successful surgery significantly improved patients' QoL and reduced their symptoms for at least 24 months.
BMC ENDOCRINE DISORDERS
(2023)
Article
Anesthesiology
Sergey Efremov, Mikhail Alexeev, Oleg Kuleshov, Alexander Safronov, Vyacheslav Ryndin, Dina Rebrova, Elisei Fedorov
Summary: In patients with pheochromocytoma undergoing retroperitoneal adrenalectomy, risk factors for postoperative vasopressor requirement include baseline coronary artery disease, maximal systolic blood pressure >195 mmHg, and a significant increase in baseline adrenergic activity. These factors can predict the need for vasopressor support after surgery.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Anesthesiology
M. Alexeev, E. Fedorov, O. Kuleshov, D. Rebrova, S. Efremov
Summary: This case report describes a massive carbon dioxide embolism associated with injury to the inferior vena cava during posterior retroperitoneoscopic adrenalectomy. Despite the absence of bleeding, severe hypotension, or abrupt increase in end-tidal carbon dioxide, the patient showed tachycardia, rapid oxygen desaturation, and severe respiratory acidosis. The patient was successfully resuscitated by increasing the fraction of inspired oxygen, administering intravenous fluid, and converting to an open procedure to suture the vein.
ANAESTHESIA REPORTS
(2022)
Letter
Endocrinology & Metabolism
Sergey Efremov, Mikhail Alexeev