Article
Cardiac & Cardiovascular Systems
Xinguang Chen, Yao Lu, Yanmin Liu, Qiushi Chen, Hongwu Chen, Weizhu Ju, Gang Yang, Yeqian Zhu, Pengcheng Zhao, Jian Zhang, Yangming Mao, Xiaoling Su, Fengxiang Zhang, Minglong Chen
Summary: This study compared the electroanatomical characteristics between atrial fibrillation (AF) and non-AF patients, and found that the majority of patients with AF had the earliest atrial activation (EAA) site located in the superior vena cava (SVC), especially in patients with persistent AF (PsAF).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Baptiste Maille, Nathalie Lalevee, Marion Marlinge, Juliette Vahdat, Giovanna Mottola, Clara Degioanni, Lucille De Maria, Victor Klein, Franck Thuny, Frederic Franceschi, Jean-Claude Deharo, Regis Guieu, Julien Fromonot
Summary: This narrative review discusses the potential role of the adenosinergic system in the pathophysiology of atrial fibrillation (AF). It provides insights into adenosinergic system signaling and its interactions with AF. Activation of adenosine receptors can affect the occurrence and maintenance of AF, and the adenosinergic system is also associated with the modulation of the autonomic nervous system and AF risk factors.
Review
Cardiac & Cardiovascular Systems
Anuradha Kalyanasundaram, Ning Li, Ralph S. Augostini, Raul Weiss, John D. Hummel, Vadim V. Fedorov
Summary: This article introduces the anatomy, activation mechanism, and arrhythmias related to the sinoatrial node (SAN). The complex structure and conduction mechanism of the SAN pose challenges in clinical mapping and ablation procedures, and incorrect diagnosis and treatment may lead to poor outcomes. The aim of the article is to provide a state-of-the-art overview of the 3D structure, function, and treatment approaches of SAN and atrial arrhythmias to improve diagnosis and mechanistic treatment.
Article
Biochemistry & Molecular Biology
Hector Godoy-Marin, Romain Duroux, Kenneth A. Jacobson, Concepcio Soler, Hildegard Colino-Lage, Veronica Jimenez-Sabado, Jose Montiel, Leif Hove-Madsen, Francisco Ciruela
Summary: Atrial fibrillation (AF) is influenced by various factors such as oxidative stress, calcium overload, inflammation, as well as adenosine and its receptors. Studies have found increased A2AR expression in the right atrium of AF patients, elevated levels of adenosine content in plasma, and reduced ADA activity. Importantly, there is a positive correlation between A2AR expression in PBMCs and in the right atrium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Hee Jung Park Frausing, Martijn E. Van De Lande, Alexander H. Maass, Bao-Oanh Nguyen, Martin E. W. Hemels, Robert G. Tieleman, Tim Koldenhof, Mirko De Melis, Dominik Linz, Ulrich Schotten, Vanessa Weberndoerfer, Harry J. G. M. Crijns, Isabelle C. Van Gelder, Jens Cosedis Nielsen, Michiel Rienstra
Summary: This study aimed to examine brady- and tachyarrhythmias using continuous rhythm monitoring in patients with paroxysmal self-terminating AF (PAF). The results showed that almost half of the PAF patients experienced severe bradyarrhythmias or rapid ventricular tachyarrhythmias during continuous rhythm monitoring.
Article
Cardiac & Cardiovascular Systems
Sushravya Raghunath, John M. Pfeifer, Alvaro E. Ulloa-Cerna, Arun Nemani, Tanner Carbonati, Linyuan Jing, David P. Van Maanen, Dustin N. Hartzel, Jeffery A. Ruhl, Braxton F. Lagerman, Daniel B. Rocha, Nathan J. Stoudt, Gargi Schneider, Kipp W. Johnson, Noah Zimmerman, Joseph B. Leader, H. Lester Kirchner, Christoph J. Griessenauer, Ashraf Hafez, Christopher W. Good, Brandon K. Fornwalt, Christopher M. Haggerty
Summary: Deep learning can predict new-onset atrial fibrillation from the 12-lead ECG in patients without a previous history of AF, thereby helping to identify individuals at risk for AF-related strokes.
Article
Medicine, General & Internal
Maciej T. Wybraniec, Kamil Gorny, Kamil Jablonski, Julia Jung, Kiryl Rabtsevich, Przemyslaw Szyszka, Fabian Wesolek, Karolina Bula, Malgorzata Cichon, Wojciech Wrobel, Katarzyna Mizia-Stec
Summary: Unlike AF, AFl has a lower pharmacological cardioversion efficacy and higher rate of electrical cardioversion use. AFl patients have a longer hospitalization time, lower left ventricular ejection fraction, and more pronounced cardiovascular risk factors compared to AF patients. The efficacy of amiodarone in pharmacological cardioversion is significantly lower in AFl patients than in AF patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
Jibin Wang, Xiaotai Wu
Summary: This study focuses on automatic detection of arrhythmias using BiLSTM and BiGRU network modules with feature recalibration approach, achieving high accuracy of 99.2% and 99.3% respectively, demonstrating great potential for various computer vision tasks.
APPLIED SOFT COMPUTING
(2022)
Article
Cardiac & Cardiovascular Systems
Peter Vibe Rasmussen, Paul Blanche, Frederik Dalgaard, Gunnar Hilmar Gislason, Christian Torp-Pedersen, Jacob Tonnesen, Martin H. Ruwald, Jannik Langtved Pallisgaard, Morten Lock Hansen
Summary: Electrical cardioversion (ECV) is commonly used to terminate atrial fibrillation (AF), but the risks of brady-arrhythmic events associated with ECV vary with age. Factors such as cardiovascular disease and a history of syncope are associated with increased risks of brady-arrhythmias. Pre-treatment with anti-arrhythmic drugs does not seem to increase the risk of brady-arrhythmic events.
AMERICAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Jien-Jiun Chen, Fu-Chun Chiu, Sheng-Nan Chang, Hsiao-Liang Cheng, Pang-shuo Huang, Cho-Kai Wu, Yi-Chih Wang, Juey-Jen Hwang, Chia-Ti Tsai
Summary: This pioneer study investigated the impact of pre-existing left atrial appendage occluder (LAAO) on atrial fibrillation (AF) substrates and outcomes of pulmonary vein isolation (PVI). Results showed that LAAO may modulate left atrial substrate and induce peridevice fibrosis, peridevice left atrial flutter, and complex fractionate atrial electrogram.
Article
Physiology
Jia-hui Li, Hai-yang Xie, Yan-qiao Chen, Zhong-jing Cao, Qing-hui Tang, Xiao-gang Guo, Qi Sun, Jian Ma
Summary: The study aimed to describe the incidence of AF in patients with typical AFL after CTI ablation and found that obstructive sleep apnea, advanced interatrial block, left atrial diameter > 42 mm, and CHA(2)DS(2)-VASc score > 2 were independent risk factors for new-onset AF.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Armin Luik, Kerstin Schmidt, Annika Haas, Laura Unger, Panagiotis Tzamalis, Bernd Brueggenjuergen
Summary: The treatment of atrial tachycardia following catheter ablation of atrial fibrillation is often challenging, but new ablation approaches have shown promising results. However, long-term data on the freedom from any atrial tachycardia or any arrhythmia are still limited. This study presents 12-month success and mean 30 month follow-up data of catheter ablation of left atrial tachycardia, demonstrating high long-term clinical success rates with individual ablation strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Muhamed Vila, Massimo Walter Rivolta, Giorgio Luongo, Laura Anna Unger, Armin Luik, Lorenzo Gigli, Federico Lombardi, Axel Loewe, Roberto Sassi
Summary: This study utilized network theory to model the electrical propagation pattern of atrial flutter, successfully detecting cycles resembling the main propagation of AFL using a cycle-finding algorithm. The method showed promising results in identifying the mechanisms of AFL in most cases, including sinus rhythm cases and in-silico simulations. Further investigations are required to evaluate its reliability in different clinical scenarios.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Rohit K. Kharbanda, Fons J. Wesselius, Mathijs S. van Schie, Yannick J. H. J. Taverne, Ad J. J. C. Bogers, Natasja M. S. de Groot
Summary: "The study found three distinct activation patterns of the SAN, indicating the complex geometry of the SAN and individual differences in SAN exit pathways. SAN activity occurred more caudally in patients with a history of atrial fibrillation, suggesting changes in preferential SAN exit pathways."
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jari M. Tuomi, Loryn J. Bohne, Tristan W. Dorey, Hailey J. Jansen, Yingjie Liu, Douglas L. Jones, Robert A. Rose
Summary: The study showed that ibrutinib and acalabrutinib have distinct effects on atrial electrophysiology and ion channel function. Ibrutinib increased atrial fibrillation susceptibility and impaired sinus node function, while acalabrutinib had no such effects.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Chemistry, Analytical
Muhammad Erfan Uddin, Xinxin Sun, Kevin M. Huang, Shuiying Hu, Cynthia A. Carnes, Alex Sparreboom, Qiang Fu
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2019)
Article
Medicine, Research & Experimental
Victor P. Long, Ingrid M. Bonilla, Stephen Baine, Patric Glynn, Sanjay Kumar, Karsten Schober, Kent Mowrey, Raul Weiss, Nam Y. Lee, Peter J. Mohler, Sandor Gyorke, Thomas J. Hund, Vadim V. Fedorov, Cynthia A. Carnes
Article
Medicine, Research & Experimental
Jacob A. Grimmer, Vineeta Tanwar, Dane J. Youtz, Jeremy M. Adelstein, Stephen H. Baine, Cynthia A. Carnes, Lisa A. Baer, Kristin I. Stanford, Loren E. Wold
Article
Cardiac & Cardiovascular Systems
Mark A. Munger, Yusuf Olgar, Megan L. Koleske, Heather L. Struckman, Jessica Mandrioli, Qing Lou, Ingrid Bonila, Kibum Kim, Roberto Ramos Mondragon, Silvia G. Priori, Pompeo Volpe, Hector H. Valdivia, Joseph Biskupiak, Cynthia A. Carnes, Rengasayee Veeraraghavan, Sandor Gyorke, Przemyslaw B. Radwanski
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Biochemistry & Molecular Biology
Stephen Baine, Justin Thomas, Ingrid Bonilla, Marina Ivanova, Andriy Belevych, Jiaoni Li, Rengasayee Veeraraghavan, Przemyslaw B. Radwanski, Cynthia Carnes, Sandor Gyorke
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Kevin M. Huang, Megan Zavorka Thomas, Tarek Magdy, Eric D. Eisenmann, Muhammad Erfan Uddin, Duncan F. DiGiacomo, Alexander Pan, Markus Keiser, Marcus Otter, Sherry H. Xia, Yang Li, Yan Jin, Qiang Fu, Alice A. Gibson, Ingrid M. Bonilla, Cynthia A. Carnes, Kara N. Corps, Vincenzo Coppola, Sakima A. Smith, Daniel Addison, Anne T. Nies, Ralf Bundschuh, Taosheng Chen, Maryam B. Lustberg, Joanne Wang, Stefan Oswald, Moray J. Campbell, Pearlly S. Yan, Sharyn D. Baker, Shuiying Hu, Paul W. Burridge, Alex Sparreboom
Summary: By studying the critical transporter OCT3 for doxorubicin accumulation in the heart, researchers have revealed the mechanism of doxorubicin-induced cardiotoxicity, providing a theoretical basis for a targeted intervention strategy to prevent this side effect.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Stephen Baine, Ingrid Bonilla, Andriy Belevych, Andrei Stepanov, Lisa E. Dorn, Radmila Terentyeva, Dmitry Terentyev, Federica Accornero, Cynthia A. Carnes, Sandor Gyorke
Summary: Chronic treatment with the cholinesterase inhibitor, pyridostigmine (PYR), improves cardiac function in pressure overload heart failure by alleviating aberrant calcium handling and modulating pathological signaling pathways related to arrhythmogenesis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Shanna Hamilton, Radmila Terentyeva, Vladimir Bogdanov, Tae Yun Kim, Fruzsina Perger, Jiajie Yan, Xun Ai, Cynthia A. Carnes, Andriy E. Belevych, Christopher H. George, Jonathan P. Davis, Sandor Gyorke, Bum-Rak Choi, Dmitry Terentyev
Summary: This study demonstrates that oxidative stress in cardiac disease impairs the regulation of Ca2+ release channel RyR2, leading to proarrhythmic disturbances. The researchers discovered a new intraluminal interaction axis involving RyR2, ERp44, and Ero1 alpha. Inhibition of Ero1 alpha has the potential to stabilize the RyR2-ERp44 complex and reduce spontaneous Ca2+ release and tachyarrhythmias.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Erfan Uddin, Eric D. Eisenmann, Yang Li, Kevin M. Huang, Dominique A. Garrison, Zahra Talebi, Alice A. Gibson, Yan Jin, Mahesh Nepal, Ingrid M. Bonilla, Qiang Fu, Xinxin Sun, Alec Millar, Mikhail Tarasov, Christopher E. Jay, Xiaoming Cui, Heidi J. Einolf, Ryan M. Pelis, Sakima A. Smith, Przemyslaw B. Radwanski, Douglas H. Sweet, Joerg Koenig, Martin F. Fromm, Cynthia A. Carnes, Shuiying Hu, Alex Sparreboom
Summary: Dofetilide, a potassium current inhibitor used to prevent atrial fibrillation recurrence, can cause QTc interval prolongation and increase the risk of ventricular arrhythmias. This study identified MATE1 as a transporter for Dofetilide and showed that inhibiting or knocking out MATE1 resulted in increased retention of Dofetilide in cardiomyocytes and prolonged QTc interval in mice. The findings also explained the drug-drug interactions between Dofetilide and contraindicated drugs and were validated using a pharmacokinetic model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Charlotte M. Forshay, John Mellett, Marcia M. Worley, Cynthia A. Carnes, Andre Fernandes, Trisha A. Jordan
Summary: This study developed an identification tool and documentation process to identify and complete prior authorizations for medications before patient discharge during the inpatient setting. The results showed that most medications did not require prior authorization, some had prior authorization started, and a few medications were discontinued or transferred to other facilities. The implementation of this method helps improve the workflow of prior authorizations and discharge care coordination.
Review
Oncology
Jennifer P. Booth, Julie M. Kennerly-Shah, Lindsey R. Kelley, Donna Capozzi, Hillary A. Prescott, Scott A. Soefje, Makala B. Pace, Sally Y. Barbour, Ricky F. Tizon, Sarah DeVincenzo, Cynthia A. Carnes, Marjorie Neidecker
Summary: The National Comprehensive Cancer Network's Pharmacy Directors Forum conducted a survey to establish consensus on acuity factors associated with hematology/oncology patients that are high priority for ambulatory clinical pharmacist review. A final consensus was achieved for 18 acuity factors, which can be incorporated into a pharmacy-specific electronic scoring tool.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2023)
Meeting Abstract
Biophysics
Benjamin Hernandez Orengo, Ingrid M. Bonilla, Galina Sakuta, Dennison Min, Stephen Baine, Andriy E. Belevych, Cynthia A. Carnes, Przemyslaw Radwanski, Sandor Gyorke
BIOPHYSICAL JOURNAL
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Muhammad Erfan Uddin, Yan Jin, Alice A. Gibson, Ingrid M. Bonilla, Cynthia A. Carnes, Shuiying Hu, Alex Sparreboom
Meeting Abstract
Cardiac & Cardiovascular Systems
Stephen H. Baine, Andriy Belevych, Ingrid M. Bonilla, Cynthia A. Carnes, Sandor Gyorke
Article
Veterinary Sciences
Pedro Vargas-Pinto, Johanna Rincon, Sebastian Ruiz, Lina Tapasco, Adriana Pedraza-Toscano, Piero Vargas-Pinto
REVISTA DE INVESTIGACIONES VETERINARIAS DEL PERU
(2019)