Article
Cardiac & Cardiovascular Systems
Fabian Laumer, Davide Di Vece, Victoria L. Cammann, Michael Wuerdinger, Vanya Petkova, Maximilian Schoenberger, Alexander Schoenberger, Julien C. Mercier, David Niederseer, Burkhardt Seifert, Moritz Schwyzer, Rebekka Burkholz, Luca Corinzia, Anton S. Becker, Frank Scherff, Sofie Brouwers, Aju P. Pazhenkottil, Svetlana Dougoud, Michael Messerli, Felix C. Tanner, Thomas Fischer, Victoria Delgado, P. Christian Schulze, Christian Hauck, Lars S. Maier, Ha Nguyen, Sven Y. Surikow, John Horowitz, Kan Liu, Rodolfo Citro, Jeroen Bax, Frank Ruschitzka, Jelena-Rima Ghadri, Joachim M. Buhmann, Christian Templin
Summary: This cohort study established a real-time system for fully automated interpretation of echocardiogram videos and used machine learning to differentiate takotsubo syndrome (TTS) from acute myocardial infarction (AMI). The system achieved higher accuracy in echocardiography-based disease classification compared to cardiologists.
Review
Pharmacology & Pharmacy
Jaime Andres Pereanez, Johan Granados, Raquel Agudelo
Summary: This study investigated the relationship between Tako-tsubo cardiomyopathy (TTC) and exposure to animal venoms, toxins, or poisons. The findings suggest that most cases of TTC are triggered by venomous species such as snakes and insects. The study hypothesized that the release of catecholamines may be the mechanism behind this association. Further research is needed to explore other possible mechanisms in this field.
Article
Medicine, General & Internal
Volkan Gur, Furkan Yapici, Ugur Kucuk, Izzet Ozay Subasi, Mehmet Burak Gokgoz, Resit Karakose, Nizamettin Kockara
Summary: This study aimed to compare the ventricular repolarization disturbances between patients with acute spontaneous Achilles tendon ruptures (ATRs) and a healthy control group. The results showed that ATR patients had longer Tp-e intervals and higher Tp-e/QT ratios, indicating a higher risk of ventricular arrhythmia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yangyang Zhang, Liang Zhang, Pengcheng Ge, Ruyi Xu, Zhen Ye
Summary: This study suggests that Roxadustat can improve ventricular repolarization in peritoneal dialysis patients, indicating a potential cardiovascular protective effect.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Surgery
Ersin Ibisoglu, Deniz Dilan Naki Tekin, Filiz Kizilirmak, Saime Turgut Gunes, Bedrettin Boyraz, Yasar Ozdenkaya, Sinem Cakal, Beytullah Cakal, Umeyir Savur, Aslan Erdogan, Fatih Erkam Olgun, H. Murat Gunes
Summary: The study found that patients who underwent bariatric surgery showed significant improvements in ventricular repolarization parameters at 6 months post-op.
Article
Physiology
Yiheng Yang, Cheng Chen, Penghong Duan, Suman Thapaliya, Lianjun Gao, Yingxue Dong, Xiaomeng Yin, Xiaolei Yang, Rongfeng Zhang, Ruopeng Tan, Simei Hui, Yue Wang, Richard Sutton, Yunlong Xia
Summary: In patients with isolated hypomagnesemia, P wave duration, QTc, Tpec, and Tpe/QT ratio suggesting atrial depolarization and ventricular repolarization dispersion were significantly increased compared with normal magnesium levels in the same patients after restoration to normal levels. However, no significant differences were found in PR interval, QRS duration, and ST-T segments between the patients and their own controls.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Irene Martin de Miguel, Ivan J. Nunez-Gil, Alberto Perez-Castellanos, Aitor Uribarri, Albert Duran-Cambra, Agustin Martin-Garcia, Miguel Corbi-Pascual, Marta Guillen Marzo, Manuel Martinez-Selles
Summary: The study found that patients with Takotsubo syndrome have distinct electrocardiographic features, including ST-segment elevation, negative T waves, pathological Q waves, etc. Prolonged corrected QT interval, tachyarrhythmias, higher heart rate at admission, and more extensive repolarization alterations are associated with poor outcomes.
CURRENT PROBLEMS IN CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Giovanni Napoli, Martina Rubin, Gianni Cutillo, Paride Schito, Tommaso Russo, Angelo Quattrini, Massimo Filippi, Nilo Riva
Summary: This study summarizes four cases of amyotrophic lateral sclerosis (ALS) patients with Tako-Tsubo syndrome (TTS) and reviews the relevant literature, revealing the association between ALS and TTS. Among these cases, one ALS patient developed TTS during hospitalization, and three additional cases with ALS-TTS were identified retrospectively. The study found that cardiovascular autonomic dysfunction in ALS is especially pronounced in cases with bulbar involvement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Boukje C. Eveleens Maarse, Claus Graff, Jorgen K. Kanters, Michiel J. van Esdonk, Michiel J. B. Kemme, Aliede E. In 't Veld, Manon A. A. Jansen, Matthijs Moerland, Pim Gal
Summary: In this study, hydroxychloroquine did not affect ventricular repolarization, including the QTcF-interval and T-wave morphology, at plasma concentrations up to 200 ng/mL. Based on this analysis, hydroxychloroquine does not appear to increase the risk of QTcF-induced arrhythmias.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Majd Al Deen Alhuarrat, Diego Barzallo, Jiyoung Seo, Ahmad Naser, Mohammad Rasoul Alhuarrat, Aurelia Minuti, Damianos G. Kokkinidis, Dimitrios Schizas
Summary: Perioperative takotsubo cardiomyopathy (pTCM) is a type of cardiomyopathy that occurs during surgery due to emotional and physiological stress. This study aimed to classify and understand the clinical features, management, and prognosis of noncardiac surgery pTCM. The analysis of 101 cases showed that pTCM commonly occurred during general surgery and transplant procedures, with a median age of 55 years. Hypertension and mood disorders were prevalent in these cases. Initial symptoms included STT-wave changes, arrhythmias, and hypotension. Mechanical circulatory support was required in some cases, and the all-cause in-hospital mortality rate was 6.9%.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Giulio La Rosa, Gemma Pelargonio, Maria Lucia Narducci, Gaetano Pinnacchio, Gianluigi Bencardino, Francesco Perna, Federico Follesa, Leonarda Galiuto, Filippo Crea
Summary: The clinical value of ECG repolarization parameters associated with ventricular arrhythmias in tako-tsubo syndrome is still uncertain. This study found that the corrected global Tpeak-Tend interval at 48 hours from admission is an independent predictor of subacute ventricular arrhythmias and is superior to the standard corrected QT interval.
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Matteo Matteucci, Sandro Ferrarese, Claudio Corazzari, Gaia Telli, Vittorio Mantovani, Roberto Lorusso, Cesare Beghi
Summary: Tako-tsubo cardiomyopathy (TC) is characterized by acute but transient ventricular dysfunction without obstructive coronary artery disease, typically triggered by emotional and physical stress. This case report describes a 76-year-old woman with TC causing chest pain and a concurrent giant ascending aortic aneurysm, with delayed surgical intervention for ventricular recovery followed by ascending aorta replacement. Individualized perioperative management was implemented to prevent TC recurrence, resulting in an uneventful postoperative course.
Article
Cardiac & Cardiovascular Systems
Pierre-Antoine Cotinet, Philippe Bizouarn, Francois Roux, Bertrand Rozec
Summary: Amphetamine use can lead to reverse TTC requiring transient mechanical assistance and inotropic support.
Article
Cardiac & Cardiovascular Systems
Martin Nerad, Dita Schaffelhoferova, Jiri Hanis
Summary: Tako-tsubo cardiomyopathy, also known as stress cardiomyopathy, is a relatively rare and reversible disease of the myocardium, which shares similar early symptoms with acute coronary syndrome. Its pathophysiology remains unclear, but an excess of catecholamines is believed to play a key role in damaging the myocardium. Both work-related stress and emotional stress can lead to the development of Tako-tsubo syndrome.
Article
Physiology
Eric Sung, Adityo Prakosa, Natalia A. Trayanova
Summary: The addition of apicobasal and transmural repolarization gradients did not affect the VT inducibility, but significantly impacted the reentrant pathways and exit sites of VT. Different VT morphologies were uncovered within the same structural, conducting channels, suggesting the importance of considering ventricular repolarization gradients during ablation procedures targeting VTs.
FRONTIERS IN PHYSIOLOGY
(2021)
