Review
Cardiac & Cardiovascular Systems
Ann-Kathrin Kahle, Christiane Jungen, Fares-Alexander Alken, Katharina Scherschel, Stephan Willems, Helmut Purerfellner, Shaojie Chen, Lars Eckardt, Christian Meyer
Summary: Sudden cardiac death caused by ischaemic cardiomyopathy is a major concern, with implantation of cardioverter-defibrillator being a common preventive measure. Catheter ablation has been shown to reduce ventricular tachycardia recurrences in patients with ICM, and emerging concepts like sympathetic cardiac denervation hold promise for expanding therapeutic options in therapy-refractory VT. Further research is needed to investigate the potential benefits of these novel strategies for improving patient outcomes.
Article
Cardiac & Cardiovascular Systems
Arwa Younis, Ilan Goldenberg, Shamroz Farooq, Hagai Yavin, James Daubert, Merritt Raitt, Alexander Mazur, David T. Huang, Brent L. Mitchell, Mayer R. Rashtian, Stephen Winters, Margot Vloka, Mehmet Aktas, Matthew A. Bernabei, Christopher A. Beck, Scott McNitt, Wojciech Zareba
Summary: The study analyzed data from the RAID trial and found that ranolazine treatment reduced VTA burden in patients at high risk, particularly in those without concomitant AAD therapy, cardiac resynchronization therapy (CRT)-treated patients, and patients without atrial fibrillation (AF). However, the addition of ranolazine did not affect VTA burden in patients already on AADs or those with AF.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Michal Miroslaw Farkowski, Michal Karlinski, Mariusz Pytkowski, Carlo de Asmundis, Michal Lewandowski, Giacomo Mugnai, Giulio Conte, Eloi Marijon, Ante Anic, Serge Boveda, Rui Providencia
Summary: This study systematically reviewed the effectiveness and safety of oral mexiletine in adult patients with structural heart disease and implantable cardioverter defibrillators for recurrent ventricular arrhythmia. The results showed that mexiletine reduced the number of ICD therapies, especially in patients where catheter ablation was not successful or contraindicated. However, in patients with ischemic cardiomyopathy, mexiletine seemed to be less effective than catheter ablation. The main side effects of mexiletine were related to gastrointestinal and neurological systems.
Article
Cardiac & Cardiovascular Systems
Alex Horby Christensen, Pyotr G. Platonov, Anneli Svensson, Henrik K. Jensen, Christine Rootwelt-Norberg, Pia Dahlberg, Trine Madsen, Tanja Charlotte Frederiksen, Tiina Helio, Kristina H. Haugaa, Henning Bundgaard, Jesper H. Svendsen
Summary: This study describes the complications associated with implantable cardioverter-defibrillators (ICD) treatment in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). The results show that during long-term follow-up, approximately 41% of patients experienced potentially life-saving ICD therapy, while 27% had complications requiring surgery, mainly lead-related complications.
Article
Cardiac & Cardiovascular Systems
Artak Margkarian, Harilaos Bogossian, Dirk Bandorski, Atisha Khan, Fuad Hasan, Tobias Fortmann, Klothilda Jahaj, Bernd Lemke, Markus Zarse
Summary: This study examined the long-term effects of substrate modification in patients undergoing electrical storm (ES) ablation, considering factors such as age, gender, heart function, scare location, VT documentation, postprocedural electrical stimulation (PES), and induced VTs. The findings showed that VT recurrences and mortality rates followed different patterns, with an initial steep decline and then a plateau. Gender, age, scare localization, and missing VT documentation did not affect outcomes significantly, while the induction of more than three VTs and the lack of PES due to hemodynamic instability decreased the effectiveness of the treatment. The study concluded that ES ablation is safe and feasible, and further advancements in understanding the reentry mechanism can improve long-term outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Catherine J. O'Shea, Gijo Thomas, Melissa E. Middeldorp, Curtis Harper, Adrian D. Elliott, Noemi Ray, Dennis H. Lau, Kevin Campbell, Prashanthan Sanders
Summary: The study found that the ventricular arrhythmia burden in ICD patients decreased gradually during the COVID-19 pandemic, and patients in states with higher COVID-19 incidence had a lower risk of ventricular arrhythmias. Real-life stressors may have a potential impact on ventricular arrhythmias in individuals with ICDs.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Angel Arenal, Pablo Avila, Javier Jimenez-Candil, Luis Tercedor, David Calvo, Fernando Arribas, Javier Fernandez-Portales, Jose Luis Merino, Antonio Hernandez-Madrid, Francisco J. Fernandez-Aviles, Antonio Berruezo
Summary: In patients with ischemic cardiomyopathy and an implantable cardioverter-defibrillator (ICD), catheter ablation and antiarrhythmic drugs (AADs) reduce ICD shocks, but the most effective approach remains uncertain.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lorne J. Gula, Asher Frydman, Habib R. Khan, George J. Klein, Peter Leong-Sit, Jaimie Manlucu, Jason D. Roberts, Anthony S. L. Tang, Raymond Yee, Allan C. Skanes
Summary: Patients with mildly impaired LV function and hemodynamically tolerated VT receive appropriate ICD therapies over the 3 years following implant. Recurrent VT/VF rates can be much more rapid after ICD placement, with 23% of patients going on to receive appropriate ICD shocks.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander Diamond, Ilan Goldenberg, Arwa Younis, Ido Goldenberg, Ramya Sampath, Valentina Kutyifa, Anita Y. Chen, Scott Mcnitt, Bronislava Polonsky, Jonathan S. Steinberg, Wojciech Zareba, Mehmet K. Aktas
Summary: This study found that among heart failure patients with an implantable cardioverter-defibrillator, treatment with carvedilol was associated with a lower risk of atrial arrhythmia and inappropriate ICD shocks compared to treatment with metoprolol.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Syed Bukhari, Bilal Khan
Summary: Cardiac amyloidosis is a disease caused by deposition of misfolded AL or ATTR amyloid fibrils in the myocardium, resulting in restrictive cardiomyopathy and potential death. Ventricular arrhythmias are common, especially in AL, and can be due to several mechanisms including inflammatory cascade activation and systemic amyloid deposition. There is an increased risk of sudden cardiac death in cardiac amyloidosis, particularly in AL. The use of implantable cardioverter-defibrillators in cardiac amyloidosis remains controversial, as there is limited evidence for their effectiveness in primary prevention.(c) 2023 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
JOURNAL OF CARDIOLOGY
(2023)
Article
Oncology
Martijn H. van der Ree, Wiert F. Hoeksema, Adrian Luca, Jorrit Visser, Brian Balgobind, Michiel Zumbrink, Raymond Spier, Claudia Herrera-Siklody, Justin Lee, Matthew Bates, Jim Daniel, Clive Peedell, Judit Boda-Heggemann, Boris Rudic, Roland Merten, Edith M. Dieleman, Cristopher A. Rinaldi, Shahreen Ahmad, John Whitaker, Pranav Bhagirath, Matthew Q. Hatton, Stephen Riley, Melanie Grehn, Luis Schiappacasse, Oliver Blanck, Stephan Hohmann, Etienne Pruvot, Pieter G. Postema
Summary: This retrospective study evaluated the impact of STAR treatment on ICD functioning. The results showed that within the reported dose range, STAR treatment did not result in major ICD malfunction or clinically relevant alterations in ICD functioning. This indicates that STAR treatment is safe in terms of ICD functioning.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Christian Hauck, Andreas Schober, Alexander Schober, Sabine Fredersdorf, Ute Hubauer, Lars Maier, Andreas Keyser, Moritz Huttelmaier, Thomas Fischer, Carsten Jungbauer, Ekrem Uecer
Summary: This study investigated the impact of changes in patient care during the COVID-19 pandemic on the arrhythmic and clinical condition of patients with an implantable cardioverter defibrillator (ICD). The findings showed that the reduction of in-person visits did not result in a deterioration of the patients' arrhythmic and clinical condition.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Alwin B. P. Noordman, Alexander H. Maass, Hessel Groenveld, Bart A. Mulder, Michiel Rienstra, Yuri Blaauw
Summary: This study showed that myocardial scar characterization based on cardiac magnetic resonance imaging can improve risk stratification for ventricular arrhythmia occurrence in patients with ischemic cardiomyopathy who received an Implantable Cardioverter-Defibrillator (ICD). The analysis revealed that total scar mass and border zone mass independently predicted appropriate ICD therapy, suggesting the importance of myocardial scar assessment in determining the risk of ventricular arrhythmias in this patient population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biology
Fabrizio Guarracini, Alberto Preda, Eleonora Bonvicini, Alessio Coser, Marta Martin, Silvia Quintarelli, Lorenzo Gigli, Matteo Baroni, Sara Vargiu, Marisa Varrenti, Giovanni Battista Forleo, Patrizio Mazzone, Roberto Bonmassari, Massimiliano Marini, Andrea Droghetti
Summary: The difference between subcutaneous implantable cardioverter defibrillators (S-ICDs) and transvenous ICDs (TV-ICDs) lies in the extra-thoracic implantation of S-ICDs, without endovascular components. S-ICDs have been rapidly adopted due to their improved safety profile, especially among younger patients. Although S-ICDs show comparable efficacy, reliability, and safety outcomes to TV-ICDs, technical issues limit their employment, making them an alternative rather than a mainstream option.
Article
Cardiac & Cardiovascular Systems
Maarten Z. H. Kolk, Samuel Ruiperez-Campillo, Brototo Deb, Erik J. Bekkers, Cornelis P. Allaart, Albert J. Rogers, Anne-Lotte C. J. van der Lingen, Laura Alvarez Florez, Ivana Isgum, Bob D. De Vos, Paul Clopton, Arthur A. M. Wilde, Reinoud E. Knops, Sanjiv M. Narayan, Fleur V. Y. Tjong
Summary: This study aimed to improve risk stratification for implantable cardioverter-defibrillator (ICD) implantation by using machine learning (ML) models that combine clinical variables with 12-lead electrocardiograms (ECG) time-series features.
Article
Cardiac & Cardiovascular Systems
Piotr Futyma, Jaroslaw Sander, Kamil Ciapala, Ryszard Gluszczyk, Agnieszka Wysokinska, Marian Futyma, Piotr Kulakowski
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Aleksander Kusiak, Marek Jastrzebski, Adam Bednarski, Piotr Kulakowski, Roman Piotrowski, Edward Kozluk, Artur Baszko, Danuta Czarnecka
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Piotr Futyma, Piotr Kulakowski
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Piotr Futyma, Kamil Ciapala, Jaroslaw Sander, Ryszard Gluszczyk, Marian Futyma, Piotr Kulakowski
KARDIOLOGIA POLSKA
(2020)
Article
Cardiac & Cardiovascular Systems
Konrad Dudek, Piotr Futyma, Marian Futyma, Sebastian Stec, Piotr Kulakowski
KARDIOLOGIA POLSKA
(2020)
Article
Cardiac & Cardiovascular Systems
Anna Kucharz, Piotr Kulakowski
KARDIOLOGIA POLSKA
(2020)
Article
Biochemistry & Molecular Biology
Joanna Giebultowicz, Natalia Korytowska, Roman Piotrowski, Piotr Kulakowski, Gniewomir Latacz, Ewa Szymanska, Barbara Wisniowska, Sebastian Polak
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cardiac & Cardiovascular Systems
Piotr Kulakowski, Agnieszka Sikorska, Roman Piotrowski, Tomasz Krynski, Jakub Baran
Summary: This study evaluates the efficacy of ablation for paroxysmal atrial fibrillation (PAF) in a medium volume EP center over the past years. The overall efficacy of ablation increased over time, especially with radiofrequency ablation (RF), while the rate of peri-procedural complications remained stable. The results demonstrate that progress in PAF ablation reported by highly-skilled centers can be reproduced in real-life settings by less experienced operators.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Roman Piotrowski, Jakub Baran, Tomasz Krynski, Agnieszka Sikorska, Piotr Kulakowski
Summary: Experimental studies showed a shift in the leading pacemaker site based on parasympathetic or sympathetic dominance, and radiofrequency catheter ablation of ganglionated plexi can overcome deleterious effects of enhanced parasympathetic tone. Two patients who underwent GP ablation achieved complete vagal denervation, leading to a cranial shift of sinus node activation area and changes in surface P wave morphology. Confirmation of this unique phenomenon is needed in larger prospective studies.
JOURNAL OF ELECTROCARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ilona Michalowska, Katarzyna Dudzinska, Ilona Kowalik, Pawel Kwiatek, Roman Piotrowski, Piotr Kulakowski, Jakub Baran
Summary: The aim of this study was to evaluate the coexistence of left atrial septal pouch (LASP) and atrial fibrillation (AF) in patients with a history of stroke. The results showed that the presence of LASP is not more prevalent in patients with a history of stroke.
JOURNAL OF THORACIC IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Katarzyna Dudzinska-Szczerba, Ilona Michalowska, Roman Piotrowski, Agnieszka Sikorska, Agnieszka Paszkowska, Urszula Stachnio, Ilona Kowalik, Piotr Kulakowski, Jakub Baran
Summary: The ASSAM study revealed that there are differences in LAA morphology between AF patients who had a stroke and those who did not, with the distance from LAA ostium to the first LAA bend being an independent predictor of stroke risk.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joanna Giebultowicz, Natalia Korytowska, Monika Sobiech, Sebastian Polak, Barbara Wisniowska, Roman Piotrowski, Piotr Kulakowski, Piotr Lulinski
Summary: This study aimed to develop a magnetic molecularly imprinted nano-conjugate sorbent for effective dispersive solid phase extraction of ANT and ANT-OH. The sorbent was characterized in terms of adsorption properties, morphology, structure, and elemental composition. Results showed that the sorbent could successfully extract ANT and ANT-OH from human plasma, and the analytical strategy could be a versatile tool to explain the pharmacological activity of these compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Roman Piotrowski, Anna Zuk, Jakub Baran, Agnieszka Sikorska, Tomasz Krynski, Piotr Kulakowski
Summary: The study findings demonstrate that Cardioneuroablation significantly affects the type of VV reaction, changing cardioinhibition to vasodepression or normalizing the response to orthostatic stress. Changes in heart rate and heart rate variability suggest attenuation of parasympathetic activity post-procedure.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Article
Cardiac & Cardiovascular Systems
Piotr Futyma, Lukasz Zarebski, Aleksandra Wrzos, Piotr Kulakowski
JOURNAL OF ELECTROCARDIOLOGY
(2020)
Article
Medicine, General & Internal
Roman Piotrowski, Beata Zaborska, Ewa Pilichowska-Paszkiet, Malgorzata Sikora-Frac, Jakub Baran, Piotr Kulakowski
ARCHIVES OF MEDICAL SCIENCE
(2020)