Review
Medicine, General & Internal
Francesco Condello, Carmen Spaccarotella, Sabato Sorrentino, Ciro Indolfi, Giulio G. G. Stefanini, Alberto Polimeni
Summary: The advancements in stent technologies, pharmacotherapy, and understanding of implantation techniques have reduced the risk of stent failure. However, stent thrombosis and in-stent restenosis still pose a public health problem. Various risk factors associated with patient, lesion, device, and procedure have been identified. Further research is needed to determine the time-dependence of these risk factors in the occurrence of in-stent restenosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Hyo-Soo Kim, Jeehoon Kang, Doyeon Hwang, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo, Seok Yeon Kim, Keun-Ho Park, Seung-Woon Rha, Won-Yong Shin, Hong-Seok Lim, Kyungil Park, Kyung Woo Park
Summary: The study demonstrated that in patients with acute coronary syndrome (ACS), durable polymer drug-eluting stents (DP-DES) were noninferior to biodegradable polymer DES (BP-DES) in terms of patient-oriented composite outcomes at 12 months after percutaneous coronary intervention.
Article
Chemistry, Multidisciplinary
Jung-Hoon Park, Jieun Park, Yejong Park, Jeon Min Kang, Dae Sung Ryu, Jeongsu Kyung, Jong Keon Jang, Changmo Hwang, In Kyong Shim, Ho-Young Song, Su-Geun Yang, Song Cheol Kim
Summary: The study investigated the efficacy and safety of an acetazolamide-eluting biodegradable tubular stent for preventing self-digestion and inflammatory diseases caused by pancreatic juice leakage in a porcine model. Results showed that the stent significantly suppressed intra-abdominal inflammatory diseases and prevented late stricture formation at the anastomotic site.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Mangesh Sane, Vikas Dighe, Rucha Patil, Puthusserickal A. Hassan, Santosh Gawali, Vandana Patravale
Summary: Localized drug delivery with sustained elution characteristics from nanocarrier coated stents is a viable therapeutic approach to address concerns related to coronary stent therapy. A Sirolimus and Bivalirudin releasing nanoparticles (NPs) coated stent was fabricated for concurrent mitigation of vascular restenosis and acute stent thrombosis, showing superior anti-proliferative activity and higher cellular uptake in human coronary artery smooth muscle cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Biomedical
Jiabin Zong, Quanwei He, Yuxiao Liu, Min Qiu, Jiehong Wu, Bo Hu
Summary: This review comprehensively summarizes the development of bioresorbable stents based on their preclinical/clinical trials and discusses translational research and novel technologies related to these stents. These findings are expected to inspire the design of novel stents and optimization approaches to improve the efficacy of treatments for cardiovascular diseases.
MATERIALS TODAY BIO
(2022)
Article
Medicine, General & Internal
Haoyong Yuan, Zhongshi Wu, Ting Lu, Tingting Wei, Yifan Zeng, Yalin Liu, Can Huang
Summary: This meta-analysis compared the safety and effectiveness of biodegradable polymer drug-eluting stents (BP-DES) and durable polymer drug-eluting stents (DP-DES) in patients with acute coronary syndrome (ACS). The study found that both types of stents demonstrated similar safety and efficacy profiles at 12 months, but a slight increase in adverse cardiovascular events was observed in the BP-DES group over the 2-year follow-up period.
Article
Multidisciplinary Sciences
Jinzhou Zhu, Xiyuan Zhang, Jialin Niu, Yongjuan Shi, Zhengbin Zhu, Daopeng Dai, Chenxin Chen, Jia Pei, Guangyin Yuan, Ruiyan Zhang
Summary: A drug-eluting bioresorbable stent (BRS) has been developed as an alternative to the standard drug-eluting stent (DES) due to concerns over the rigid constraint of DES. A new patented Mg-Nd-Zn-Zr alloy (JDBM) was developed to reduce the rapid degradation rate of Mg-based BRSs. In vitro and in vivo experiments showed that a PDLLA/RAPA coated JDBM BRS demonstrated low risks and maintained mechanical integrity after 6 months, with similar efficacy to standard DES.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Valentin Chioncel, Catalina Liliana Andrei, Radu Brezeanu, Crina Sinescu, Anamaria Avram, Alin Laurentiu Tatu
Summary: The development of coronary stents has revolutionized the treatment of coronary heart disease, but allergic reactions are a common complication. Careful selection of treatment for allergic patients can help reduce the occurrence of complications.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yong Zhu, Kesen Liu, Maolin Chen, Yan Liu, Ang Gao, Chengping Hu, Hong Li, Huagang Zhu, Hongya Han, Jianwei Zhang, Yingxin Zhao
Summary: The triglyceride-glucose (TyG) index is positively associated with in-stent restenosis (ISR) after drug-eluting stent (DES) implantation in patients with acute coronary syndrome (ACS). Higher TyG index is related to higher prevalence of DES-ISR in ACS patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Johny Nicolas, Carlo Andrea Pivato, Mauro Chiarito, Frans Beerkens, Davide Cao, Roxana Mehran
Summary: Coronary stents have revolutionized the treatment of coronary artery disease. The introduction of new-generation drug-eluting stents has greatly improved the safety and efficacy compared to bare-metal stents. There are now over 20 different DES types available, each with its unique features and characteristics. The clinical implications of stent design in high-risk subsets of patients are also discussed.
CARDIOVASCULAR RESEARCH
(2023)
Review
Health Care Sciences & Services
Flavius-Alexandru Gherasie, Chioncel Valentin, Stefan-Sebastian Busnatu
Summary: In patients undergoing percutaneous coronary intervention, second-generation drug-eluting stents (DES) are the gold standard for revascularization. These stents reduce the need for repeat revascularizations compared to conventional stents. However, there are concerns about the risk of stent thrombosis and recoil in certain lesion types. Ultra-thin strut stents offer advantages such as improved deliverability and reduced thrombosis risk, but they may not be suitable for all lesions.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Engineering, Biomedical
Hongjie Zhang, Wanqian Zhang, Hong Qiu, Gui Zhang, Xin Li, Haiping Qi, Jingzhen Guo, Jie Qian, Xiaoli Shi, Xian Gao, Daokun Shi, Deyuan Zhang, Runlin Gao, Jiandong Ding
Summary: This study applies a metal-polymer composite strategy to accelerate the degradation of iron-based stents and highlights the importance of serum, particularly albumin, in evaluating the biocompatibility of vascular stents in vitro conditions. The study confirms the safety, efficacy, and appropriate biodegradability of the resultant metal-polymer composite stent through clinical research and patient follow-up.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Eunyoung Jeon, Jeon Min Kang, Ga-Hyun Bae, Chu Hui Zeng, Seungyong Shin, Byeongdu Lee, Wooram Park, Jung-Hoon Park, Joonseok Lee
Summary: A flexible 3D nanonetworked silica film (NSF) was developed as a drug delivery platform for self-expandable metallic stents (SEMSs), capable of withstanding mechanical stress during dynamic expansion and improving therapeutic effects.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Medicine, General & Internal
Katharina Schochlow, Melissa Weissner, Florian Blachutzik, Niklas F. Boeder, Monique Trobs, Liv Lorenz, Jouke Dijkstra, Thomas Munzel, Stephan Achenbach, Holger Nef, Tommaso Gori
Summary: The prevalence of stent fractures (SFs) is high and associated with calcific and bifurcation lesions, as well as device asymmetry/eccentricity. SFs are also related to device thrombosis and restenosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Kyung Hoon Cho, Myung Ho Jeong, Dae Sung Park, Moonki Kim, JungHa Kim, Jun-Kyu Park, Xiongyi Han, Dae Young Hyun, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn
Summary: The study showed that the TIGEREVOLUTION® stent demonstrated efficacy and safety comparable to the XIENCE Alpine® stent 6 months after implantation, supporting the need for further clinical studies on the TIGEREVOLUTION® stent.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
