The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis

JTV519 (K201) reduces sarcoplasmic reticulum Ca2+leak and improves diastolic functionin vitroin murine and human non-failing myocardium

(2012) M Sacherer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Enhanced Sarcoplasmic Reticulum Ca 2+ Leak and Increased Na + -Ca 2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

(2012) Niels Voigt et al.   CIRCULATION

Shortened Ca 2+ Signaling Refractoriness Underlies Cellular Arrhythmogenesis in a Postinfarction Model of Sudden Cardiac Death

(2012) Andriy E. Belevych et al.   CIRCULATION RESEARCH

Hyperphosphorylation of the Cardiac Ryanodine Receptor at Serine 2808 Is Not Involved in Cardiac Dysfunction After Myocardial Infarction

(2012) Hongyu Zhang et al.   CIRCULATION RESEARCH

Role of RyR2 Phosphorylation at S2814 During Heart Failure Progression

(2012) Jonathan L. Respress et al.   CIRCULATION RESEARCH

Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome

(2012) Evangelia G. Kranias et al.   CIRCULATION RESEARCH

The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function

(2011) Andriy E. Belevych et al.   CARDIOVASCULAR RESEARCH

Phosphatase-1 inhibitor-1 in physiological and pathological  -adrenoceptor signalling

(2011) K. Wittkopper et al.   CARDIOVASCULAR RESEARCH

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone

(2011) B Julie He et al.   NATURE MEDICINE

Differential Cardiac Remodeling in Preload Versus Afterload

(2010) Karl Toischer et al.   CIRCULATION

Kinetics of FKBP12.6 Binding to Ryanodine Receptors in Permeabilized Cardiac Myocytes and Effects on Ca Sparks

(2010) Tao Guo et al.   CIRCULATION RESEARCH

Inhibition of Elevated Ca 2+ /Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium

(2010) Samuel Sossalla et al.   CIRCULATION RESEARCH

CaMKII-Dependent Diastolic SR Ca 2+ Leak and Elevated Diastolic Ca 2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation

(2010) Stefan Neef et al.   CIRCULATION RESEARCH

CaMKII regulation of phospholamban and SR Ca2+ load

(2010) Alicia Mattiazzi et al.   HEART RHYTHM

Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure

(2010) Tim Seidler et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Heart Failure Epidemic

(2010) Véronique L. Roger   International Journal of Environmental Research and Public Health

Risk Factors for Heart Failure: A Population-Based Case-Control Study

(2009) Shannon M. Dunlay et al.   AMERICAN JOURNAL OF MEDICINE

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum

(2009) Karl Toischer et al.   BASIC RESEARCH IN CARDIOLOGY

Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Cardiac Arrhythmogenesis in Heart Failure

(2009) Can M. Sag et al.   Circulation-Heart Failure

Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes

(2008) Sabine Huke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

Conditional FKBP12.6 Overexpression in Mouse Cardiac Myocytes Prevents Triggered Ventricular Tachycardia Through Specific Alterations in Excitation- Contraction Coupling

(2008) Barnabas Gellen et al.   CIRCULATION

Termination of Cardiac Ca 2+ Sparks

(2008) Aleksey V. Zima et al.   CIRCULATION RESEARCH

Heart Failure-Related Hospitalization in the U.S., 1979 to 2004

(2008) Jing Fang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY