Article
Urology & Nephrology
Ken Iseri, Masahide Mizobuchi, Renaud Winzenrieth, Ludovic Humbert, Tomohiro Saitou, Tadashi Kato, Yutaka Nakajima, Mikio Wakasa, Kanji Shishido, Hirokazu Honda
Summary: This retrospective study investigated the effects of long-term denosumab therapy and discontinuation on the cortical bone of the hip regions in dialysis patients. The study found that denosumab therapy led to higher bone mineral densities and improved strength indices in the hip region. However, discontinuation of denosumab resulted in a decline in these measurements.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Transplantation
Aarti Mathur, JiYoon B. Ahn, Whitney Sutton, Nadia M. Chu, Alden L. Gross, Dorry L. Segev, Mara McAdams-DeMarco
Summary: Receiving treatment for secondary hyperparathyroidism (SHPT) was associated with a lower risk of incident dementia among older patients with end-stage renal disease (ESRD). The beneficial effect of SHPT treatment differed by sex and race, with females and those of Asian or Black race experiencing the greatest reduction in dementia risk.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Urology & Nephrology
Mathias Haarhaus, Louise Aaltonen, Daniel Cejka, Mario Cozzolino, Renate T. de Jong, Patrick D'Haese, Pieter Evenepoel, Marie-Helene Lafage-Proust, Sandro Mazzaferro, Eugene McCloskey, Syazrah Salam, Hanne Skou Jorgensen, Marc Vervloet
Summary: Patients with chronic kidney disease (CKD) are at increased risk of fractures, and diagnosing and treating fracture risk in CKD patients can be challenging. This review discusses diagnostic and treatment options for fracture risk in CKD patients based on disease mechanisms, clinical experience, and research findings. The authors conclude that many approaches to diagnosing and treating osteoporosis can be applied to CKD patients.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Cleo C. L. van Aanhold, Angela Koudijs, Kyra L. Dijkstra, Ron Wolterbeek, Jan A. Bruijn, Cees van Kooten, Hans J. Baelde
Summary: The study found that transfection with sFLT1 did not aggravate renal fibrosis and peritubular capillary loss, but reduced the expression of pro-fibrotic and pro-inflammatory markers. sFLT1 mRNA levels were not correlated with interstitial fibrosis or PTC loss in human samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Ana Carina Ferreira, Patricia Cotovio, Ines Aires, Marco Mendes, David Navarro, Cecilia Silva, Fernando Caeiro, Rute Salvador, Bruna Correia, Guadalupe Cabral, Fernando Nolasco, Anibal Ferreira
Summary: This study investigated the prevalence and phenotype of bone disease in kidney transplant patients, and examined the associations between FGF23, sclerostin, bone histomorphometry, cardiovascular disease, and mortality. The results showed that age, sclerostin levels, and other factors were associated with different types of bone diseases. High levels of FGF23 and sclerostin were found to be correlated with higher cardiovascular risk and involvement of low bone volume in extra-osseous calcifications.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Editorial Material
Medicine, Research & Experimental
Keiichi Torimoto, Satoru Eguchi
Summary: The study highlights the role of sPRR as a ligand for AT1R, causing endothelial dysfunction and hypertension. The interaction between sPRR and AT1R contributes to obesity-induced cardiovascular diseases. The sPRR/AT1R complex may be a potential therapeutic target for endothelial dysfunction.
Article
Urology & Nephrology
Pierre-Emmanuel Cailleaux, Agnes Ostertag, Marie Metzger, Benedicte Stengel, Julie Boucquemont, Pascal Houillier, Martin Flamant, Pablo Urena-Torres, Martine Cohen-Solal
Summary: The study in the NephroTest cohort found that CKD is associated with lower BMD and higher PTH levels, emphasizing the importance of early detection and intervention. Longitudinal analysis revealed that the proximal radius was the most significantly affected site of bone loss after 4.3 years.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Urology & Nephrology
Kalani L. Raphael, Ronit Katz, Brett Larive, Cynthia Kendrick, Tamara Isakova, Stuart Sprague, Myles Wolf, Dominic S. Raj, Linda F. Fried, Jennifer Gassman, Andy Hoofnagle, Alfred K. Cheung, Joachim H. Ix
Summary: This study aimed to investigate the effect of sodium bicarbonate treatment on bone metabolism in CKD patients. The results showed that sodium bicarbonate treatment increased soluble klotho levels, but had no effect on other bone biomarkers.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuan Li, Qingya Dang, Zhiyi Li, Chuting Han, Yan Yang, Miaoling Li, Pengyun Li
Summary: This study found that acacetin protects against endothelial dysfunction in hypertension by activating the AKT/eNOS pathway and modulating mitochondrial function. The findings suggest that acacetin may be a potential therapeutic agent for the prevention and treatment of hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chen Liang, Di Zhu, Wei Xia, Zi Hong, Qiu-Shi Wang, Yu Sun, Yan-Chao Yang, Song-Qi Han, Liang-Liang Tang, Jie Lou, Ming-Ming Wu, Zhi-Ren Zhang
Summary: Lenvatinib-induced hypertension is associated with ferroptosis of endothelial cells, and inhibition of ferroptosis alleviates hypertension and endothelial dysfunction.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Psychiatry
Siddharam S. Janti, Sai Krishna Tikka
Summary: We conducted meta-analyses on schizophrenia studies using OCTA to assess vessel density (VD). The results showed significantly lower VD in schizophrenia patients compared to healthy controls in the peripapillary region of the optic disc, including both superior and inferior hemispheres.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Janae Gonzales, Kelsey Holbert, Kamryn Czysz, Joseph George, Caroline Fernandes, Dustin R. Fraidenburg
Summary: Pulmonary hypertension in sickle cell disease is an independent predictor of mortality. This study explores the direct effects of hemin on pulmonary artery endothelium and found that it leads to endothelial dysfunction through endothelial to mesenchymal transition (EndoMT).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Medicine, General & Internal
Baris Afsar, Mehmet Kanbay, Rengin Elsurer Afsar
Summary: This article discusses the use of chlorthalidone as an antihypertensive agent in patients with advanced chronic kidney disease and poorly controlled hypertension, highlighting its potential in controlling high blood pressure. However, the article lacks a thorough discussion of the common and potentially harmful side effects of thiazide diuretics.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Geoffrey Newcomb, Laszlo Farkas
Summary: Our understanding of the pathophysiology of pulmonary arterial hypertension (PAH) has evolved over recent years, highlighting the importance of endothelial cell dysfunction and inflammation. Pulmonary vascular endothelial cells play a unique role in maintaining vascular integrity and function, and their dysregulated response to injury contributes to the development of PAH. Recent research has shown the presence of multiple distinct subpopulations of endothelial cells and their involvement in aberrant endothelial injury repair. Factors such as clonal expansion, immune dysregulation, and genetic mutations also play a role in the pathogenesis of PAH.
FRONTIERS IN MEDICINE
(2023)
Review
Physiology
Karim Ullah, Rongxue Wu
Summary: Endothelial cells play a crucial role in maintaining cardiovascular homeostasis, tissue growth, and repair, relying on glycolysis to resist hypoxic damage and promote angiogenesis in ischemic regions. Hypoxia-inducible factors (HIFs) are key regulators of endothelial cell metabolism and angiogenesis, with varying effects on cardiovascular dysfunction in different disease settings.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Alexandre Persu, Piotr Dobrowolski, Heather L. Gornik, Jeffrey W. Olin, David Adlam, Michel Azizi, Pierre Boutouyrie, Rosa Maria Bruno, Marion Boulanger, Jean-Baptiste Demoulin, Santhi K. Ganesh, Tomasz J. Guzik, Magdalena Januszewicz, Jason C. Kovacic, Mariusz Kruk, Peter de Leeuw, Bart L. Loeys, Marco Pappaccogli, Melanie H. A. M. Perik, Emmanuel Touze, Patricia Van der Niepen, Daan J. L. Van Twist, Ewa Warchol-Celinska, Aleksander Prejbisz, Andrzej Januszewicz
Summary: Fibromuscular dysplasia (FMD) is a non-atherosclerotic vascular disease that predominantly affects women. Its exact cause is still poorly understood, but it is likely to involve a combination of genetic and environmental factors, leading to arterial fibrosis, cellular hyperplasia, and distortion of the arterial wall architecture. FMD can affect various arteries throughout the body, not just the renal and cerebrovascular arteries.
CARDIOVASCULAR RESEARCH
(2022)
Editorial Material
Peripheral Vascular Disease
Pierre Boutouyrie, Rachel E. Climie, Rosa-Maria Bruno
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Biology
Kristen M. Meiburger, Francesco Marzola, Guillaume Zahnd, Francesco Faita, Christos P. Loizou, Nolann Laine, Catarina Carvalho, David A. Steinman, Lorenzo Gibello, Rosa Maria Bruno, Ricarda Clarenbach, Martina Francesconi, Andrew N. Nicolaides, Herve Liebgott, Aurelio Campilho, Reza Ghotbi, Efthyvoulos Kyriacou, Nassir Navab, Maura Griffin, Andrie G. Panayiotou, Rachele Gherardini, Gianfranco Varetto, Elisabetta Bianchini, Constantinos S. Pattichis, Lorenzo Ghiadoni, Jose Rouco, Maciej Orkisz, Filippo Molinari
Summary: This study presents technical outlooks on computerized carotid intima-media thickness (CIMT) measurements and provides considerations for the development and comparison of these methods. A multi-center database of 500 images was collected and three manual segmentations and seven computerized methods were employed to measure the CIMT. The computerized methods showed comparable results with previous studies and demonstrated promising segmentation outcomes. The entire database has been made publicly available for further research and comparison.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Peripheral Vascular Disease
Agnieszka Latosinska, Rosa Maria Bruno, Marco Pappaccogli, Alessandra Bacca, Christophe Beauloye, Pierre Boutouyrie, Hakim Khettab, Jan A. Staessen, Stefano Taddei, Laurent Toubiana, Miikka Vikkula, Harald Mischak, Alexandre Persu
Summary: This study investigates the use of urinary proteomics in the diagnosis of FMD and develops a classifier to distinguish FMD patients from healthy controls and other diseases. Furthermore, the study finds a positive correlation between the proteomic score and the arterial geometry and mechanics in FMD patients.
Review
Cardiac & Cardiovascular Systems
Celia Alvarez-Bueno, Ivan Cavero-Redondo, Rosa Maria Bruno, Alicia Saz-Lara, Irene Sequi-Dominguez, Blanca Notario-Pacheco, Vicente Martinez-Vizcaino
Summary: This study utilized systematic review and meta-analysis to explore the relationship between carotid intima media thickness (IMT) and cognitive function. The results showed a negative association between IMT and cognitive function, particularly in cross-sectional studies. However, this association lost significance in longitudinal studies and when controlling for covariates in cross-sectional studies. Furthermore, the strength of these associations did not appear to be modified by age, sex, body mass index, and baseline IMT values.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Cardiac & Cardiovascular Systems
Alicia Saz-Lara, Rosa Maria Bruno, Ivan Cavero-Redondo, Celia Alvarez-Bueno, Blanca Notario-Pacheco, Vicente Martinez-Vizcaino
Summary: This systematic review and meta-analysis found that arterial stiffness, systolic blood pressure, and diastolic blood pressure are associated with incident hypertension. These findings are clinically important for the prevention of arterial hypertension and reducing cardiovascular morbidity and mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Peripheral Vascular Disease
Stephane Laurent, Claudia Agabiti-Rosei, Rosa Maria Bruno, Damiano Rizzoni
Summary: Microcirculation and macrocirculation form a dangerous cross-link in hypertension, leading to vessel damage and elevated blood pressure. This vicious cycle can be reversed through pharmacological treatment.
Article
Acoustics
Federica Poli, Catherine Fortier, Hakim Khettab, Francesco Faita, Saverio Vitali, Giacomo Aringhieri, Lorenzo Ghiadoni, Stefano Taddei, Laurence Amar, Aurelien Lorthioir, Pierre Boutouyrie, Rosa Maria Bruno
Summary: Ultrahigh-frequency ultrasound is a useful tool for studying human small muscular arteries and understanding arterial aging. The Carotid Studio software is a valid and reproducible tool for analyzing UHFUS scans of digital arteries.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Review
Medicine, General & Internal
Junior Justin, Antoine Fayol, Rosa-Maria Bruno, Hakim Khettab, Pierre Boutouyrie
Summary: High blood pressure is the leading cause of death worldwide, with approximately 1.5 billion people suffering from hypertension in 2010. The guidelines for hypertension management by Canadian, American, International, and European organizations provide the basic principles, but they differ in the definition, measurement, and treatment of blood pressure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Francesca Saladini, Costantino Mancusi, Fabio Bertacchini, Francesco Spannella, Alessandro Maloberti, Alessandra Giavarini, Martina Rosticci, Rosa Maria Bruno, Giacomo Pucci, Davide Grassi, Martino Pengo, Maria Lorenza Muiesan
Summary: Management and treatment of hypertension emergency and urgency may vary according to the work setting of the physicians. Cardiologists and intensive care unit doctors have different preferences in defining the conditions, assessing blood pressure, and prescribing medications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Correction
Cardiac & Cardiovascular Systems
Alicia Saz-Lara, Rosa Maria Bruno, Ivan Cavero-Redondo, Celia alvarez-Bueno, Blanca Notario-Pacheco, Vicente Martinez-Vizcaino
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Eva Gerdts, Isabella Sudano, Sofie Brouwers, Claudio Borghi, Rosa Maria Bruno, Claudio Ceconi, Veronique Cornelissen, Francois Dievart, Marc Ferrini, Thomas Kahan, Maja Lisa Lochen, Angela H. E. M. Maas, Felix Mahfoud, Anastasia S. Mihailidou, Trine Moholdt, Gianfranco Parati, Giovanni de Simone
Summary: Sex chromosomes and sex hormones play differential roles in blood pressure regulation and cardiovascular risk factors between females and males with essential arterial hypertension. The risk for cardiovascular disease is higher in females at lower blood pressure levels, suggesting the need for sex-specific thresholds in hypertension diagnosis. It is currently unknown if hypertension should be managed differently in females and males, highlighting the need for focused research on sex-specific prevention and management.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Jordi Alastruey, Peter H. Charlton, Vasiliki Bikia, Birute Paliakaite, Bernhard Hametner, Rosa Maria Bruno, Marijn P. Mulder, Samuel Vennin, Senol Piskin, Ashraf W. Khir, Andrea Guala, Christopher C. Mayer, Jonathan Mynard, Alun D. Hughes, Patrick Segers, Berend E. Westerhof
Summary: Arterial pulse waves (PWs), such as blood pressure and photoplethysmogram (PPG) signals, are rich sources of information for assessing vascular age and identifying individuals at elevated cardiovascular risk. This review explores the possibilities and limitations of reduced-order biophysical models and theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information. Detailed mathematical derivations are provided, demonstrating the relationships between these models and methods. Suggestions for future research are also outlined to fully utilize the potential of modeling and analyzing PW signals for accurate vascular age assessment.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Peripheral Vascular Disease
Keeron Stone, Dave Veerasingam, Michelle L. Meyer, Kevin S. Heffernan, Simon Higgins, Rosa Maria Bruno, Celia Alvarez Bueno, Marcus Doeerr, Arno Schmidt-Trucksass, Dimitrios Terentes-Printzios, Julija Voicehovska, Rachel E. Climie, Chloe Park, Giacomo Pucci, Martin Bahls, Lee Stoner
Summary: This review critiques the literature on the clinical assessment and management of cardiovascular disease using brachial-ankle pulse wave velocity (baPWV). It discusses the measurement of baPWV, its differences from carotid-femoral pulse wave velocity, and its value as an independent vascular biomarker. The review also identifies the evidence supporting baPWV in terms of concept validation, prospective validation, incremental value, and clinical utility, as well as the areas where evidence is limited or lacking.
Review
Peripheral Vascular Disease
Rosa-Maria Bruno, Szabolcs Varbiro, Giacomo Pucci, Janos Nemcsik, Mai Tone Lonnebakken, Karolina Kublickiene, Helena Schluchter, Chloe Park, Ioana Mozos, Andrea Guala, Bernhard Hametner, Ute Seeland, Pierre Boutouyrie
Summary: Blood pressure and vascular ageing trajectories differ between men and women due to sex-related and gender-related factors. Endogenous 17β-estradiol plays a protective role in women's vascular aging, but gender-related factors such as psychological stress and low socioeconomic status have a greater impact on vascular aging in women. On the other hand, men are more susceptible to the adverse effects of alcohol consumption and social deprivation. Unhealthy diet habits and smoking have a disproportional negative effect on women's vascular health. Therefore, future research and prevention strategies should take into account the complex role of gender-related factors.
JOURNAL OF HUMAN HYPERTENSION
(2023)