Article
Cardiac & Cardiovascular Systems
So Mi Jemma Cho, Satoshi Koyama, Michael C. Honigberg, Ida Surakka, Sara Haidermota, Shriienidhie Ganesh, Aniruddh P. Patel, Romit Bhattacharya, Hokyou Lee, Hyeon Chang Kim, Pradeep Natarajan
Summary: This study examined the associations and clinical utilities of various factors on coronary artery disease (CAD) recurrence, including genetic, sociodemographic, lifestyle, and clinical risk factors. The findings showed that current smoking and age at first CAD diagnosis were the most significant predictors of CAD recurrence. Other factors such as age at enrolment, CAD polygenic risk score, laboratory test results, and HDL cholesterol concentration were also significantly associated with recurrence risk.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yeela Talmor-Barkan, Noam Bar, Aviv A. Shaul, Nir Shahaf, Anastasia Godneva, Yuval Bussi, Maya Lotan-Pompan, Adina Weinberger, Alon Shechter, Chava Chezar-Azerrad, Ziad Arow, Yoav Hammer, Kanta Chechi, Sofia K. Forslund, Sebastien Fromentin, Marc-Emmanuel Dumas, S. Dusko Ehrlich, Oluf Pedersen, Ran Kornowski, Eran Segal
Summary: Multi-omic profiling of patients with coronary artery disease reveals links between alterations in the serum metabolome with genetics, diet, and the microbiome. The study found that these metabolomic alterations are associated with metabolic impairment preceding clinically overt coronary artery disease. The results highlight the importance of understanding risk-factor heterogeneity in coronary artery disease through the serum metabolome.
Article
Health Care Sciences & Services
Mikolaj Matysek, Krzysztof Wojcicki, Tomasz Tokarek, Artur Dziewierz, Tomasz Rakowski, Stanislaw Bartus, Dariusz Dudek
Summary: This study evaluated the impact of coronary artery bypass grafting (CABG) on lifestyle modifications and knowledge about coronary artery disease (CAD) compared to percutaneous coronary intervention (PCI). The study found that patients with a history of CABG had higher knowledge scores and better control of risk factors compared to patients with a history of PCI. This suggests that CABG may be more effective in educating patients and improving secondary prevention.
Article
Sport Sciences
Charles A. German, Jason Fanning, Matthew J. Singleton, Michael D. Shapiro, Peter H. Brubaker, Alain G. Bertoni, Joseph Yeboah
Summary: This study found that high levels of physical activity are negatively correlated with cardiovascular disease and all-cause mortality, indicating that high PA can reduce the risk of CVD and overall death. The research also suggests that even among individuals at high risk of CVD, high levels of PA do not pose additional risks.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Oncology
Kyle Wang, Hayley E. Malkin, Nicholas D. Patchett, Kevin A. Pearlstein, Hillary M. Heiling, Sean D. McCabe, Allison M. Deal, Panayiotis Mavroidis, Mary Oakey, Jeffrey Fenoli, Carrie B. Lee, J. Larry Klein, Brian C. Jensen, Thomas E. Stinchcombe, Lawrence B. Marks, Ashley A. Weiner
Summary: This study found that computed tomography (CT) coronary calcifications are associated with cardiac toxicity and can help ascertain baseline heart disease. The presence of coronary calcifications can identify high-risk patients and guide clinicians in taking measures before potentially cardiotoxic cancer treatments.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Multidisciplinary Sciences
Mehran Jaberinezhad, Mehdi Farhoudi, Seyed Aria Nejadghaderi, Mahasti Alizadeh, Mark J. M. Sullman, Kristin Carson-Chahhoud, Gary S. Collins, Saeid Safiri
Summary: This article reports on the burden of stroke and its risk factors in the Middle East and North Africa (MENA) region. The study shows a decrease in stroke prevalence and death rates over the past three decades, with significant differences among countries. Metabolic risk factors, particularly among older females in low socio-demographic index (SDI) countries, contribute the most to the burden of stroke in the region.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Goran Bergstrom, Margaretha Persson, Martin Adiels, Elias Bjornson, Carl Bonander, Hakan Ahlstrom, Joakim Alfredsson, Oskar Angeras, Goran Berglund, Anders Blomberg, John Brandberg, Mats Borjesson, Kerstin Cederlund, Ulf de Faire, Olov Duvernoy, Orjan Ekblom, Gunnar Engstrom, Jan E. Engvall, Erika Fagman, Mats Eriksson, David Erlinge, Bjorn Fagerberg, Agneta Flinck, Isabel Goncalves, Emil Hagstrom, Ola Hjelmgren, Lars Lind, Eva Lindberg, Per Lindqvist, Johan Ljungberg, Martin Magnusson, Maria Mannila, Hanna Markstad, Moman A. Mohammad, Fredrik H. Nystrom, Ellen Ostenfeld, Anders Persson, Annika Rosengren, Anette Sandstrom, Anders Sjalander, Magnus C. Skold, Johan Sundstrom, Eva Swahn, Stefan Soderberg, Kjell Toren, Carl Johan Ostgren, Tomas Jernberg
Summary: Through conducting a study using CCTA on a random sample of individuals aged 50 to 64, we found that silent coronary atherosclerosis is common in this population, particularly in individuals with higher CAC scores.
Article
Medicine, General & Internal
Afrose Liaquat, Ameerdad Khan, Saeed Ullah Shah, Hania Iqbal, Safa Iqbal, Atif Iqbal Rana, Habib Ur Rahman
Summary: This study investigates the use of coronary artery calcium scoring (CACS) as a tool for coronary artery disease (CAD) risk stratification and its association with conventional cardiovascular risk factors. The results demonstrate a strong positive correlation between CACS and coronary artery stenosis, indicating the potential of CACS as a useful tool for CAD risk assessment.
Review
Clinical Neurology
Petra Ijas
Summary: Pregnancy is a specific risk factor for stroke in women, and although rare, it leads to high maternal mortality and persistent neurological deficits. Recent studies have shown an increasing incidence of pregnancy-associated stroke, likely due to the rising prevalence of stroke risk factors among pregnant women. To reduce pregnancy-related stroke, increased awareness and preventive measures focusing on risk factor management and symptom recognition are necessary.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anurag Mehta, Nestor Vasquez, Colby R. Ayers, Jaideep Patel, Ananya Hooda, Amit Khera, Roger S. Blumenthal, Michael D. Shapiro, Carlos J. Rodriguez, Michael Y. Tsai, Laurence S. Sperling, Salim S. Virani, Michael J. Blaha, Parag H. Joshi
Summary: Elevated lipoprotein(a) and coronary artery calcium are independently associated with ASCVD risk, and may be concurrently useful in guiding primary prevention therapy decisions, as demonstrated in the MESA and DHS cohorts.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Jade Geerlings-Batt, Ashu Gupta, Zhonghua Sun
Summary: This study retrospectively reviewed the coronary computed tomography angiography datasets and CAD risk factor checklists of 250 patients, and found a relationship between narrow RCA-aorta angles and CAD, smoking, and increasing BMI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Andrew M. Freeman, Subha Raman, Monica Aggarwal, David J. Maron, Deepak L. Bhatt, Purvi Parwani, John Osborne, James P. Earls, James K. Min, Jeroen J. Bax, Michael D. Shapiro
Summary: This article introduces a precision heart care approach that focuses on atherosclerosis as the primary target for evaluation and treatment. By directly quantifying and characterizing atherosclerosis, it aims to improve diagnosis, risk stratification, therapeutic decision-making, and personalized disease tracking. The American College of Cardiology has introduced the Atherosclerosis Treatment Algorithms, which personalize medical interventions based on coronary computed tomography angiography findings and cardiovascular risk factors, leveraging atherosclerosis burden and progression as primary targets for therapeutic intervention.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Nutrition & Dietetics
Yuk-Lam Ho, Xuan-Mai T. Nguyen, Kelly Cho, Jason L. Vassy, David R. Gagnon, Christopher J. O'Donnell, J. Michael Gaziano, Peter W. F. Wilson, Luc Djousse
Summary: Regular chocolate consumption was associated with a lower risk of coronary artery disease among veterans, but this association was not observed among veterans with type 2 diabetes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Peripheral Vascular Disease
Takashi Hisamatsu, Minako Kinuta
Summary: Coronary artery calcium (CAC) detected by computed tomography scanning is a reliable indicator of subclinical atherosclerosis and has important implications for ASCVD risk assessment and primary prevention. However, more research is needed to validate its use and clinical efficacy in non-Western populations, including Japan.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Cardiac & Cardiovascular Systems
Laurits Juhl Heinsen, Gokulan Pararajasingam, Thomas Rueskov Andersen, Soren Auscher, Hussam Mahmoud Sheta, Helle Precht, Jess Lambrechtsen, Kenneth Egstrup
Summary: This study found a high prevalence of HRP in asymptomatic T2D patients, with HRP detection associated with specific patient characteristics. HRP was not correlated with high CACS, as HRP could be found even in patients with zero CACS.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Veerle Dam, N. Charlotte Onland-Moret, Stephen Burgess, Maria-Dolores Chirlaque, Sanne A. E. Peters, Ewoud Schuit, Kaja Tikk, Elisabete Weiderpass, Clare Oliver-Williams, Angela M. Wood, Anne Tjonneland, Christina C. Dahm, Kim Overvad, Marie-Christine Boutron-Ruault, Matthias B. Schulze, Antonia Trichopoulou, Pietro Ferrari, Giovanna Masala, Vittorio Krogh, Rosario Tumino, Giuseppe Matullo, Salvatore Panico, Jolanda M. A. Boer, W. M. Monique Verschuren, Marit Waaseth, Maria Jose Sanchez Perez, Pilar Amiano, Liher Imaz, Conchi Moreno-Iribas, Olle Melander, Sophia Harlid, Maria Nordendahl, Patrik Wennberg, Timothy J. Key, Elio Riboli, Carmen Santiuste, Rudolf Kaaks, Verena Katzke, Claudia Langenberg, Nicholas J. Wareham, Heribert Schunkert, Jeanette Erdmann, Christina Willenborg, Christian Hengstenberg, Marcus E. Kleber, Graciela Delgado, Winfried Marz, Stavroula Kanoni, George Dedoussis, Panos Deloukas, Majid Nikpay, Ruth McPherson, Markus Scholz, Andrej Teren, Adam S. Butterworth, Yvonne T. van der Schouw
Summary: This study used a Mendelian randomization approach to investigate the relationship between reproductive aging and coronary heart disease (CHD) risk. The results showed no causal association between genetically determined reproductive aging and CHD risk in women or men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Hematology
Carolina E. Touw, Banne Nemeth, Araci M. R. Rondon, Raymond A. van Adrichem, Ton Lisman, Henri H. Versteeg, Inger B. Schipper, Rob G. H. H. Nelissen, Mettine H. A. Bos, Suzanne C. Cannegieter
Summary: This study aimed to investigate the effects of lower-leg injury and knee arthroscopy on coagulation. The results showed that lower-leg trauma is associated with increased procoagulant factor levels, while all parameters decreased after knee arthroscopy. This suggests that different pathways may be involved in the development of venous thromboembolism in these two situations.
Article
Respiratory System
Inge A. H. van den Berk, Maadrika M. N. P. Kanglie, Tjitske S. R. van Engelen, Josje Altenburg, Jouke T. Annema, Ludo F. M. Beenen, Bart Boerrigter, Marije K. Bomers, Paul Bresser, Elvin Eryigit, Maarten Groenink, Suzanne M. R. Hochheimer, Frits Holleman, Jos A. J. Kooter, Ramon B. van Loon, Mitran Keijzers, Ivo van der Lee, Paul Luijendijk, Lilian J. Meijboom, Saskia Middeldorp, Laura J. Schijf, Robin Soetekouw, Ralf W. Sprengers, Alexander D. Montauban van Swijndregt, Wouter de Monye, Milan L. Ridderikhof, Michiel M. Winter, Shandra Bipat, Marcel G. W. Dijkgraaf, Patrick M. M. Bossuyt, Jan M. Prins, Jaap Stoker
Summary: Replacing chest X-ray with ultra-low-dose chest CT (ULDCT) in the diagnostic work-up of patients suspected of non-traumatic pulmonary disease at the emergency department has similar effects on short-term functional health, hospital admissions, and length of stay. However, more incidental findings were found in the ULDCT group.
Editorial Material
Critical Care Medicine
Julie Helms, Saskia Middeldorp, Alex C. Spyropoulos
INTENSIVE CARE MEDICINE
(2023)
Article
Obstetrics & Gynecology
Marlise N. Gunning, Jacob P. Christ, Bas B. van Rijn, Maria P. H. Koster, Gouke J. Bonsel, Joop S. E. Laven, Marinus J. C. Eijkemans, Bart C. J. M. Fauser
Summary: This prospective cohort follow-up study aimed to identify patient features that predict the time to pregnancy leading to term live birth in infertile women diagnosed with polycystic ovary syndrome (PCOS). The results showed that race, smoking, BMI, insulin, total testosterone, and SHBG concentrations were associated with the chance of pregnancy.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Hematology
Fleur H. J. Kaptein, Milou A. M. Stals, Richard E. Evenhuis, Hans Gelderblom, Menno V. Huisman, Diederik S. A. Karis, Renee W. D. Noten, Suzanne C. Cannegieter, Frank M. Speetjens, Arjan J. Verschoor, Henri H. Versteeg, Michiel A. J. van de Sande, Frederikus A. Klok
Summary: Patients with osteosarcoma and Ewing sarcoma have a high risk of venous thromboembolism, especially in patients aged 18 and above. Catheter-related upper-extremity thrombosis is the most frequent presentation of venous thromboembolism. Major bleeding is common in both types of sarcoma.
THROMBOSIS RESEARCH
(2023)
Article
Hematology
Maaike Y. Kapteijn, Fleur H. J. Kaptein, Milou A. M. Stals, Eva E. Klaase, Ronald van Eijk, Dina Ruano, Sjoerd G. van Duinen, Suzanne C. Cannegieter, Martin J. B. Taphoorn, Linda Dirven, Johan A. F. Koekkoek, Frederikus A. Klok, Henri H. Versteeg, Jeroen T. Buijs, Ines Garcia-Ortiz
Summary: This study suggests a potential role for CDKN2A deletion in glioblastoma-related VTE, providing a potential predictive marker for this population.
THROMBOSIS RESEARCH
(2023)
Article
Medicine, General & Internal
Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. B. van Rijn, Henry Volzke, Charlotte A. M. Cecil, Janine F. F. Felix, Hans J. J. Grabe, Tilo Kircher, Karim Lekadir, Margreet ten Have, Esther Walton, Brenda W. J. H. Penninx
Summary: Childhood maltreatment is associated with depression, cardiometabolic disease, and their comorbidity in adulthood. A meta-analysis of 13 international observational studies found that adults with a history of childhood maltreatment have higher odds of depression, cardiometabolic disease, and comorbidity between both conditions. The associations remained significant after adjusting for lifestyle factors.
Article
Cardiac & Cardiovascular Systems
Jr Tuman J. Milling, Saskia Middeldorp, Lizhen Xu, Bruce Koch, Andrew Demchuk, John W. Eikelboom, Peter Verhamme, Alexander T. Cohen, Jan Beyer-Westendorf, C. Michael Gibson, Jose Lopez-Sendon, Mark Crowther, Ashkan Shoamanesh, Michiel Coppens, Jeannot Schmidt, Pierre Albaladejo, Stuart J. Connolly
Summary: This study evaluated the safety and efficacy of andexanet alfa in patients with major bleeding caused by factor Xa inhibitors. The results showed that the drug reduced anti-FXa activity and achieved good or excellent hemostatic efficacy in 80% of the patients.
Review
Cardiac & Cardiovascular Systems
Deborah N. Kalkman, Emile G. M. Couturier, Abdelhak El Bouziani, Jorge Dahdal, Jolien Neefs, Janneke Woudstra, Birgit Vogel, Daniela Trabattoni, Antoinette MaassenVanDenBrink, Roxana Mehran, Robbert J. de Winter, Yolande Appelman
Summary: Migraine is a chronic neurovascular disease with complex pathophysiology and multiple causes. Women are more likely to suffer from migraine, and it is the most disabling disease in women under 50 years old. Migraine with aura is associated with increased risk of cardiovascular diseases, such as stroke, atrial fibrillation, myocardial infarction, and cardiovascular death. Medications for migraine treatment may have potential risks for patients with cardiovascular disease. Further research is needed to understand the contraindications for newer treatments. This review discusses the pathophysiology, associations with cardiovascular diseases, current therapies, and future research directions.
EUROPEAN HEART JOURNAL
(2023)
Article
Obstetrics & Gynecology
C. H. Statema-Lohmeijer, R. Schats, B. Lissenberg-Witte, E. H. Kostelijk, C. B. Lambalk, C. G. Vergouw
Summary: Does a shorter interval between semen collection and IUI increase the chance of ongoing pregnancy? A long interval resulted in a significant improvement in cumulative ongoing pregnancies and a shorter time to pregnancy.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Siobhan Quenby, Katie Booth, Louise Hiller, Arri Coomarasamy, Paulien G. de Jong, Eva N. Hamulyak, Luuk J. Scheres, Thijs F. van Haaps, Lauren Ewington, Mariette Gojjin, Shreeya Tewary, Saskia Middeldorp
Summary: The use of low-molecular-weight heparin (LMWH) did not increase livebirth rates in women with recurrent pregnancy loss and inherited thrombophilia. Therefore, the use of LMWH is not recommended in these women.
Review
Clinical Neurology
Dimos D. Mitsikostas, Christian Waeber, Margarita Sanchez-del-Rio, Bianca Raffaelli, Hakan Ashina, Antoinette Maassen van den Brink, Anna Andreou, Patricia Pozo-Rosich, Alan Rapoport, Messoud Ashina, Michael A. Moskowitz
Summary: Migraine, a leading cause of disability in over one billion people globally, is underestimated even by those who suffer from it. Current treatments have limited efficacy and potential side effects, resulting in low treatment adherence. Recently, a new class of drugs called ditans, selective serotonin 5-HT1F receptor agonists, has been introduced to the international market. This article reviews preclinical studies from the late 1990s and recent clinical research that led to the development and approval of ditans for acute migraine treatment by the US FDA and the European Medicines Agency.
NATURE REVIEWS NEUROLOGY
(2023)
Review
Hematology
Dorien M. Salet, Siroon Bekkering, Saskia Middeldorp, Lucas L. van den Hoogen
Summary: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies (aPL) that cause thrombotic and obstetric complications. APS serves as a model for studying the mechanisms of thromboinflammation and the relationship between innate immune cells and thrombosis. Monocytes are activated by aPL to produce proinflammatory cytokines and tissue factor, while neutrophils generate neutrophil extracellular traps and interact with endothelial cells, leading to thrombosis. Platelets become procoagulant upon activation by aPL and increase interactions with leukocytes. Understanding these mechanisms provides potential therapeutic targets for APS and other thromboinflammatory diseases.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Obstetrics & Gynecology
Ruth Bender Atik, Ole Bjarne Christiansen, Janine Elson, Astrid Marie Kolte, Sheena Lewis, Saskia Middeldorp, Saria Mcheik, Braulio Peramo, Siobhan Quenby, Henriette Svarre Nielsen, Marie-Louise van der Hoorn, Nathalie Vermeulen, Mariette Goddijn
Summary: The guideline on the management of women with recurrent pregnancy loss (RPL) has been updated based on the best available evidence from 2017 to 2022. The updated guideline includes 11 updated recommendations and one new recommendation on adenomyosis investigation.
HUMAN REPRODUCTION OPEN
(2022)